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Relationship between birth size and coronary heart disease in China.

Publication ,  Journal Article
Fan, Z; Zhang, Z-X; Li, Y; Wang, Z; Xu, T; Gong, X; Zhou, X; Wen, H; Zeng, Y
Published in: Ann Med
December 2010

BACKGROUND: Clinical epidemiological studies suggested a link between fetal growth conditions and later coronary heart disease (CHD) in adult life. However, no such studies have been conducted in a Chinese population. OBJECTIVES: We investigated the association between various birth characteristics and CHD occurrence in a Chinese cohort. DESIGN: Retrospective cohort study. SETTING: Peking Union Medical College Hospital, Beijing, China. PARTICIPANTS: A total of 2,033 subjects who were born at Peking Union Medical College Hospital between 1921 and 1954. MEASUREMENTS: Neonatal birth-weight, placental weight, length from crown to heel, head circumference, and biparietal and occipitofrontal diameters were routinely recorded at the time of birth. All participants were followed up between May 2002 and April 2004 for the occurrence of CHD. RESULTS: CHD was identified in 135 patients. The occurrence of CHD was inversely related to birth sizes, such as birth-weight, head circumference, placental weight (P < 0.05), but was not significantly related to birth length or ponderal index (birth-weight/birth length(3)). After multivariable logistic regression, the ratio of birth-weight to birth length was an independent predictor of CHD along with two other variables: obesity and age. LIMITATIONS: This was a single-center retrospective study. CONCLUSIONS: In China low birth size or birth disproportion, which is suggestive of fetal growth retardation, has an effect on CHD occurrence during adulthood. This suggests that environmental factors operate in both the prenatal and postnatal periods with regard to the development of CHD.

Duke Scholars

Published In

Ann Med

DOI

EISSN

1365-2060

Publication Date

December 2010

Volume

42

Issue

8

Start / End Page

596 / 602

Location

England

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Prevalence
  • Pregnancy
  • Placentation
  • Organ Size
  • Middle Aged
  • Male
  • Logistic Models
  • Infant, Newborn
 

Citation

APA
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ICMJE
MLA
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Fan, Z., Zhang, Z.-X., Li, Y., Wang, Z., Xu, T., Gong, X., … Zeng, Y. (2010). Relationship between birth size and coronary heart disease in China. Ann Med, 42(8), 596–602. https://doi.org/10.3109/07853890.2010.514283
Fan, Zhongjie, Zhen-Xin Zhang, Yinxiong Li, Zishi Wang, Tao Xu, Xiaomin Gong, Xioaling Zhou, Hongbo Wen, and Yi Zeng. “Relationship between birth size and coronary heart disease in China.Ann Med 42, no. 8 (December 2010): 596–602. https://doi.org/10.3109/07853890.2010.514283.
Fan Z, Zhang Z-X, Li Y, Wang Z, Xu T, Gong X, et al. Relationship between birth size and coronary heart disease in China. Ann Med. 2010 Dec;42(8):596–602.
Fan, Zhongjie, et al. “Relationship between birth size and coronary heart disease in China.Ann Med, vol. 42, no. 8, Dec. 2010, pp. 596–602. Pubmed, doi:10.3109/07853890.2010.514283.
Fan Z, Zhang Z-X, Li Y, Wang Z, Xu T, Gong X, Zhou X, Wen H, Zeng Y. Relationship between birth size and coronary heart disease in China. Ann Med. 2010 Dec;42(8):596–602.

Published In

Ann Med

DOI

EISSN

1365-2060

Publication Date

December 2010

Volume

42

Issue

8

Start / End Page

596 / 602

Location

England

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Prevalence
  • Pregnancy
  • Placentation
  • Organ Size
  • Middle Aged
  • Male
  • Logistic Models
  • Infant, Newborn