Overview
My research interests include both statistical methodology and disease-specific clinical research biostatistics. My statistical research areas include methods for outcomes, endpoints, estimands, assessing reliability/agreement between methods or raters, evaluating performance of new medical diagnostic tests, and methods for design of clinical trials. My collaborative research include the following clinical areas: liver injury, cardiovascular imaging, radiology imaging, cardiovascular disease, renal disease, reproductive medicine, Parkinson disease, and aging.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biostatistics & Bioinformatics
·
2024 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Professor of Biostatistics & Bioinformatics
·
2009 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Associate Chair for Faculty Mentorship and Development
·
2019 - Present
Biostatistics & Bioinformatics,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2003 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Clinical and Genetic Associations in Cephalosporin-Induced Liver Injury: Insights From the Drug-Induced Liver Injury Network.
Journal Article Aliment Pharmacol Ther · November 2025 INTRODUCTION: Cephalosporins are widely prescribed antibiotics due to their efficacy and safety. Although rare, idiosyncratic drug-induced liver injury (DILI) has been reported with their use. Here, we characterise the clinical features and HLA association ... Full text Link to item CiteEditorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky. Authors' Reply.
Journal Article Aliment Pharmacol Ther · November 2025 Full text Link to item CiteImpact of Individualized Versus Weight-Based Pain Protocols on Patient Satisfaction for Patients With Sickle Cell Disease Experiencing a Vaso-Occlusive Episode.
Journal Article J Emerg Nurs · July 2025 INTRODUCTION: National guidelines for the acute management of sickle cell disease vaso-occlusive episodes recommend the use of a patient-specific or a weight-based protocol. The authors compared patient satisfaction with pain management between those rando ... Full text Link to item CiteRecent Grants
Trial of Sequential Medications AfteR TNF failure in JIA (SMART-JIA)
ResearchCo-Principal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2031Drug Induced Liver Injury Network Data Coordinating Center
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2028Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 1988 - 2027View All Grants
Education, Training & Certifications
University of Pittsburgh ·
1992
Ph.D.
University of Pittsburgh ·
1988
M.A.