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Liu, Yu, Alan Kuang, Octavious Talbot, James R. Bain, Michael J. Muehlbauer, M Geoffrey Hayes, Olga R. Ilkayeva, et al. “Metabolomic and genetic associations with insulin resistance in pregnancy.” Diabetologia 63, no. 9 (September 2020): 1783–95. https://doi.org/10.1007/s00125-020-05198-1.

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Yurdagul, Arif, Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga R. Ilkayeva, Lancia Darville, Gopi K. Kolluru, et al. “Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.” Cell Metab 31, no. 3 (March 3, 2020): 518-533.e10. https://doi.org/10.1016/j.cmet.2020.01.001.

Duan, Wei, Jonné Hicks, Michael A. Makara, Olga Ilkayeva, and Dennis M. Abraham. “TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.” Am J Physiol Heart Circ Physiol 318, no. 3 (March 1, 2020): H566–80. https://doi.org/10.1152/ajpheart.00739.2018.

McGarrah, Robert W., Guo-Fang Zhang, Bridgette A. Christopher, Yann Deleye, Jacquelyn M. Walejko, Stephani Page, Olga Ilkayeva, Phillip J. White, and Christopher B. Newgard. “Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.” Am J Physiol Endocrinol Metab 318, no. 2 (February 1, 2020): E216–23. https://doi.org/10.1152/ajpendo.00334.2019.

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Kadakia, Rachel, Octavious Talbot, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Olga R. Ilkayeva, et al. “Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.” J Clin Endocrinol Metab 104, no. 10 (October 1, 2019): 4459–72. https://doi.org/10.1210/jc.2019-00238.

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Elliott, Brittany A., Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris, and Christopher L. Holley. “Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo.” Nat Commun 10, no. 1 (July 30, 2019): 3401. https://doi.org/10.1038/s41467-019-11375-7.

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Nicholatos, Justin W., Timothy M. Robinette, Saurabh V. P. Tata, Jennifer D. Yordy, Adam B. Francisco, Michael Platov, Tiffany K. Yeh, et al. “Cellular energetics and mitochondrial uncoupling in canine aging.” Geroscience 41, no. 2 (April 2019): 229–42. https://doi.org/10.1007/s11357-019-00062-6.

Kadakia, Rachel, Michael Nodzenski, Octavious Talbot, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, et al. “Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries.” Diabetologia 62, no. 3 (March 2019): 473–84. https://doi.org/10.1007/s00125-018-4781-1.

Parker, Daniel, Richard Sloane, Carl F. Pieper, Katherine S. Hall, Virginia B. Kraus, William E. Kraus, Janet L. Huebner, et al. “Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.” J Gerontol A Biol Sci Med Sci 74, no. 3 (February 15, 2019): 283–89. https://doi.org/10.1093/gerona/gly121.

Fisher-Wellman, Kelsey H., James A. Draper, Michael T. Davidson, Ashley S. Williams, Tara M. Narowski, Dorothy H. Slentz, Olga R. Ilkayeva, et al. “Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.” Cell Rep 26, no. 6 (February 5, 2019): 1557-1572.e8. https://doi.org/10.1016/j.celrep.2019.01.057.

Dai, Qunsheng, Creighton E. Likes, Anthony L. Luz, Lan Mao, Jason S. Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R. Ilkayeva, Timothy R. Koves, and Thomas M. Price. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.” J Endocr Soc 3, no. 2 (February 1, 2019): 446–67. https://doi.org/10.1210/js.2018-00219.

Andonian, Brian J., Ching-Heng Chou, Olga R. Ilkayeva, Timothy R. Koves, Margery A. Connelly, William E. Kraus, Virginia B. Kraus, and Kim M. Huffman. “Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.” Front Immunol 10 (2019): 1475. https://doi.org/10.3389/fimmu.2019.01475.

Kavanagh, Kylie, Stephen M. Day, Morgan C. Pait, William R. Mortiz, Christopher B. Newgard, Olga Ilkayeva, Donald A. Mcclain, and Shannon L. Macauley. “Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys.” Front Neurosci 13 (2019): 843. https://doi.org/10.3389/fnins.2019.00843.

Kadakia, Rachel, Denise M. Scholtens, Gerald W. Rouleau, Octavious Talbot, Olga R. Ilkayeva, Tabitha George, and Jami L. Josefson. “Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia.” J Pediatr 203 (December 2018): 144-149.e1. https://doi.org/10.1016/j.jpeds.2018.07.056.

Ravi, Saranya, Traci L. Parry, Monte S. Willis, Pamela Lockyer, Cam Patterson, James R. Bain, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, and Jonathan C. Schisler. “Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP.” J Cardiovasc Dev Dis 5, no. 3 (August 15, 2018). https://doi.org/10.3390/jcdd5030043.

Shantavasinkul, Prapimporn Chattranukulchai, Michael J. Muehlbauer, James R. Bain, Olga R. Ilkayeva, Damian M. Craig, Christopher B. Newgard, Laura P. Svetkey, Svati H. Shah, and Alfonso Torquati. “Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.” Surg Obes Relat Dis 14, no. 8 (August 2018): 1126–32. https://doi.org/10.1016/j.soard.2018.03.033.

Fry, Nate J., Brittany A. Law, Olga R. Ilkayeva, Kristen R. Carraway, Christopher L. Holley, and Kyle D. Mansfield. “N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression.” Oncotarget 9, no. 58 (July 27, 2018): 31231–43. https://doi.org/10.18632/oncotarget.25782.

Peterson, Brett S., Jonathan E. Campbell, Olga Ilkayeva, Paul A. Grimsrud, Matthew D. Hirschey, and Christopher B. Newgard. “Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.” Cell Rep 24, no. 1 (July 3, 2018): 209-223.e6. https://doi.org/10.1016/j.celrep.2018.05.088.

Bhupathiraju, Shilpa N., Marta Guasch-Ferré, Meghana D. Gadgil, Christopher B. Newgard, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, et al. “Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.” J Nutr 148, no. 7 (July 1, 2018): 1150–59. https://doi.org/10.1093/jn/nxy074.

