Overview
Lesley H. Curtis is Chair and Professor in the Department of Population Health Sciences and Professor in Medicine in the Duke School of Medicine. A health services researcher by training, Dr. Curtis is an expert in the use of health care and Medicare claims data for health services and clinical outcomes research, and a leader in national data quality efforts. Dr. Curtis has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. Dr. Curtis recently served as a senior policy advisor at the Food and Drug Administration supporting the Agency’s evidence generation initiative, serves as an Investigator in the Coordinating Center for PCORI's PCORnet, and is co-PI of the NIH Pragmatic Trials Collaboratory, an NIH initiative to strengthen the national capacity for large-scale research studies embedded in health care delivery.
Areas of expertise: Health Services Research and Health Policy
Current Appointments & Affiliations
Recent Publications
Medicare coverage gap status, adherence to oral anticoagulation, and stroke rates in patients with atrial fibrillation.
Journal Article Am Heart J · January 2026 BACKGROUND: Prior to 2025, Medicare Part D included a coverage gap during which beneficiaries were responsible for substantially higher portions of medication costs. The impact of this on oral anticoagulant (OAC) prescription fills and subsequent stroke in ... Full text Link to item CiteRacial and ethnic disparities in longitudinal trajectories of hospitalizations in patients diagnosed with heart failure.
Journal Article Am Heart J · September 2025 BACKGROUND: Racial and ethnic disparities in hospitalizations among heart failure (HF) patients have been well documented. However, little is known about racial and ethnic differences in the long-term trajectories of hospital admissions that follow the dia ... Full text Link to item CiteThe Promise of Real-World Data for Research - What Are We Missing?
Journal Article N Engl J Med · July 24, 2025 Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Nurse LEADS: Training in Nurse-LEd models of care ADdressing the Social Determinants of Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Nursing Research · 2024 - 2029NIH Health Care Systems Research Collaboratory-Coordinating Center (U24 Clinical Trial Not Allowed)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2028View All Grants