White, Phillip J., Nicolai J. Wewer Albrechtsen, and Jonathan E. Campbell. “Islet hormones at the intersection of glucose and amino acid metabolism.” Nat Rev Endocrinol, March 7, 2025. https://doi.org/10.1038/s41574-025-01100-4.

Shilleh, Ali H., Katrina Viloria, Johannes Broichhagen, Jonathan E. Campbell, and David J. Hodson. “GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells.” Peptides 175 (May 2024): 171179. https://doi.org/10.1016/j.peptides.2024.171179.

Campbell, Jonathan E., Timo D. Müller, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, and David A. D’Alessio. “GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications.” Cell Metab 35, no. 9 (September 5, 2023): 1519–29. https://doi.org/10.1016/j.cmet.2023.07.010.

Le, Thao D. V., Payam Fathi, Amanda B. Watters, Blair J. Ellis, Gai-Linn K. Besing, Nadejda Bozadjieva-Kramer, Misty B. Perez, et al. “Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets.” Mol Metab 72 (June 2023): 101718. https://doi.org/10.1016/j.molmet.2023.101718.

El, Kimberley, Jonathan D. Douros, Francis S. Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B. Wainscott, et al. “The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.” Nat Metab 5, no. 6 (June 2023): 945–54. https://doi.org/10.1038/s42255-023-00811-0.

Capozzi, Megan E., David A. D’Alessio, and Jonathan E. Campbell. “The past, present, and future physiology and pharmacology of glucagon.” Cell Metab 34, no. 11 (November 1, 2022): 1654–74. https://doi.org/10.1016/j.cmet.2022.10.001.

Campbell, Jonathan E. “Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.” Mol Metab 46 (April 2021): 101139. https://doi.org/10.1016/j.molmet.2020.101139.

El, K., S. M. Gray, M. E. Capozzi, E. R. Knuth, E. Jin, B. Svendsen, A. Clifford, et al. “GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.” Sci Adv 7, no. 11 (March 2021). https://doi.org/10.1126/sciadv.abf1948.

Huynh, Frank K., Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M. S. Llaguno, Thi-Tina N. Nguyen, et al. “β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.” Am J Physiol Endocrinol Metab 319, no. 4 (October 1, 2020): E805–13. https://doi.org/10.1152/ajpendo.00170.2020.

Willard, Francis S., Jonathan D. Douros, Maria Bn Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, et al. “Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.” JCI Insight 5, no. 17 (September 3, 2020). https://doi.org/10.1172/jci.insight.140532.

Capozzi, Megan E., and Jonathan E. Campbell. “Could micro changes in β-cells enable major changes in metabolism?” EBioMedicine 59 (September 2020): 102936. https://doi.org/10.1016/j.ebiom.2020.102936.

Gray, Sarah M., Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, et al. “Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.” J Biol Chem 295, no. 33 (August 14, 2020): 11529–41. https://doi.org/10.1074/jbc.RA120.014368.

Gilroy, C. A., M. E. Capozzi, A. K. Varanko, J. Tong, D. A. D’Alessio, J. E. Campbell, and A. Chilkoti. “Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia.” Sci Adv 6, no. 35 (August 2020): eaaz9890. https://doi.org/10.1126/sciadv.aaz9890.

Al Batran, Rami, Keshav Gopal, Megan E. Capozzi, Jadin J. Chahade, Bruno Saleme, S Amirhossein Tabatabaei-Dakhili, Amanda A. Greenwell, et al. “Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.” Cell Metab 31, no. 5 (May 5, 2020): 909-919.e8. https://doi.org/10.1016/j.cmet.2020.03.017.

Capozzi, Megan E., Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, et al. “The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.” Diabetes 69, no. 5 (May 2020): 882–92. https://doi.org/10.2337/db19-1216.

Finan, Brian, Megan E. Capozzi, and Jonathan E. Campbell. “Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.” Diabetes 69, no. 4 (April 2020): 532–41. https://doi.org/10.2337/dbi19-0004.

El, Kimberley, and Jonathan E. Campbell. “The role of GIP in α-cells and glucagon secretion.” Peptides 125 (March 2020): 170213. https://doi.org/10.1016/j.peptides.2019.170213.

Eshreif, Amina, Rami Al Batran, K Lockhart Jamieson, Ahmed M. Darwesh, Keshav Gopal, Amanda A. Greenwell, Igor Zlobine, et al. “l-Citrulline supplementation improves glucose and exercise tolerance in obese male mice.” Exp Physiol 105, no. 2 (February 2020): 270–81. https://doi.org/10.1113/EP088109.