White, Phillip J., Robert W. McGarrah, Paul A. Grimsrud, Shih-Chia Tso, Wen-Hsuan Yang, Jonathan M. Haldeman, Thomas Grenier-Larouche, et al. “The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.” Cell Metab 27, no. 6 (June 5, 2018): 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015.

An, Jie, Liping Wang, Michael L. Patnode, Vanessa K. Ridaura, Jonathan M. Haldeman, Robert D. Stevens, Olga Ilkayeva, et al. “Physiological mechanisms of sustained fumagillin-induced weight loss.” JCI Insight 3, no. 5 (March 8, 2018). https://doi.org/10.1172/jci.insight.99453.

Okeke, Nwora Lance, Damian M. Craig, Michael J. Muehlbauer, Olga Ilkayeva, Meredith E. Clement, Susanna Naggie, and Svati H. Shah. “Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.” Metabolomics 14, no. 3 (March 2018). https://doi.org/10.1007/s11306-018-1318-z.

Sugi, Keiki, Paishiun N. Hsieh, Olga Ilkayeva, Shamanthika Shelkay, Bridget Moroney, Palvir Baadh, Browning Haynes, et al. “Kruppel-like factor 15 is required for the cardiac adaptive response to fasting.” PLoS One 13, no. 2 (2018): e0192376. https://doi.org/10.1371/journal.pone.0192376.

Meyer, Jesse G., Samir Softic, Nathan Basisty, Matthew J. Rardin, Eric Verdin, Bradford W. Gibson, Olga Ilkayeva, Christopher B. Newgard, C Ronald Kahn, and Birgit Schilling. “Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.” PLoS One 13, no. 12 (2018): e0208973. https://doi.org/10.1371/journal.pone.0208973.

Stöckli, Jacqueline, Kelsey H. Fisher-Wellman, Rima Chaudhuri, Xiao-Yi Zeng, Daniel J. Fazakerley, Christopher C. Meoli, Kristen C. Thomas, et al. “Metabolomic analysis of insulin resistance across different mouse strains and diets.” J Biol Chem 292, no. 47 (November 24, 2017): 19135–45. https://doi.org/10.1074/jbc.M117.818351.

Softic, Samir, Manoj K. Gupta, Guo-Xiao Wang, Shiho Fujisaka, Brian T. O’Neill, Tata Nageswara Rao, Jennifer Willoughby, et al. “Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.” J Clin Invest 127, no. 11 (November 1, 2017): 4059–74. https://doi.org/10.1172/JCI94585.

Bolton, Jessica L., Melanie G. Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y. Yang, et al. “Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.” Brain Behav 7, no. 10 (October 2017): e00828. https://doi.org/10.1002/brb3.828.

Fry, Nate J., Brittany A. Law, Olga R. Ilkayeva, Christopher L. Holley, and Kyle D. Mansfield. “N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.” RNA 23, no. 9 (September 2017): 1444–55. https://doi.org/10.1261/rna.061044.117.

Wang, Hanghang, Kevin Anstrom, Olga Ilkayeva, Michael J. Muehlbauer, James R. Bain, Steven McNulty, Christopher B. Newgard, et al. “Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.” JAMA Cardiol 2, no. 8 (August 1, 2017): 896–901. https://doi.org/10.1001/jamacardio.2017.1239.

Lowe, William L., James R. Bain, Michael Nodzenski, Anna C. Reisetter, Michael J. Muehlbauer, Robert D. Stevens, Olga R. Ilkayeva, et al. “Maternal BMI and Glycemia Impact the Fetal Metabolome.” Diabetes Care 40, no. 7 (July 2017): 902–10. https://doi.org/10.2337/dc16-2452.

Jacob, Saya, Michael Nodzenski, Anna C. Reisetter, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Olga R. Ilkayeva, et al. “Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups.” Diabetes Care 40, no. 7 (July 2017): 911–19. https://doi.org/10.2337/dc16-2453.

Dean, E Danielle, Mingyu Li, Nripesh Prasad, Scott N. Wisniewski, Alison Von Deylen, Jason Spaeth, Lisette Maddison, et al. “Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.” Cell Metab 25, no. 6 (June 6, 2017): 1362-1373.e5. https://doi.org/10.1016/j.cmet.2017.05.011.

Wagner, Gregory R., Dhaval P. Bhatt, Thomas M. O’Connell, J Will Thompson, Laura G. Dubois, Donald S. Backos, Hao Yang, et al. “A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.” Cell Metab 25, no. 4 (April 4, 2017): 823-837.e8. https://doi.org/10.1016/j.cmet.2017.03.006.

Anderson, Kristin A., Frank K. Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, et al. “SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.” Cell Metab 25, no. 4 (April 4, 2017): 838-855.e15. https://doi.org/10.1016/j.cmet.2017.03.003.

Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.

Sandler, Victoria, Anna C. Reisetter, James R. Bain, Michael J. Muehlbauer, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, et al. “Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes.” Diabetologia 60, no. 3 (March 2017): 518–30. https://doi.org/10.1007/s00125-016-4182-2.

Luo, Nancy, Damian Craig, Olga Ilkayeva, Michael Muehlbauer, William E. Kraus, Christopher B. Newgard, Svati H. Shah, and Sudarshan Rajagopal. “Plasma acylcarnitines are associated with pulmonary hypertension.” Pulm Circ 7, no. 1 (March 2017): 211–18. https://doi.org/10.1086/690554.

Reisetter, Anna C., Michael J. Muehlbauer, James R. Bain, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, Boyd E. Metzger, Christopher B. Newgard, William L. Lowe, and Denise M. Scholtens. “Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data.” BMC Bioinformatics 18, no. 1 (February 2, 2017): 84. https://doi.org/10.1186/s12859-017-1501-7.

Griffin, Nicholas W., Philip P. Ahern, Jiye Cheng, Andrew C. Heath, Olga Ilkayeva, Christopher B. Newgard, Luigi Fontana, and Jeffrey I. Gordon. “Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.” Cell Host Microbe 21, no. 1 (January 11, 2017): 84–96. https://doi.org/10.1016/j.chom.2016.12.006.

Bradley, Todd, Guang Yang, Olga Ilkayeva, T Matt Holl, Ruijun Zhang, Jinsong Zhang, Sampa Santra, et al. “HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.” J Immunol 197, no. 12 (December 15, 2016): 4663–73. https://doi.org/10.4049/jimmunol.1601484.

