Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.
Publication
, Journal Article
Raskatov, JA; Hargrove, AE; So, AY; Dervan, PB
Published in: Journal of the American Chemical Society
May 2012
The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5'-WGGWWW-3' displayed distinct pharmacokinetic properties. Furthermore, the hairpin 1 and cycle 2 exhibited vastly different animal toxicities. These data provide a foundation for design of DNA binding Py-Im polyamides to be tested in vivo.
Duke Scholars
Published In
Journal of the American Chemical Society
DOI
EISSN
1520-5126
ISSN
0002-7863
Publication Date
May 2012
Volume
134
Issue
18
Start / End Page
7995 / 7999
Related Subject Headings
- Pyrroles
- Nylons
- Mice, Inbred C57BL
- Mice
- Imidazoles
- General Chemistry
- Body Weight
- Animals
- 40 Engineering
- 34 Chemical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Raskatov, J. A., Hargrove, A. E., So, A. Y., & Dervan, P. B. (2012). Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. Journal of the American Chemical Society, 134(18), 7995–7999. https://doi.org/10.1021/ja302588v
Raskatov, Jevgenij A., Amanda E. Hargrove, Alex Y. So, and Peter B. Dervan. “Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.” Journal of the American Chemical Society 134, no. 18 (May 2012): 7995–99. https://doi.org/10.1021/ja302588v.
Raskatov JA, Hargrove AE, So AY, Dervan PB. Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. Journal of the American Chemical Society. 2012 May;134(18):7995–9.
Raskatov, Jevgenij A., et al. “Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.” Journal of the American Chemical Society, vol. 134, no. 18, May 2012, pp. 7995–99. Epmc, doi:10.1021/ja302588v.
Raskatov JA, Hargrove AE, So AY, Dervan PB. Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. Journal of the American Chemical Society. 2012 May;134(18):7995–7999.
Published In
Journal of the American Chemical Society
DOI
EISSN
1520-5126
ISSN
0002-7863
Publication Date
May 2012
Volume
134
Issue
18
Start / End Page
7995 / 7999
Related Subject Headings
- Pyrroles
- Nylons
- Mice, Inbred C57BL
- Mice
- Imidazoles
- General Chemistry
- Body Weight
- Animals
- 40 Engineering
- 34 Chemical sciences