Svendsen, Berit, Megan E. Capozzi, Jingjing Nui, Sarah A. Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A. D’Alessio, and Jonathan E. Campbell. “Pharmacological antagonism of the incretin system protects against diet-induced obesity.” Mol Metab 32 (February 2020): 44–55. https://doi.org/10.1016/j.molmet.2019.11.018.

Douros, Jonathan D., Jingjing Niu, Sophia Sdao, Trillian Gregg, Matthew J. Merrins, Jonathan Campbell, Jenny Tong, and David D’Alessio. “Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control.” Mol Metab 28 (October 2019): 144–50. https://doi.org/10.1016/j.molmet.2019.07.003.

Beaudry, Jacqueline L., Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, and Daniel J. Drucker. “Physiological roles of the GIP receptor in murine brown adipose tissue.” Mol Metab 28 (October 2019): 14–25. https://doi.org/10.1016/j.molmet.2019.08.006.

Herman, Mark A., Jonathan E. Campbell, and David A. D’Alessio. “One small step for mice, one giant leap for GWAS?” J Clin Invest 129, no. 10 (October 1, 2019): 4083–85. https://doi.org/10.1172/JCI131650.

Gray, Sarah M., Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E. Campbell, David A. D’Alessio, and Jenny Tong. “Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.” Diabetes 68, no. 9 (September 2019): 1795–1805. https://doi.org/10.2337/db19-0079.

Capozzi, Megan E., Jacob B. Wait, Jepchumba Koech, Andrew N. Gordon, Reilly W. Coch, Berit Svendsen, Brian Finan, David A. D’Alessio, and Jonathan E. Campbell. “Glucagon lowers glycemia when β-cells are active.” JCI Insight 5, no. 16 (July 23, 2019). https://doi.org/10.1172/jci.insight.129954.

Douros, Jonathan D., and Jonathan E. Campbell. “Reg3 Proteins as Gut Hormones? Don't Be Hasty.” Endocrinology 160, no. 7 (July 1, 2019): 1677–78. https://doi.org/10.1210/en.2019-00356.

Beaudry, Jacqueline L., Kiran Deep Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Jennifer H. Stern, Jonathan E. Campbell, Phillip E. Scherer, and Daniel J. Drucker. “The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.” Mol Metab 22 (April 2019): 37–48. https://doi.org/10.1016/j.molmet.2019.01.011.

Douros, Jonathan D., Jingjing Niu, Sophia Sdao, Trillian Gregg, Kelsey Fisher-Wellman, Manish Bharadwaj, Anthony Molina, et al. “Sleeve gastrectomy rapidly enhances islet function independently of body weight.” JCI Insight 4, no. 6 (March 21, 2019). https://doi.org/10.1172/jci.insight.126688.

Capozzi, Megan E., Berit Svendsen, Sara E. Encisco, Sophie L. Lewandowski, Mackenzie D. Martin, Haopeng Lin, Justin L. Jaffe, et al. “β Cell tone is defined by proglucagon peptides through cAMP signaling.” JCI Insight 4, no. 5 (March 7, 2019). https://doi.org/10.1172/jci.insight.126742.

Varin, Elodie M., Erin E. Mulvihill, Jacqueline L. Beaudry, Gemma Pujadas, Shai Fuchs, Jean-François Tanti, Sofia Fazio, et al. “Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition.” Cell Metab 29, no. 2 (February 5, 2019): 320-334.e5. https://doi.org/10.1016/j.cmet.2018.10.001.

Capozzi, Megan E., Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, and Jonathan E. Campbell. “Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes.” Endocr Rev 39, no. 5 (October 1, 2018): 719–38. https://doi.org/10.1210/er.2018-00117.

Al Batran, Rami, Keshav Gopal, Mackenzie D. Martin, Kim L. Ho, Malak Almutairi, Hanin Aburasayn, Farah Eaton, Jonathan E. Campbell, and John R. Ussher. “Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.” Diabetologia 61, no. 8 (August 2018): 1849–55. https://doi.org/10.1007/s00125-018-4643-x.

Douros, Jonathan D., Alfor G. Lewis, Eric P. Smith, JingJing Niu, Megan Capozzi, April Wittmann, Jonathan Campbell, et al. “Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.” Diabetes 67, no. 8 (August 2018): 1504–11. https://doi.org/10.2337/db18-0081.

Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.