Gurley, Jami M., Olga Ilkayeva, Robert M. Jackson, Beth A. Griesel, Phillip White, Satochi Matsuzaki, Rizwan Qaisar, et al. “Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.” Diabetes 65, no. 12 (December 2016): 3585–97. https://doi.org/10.2337/db16-0709.

Wagner, Vitas E., Neelendu Dey, Janaki Guruge, Ansel Hsiao, Philip P. Ahern, Nicholas P. Semenkovich, Laura V. Blanton, et al. “Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition.” Sci Transl Med 8, no. 366 (November 23, 2016): 366ra164. https://doi.org/10.1126/scitranslmed.aah4669.

Gokhale, Nandan S., Alexa B. R. McIntyre, Michael J. McFadden, Allison E. Roder, Edward M. Kennedy, Jorge A. Gandara, Sharon E. Hopcraft, et al. “N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.” Cell Host Microbe 20, no. 5 (November 9, 2016): 654–65. https://doi.org/10.1016/j.chom.2016.09.015.

Luz, Anthony T., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.” Toxicol Sci 154, no. 1 (November 2016): 195. https://doi.org/10.1093/toxsci/kfw185.

McDonnell, Eoin, Scott B. Crown, Douglas B. Fox, Betül Kitir, Olga R. Ilkayeva, Christian A. Olsen, Paul A. Grimsrud, and Matthew D. Hirschey. “Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.” Cell Rep 17, no. 6 (November 1, 2016): 1463–72. https://doi.org/10.1016/j.celrep.2016.10.012.

Hunter, W., J. P. Kelly, R. W. McGarrah, M. G. Khouri, D. M. Craig, C. Haynes, O. Ilkayeva, et al. “Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF.” In European Heart Journal, 37:S1-P1671. Oxford University Press, 2016.

Luz, Anthony L., Tewodros R. Godebo, Dhaval P. Bhatt, Olga R. Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, and Joel N. Meyer. “From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans.” Toxicol Sci 152, no. 2 (August 2016): 349–62. https://doi.org/10.1093/toxsci/kfw093.

Hunter, Wynn G., Jacob P. Kelly, Robert W. McGarrah, Michel G. Khouri, Damian Craig, Carol Haynes, Olga Ilkayeva, et al. “Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.” J Am Heart Assoc 5, no. 8 (July 29, 2016). https://doi.org/10.1161/JAHA.115.003190.

Kucejova, Blanka, Joao Duarte, Santhosh Satapati, Xiaorong Fu, Olga Ilkayeva, Christopher B. Newgard, James Brugarolas, and Shawn C. Burgess. “Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.” Cell Rep 16, no. 2 (July 12, 2016): 508–19. https://doi.org/10.1016/j.celrep.2016.06.006.

Scholtens, Denise M., James R. Bain, Anna C. Reisetter, Michael J. Muehlbauer, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, et al. “Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth.” Diabetes 65, no. 7 (July 2016): 2039–50. https://doi.org/10.2337/db15-1748.

White, Phillip J., Amanda L. Lapworth, Jie An, Liping Wang, Robert W. McGarrah, Robert D. Stevens, Olga Ilkayeva, et al. “Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.” Mol Metab 5, no. 7 (July 2016): 538–51. https://doi.org/10.1016/j.molmet.2016.04.006.

Sun, Haipeng, Kristine C. Olson, Chen Gao, Domenick A. Prosdocimo, Meiyi Zhou, Zhihua Wang, Darwin Jeyaraj, et al. “Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.” Circulation 133, no. 21 (May 24, 2016): 2038–49. https://doi.org/10.1161/CIRCULATIONAHA.115.020226.

Marcelo, Kathrina L., Thomas Ribar, Christopher R. Means, Anna Tsimelzon, Robert D. Stevens, Olga Ilkayeva, James R. Bain, et al. “Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.” Mol Endocrinol 30, no. 5 (May 2016): 557–72. https://doi.org/10.1210/me.2016-1021.

Zhang, Wenwei, So Young Bu, Mara T. Mashek, InSug O-Sullivan, Zakaria Sibai, Salmaan A. Khan, Olga Ilkayeva, Christopher B. Newgard, Douglas G. Mashek, and Terry G. Unterman. “Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins.” Cell Rep 15, no. 2 (April 12, 2016): 349–59. https://doi.org/10.1016/j.celrep.2016.03.021.

Charbonneau, Mark R., David O’Donnell, Laura V. Blanton, Sarah M. Totten, Jasmine C. C. Davis, Michael J. Barratt, Jiye Cheng, et al. “Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.” Cell 164, no. 5 (February 25, 2016): 859–71. https://doi.org/10.1016/j.cell.2016.01.024.

Sommer, Felix, Marcus Ståhlman, Olga Ilkayeva, Jon M. Arnemo, Jonas Kindberg, Johan Josefsson, Christopher B. Newgard, Ole Fröbert, and Fredrik Bäckhed. “The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.” Cell Rep 14, no. 7 (February 23, 2016): 1655–61. https://doi.org/10.1016/j.celrep.2016.01.026.

Ahmad, Tariq, Jacob P. Kelly, Robert W. McGarrah, Anne S. Hellkamp, Mona Fiuzat, Jeffrey M. Testani, Teresa S. Wang, et al. “Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.” J Am Coll Cardiol 67, no. 3 (January 26, 2016): 291–99. https://doi.org/10.1016/j.jacc.2015.10.079.

Davies, Michael N., Lilja Kjalarsdottir, J Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, and Deborah M. Muoio. “The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.” Cell Rep 14, no. 2 (January 12, 2016): 243–54. https://doi.org/10.1016/j.celrep.2015.12.030.

Irizarry, Krystal A., James Bain, Merlin G. Butler, Olga Ilkayeva, Michael Muehlbauer, Andrea M. Haqq, and Michael Freemark. “Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone.” Clin Endocrinol (Oxf) 83, no. 6 (December 2015): 797–805. https://doi.org/10.1111/cen.12766.

