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The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women.

Publication ,  Journal Article
Kornstein, SG; Young, EA; Harvey, AT; Wisniewski, SR; Barkin, JL; Thase, ME; Trivedi, MH; Nierenberg, AA; Rush, AJ
Published in: Menopause
July 2010

OBJECTIVE: The purpose of this study was to determine whether there are differences in depression characteristics among premenopausal, perimenopausal, and postmenopausal women with major depressive disorder. This study also evaluated these differences between postmenopausal women with major depressive disorder who are taking and not taking hormone therapy. METHODS: Analyses conducted with data from the Sequenced Treatment Alternatives to Relieve Depression study focused on female outpatients with nonpsychotic major depressive disorder seeking treatment in 41 primary or psychiatric care settings across the United States. Baseline demographic and clinical characteristics were compared among women not taking hormone therapy who were premenopausal (n = 950), perimenopausal (n = 380), or postmenopausal (n = 562). These comparisons were also made between postmenopausal women (n = 768) taking (n = 171) or not taking (n = 562) hormone therapy. RESULTS: After adjusting for sociodemographic and clinical baseline differences, premenopausal women were more likely to present with irritability than were either perimenopausal or postmenopausal women and were more likely to have decreased appetite and less likely to have early-morning insomnia than were perimenopausal women. Postmenopausal women were more likely to have suicidal ideation and poorer physical functioning than were either of the other groups and were more likely to have sympathetic arousal and gastrointestinal symptoms than were premenopausal women. After adjusting for baseline differences, postmenopausal women taking hormone therapy had better physical functioning, fewer melancholic features, less sympathetic arousal, and more lack of involvement in activities than did women not taking hormone therapy. CONCLUSIONS: Menopause status and postmenopausal use of hormone therapy may influence the clinical presentation of major depressive episodes in women.

Duke Scholars

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

July 2010

Volume

17

Issue

4

Start / End Page

828 / 839

Location

United States

Related Subject Headings

  • Suicide
  • Sleep Initiation and Maintenance Disorders
  • Severity of Illness Index
  • Prospective Studies
  • Postmenopause
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Irritable Mood
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kornstein, S. G., Young, E. A., Harvey, A. T., Wisniewski, S. R., Barkin, J. L., Thase, M. E., … Rush, A. J. (2010). The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women. Menopause, 17(4), 828–839. https://doi.org/10.1097/gme.0b013e3181d770a8
Kornstein, Susan G., Elizabeth A. Young, Annie T. Harvey, Stephen R. Wisniewski, Jennifer L. Barkin, Michael E. Thase, Madhukar H. Trivedi, Andrew A. Nierenberg, and A John Rush. “The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women.Menopause 17, no. 4 (July 2010): 828–39. https://doi.org/10.1097/gme.0b013e3181d770a8.
Kornstein SG, Young EA, Harvey AT, Wisniewski SR, Barkin JL, Thase ME, et al. The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women. Menopause. 2010 Jul;17(4):828–39.
Kornstein, Susan G., et al. “The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women.Menopause, vol. 17, no. 4, July 2010, pp. 828–39. Pubmed, doi:10.1097/gme.0b013e3181d770a8.
Kornstein SG, Young EA, Harvey AT, Wisniewski SR, Barkin JL, Thase ME, Trivedi MH, Nierenberg AA, Rush AJ. The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women. Menopause. 2010 Jul;17(4):828–839.

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

July 2010

Volume

17

Issue

4

Start / End Page

828 / 839

Location

United States

Related Subject Headings

  • Suicide
  • Sleep Initiation and Maintenance Disorders
  • Severity of Illness Index
  • Prospective Studies
  • Postmenopause
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Irritable Mood
  • Humans