Overview
My research interests include both statistical methodology and disease-specific clinical research biostatistics. My statistical research areas include methods for outcomes, endpoints, estimands, assessing reliability/agreement between methods or raters, evaluating performance of new medical diagnostic tests, and methods for design of clinical trials. My collaborative research include the following clinical areas: liver injury, cardiovascular imaging, radiology imaging, cardiovascular disease, renal disease, reproductive medicine, Parkinson disease, and aging.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biostatistics & Bioinformatics
·
2024 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Professor of Biostatistics & Bioinformatics
·
2009 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Associate Chair for Faculty Mentorship and Development
·
2019 - Present
Biostatistics & Bioinformatics,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2003 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Clinical and HLA Associations of Fluoroquinolone-Induced Liver Injury: Results From the Drug-Induced Liver Injury Network.
Journal Article Am J Gastroenterol · January 1, 2026 INTRODUCTION: Fluoroquinolones (FQ) have a favorable safety profile, but the risk of drug-induced liver injury (DILI) is well described. The aim of this study was to identify clinical features and HLA genetic variants associated with FQ-DILI in a large nat ... Full text Link to item CiteClinical and Genetic Associations in Cephalosporin-Induced Liver Injury: Insights From the Drug-Induced Liver Injury Network.
Journal Article Aliment Pharmacol Ther · November 2025 INTRODUCTION: Cephalosporins are widely prescribed antibiotics due to their efficacy and safety. Although rare, idiosyncratic drug-induced liver injury (DILI) has been reported with their use. Here, we characterise the clinical features and HLA association ... Full text Link to item CiteEditorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky. Authors' Reply.
Journal Article Aliment Pharmacol Ther · November 2025 Full text Link to item CiteRecent Grants
Trial of Sequential Medications AfteR TNF failure in JIA (SMART-JIA)
ResearchCo-Principal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2031Drug Induced Liver Injury Network Data Coordinating Center
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2028Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 1988 - 2027View All Grants
Education, Training & Certifications
University of Pittsburgh ·
1992
Ph.D.
University of Pittsburgh ·
1988
M.A.