Glynn, Erin L., Lucy W. Piner, Kim M. Huffman, Cris A. Slentz, Lorraine Elliot-Penry, Hiba AbouAssi, Phillip J. White, et al. “Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.” Diabetologia 58, no. 10 (October 2015): 2324–35. https://doi.org/10.1007/s00125-015-3705-6.

Ferdaoussi, Mourad, Xiaoqing Dai, Mette V. Jensen, Runsheng Wang, Brett S. Peterson, Chao Huang, Olga Ilkayeva, et al. “Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.” J Clin Invest 125, no. 10 (October 1, 2015): 3847–60. https://doi.org/10.1172/JCI82498.

Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.” PLoS Genet 11, no. 10 (October 2015): e1005599. https://doi.org/10.1371/journal.pgen.1005599.

Otsubo, Chikara, Sivakama Bharathi, Radha Uppala, Olga R. Ilkayeva, Dongning Wang, Kevin McHugh, Ye Zou, et al. “Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.” J Biol Chem 290, no. 39 (September 25, 2015): 23897–904. https://doi.org/10.1074/jbc.M115.655837.

Seiler, Sarah E., Timothy R. Koves, Jessica R. Gooding, Kari E. Wong, Robert D. Stevens, Olga R. Ilkayeva, April H. Wittmann, et al. “Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.” Cell Metab 22, no. 1 (July 7, 2015): 65–76. https://doi.org/10.1016/j.cmet.2015.06.003.

Teh, J. T., W. L. Zhu, O. R. Ilkayeva, Y. Li, J. Gooding, P. J. Casey, S. A. Summers, C. B. Newgard, and M. Wang. “Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.” Oncogene 34, no. 25 (June 2015): 3296–3304. https://doi.org/10.1038/onc.2014.260.

Zhang, Minsi, Qiong Qiu, Zhizhong Li, Mohit Sachdeva, Hooney Min, Diana M. Cardona, Thomas F. DeLaney, et al. “HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.” Radiat Res 183, no. 6 (June 2015): 594–609. https://doi.org/10.1667/RR14016.1.

Baker, P. R., K. E. Boyle, T. R. Koves, O. R. Ilkayeva, D. M. Muoio, J. A. Houmard, and J. E. Friedman. “Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.” Obesity 23, no. 5 (May 1, 2015): 981–88. https://doi.org/10.1002/oby.21046.

Wong, Kari E., Catherine R. Mikus, Dorothy H. Slentz, Sarah E. Seiler, Karen L. DeBalsi, Olga R. Ilkayeva, Karen I. Crain, et al. “Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction.” Diabetes 64, no. 5 (May 2015): 1532–43. https://doi.org/10.2337/db14-0827.

Baker, Peter R., Kristen E. Boyle, Timothy R. Koves, Olga R. Ilkayeva, Deborah M. Muoio, Joseph A. Houmard, and Jacob E. Friedman. “Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.” Obesity (Silver Spring) 23, no. 5 (May 2015): 981–88. https://doi.org/10.1002/oby.21046.

Newbern, D., P. Gumus Balikcioglu, M. Balikcioglu, J. Bain, M. Muehlbauer, R. Stevens, O. Ilkayeva, et al. “Erratum: Sex differences in biomarkers associated with insulin resistance in obese adolescents: Metabolomic profiling and principal components analysis (Journal of Clinical Endocrinology and Metabolism (2014) 99 (4730-4739) DOI: 10.1210/jc.2014-2080).” Journal of Clinical Endocrinology and Metabolism 100, no. 4 (April 1, 2015): 1709. https://doi.org/10.1210/jc.2015-1354.

Kang, Yun Kyoung, Nagireddy Putluri, Suman Maity, Anna Tsimelzon, Olga Ilkayeva, Qianxing Mo, David Lonard, et al. “CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC.” PLoS Genet 11, no. 4 (April 2015): e1005116. https://doi.org/10.1371/journal.pgen.1005116.

Kelly, J. P., W. Hunter, D. Craig, C. Haynes, R. McGarrah, E. Velazquez, M. Felker, et al. “Metabolomic Profiling Identifies Biomarkers Predicting Adverse Outcomes in Patients with Heart Failure with Preserved Ejection Fraction.” In Journal of the American College of Cardiology, 65:A772–A772, 2015. https://doi.org/10.1016/S0735-1097(15)60772-0.

Hunter, W., J. Kelly, D. Craig, C. Haynes, R. McGarrah, E. Velazquez, G. M. Felker, et al. “Metabolomic Profiling Identifies Biomarkers of Mitochondrial Function in Heart Failure with Preserved versus Reduced Ejection Fraction.” In Journal of the American College of Cardiology, 65:A774–A774, 2015. https://doi.org/10.1016/S0735-1097(15)60774-4.

Burkewitz, Kristopher, Ianessa Morantte, Heather J. M. Weir, Robin Yeo, Yue Zhang, Frank K. Huynh, Olga R. Ilkayeva, Matthew D. Hirschey, Ana R. Grant, and William B. Mair. “Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.” Cell 160, no. 5 (February 26, 2015): 842–55. https://doi.org/10.1016/j.cell.2015.02.004.

Ali, Safina, John R. Ussher, Laurie L. Baggio, M Golam Kabir, Maureen J. Charron, Olga Ilkayeva, Christopher B. Newgard, and Daniel J. Drucker. “Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.” Mol Metab 4, no. 2 (February 2015): 132–43. https://doi.org/10.1016/j.molmet.2014.11.005.

Ali, S., J. R. Ussher, L. L. Baggio, M. G. Kabir, M. J. Charron, O. Ilkayeva, C. B. Newgard, and D. J. Drucker. “Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.” Molecular Metabolism 4, no. 2 (February 1, 2015): 132–43. https://doi.org/10.1016/j.molmet.2014.11.005.

Li, Lei O., Trisha J. Grevengoed, David S. Paul, Olga Ilkayeva, Timothy R. Koves, Florencia Pascual, Christopher B. Newgard, Deborah M. Muoio, and Rosalind A. Coleman. “Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.” Diabetes 64, no. 1 (January 2015): 23–35. https://doi.org/10.2337/db13-1070.

Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.

Morgan, P. G., R. Higdon, N. Kolker, A. T. Bauman, O. Ilkayeva, C. B. Newgard, E. Kolker, L. M. Steele, and M. M. Sedensky. “Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans.” Mitochondrion 20 (January 2015): 95–102. https://doi.org/10.1016/j.mito.2014.12.004.

