Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.
Publication
, Journal Article
Pellmar, TC; Wilson, WA
Published in: Science (New York, N.Y.)
August 1977
In the neurons of Aplysia californica pentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action--reduction of transmitter-induced chloride conductances--is hypothesized.
Duke Scholars
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
August 1977
Volume
197
Issue
4306
Start / End Page
912 / 914
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Membranes
- Sodium
- Serotonin
- Potassium
- Pentylenetetrazole
- Mollusca
- Membrane Potentials
- General Science & Technology
- Electric Conductivity
Citation
APA
Chicago
ICMJE
MLA
NLM
Pellmar, T. C., & Wilson, W. A. (1977). Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. Science (New York, N.Y.), 197(4306), 912–914. https://doi.org/10.1126/science.887932
Pellmar, T. C., and W. A. Wilson. “Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.” Science (New York, N.Y.) 197, no. 4306 (August 1977): 912–14. https://doi.org/10.1126/science.887932.
Pellmar TC, Wilson WA. Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. Science (New York, NY). 1977 Aug;197(4306):912–4.
Pellmar, T. C., and W. A. Wilson. “Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.” Science (New York, N.Y.), vol. 197, no. 4306, Aug. 1977, pp. 912–14. Epmc, doi:10.1126/science.887932.
Pellmar TC, Wilson WA. Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. Science (New York, NY). 1977 Aug;197(4306):912–914.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
August 1977
Volume
197
Issue
4306
Start / End Page
912 / 914
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Membranes
- Sodium
- Serotonin
- Potassium
- Pentylenetetrazole
- Mollusca
- Membrane Potentials
- General Science & Technology
- Electric Conductivity