Overview
My research interests include both statistical methodology and disease-specific clinical research biostatistics. My statistical research areas include methods for outcomes, endpoints, estimands, assessing reliability/agreement between methods or raters, evaluating performance of new medical diagnostic tests, and methods for design of clinical trials. My collaborative research include the following clinical areas: liver injury, cardiovascular imaging, radiology imaging, cardiovascular disease, renal disease, reproductive medicine, Parkinson disease, and aging.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biostatistics & Bioinformatics
·
2024 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Professor of Biostatistics & Bioinformatics
·
2009 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Associate Chair for Faculty Mentorship and Development
·
2019 - Present
Biostatistics & Bioinformatics,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2003 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Testing Interventions that Address Kidney Health Disparities.
Journal Article J Am Soc Nephrol · May 1, 2025 Full text Link to item CiteSample Size and Power Calculations With Win Measures Based on Hierarchical Endpoints.
Journal Article Stat Med · May 2025 Win measures, such as win ratio, win odds, net benefit, and desirability of outcome ranking (DOOR), have become popular approaches for the analysis of hierarchical endpoints in clinical studies. Sample size and power calculations with win measures based on ... Full text Link to item CiteClinical and HLA associations of fluoroquinolone induced liver injury: results from the Drug-Induced Liver Injury Network.
Journal Article Am J Gastroenterol · April 10, 2025 BACKGROUND AND AIMS: Fluoroquinolones (FQ) have a favorable safety profile, but the risk of drug-induced liver injury (DILI) is well described. The aim of this study was to identify clinical features and HLA genetic variants associated with FQ-DILI in a la ... Full text Link to item CiteRecent Grants
Trial of Sequential Medications AfteR TNF failure in JIA (SMART-JIA)
ResearchCo-Principal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2030Drug Induced Liver Injury Network Data Coordinating Center
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2028Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027View All Grants
Education, Training & Certifications
University of Pittsburgh ·
1992
Ph.D.
University of Pittsburgh ·
1988
M.A.