Todor, Horia, Jessica Gooding, Olga R. Ilkayeva, and Amy K. Schmid. “Dynamic Metabolite Profiling in an Archaeon Connects Transcriptional Regulation to Metabolic Consequences.” PLoS One 10, no. 8 (2015): e0135693. https://doi.org/10.1371/journal.pone.0135693.

Moffat, Cynthia, Lavesh Bhatia, Teresa Nguyen, Peter Lynch, Miao Wang, Dongning Wang, Olga R. Ilkayeva, et al. “Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.” J Lipid Res 55, no. 12 (December 2014): 2458–70. https://doi.org/10.1194/jlr.M046961.

Newbern, Dorothee, Pinar Gumus Balikcioglu, Metin Balikcioglu, James Bain, Michael Muehlbauer, Robert Stevens, Olga Ilkayeva, et al. “Sex differences in biomarkers associated with insulin resistance in obese adolescents: metabolomic profiling and principal components analysis.” J Clin Endocrinol Metab 99, no. 12 (December 2014): 4730–39. https://doi.org/10.1210/jc.2014-2080.

Tennakoon, J. B., Y. Shi, J. J. Han, E. Tsouko, M. A. White, A. R. Burns, A. Zhang, et al. “Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.” Oncogene 33, no. 45 (November 6, 2014): 5251–61. https://doi.org/10.1038/onc.2013.463.

Shin, Andrew C., Martin Fasshauer, Nika Filatova, Linus A. Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, et al. “Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.” Cell Metab 20, no. 5 (November 4, 2014): 898–909. https://doi.org/10.1016/j.cmet.2014.09.003.

Lai, Ling, Teresa C. Leone, Mark P. Keller, Ola J. Martin, Aimee T. Broman, Jessica Nigro, Kapil Kapoor, et al. “Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.” Circ Heart Fail 7, no. 6 (November 2014): 1022–31. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001469.

Soni, Mufaddal S., Mary E. Rabaglia, Sushant Bhatnagar, Jin Shang, Olga Ilkayeva, Randall Mynatt, Yun-Ping Zhou, et al. “Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion.” Diabetes 63, no. 11 (November 2014): 3805–14. https://doi.org/10.2337/db13-1677.

Huffman, Kim M., Timothy R. Koves, Monica J. Hubal, Hiba Abouassi, Nina Beri, Lori A. Bateman, Robert D. Stevens, et al. “Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.” Diabetologia 57, no. 11 (November 2014): 2282–95. https://doi.org/10.1007/s00125-014-3343-4.

Ussher, John R., Wendy Keung, Natasha Fillmore, Timothy R. Koves, Jun Mori, Liyan Zhang, David G. Lopaschuk, et al. “Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.” J Pharmacol Exp Ther 349, no. 3 (June 2014): 487–96. https://doi.org/10.1124/jpet.114.214197.

Gupte, Anisha A., Dale J. Hamilton, Andrea M. Cordero-Reyes, Keith A. Youker, Zheng Yin, Jerry D. Estep, Robert D. Stevens, et al. “Mechanical unloading promotes myocardial energy recovery in human heart failure.” Circ Cardiovasc Genet 7, no. 3 (June 2014): 266–76. https://doi.org/10.1161/CIRCGENETICS.113.000404.

Sinha, Rohit A., Benjamin L. Farah, Brijesh K. Singh, Monowarul M. Siddique, Ying Li, Yajun Wu, Olga R. Ilkayeva, et al. “Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.” Hepatology 59, no. 4 (April 2014): 1366–80. https://doi.org/10.1002/hep.26667.

Seiler, Sarah E., Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, and Deborah M. Muoio. “Obesity and lipid stress inhibit carnitine acetyltransferase activity.” J Lipid Res 55, no. 4 (April 2014): 635–44. https://doi.org/10.1194/jlr.M043448.

Tan, Minjia, Chao Peng, Kristin A. Anderson, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, et al. “Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.” Cell Metab 19, no. 4 (April 1, 2014): 605–17. https://doi.org/10.1016/j.cmet.2014.03.014.

DeBalsi, Karen L., Kari E. Wong, Timothy R. Koves, Dorothy H. Slentz, Sarah E. Seiler, April H. Wittmann, Olga R. Ilkayeva, et al. “Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.” J Biol Chem 289, no. 12 (March 21, 2014): 8106–20. https://doi.org/10.1074/jbc.M113.511535.

Thalacker-Mercer, Anna E., Katherine H. Ingram, Fangjian Guo, Olga Ilkayeva, Christopher B. Newgard, and W Timothy Garvey. “BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans.” Diabetes 63, no. 2 (February 2014): 791–800. https://doi.org/10.2337/db13-0396.

Schechter, Matthew A., Michael K. H. Hsieh, Linda W. Njoroge, J Will Thompson, Erik J. Soderblom, Bryan J. Feger, Constantine D. Troupes, et al. “Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.” PLoS One 9, no. 8 (2014): e104157. https://doi.org/10.1371/journal.pone.0104157.

Rardin, Matthew J., Wenjuan He, Yuya Nishida, John C. Newman, Chris Carrico, Steven R. Danielson, Ailan Guo, et al. “SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.” Cell Metab 18, no. 6 (December 3, 2013): 920–33. https://doi.org/10.1016/j.cmet.2013.11.013.

Peek, Clara Bien, Alison H. Affinati, Kathryn Moynihan Ramsey, Hsin-Yu Kuo, Wei Yu, Laura A. Sena, Olga Ilkayeva, et al. “Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.” Science 342, no. 6158 (November 1, 2013): 1243417. https://doi.org/10.1126/science.1243417.

Wendel, Angela A., Daniel E. Cooper, Olga R. Ilkayeva, Deborah M. Muoio, and Rosalind A. Coleman. “Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation.” J Biol Chem 288, no. 38 (September 20, 2013): 27299–306. https://doi.org/10.1074/jbc.M113.485219.