Ussher, John R., Jonathan E. Campbell, Erin E. Mulvihill, Laurie L. Baggio, Holly E. Bates, Brent A. McLean, Keshav Gopal, et al. “Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.” Cell Metab 27, no. 2 (February 6, 2018): 450-460.e6. https://doi.org/10.1016/j.cmet.2017.11.003.

Panaro, Brandon L., Grace B. Flock, Jonathan E. Campbell, Jacqueline L. Beaudry, Xiemin Cao, and Daniel J. Drucker. “β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.” Diabetes 66, no. 6 (June 2017): 1626–35. https://doi.org/10.2337/db17-0017.

Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.

Campbell, Jonathan E., and David A. D’Alessio. “DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.” J Clin Invest 127, no. 3 (March 1, 2017): 793–95. https://doi.org/10.1172/JCI92845.

Mulvihill, Erin E., Elodie M. Varin, Bojana Gladanac, Jonathan E. Campbell, John R. Ussher, Laurie L. Baggio, Bernardo Yusta, et al. “Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.” Cell Metab 25, no. 1 (January 10, 2017): 152–65. https://doi.org/10.1016/j.cmet.2016.10.007.

Mulvihill, Erin E., Elodie M. Varin, John R. Ussher, Jonathan E. Campbell, KW Annie Bang, Tahmid Abdullah, Laurie L. Baggio, and Daniel J. Drucker. “Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.” Diabetes 65, no. 3 (March 2016): 742–54. https://doi.org/10.2337/db15-1224.

Campbell, Jonathan E., John R. Ussher, Erin E. Mulvihill, Jelena Kolic, Laurie L. Baggio, Xiemen Cao, Yu Liu, et al. “TCF1 links GIPR signaling to the control of beta cell function and survival.” Nat Med 22, no. 1 (January 2016): 84–90. https://doi.org/10.1038/nm.3997.

Ussher, J. R., and J. E. Campbell. “Incretin-based therapies for the failing heart.” Cardiovascular Endocrinology 5, no. 3 (January 1, 2016): 86–92. https://doi.org/10.1097/XCE.0000000000000086.

Oropeza, Daniel, Nathalie Jouvet, Lionel Budry, Jonathan E. Campbell, Khalil Bouyakdan, Julie Lacombe, Gabrielle Perron, et al. “Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.” Diabetes 64, no. 11 (November 2015): 3798–3807. https://doi.org/10.2337/db15-0272.

Campbell, Jonathan E., and Daniel J. Drucker. “Islet α cells and glucagon--critical regulators of energy homeostasis.” Nat Rev Endocrinol 11, no. 6 (June 2015): 329–38. https://doi.org/10.1038/nrendo.2015.51.

Koehler, Jacqueline A., Laurie L. Baggio, Xiemin Cao, Tahmid Abdulla, Jonathan E. Campbell, Thomas Secher, Jacob Jelsing, Brett Larsen, and Daniel J. Drucker. “Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis.” Diabetes 64, no. 3 (March 2015): 1046–56. https://doi.org/10.2337/db14-0883.

Finan, Brian, Bin Yang, Nickki Ottaway, David L. Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, et al. “A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.” Nat Med 21, no. 1 (January 2015): 27–36. https://doi.org/10.1038/nm.3761.

Ussher, John R., Laurie L. Baggio, Jonathan E. Campbell, Erin E. Mulvihill, Minsuk Kim, M Golam Kabir, Xiemin Cao, et al. “Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection.” Mol Metab 3, no. 5 (August 2014): 507–17. https://doi.org/10.1016/j.molmet.2014.04.009.

Campbell, Jonathan E., and Daniel J. Drucker. “Pharmacology, physiology, and mechanisms of incretin hormone action.” Cell Metab 17, no. 6 (June 4, 2013): 819–37. https://doi.org/10.1016/j.cmet.2013.04.008.

Panjwani, Naim, Erin E. Mulvihill, Christine Longuet, Bernardo Yusta, Jonathan E. Campbell, Theodore J. Brown, Catherine Streutker, et al. “GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.” Endocrinology 154, no. 1 (January 2013): 127–39. https://doi.org/10.1210/en.2012-1937.

Shpilberg, Yaniv, Jacqueline L. Beaudry, Anna D’Souza, Jonathan E. Campbell, Ashley Peckett, and Michael C. Riddell. “A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.” Dis Model Mech 5, no. 5 (September 2012): 671–80. https://doi.org/10.1242/dmm.008912.

