Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.
Publication
, Journal Article
Fang, Y; Chen, X; Bajpai, M; Verma, A; Das, KM; Souza, RF; Garman, KS; Donohoe, CL; O'Farrell, NJ; Reynolds, JV; Dvorak, K
Published in: Ann N Y Acad Sci
October 2013
This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.
Duke Scholars
Published In
Ann N Y Acad Sci
DOI
EISSN
1749-6632
Publication Date
October 2013
Volume
1300
Start / End Page
187 / 199
Location
United States
Related Subject Headings
- Humans
- General Science & Technology
- Esophageal Neoplasms
- Disease Models, Animal
- DNA Methylation
- Cell Transformation, Neoplastic
- Biomarkers, Tumor
- Barrett Esophagus
- Animals
- Adenocarcinoma
Citation
APA
Chicago
ICMJE
MLA
NLM
Fang, Y., Chen, X., Bajpai, M., Verma, A., Das, K. M., Souza, R. F., … Dvorak, K. (2013). Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Ann N Y Acad Sci, 1300, 187–199. https://doi.org/10.1111/nyas.12249
Fang, Yu, Xiaoxin Chen, Manisha Bajpai, Amit Verma, Kiron M. Das, Rhonda F. Souza, Katherine S. Garman, et al. “Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.” Ann N Y Acad Sci 1300 (October 2013): 187–99. https://doi.org/10.1111/nyas.12249.
Fang Y, Chen X, Bajpai M, Verma A, Das KM, Souza RF, et al. Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Ann N Y Acad Sci. 2013 Oct;1300:187–99.
Fang, Yu, et al. “Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.” Ann N Y Acad Sci, vol. 1300, Oct. 2013, pp. 187–99. Pubmed, doi:10.1111/nyas.12249.
Fang Y, Chen X, Bajpai M, Verma A, Das KM, Souza RF, Garman KS, Donohoe CL, O’Farrell NJ, Reynolds JV, Dvorak K. Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Ann N Y Acad Sci. 2013 Oct;1300:187–199.
Published In
Ann N Y Acad Sci
DOI
EISSN
1749-6632
Publication Date
October 2013
Volume
1300
Start / End Page
187 / 199
Location
United States
Related Subject Headings
- Humans
- General Science & Technology
- Esophageal Neoplasms
- Disease Models, Animal
- DNA Methylation
- Cell Transformation, Neoplastic
- Biomarkers, Tumor
- Barrett Esophagus
- Animals
- Adenocarcinoma