Ridaura, Vanessa K., Jeremiah J. Faith, Federico E. Rey, Jiye Cheng, Alexis E. Duncan, Andrew L. Kau, Nicholas W. Griffin, et al. “Gut microbiota from twins discordant for obesity modulate metabolism in mice.” Science 341, no. 6150 (September 6, 2013): 1241214. https://doi.org/10.1126/science.1241214.

Magkos, Faidon, David Bradley, George G. Schweitzer, Brian N. Finck, J Christopher Eagon, Olga Ilkayeva, Christopher B. Newgard, and Samuel Klein. “Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.” Diabetes 62, no. 8 (August 2013): 2757–61. https://doi.org/10.2337/db13-0185.

Klett, Eric L., Shufen Chen, Matthew L. Edin, Lei O. Li, Olga Ilkayeva, Darryl C. Zeldin, Christopher B. Newgard, and Rosalind A. Coleman. “Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.” J Biol Chem 288, no. 30 (July 26, 2013): 21618–29. https://doi.org/10.1074/jbc.M113.481077.

Siddique, Monowarul M., Ying Li, Liping Wang, Jianhong Ching, Mainak Mal, Olga Ilkayeva, Ya Jun Wu, Boon Huat Bay, and Scott A. Summers. “Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.” Mol Cell Biol 33, no. 11 (June 2013): 2353–69. https://doi.org/10.1128/MCB.00226-13.

Johnson, Erika Segear, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen. “Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.” J Biol Chem 288, no. 20 (May 17, 2013): 14463–75. https://doi.org/10.1074/jbc.M112.437210.

Coppola, Anna, Brett R. Wenner, Olga Ilkayeva, Robert D. Stevens, Mauro Maggioni, Theodore A. Slotkin, Edward D. Levin, and Christopher B. Newgard. “Branched-chain amino acids alter neurobehavioral function in rats.” Am J Physiol Endocrinol Metab 304, no. 4 (February 15, 2013): E405–13. https://doi.org/10.1152/ajpendo.00373.2012.

Jackson, Kathryn C., Lindsay M. Wohlers, Richard M. Lovering, Rosemary A. Schuh, Amy C. Maher, Arend Bonen, Timothy R. Koves, et al. “Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice.” Am J Physiol Regul Integr Comp Physiol 304, no. 3 (February 2013): R206–17. https://doi.org/10.1152/ajpregu.00428.2012.

York, Brian, Jørn V. Sagen, Anna Tsimelzon, Jean-Francios Louet, Atul R. Chopra, Erin L. Reineke, Suoling Zhou, et al. “Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.” Mol Endocrinol 27, no. 2 (February 2013): 366–80. https://doi.org/10.1210/me.2012-1324.

Vernochet, Cecile, Arnaud Mourier, Olivier Bezy, Yazmin Macotela, Jeremie Boucher, Matthew J. Rardin, Ding An, et al. “Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.” Cell Metab 16, no. 6 (December 5, 2012): 765–76. https://doi.org/10.1016/j.cmet.2012.10.016.

Chao, Lily C., Kevin Wroblewski, Olga R. Ilkayeva, Robert D. Stevens, James Bain, Gretchen A. Meyer, Simon Schenk, et al. “Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization.” J Lipid Res 53, no. 12 (December 2012): 2610–19. https://doi.org/10.1194/jlr.M029355.

Muoio, Deborah M., Robert C. Noland, Jean-Paul Kovalik, Sarah E. Seiler, Michael N. Davies, Karen L. DeBalsi, Olga R. Ilkayeva, et al. “Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.” Cell Metab 15, no. 5 (May 2, 2012): 764–77. https://doi.org/10.1016/j.cmet.2012.04.005.

York, Brian, Erin L. Reineke, Jørn V. Sagen, Bryan C. Nikolai, Suoling Zhou, Jean-Francois Louet, Atul R. Chopra, et al. “Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.” Cell Metab 15, no. 5 (May 2, 2012): 752–63. https://doi.org/10.1016/j.cmet.2012.03.020.

Sampey, Brante P., Alex J. Freemerman, Jimmy Zhang, Pei-Fen Kuan, Joseph A. Galanko, Thomas M. O’Connell, Olga R. Ilkayeva, et al. “Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation.” PLoS One 7, no. 6 (2012): e38812. https://doi.org/10.1371/journal.pone.0038812.

Ku, Bon Jeong, Tae Hoon Kim, Jae Hee Lee, Eric D. Buras, Lisa D. White, Robert D. Stevens, Olga R. Ilkayeva, et al. “Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.” PLoS One 7, no. 8 (2012): e42915. https://doi.org/10.1371/journal.pone.0042915.

Albaugh, Vance L., Thomas C. Vary, Olga Ilkayeva, Brett R. Wenner, Kevin P. Maresca, John L. Joyal, Steven Breazeale, Tedd D. Elich, Charles H. Lang, and Christopher J. Lynch. “Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.” Schizophr Bull 38, no. 1 (January 2012): 153–66. https://doi.org/10.1093/schbul/sbq053.

Michalek, Ryan D., Valerie A. Gerriets, Amanda G. Nichols, Makoto Inoue, Dmitri Kazmin, Ching-Yi Chang, Mary A. Dwyer, et al. “Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348–53. https://doi.org/10.1073/pnas.1108856108.

Altman, B. J., S. R. Jacobs, E. F. Mason, R. D. Michalek, A. N. MacIntyre, J. L. Coloff, O. Ilkayeva, W. Jia, Y. -. W. He, and J. C. Rathmell. “Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.” Oncogene 30, no. 16 (April 21, 2011): 1855–67. https://doi.org/10.1038/onc.2010.561.

Horn, Sarah R., Michael J. Thomenius, Erika Segear Johnson, Christopher D. Freel, Judy Q. Wu, Jonathan L. Coloff, Chih-Sheng Yang, et al. “Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.” Mol Biol Cell 22, no. 8 (April 15, 2011): 1207–16. https://doi.org/10.1091/mbc.E10-07-0567.

Boyle, K. E., J. P. Canham, L. A. Consitt, D. Zheng, T. R. Koves, T. P. Gavin, D. Holbert, et al. “A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.” J Clin Endocrinol Metab 96, no. 3 (March 2011): 775–81. https://doi.org/10.1210/jc.2010-2253.

