Overview
My research interests include both statistical methodology and disease-specific clinical research biostatistics. My statistical research areas include methods for outcomes, endpoints, estimands, assessing reliability/agreement between methods or raters, evaluating performance of new medical diagnostic tests, and methods for design of clinical trials. My collaborative research include the following clinical areas: liver injury, cardiovascular imaging, radiology imaging, cardiovascular disease, renal disease, reproductive medicine, Parkinson disease, and aging.
Current Duke Appointments & Affiliations
James B. Duke Distinguished Professor of Biostatistics & Bioinformatics
·
2024 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Professor of Biostatistics & Bioinformatics
·
2009 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Associate Chair for Faculty Mentorship and Development
·
2019 - Present
Biostatistics & Bioinformatics,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2003 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Scholarly Works
Beyond Hy's Law: Importance of Markedly Elevated Aminotransferases without Hyperbilirubinemia.
Journal article Clin Pharmacol Ther · July 25, 2026 Elevated aminotransferases with concomitant jaundice in drug-induced liver injury (DILI) are associated with adverse outcomes, but the prognostic significance of very high aminotransferases without jaundice is unclear. We examined selected outcomes of pati ... Full text Link to item CiteLiver Injury From Medications Used for Treating Inflammatory Bowel Disease: The Drug-Induced Liver Injury Network Experience.
Journal article Liver Int · July 2026 BACKGROUND: We aimed to investigate and characterise DILI due to approved therapies for inflammatory bowel disease (IBD). METHODS: Using the Drug-Induced Liver Injury Network (DILIN) prospective study, we evaluated definite, highly likely, or probable DILI ... Full text Link to item CitePatient-Centered Evaluation of Anticoagulation in Atrial Fibrillation.
Journal article NEJM Evid · June 2026 BACKGROUND: Prior analyses of trials comparing direct oral anticoagulants (DOACs) to warfarin in atrial fibrillation (AF) have not routinely incorporated patient preferences, despite substantial variation in how patients value the trade-off between outcome ... Full text Link to item CiteRecent Grants
Trial of Sequential Medications AfteR TNF failure in JIA (SMART-JIA)
ResearchCo-Principal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2024 - 2031Drug Induced Liver Injury Network Data Coordinating Center
ResearchPrincipal Investigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2003 - 2028Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 1988 - 2027View All Grants
Education
University of Pittsburgh ·
1992
Ph.D.
University of Pittsburgh ·
1988
M.A.