Involvement of the mt1 melatonin receptor in human breast cancer.
Publication
, Journal Article
Ram, PT; Dai, J; Yuan, L; Dong, C; Kiefer, TL; Lai, L; Hill, SM
Published in: Cancer Lett
May 28, 2002
Two putative melatonin receptors have been described including the cell surface G-protein-linked receptors, mt1 and MT2, and the nuclear retinoic orphan receptor alpha (RORalpha). The mt1 receptor, but not the MT2 receptor, is expressed in human breast tumor cell lines, and melatonin-induced growth suppression can be mimicked by the mt1 and MT2 agonist, AMMTC, and blocked by the antagonist, CBPT. RORalpha receptors are also expressed in MCF-7 breast cancer cells and the putative RORalpha agonist CPG-52608 inhibits MCF-7 cell growth but with a very different dose-response than melatonin. Finally, melatonin and AMMTC, but not CPG-52608, can repress RORalpha transcriptional activity in MCF-7 cells.
Duke Scholars
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
May 28, 2002
Volume
179
Issue
2
Start / End Page
141 / 150
Location
Ireland
Related Subject Headings
- Tumor Cells, Cultured
- Trans-Activators
- Thiosemicarbazones
- Thiazoles
- Reverse Transcriptase Polymerase Chain Reaction
- Recombinant Fusion Proteins
- Receptors, Melatonin
- Receptors, Cytoplasmic and Nuclear
- Receptors, Cell Surface
- RNA, Messenger
Citation
APA
Chicago
ICMJE
MLA
NLM
Ram, P. T., Dai, J., Yuan, L., Dong, C., Kiefer, T. L., Lai, L., & Hill, S. M. (2002). Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett, 179(2), 141–150. https://doi.org/10.1016/s0304-3835(01)00873-4
Ram, P. T., J. Dai, L. Yuan, C. Dong, T. L. Kiefer, L. Lai, and S. M. Hill. “Involvement of the mt1 melatonin receptor in human breast cancer.” Cancer Lett 179, no. 2 (May 28, 2002): 141–50. https://doi.org/10.1016/s0304-3835(01)00873-4.
Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, et al. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett. 2002 May 28;179(2):141–50.
Ram, P. T., et al. “Involvement of the mt1 melatonin receptor in human breast cancer.” Cancer Lett, vol. 179, no. 2, May 2002, pp. 141–50. Pubmed, doi:10.1016/s0304-3835(01)00873-4.
Ram PT, Dai J, Yuan L, Dong C, Kiefer TL, Lai L, Hill SM. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett. 2002 May 28;179(2):141–150.
Published In
Cancer Lett
DOI
ISSN
0304-3835
Publication Date
May 28, 2002
Volume
179
Issue
2
Start / End Page
141 / 150
Location
Ireland
Related Subject Headings
- Tumor Cells, Cultured
- Trans-Activators
- Thiosemicarbazones
- Thiazoles
- Reverse Transcriptase Polymerase Chain Reaction
- Recombinant Fusion Proteins
- Receptors, Melatonin
- Receptors, Cytoplasmic and Nuclear
- Receptors, Cell Surface
- RNA, Messenger