Coloff, Jonathan L., Emily F. Mason, Brian J. Altman, Valerie A. Gerriets, Tingyu Liu, Amanda N. Nichols, Yuxing Zhao, et al. “Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.” J Biol Chem 286, no. 7 (February 18, 2011): 5921–33. https://doi.org/10.1074/jbc.M110.179101.

Louet, Jean-Francois, Atul R. Chopra, Jorn V. Sagen, Jie An, Brian York, Mounia Tannour-Louet, Pradip K. Saha, et al. “The coactivator SRC-1 is an essential coordinator of hepatic glucose production.” Cell Metab 12, no. 6 (December 1, 2010): 606–18. https://doi.org/10.1016/j.cmet.2010.11.009.

Newgard, C. B., R. D. Stevens, B. R. Wenner, S. C. Burgess, O. Ilkayeva, M. J. Muehlbauer, A. Dean Sherry, and J. R. Bain. “Comprehensive Metabolic Analysis for Understanding of Disease,” December 1, 2010, 97–107. https://doi.org/10.1016/B978-0-12-374934-5.00009-X.

Thyfault, John P., Melanie G. Cree, Edward B. Tapscott, Jill A. Bell, Timothy R. Koves, Olga Ilkayeva, Robert R. Wolfe, G Lynis Dohm, and Deborah M. Muoio. “Metabolic profiling of muscle contraction in lean compared with obese rodents.” Am J Physiol Regul Integr Comp Physiol 299, no. 3 (September 2010): R926–34. https://doi.org/10.1152/ajpregu.00093.2010.

Ellis, Jessica M., Lei O. Li, Pei-Chi Wu, Timothy R. Koves, Olga Ilkayeva, Robert D. Stevens, Steven M. Watkins, Deborah M. Muoio, and Rosalind A. Coleman. “Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis.” Cell Metab 12, no. 1 (July 7, 2010): 53–64. https://doi.org/10.1016/j.cmet.2010.05.012.

Koonen, Debby P. Y., Miranda M. Y. Sung, Cindy K. C. Kao, Vernon W. Dolinsky, Timothy R. Koves, Olga Ilkayeva, René L. Jacobs, et al. “Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.” Diabetes 59, no. 6 (June 2010): 1366–75. https://doi.org/10.2337/db09-1142.

Odegaard, Matthew L., Jamie W. Joseph, Mette V. Jensen, Danhong Lu, Olga Ilkayeva, Sarah M. Ronnebaum, Thomas C. Becker, and Christopher B. Newgard. “The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.” J Biol Chem 285, no. 22 (May 28, 2010): 16530–37. https://doi.org/10.1074/jbc.M109.092593.

Curtis, Jessica M., Paul A. Grimsrud, Wendy S. Wright, Xin Xu, Rocio E. Foncea, David W. Graham, Jonathan R. Brestoff, et al. “Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.” Diabetes 59, no. 5 (May 2010): 1132–42. https://doi.org/10.2337/db09-1105.

Tai, E. S., M. L. S. Tan, R. D. Stevens, Y. L. Low, M. J. Muehlbauer, D. L. M. Goh, O. R. Ilkayeva, et al. “Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men.” Diabetologia 53, no. 4 (April 2010): 757–67. https://doi.org/10.1007/s00125-009-1637-8.

Wang, May-yun, Lijun Chen, Gregory O. Clark, Young Lee, Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, et al. “Leptin therapy in insulin-deficient type I diabetes.” Proc Natl Acad Sci U S A 107, no. 11 (March 16, 2010): 4813–19. https://doi.org/10.1073/pnas.0909422107.

Hirschey, Matthew D., Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B. Lombard, Carrie A. Grueter, et al. “SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.” Nature 464, no. 7285 (March 4, 2010): 121–25. https://doi.org/10.1038/nature08778.

Chao, Lily C., Kevin Wroblewski, Zidong Zhang, Liming Pei, Laurent Vergnes, Olga R. Ilkayeva, Shi Ying Ding, et al. “Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.” Diabetes 58, no. 12 (December 2009): 2788–96. https://doi.org/10.2337/db09-0763.

Newgard, C. B., R. D. Stevens, B. R. Wenner, S. C. Burgess, O. Ilkayeva, M. J. Muehlbauer, A. D. Sherry, and J. R. Bain. “Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms,” December 1, 2009, 180–92. https://doi.org/10.1016/B978-0-12-369420-1.00015-9.

Dong, Bingning, Pradip K. Saha, Wendong Huang, Wenling Chen, Lutfi A. Abu-Elheiga, Salih J. Wakil, Robert D. Stevens, et al. “Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.” Proc Natl Acad Sci U S A 106, no. 44 (November 3, 2009): 18831–36. https://doi.org/10.1073/pnas.0909731106.

Bain, James R., Robert D. Stevens, Brett R. Wenner, Olga Ilkayeva, Deborah M. Muoio, and Christopher B. Newgard. “Metabolomics applied to diabetes research: moving from information to knowledge.” Diabetes 58, no. 11 (November 2009): 2429–43. https://doi.org/10.2337/db09-0580.

Noland, Robert C., Timothy R. Koves, Sarah E. Seiler, Helen Lum, Robert M. Lust, Olga Ilkayeva, Robert D. Stevens, Fausto G. Hegardt, and Deborah M. Muoio. “Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.” J Biol Chem 284, no. 34 (August 21, 2009): 22840–52. https://doi.org/10.1074/jbc.M109.032888.

Ussher, John R., Timothy R. Koves, Jagdip S. Jaswal, Liyan Zhang, Olga Ilkayeva, Jason R. B. Dyck, Deborah M. Muoio, and Gary D. Lopaschuk. “Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.” Diabetes 58, no. 8 (August 2009): 1766–75. https://doi.org/10.2337/db09-0011.

Grasfeder, Linda L., Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-Yi Chang, and Donald P. McDonnell. “Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.” Mol Endocrinol 23, no. 8 (August 2009): 1171–82. https://doi.org/10.1210/me.2009-0024.

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Newgard, Christopher B., Jie An, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, Lillian F. Lien, Andrea M. Haqq, et al. “A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.” Cell Metab 9, no. 4 (April 2009): 311–26. https://doi.org/10.1016/j.cmet.2009.02.002.

