Keenan, E. K., A. Bareja, Y. Lam, P. A. Grimsrud, and M. D. Hirschey. “Cysteine S-acetylation is a widespread post-translational modification on metabolic proteins (Accepted).” Npj Metabolic Health and Disease 3, no. 1 (December 1, 2025). https://doi.org/10.1038/s44324-025-00081-2.

McCain, Richard S., Gerardo G. Piroli, Holland H. Smith, Aman S. Sumal, Paul A. Grimsrud, William E. Cotham, Michael D. Walla, and Norma Frizzell. “Region-Specific Quantification of 2-Hydroxyglutarate Enantiomers in Murine Brain during Mitochondrial Complex I Deficiency.” ACS Chem Neurosci 16, no. 21 (November 5, 2025): 4172–79. https://doi.org/10.1021/acschemneuro.5c00628.

Cui, Canqi, Danielle C. Leander, Sarah M. Gray, Kimberley El, Alex Chen, Paul A. Grimsrud, Jessica O. Becker, et al. “α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion.” Sci Adv 11, no. 38 (September 19, 2025): eady8048. https://doi.org/10.1126/sciadv.ady8048.

Keenan, E Keith, Akshay Bareja, Yannie Lam, Paul A. Grimsrud, and Matthew D. Hirschey. “Cysteine S-acetylation is a post-translational modification involved in metabolic regulation.,” May 21, 2024. https://doi.org/10.1101/2024.05.21.595030.

Williams, Ashley S., Scott B. Crown, Scott P. Lyons, Timothy R. Koves, Rebecca J. Wilson, Jordan M. Johnson, Dorothy H. Slentz, et al. “Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding.” Cell Metab 36, no. 2 (February 6, 2024): 422-437.e8. https://doi.org/10.1016/j.cmet.2024.01.007.

Koves, Timothy R., Guo-Fang Zhang, Michael T. Davidson, Alec B. Chaves, Scott B. Crown, Jordan M. Johnson, Dorothy H. Slentz, Paul A. Grimsrud, and Deborah M. Muoio. “Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles.” Cell Metab 35, no. 6 (June 6, 2023): 1038-1056.e8. https://doi.org/10.1016/j.cmet.2023.03.016.

Sargsyan, Ashot, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, et al. “HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.” JCI Insight 8, no. 1 (January 10, 2023). https://doi.org/10.1172/jci.insight.153740.

Lyons, Scott P., Rebecca J. Wilson, Deborah M. Muoio, and Paul A. Grimsrud. “Proteomics and phosphoproteomics datasets of a muscle-specific STIM1 loss-of-function mouse model.” Data Brief 42 (June 2022): 108051. https://doi.org/10.1016/j.dib.2022.108051.

Muoio, Deborah M., Ashley S. Williams, and Paul A. Grimsrud. “Mitochondrial lysine acylation and cardiometabolic stress: Truth or consequence?” Curr Opin Physiol 27 (June 2022). https://doi.org/10.1016/j.cophys.2022.100551.

Trub, Alec G., Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J Will Thompson, Olga R. Ilkayeva, et al. “Statin therapy inhibits fatty acid synthase via dynamic protein modifications.” Nat Commun 13, no. 1 (May 10, 2022): 2542. https://doi.org/10.1038/s41467-022-30060-w.

Bhatt, Dhaval P., C Allie Mills, Kristin A. Anderson, Bárbara J. Henriques, Tânia G. Lucas, Sara Francisco, Juan Liu, et al. “Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.” J Biol Chem 298, no. 4 (April 2022): 101723. https://doi.org/10.1016/j.jbc.2022.101723.

Wilson, Rebecca J., Scott P. Lyons, Timothy R. Koves, Victoria G. Bryson, Hengtao Zhang, TianYu Li, Scott B. Crown, et al. “Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass.” Mol Metab 57 (March 2022): 101429. https://doi.org/10.1016/j.molmet.2021.101429.

Williams, Ashley S., Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, and Deborah M. Muoio. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.” IScience 25, no. 1 (January 21, 2022): 103635. https://doi.org/10.1016/j.isci.2021.103635.

Bareja, Akshay, James A. Draper, Lauren H. Katz, David E. Lee, Paul A. Grimsrud, and James P. White. “Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle.” Mech Ageing Dev 195 (April 2021): 111443. https://doi.org/10.1016/j.mad.2021.111443.

Mills, Christine A., Xianxi Wang, Dhaval P. Bhatt, Paul A. Grimsrud, Jacob Peter Matson, Debojyoti Lahiri, Daniel J. Burke, Jeanette Gowen Cook, Matthew D. Hirschey, and Michael J. Emanuele. “Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.” Mol Cell Biol 41, no. 2 (January 25, 2021). https://doi.org/10.1128/MCB.00269-20.

Davidson, Michael T., Paul A. Grimsrud, Ling Lai, James A. Draper, Kelsey H. Fisher-Wellman, Tara M. Narowski, Dennis M. Abraham, Timothy R. Koves, Daniel P. Kelly, and Deborah M. Muoio. “Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure.” Circ Res 127, no. 8 (September 25, 2020): 1094–1108. https://doi.org/10.1161/CIRCRESAHA.120.317293.

Williams, Ashley S., Timothy R. Koves, Michael T. Davidson, Scott B. Crown, Kelsey H. Fisher-Wellman, Maria J. Torres, James A. Draper, et al. “Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.” Cell Metab 31, no. 1 (January 7, 2020): 131-147.e11. https://doi.org/10.1016/j.cmet.2019.11.003.

Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.

Hershberger, Kathleen A., Dennis M. Abraham, Juan Liu, Jason W. Locasale, Paul A. Grimsrud, and Matthew D. Hirschey. “Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.” J Biol Chem 293, no. 27 (July 6, 2018): 10630–45. https://doi.org/10.1074/jbc.RA118.002187.

Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.

WHITE, PHILLIP J., ROBERT W. MCGARRAH, PAUL A. GRIMSRUD, W. E. N. -. H. S. U. A. N. YANG, G. U. O. -. F. A. N. G. ZHANG, JONATHAN M. HALDEMAN, M. I. C. H. E. L. L. E. ARLOTTO, et al. “Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase.” In Diabetes, Vol. 67. American Diabetes Association, 2018. https://doi.org/10.2337/db18-1874-p.

White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

Martin, Angelical S., Dennis M. Abraham, Kathleen A. Hershberger, Dhaval P. Bhatt, Lan Mao, Huaxia Cui, Juan Liu, et al. “Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.” JCI Insight 2, no. 14 (July 20, 2017). https://doi.org/10.1172/jci.insight.93885.

Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.

Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.

McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.

Williams, Ashley S., Paul A. Grimsrud, Dorothy H. Slentz, April H. Wittmann, Timothy R. Koves, William E. Kraus, and Deborah M. Muoio. “Regulation of Carnitine Acetyltransferase by Lysine Acetylation.” In DIABETES, 65:A15–A15. AMER DIABETES ASSOC, 2016.

Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.

Dingley, Stephen D., Erzsebet Polyak, Julian Ostrovsky, Satish Srinivasan, Icksoo Lee, Amy B. Rosenfeld, Mai Tsukikawa, et al. “Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.” J Mol Biol 426, no. 11 (May 29, 2014): 2199–2216. https://doi.org/10.1016/j.jmb.2014.02.009.

Still, Amelia J., Brendan J. Floyd, Alexander S. Hebert, Craig A. Bingman, Joshua J. Carson, Drew R. Gunderson, Brendan K. Dolan, et al. “Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.” J Biol Chem 288, no. 36 (September 6, 2013): 26209–19. https://doi.org/10.1074/jbc.M113.483396.

Grimsrud, Paul A., Joshua J. Carson, Alex S. Hebert, Shane L. Hubler, Natalie M. Niemi, Derek J. Bailey, Adam Jochem, et al. “A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.” Cell Metab 16, no. 5 (November 7, 2012): 672–83. https://doi.org/10.1016/j.cmet.2012.10.004.

Volkening, Jeremy D., Derek J. Bailey, Christopher M. Rose, Paul A. Grimsrud, Maegen Howes-Podoll, Muthusubramanian Venkateshwaran, Michael S. Westphall, Jean-Michel Ané, Joshua J. Coon, and Michael R. Sussman. “A proteogenomic survey of the Medicago truncatula genome.” Mol Cell Proteomics 11, no. 10 (October 2012): 933–44. https://doi.org/10.1074/mcp.M112.019471.

Rose, Christopher M., Muthusubramanian Venkateshwaran, Jeremy D. Volkening, Paul A. Grimsrud, Junko Maeda, Derek J. Bailey, Kwanghyun Park, et al. “Rapid phosphoproteomic and transcriptomic changes in the rhizobia-legume symbiosis.” Mol Cell Proteomics 11, no. 9 (September 2012): 724–44. https://doi.org/10.1074/mcp.M112.019208.

Rose, Christopher M., Muthusubramanian Venkateshwaran, Paul A. Grimsrud, Michael S. Westphall, Michael R. Sussman, Joshua J. Coon, and Jean-Michel Ané. “Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data.” Front Plant Sci 3 (2012): 122. https://doi.org/10.3389/fpls.2012.00122.

Jayaraman, Dhileepkumar, Kari L. Forshey, Paul A. Grimsrud, and Jean-Michel Ané. “Leveraging proteomics to understand plant-microbe interactions.” Front Plant Sci 3 (2012): 44. https://doi.org/10.3389/fpls.2012.00044.

Hellberg, Kristina, Paul A. Grimsrud, Andrew C. Kruse, Leonard J. Banaszak, Douglas H. Ohlendorf, and David A. Bernlohr. “X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal.” Protein Sci 19, no. 8 (August 2010): 1480–89. https://doi.org/10.1002/pro.427.

Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.

Grimsrud, Paul A., Danielle L. Swaney, Craig D. Wenger, Nicole A. Beauchene, and Joshua J. Coon. “Phosphoproteomics for the masses.” ACS Chem Biol 5, no. 1 (January 15, 2010): 105–19. https://doi.org/10.1021/cb900277e.

Grimsrud, Paul A., Désirée den Os, Craig D. Wenger, Danielle L. Swaney, Daniel Schwartz, Michael R. Sussman, Jean-Michel Ané, and Joshua J. Coon. “Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes.” Plant Physiol 152, no. 1 (January 2010): 19–28. https://doi.org/10.1104/pp.109.149625.

Grimsrud, Paul A., Hongwei Xie, Timothy J. Griffin, and David A. Bernlohr. “Oxidative stress and covalent modification of protein with bioactive aldehydes.” J Biol Chem 283, no. 32 (August 8, 2008): 21837–41. https://doi.org/10.1074/jbc.R700019200.

Grimsrud, Paul A., Matthew J. Picklo, Timothy J. Griffin, and David A. Bernlohr. “Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.” Mol Cell Proteomics 6, no. 4 (April 2007): 624–37. https://doi.org/10.1074/mcp.M600120-MCP200.

Pearson, Arwen R., Teresa De La Mora-Rey, M Elizabeth Graichen, Yongting Wang, Limei H. Jones, Sudha Marimanikkupam, Sean A. Agger, Paul A. Grimsrud, Victor L. Davidson, and Carrie M. Wilmot. “Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation.” Biochemistry 43, no. 18 (May 11, 2004): 5494–5502. https://doi.org/10.1021/bi049863l.