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CD19 expression in B cells regulates atopic dermatitis in a mouse model.

Publication ,  Journal Article
Yanaba, K; Kamata, M; Asano, Y; Tada, Y; Sugaya, M; Kadono, T; Tedder, TF; Sato, S
Published in: The American journal of pathology
June 2013

Atopic dermatitis is an inflammatory cutaneous disorder characterized by dry skin and relapsing eczematous skin lesions. Besides antibody production, the contribution of B cells to the pathogenesis of atopic dermatitis is unclear. In mice, repeated epicutaneous sensitization with ovalbumin induces inflamed skin lesions resembling human atopic dermatitis and therefore serves as an experimental model for this condition. To investigate the role of B cells in a murine model of atopic dermatitis, ovalbumin-sensitized allergic skin inflammation was assessed in mice lacking CD19. In ovalbumin-sensitized skin from CD19-deficient mice, the number of eosinophils and CD4(+) T cells was reduced, and both epidermal and dermal thickening were decreased. Following in vitro stimulation with ovalbumin, CD19 deficiency significantly reduced the proliferation of CD4(+), but not CD8(+), T cells from spleen and draining lymph nodes. Furthermore, splenocytes and draining lymph node cells from ovalbumin-sensitized CD19-deficient mice secreted significantly less IL-4, IL-13, and IL-17 than ovalbumin-sensitized wild-type mice. These results suggest that CD19 expression in B cells plays a critical role in antigen-specific CD4(+) T-cell proliferation and T helper 2 and 17 responses in a murine model of atopic dermatitis. Furthermore, the present findings may have implications for B-cell-targeted therapies for the treatment of atopic dermatitis.

Published In

The American journal of pathology

DOI

EISSN

1525-2191

ISSN

0002-9440

Publication Date

June 2013

Volume

182

Issue

6

Start / End Page

2214 / 2222

Related Subject Headings

  • Th2 Cells
  • Th17 Cells
  • Spleen
  • Pathology
  • Ovalbumin
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Subsets
  • Lymph Nodes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yanaba, K., Kamata, M., Asano, Y., Tada, Y., Sugaya, M., Kadono, T., … Sato, S. (2013). CD19 expression in B cells regulates atopic dermatitis in a mouse model. The American Journal of Pathology, 182(6), 2214–2222. https://doi.org/10.1016/j.ajpath.2013.02.042
Yanaba, Koichi, Masahiro Kamata, Yoshihide Asano, Yayoi Tada, Makoto Sugaya, Takafumi Kadono, Thomas F. Tedder, and Shinichi Sato. “CD19 expression in B cells regulates atopic dermatitis in a mouse model.The American Journal of Pathology 182, no. 6 (June 2013): 2214–22. https://doi.org/10.1016/j.ajpath.2013.02.042.
Yanaba K, Kamata M, Asano Y, Tada Y, Sugaya M, Kadono T, et al. CD19 expression in B cells regulates atopic dermatitis in a mouse model. The American journal of pathology. 2013 Jun;182(6):2214–22.
Yanaba, Koichi, et al. “CD19 expression in B cells regulates atopic dermatitis in a mouse model.The American Journal of Pathology, vol. 182, no. 6, June 2013, pp. 2214–22. Epmc, doi:10.1016/j.ajpath.2013.02.042.
Yanaba K, Kamata M, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder TF, Sato S. CD19 expression in B cells regulates atopic dermatitis in a mouse model. The American journal of pathology. 2013 Jun;182(6):2214–2222.
Journal cover image

Published In

The American journal of pathology

DOI

EISSN

1525-2191

ISSN

0002-9440

Publication Date

June 2013

Volume

182

Issue

6

Start / End Page

2214 / 2222

Related Subject Headings

  • Th2 Cells
  • Th17 Cells
  • Spleen
  • Pathology
  • Ovalbumin
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Subsets
  • Lymph Nodes