Wardell, Suzanne E., Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard, and Donald P. McDonnell. “Glucose metabolism as a target of histone deacetylase inhibitors.” Mol Endocrinol 23, no. 3 (March 2009): 388–401. https://doi.org/10.1210/me.2008-0179.

Altman, Brian J., Jessica A. Wofford, Yuxing Zhao, Jonathan L. Coloff, Emily C. Ferguson, Heather L. Wieman, Amanda E. Day, Olga Ilkayeva, and Jeffrey C. Rathmell. “Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.” Mol Biol Cell 20, no. 4 (February 2009): 1180–91. https://doi.org/10.1091/mbc.e08-08-0829.

Makowski, Liza, Robert C. Noland, Timothy R. Koves, Weibing Xing, Olga R. Ilkayeva, Michael J. Muehlbauer, Robert D. Stevens, and Deborah M. Muoio. “Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.” FASEB J 23, no. 2 (February 2009): 586–604. https://doi.org/10.1096/fj.08-119420.

Lien, Lillian F., Andrea M. Haqq, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, Ross L. McMahon, James Rochon, et al. “The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.” OMICS 13, no. 1 (February 2009): 21–35. https://doi.org/10.1089/omi.2008.0035.

Ussher, J. R., T. R. Koves, J. S. Jaswal, L. Zhang, O. Ilkayeva, J. R. B. Dyck, D. M. Muoio, and G. D. Lopaschuk. “Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase (Diabetes (2009) 58, (1766-1775)).” Diabetes 58, no. 10 (2009): 2425-.

Newgard, C. B., R. D. Stevens, B. R. Wenner, S. C. Burgess, O. Ilkayeva, M. J. Muehlbauer, A. D. Sherry, and J. R. Bain. “Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms.” In Genomic and Personalized Medicine V1 2, 180–92, 2008. https://doi.org/10.1016/B978-0-12-369420-1.00015-9.

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Ronnebaum, Sarah M., Jamie W. Joseph, Olga Ilkayeva, Shawn C. Burgess, Danhong Lu, Thomas C. Becker, A Dean Sherry, and Christopher B. Newgard. “Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.” J Biol Chem 283, no. 21 (May 23, 2008): 14248–56. https://doi.org/10.1074/jbc.M800119200.

Ferrara, Christine T., Ping Wang, Elias Chaibub Neto, Robert D. Stevens, James R. Bain, Brett R. Wenner, Olga R. Ilkayeva, et al. “Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.” PLoS Genet 4, no. 3 (March 14, 2008): e1000034. https://doi.org/10.1371/journal.pgen.1000034.

Koves, Timothy R., John R. Ussher, Robert C. Noland, Dorothy Slentz, Merrie Mosedale, Olga Ilkayeva, James Bain, et al. “Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.” Cell Metab 7, no. 1 (January 2008): 45–56. https://doi.org/10.1016/j.cmet.2007.10.013.

Zhao, Yuxing, Brian J. Altman, Jonathan L. Coloff, Catherine E. Herman, Sarah R. Jacobs, Heather L. Wieman, Jessica A. Wofford, et al. “Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.” Mol Cell Biol 27, no. 12 (June 2007): 4328–39. https://doi.org/10.1128/MCB.00153-07.

Power, R. A., M. W. Hulver, J. Y. Zhang, J. Dubois, R. M. Marchand, O. Ilkayeva, D. M. Muoio, and R. L. Mynatt. “Carnitine revisited: potential use as adjunctive treatment in diabetes.” Diabetologia 50, no. 4 (April 2007): 824–32. https://doi.org/10.1007/s00125-007-0605-4.

Zhang, Yong-Mei, Shigeru Chohnan, Kristopher G. Virga, Robert D. Stevens, Olga R. Ilkayeva, Brett R. Wenner, James R. Bain, et al. “Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.” Chem Biol 14, no. 3 (March 2007): 291–302. https://doi.org/10.1016/j.chembiol.2007.01.013.

Thyfault, John P., Melanie G. Cree, Donghai Zheng, Jennifer J. Zwetsloot, Edward B. Tapscott, Timothy R. Koves, Olga Ilkayeva, Robert R. Wolfe, Deborah M. Muoio, and G Lynis Dohm. “Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.” Am J Physiol Cell Physiol 292, no. 2 (February 2007): C729–39. https://doi.org/10.1152/ajpcell.00311.2006.

Joseph, Jamie W., Mette V. Jensen, Olga Ilkayeva, Ferdinando Palmieri, Cristina Alárcon, Christopher J. Rhodes, and Christopher B. Newgard. “The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.” J Biol Chem 281, no. 47 (November 24, 2006): 35624–32. https://doi.org/10.1074/jbc.M602606200.

Ronnebaum, Sarah M., Olga Ilkayeva, Shawn C. Burgess, Jamie W. Joseph, Danhong Lu, Robert D. Stevens, Thomas C. Becker, A Dean Sherry, Christopher B. Newgard, and Mette V. Jensen. “A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.” J Biol Chem 281, no. 41 (October 13, 2006): 30593–602. https://doi.org/10.1074/jbc.M511908200.

Jensen, Mette V., Jamie W. Joseph, Olga Ilkayeva, Shawn Burgess, Danhong Lu, Sarah M. Ronnebaum, Matthew Odegaard, Thomas C. Becker, A Dean Sherry, and Christopher B. Newgard. “Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.” J Biol Chem 281, no. 31 (August 4, 2006): 22342–51. https://doi.org/10.1074/jbc.M604350200.

Koves, Timothy R., Ping Li, Jie An, Takayuki Akimoto, Dorothy Slentz, Olga Ilkayeva, G Lynis Dohm, Zhen Yan, Christopher B. Newgard, and Deborah M. Muoio. “Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.” J Biol Chem 280, no. 39 (September 30, 2005): 33588–98. https://doi.org/10.1074/jbc.M507621200.

Hammond, Linda E., Susanne Neschen, Anthony J. Romanelli, Gary W. Cline, Olga R. Ilkayeva, Gerald I. Shulman, Deborah M. Muoio, and Rosalind A. Coleman. “Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.” J Biol Chem 280, no. 27 (July 8, 2005): 25629–36. https://doi.org/10.1074/jbc.M503181200.