Bates, Holly E., Jonathan E. Campbell, John R. Ussher, Laurie L. Baggio, Adriano Maida, Yutaka Seino, and Daniel J. Drucker. “Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.” Diabetes 61, no. 1 (January 2012): 40–48. https://doi.org/10.2337/db11-1060.

Zargar, Sana, Tracy S. Moreira, Helena Samimi-Seisan, Senthure Jeganathan, Dhanshri Kakade, Nushaba Islam, Jonathan Campbell, and Olasunkanmi A. J. Adegoke. “Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats.” Am J Physiol Endocrinol Metab 300, no. 6 (June 2011): E986–92. https://doi.org/10.1152/ajpendo.00642.2010.

Peckett, Ashley Joelle, Jonathan E. Campbell, David C. Wright, and Michael C. Riddell. “Anti-lipolytic effects of glucocorticoids.” In FASEB JOURNAL, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.

Campbell, Jonathan E., Ashley J. Peckett, Anna M. D’souza, Thomas J. Hawke, and Michael C. Riddell. “Adipogenic and lipolytic effects of chronic glucocorticoid exposure.” Am J Physiol Cell Physiol 300, no. 1 (January 2011): C198–209. https://doi.org/10.1152/ajpcell.00045.2010.

Gordon, Carly S., Antonio S. Serino, Matthew P. Krause, Jonathan E. Campbell, Enzo Cafarelli, Olasunkanmi A. J. Adegoke, Thomas J. Hawke, and Michael C. Riddell. “Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?” PLoS One 5, no. 11 (November 17, 2010): e14032. https://doi.org/10.1371/journal.pone.0014032.

Campbell, Jonathan E., Michael A. Király, Daniel J. Atkinson, Anna M. D’souza, Mladen Vranic, and Michael C. Riddell. “Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats.” Am J Physiol Regul Integr Comp Physiol 299, no. 1 (July 2010): R168–76. https://doi.org/10.1152/ajpregu.00155.2010.

Király, Michael A., Jon Campbell, Edward Park, Holly E. Bates, Jessica T. Y. Yue, Venket Rao, Stephen G. Matthews, et al. “Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.” Am J Physiol Endocrinol Metab 298, no. 3 (March 2010): E671–82. https://doi.org/10.1152/ajpendo.90575.2008.

Campbell, Jonathan E., Sergiu Fediuc, Thomas J. Hawke, and Michael C. Riddell. “Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis.” Metabolism 58, no. 5 (May 2009): 651–60. https://doi.org/10.1016/j.metabol.2009.01.002.

Campbell, Jonathan E., Nasimeh Rakhshani, Sergiu Fediuc, Silvio Bruni, and Michael C. Riddell. “Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.” J Appl Physiol (1985) 106, no. 1 (January 2009): 66–72. https://doi.org/10.1152/japplphysiol.91128.2008.

Johnston, Adam P. W., Jonathan E. Campbell, Jeremy G. Found, Michael C. Riddell, and Thomas J. Hawke. “Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo.” Am J Physiol Cell Physiol 292, no. 3 (March 2007): C1033–40. https://doi.org/10.1152/ajpcell.00338.2006.

Iscoe, Katherine E., Jonathan E. Campbell, Veronica Jamnik, Bruce A. Perkins, and Michael C. Riddell. “Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system.” Diabetes Technol Ther 8, no. 6 (December 2006): 627–35. https://doi.org/10.1089/dia.2006.8.627.

Fediuc, Sergiu, Jonathan E. Campbell, and Michael C. Riddell. “Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats.” J Appl Physiol (1985) 100, no. 6 (June 2006): 1867–75. https://doi.org/10.1152/japplphysiol.01416.2005.

Coutinho, Agnes E., Jonathan E. Campbell, Sergiu Fediuc, and Michael C. Riddell. “Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster.” J Appl Physiol (1985) 100, no. 5 (May 2006): 1483–88. https://doi.org/10.1152/japplphysiol.01236.2005.

Coutinho, Agnes E., Sergiu Fediuc, Jonathan E. Campbell, and Michael C. Riddell. “Metabolic effects of voluntary wheel running in young and old Syrian golden hamsters.” Physiol Behav 87, no. 2 (February 28, 2006): 360–67. https://doi.org/10.1016/j.physbeh.2005.10.006.

Marra, Luciano E., Zhu X. Zhang, Betty Joe, Jon Campbell, Gary A. Levy, Josef Penninger, and Li Zhang. “IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.” J Immunol 172, no. 2 (January 15, 2004): 1028–35. https://doi.org/10.4049/jimmunol.172.2.1028.