Huiman Xie Barnhart

Journal Article Aliment Pharmacol Ther · September 2024 BACKGROUND: Azithromycin (AZ) is a widely used antibiotic. The aim of this study was to characterise the clinical features, outcomes, and HLA association in patients with drug-induced liver injury (DILI) due to AZ. METHODS: The clinical characteristics of ... Full text Link to item Cite

Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors.

Journal Article Hepatol Commun · September 1, 2024 BACKGROUND: The clinical features, liver histology, and genetic variants in 57 patients with moderate to severe immune-mediated liver injury from checkpoint inhibitors (ILICI) are presented. METHODS: Between 2010 and 2022, 57 high-causality ILICI cases wer ... Full text Link to item Cite

Comparison of Measures of Pain Intensity During Sickle Cell Disease Vaso-Occlusive Episodes.

Journal Article J Pain · August 21, 2024 We aimed to determine the minimal clinically important difference (MCID) in pain severity and agreement between the visual analog scale (VAS) and the verbal numeric rating scale (NRS) in people with sickle cell disease (SCD) experiencing an acute vaso-occl ... Full text Link to item Cite

Characterisation of an outbreak of acute liver injury after ingestion of plant-based food supplement.

Journal Article Aliment Pharmacol Ther · August 2024 BACKGROUND: In April 2022, French Lentil and Leek Crumble (FLLC), a new frozen food preparation manufactured by Daily Harvest™ (containing Tara flour) was offered as a natural high-protein meal product. Soon thereafter, widespread anecdotal reports of acut ... Full text Link to item Cite

Clinical Outcomes Among High-Risk Primary Care Patients With Diabetic Kidney Disease: Methodological Challenges and Results From the STOP-DKD Study.

Journal Article Med Care · July 18, 2024 BACKGROUND/OBJECTIVE: Slowing the progression of diabetic kidney disease (DKD) is critical. We conducted a randomized controlled trial to target risk factors for DKD progression. METHODS: We evaluated the effect of a pharmacist-led intervention focused on ... Full text Link to item Cite

Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations.

Journal Article Liver Int · June 2024 OBJECTIVE: To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI. METHODS: In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach. H ... Full text Link to item Cite

Drug-Induced Liver Injury in Pregnancy: The U.S. Drug-Induced Liver Injury Network Experience.

Journal Article Obstet Gynecol · June 1, 2024 There are limited data on the causative agents and characteristics of drug-induced liver injury in pregnant individuals. Data from patients with drug-induced liver injury enrolled in the ongoing multicenter Drug-Induced Liver Injury Network between 2004 an ... Full text Link to item Cite

Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations.

Journal Article Dig Dis Sci · April 2024 OBJECTIVE: To describe hepatotoxicity due to amiodarone and dronedarone from the DILIN and the US FDA's surveillance database. METHODS: Hepatotoxicity due to amiodarone and dronedarone enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) from 200 ... Full text Link to item Cite

HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.

Journal Article Am J Gastroenterol · January 1, 2024 INTRODUCTION: To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA). METHODS: In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non-AEDs ... Full text Link to item Cite

Vancomycin-Induced Liver Injury, DRESS, and HLA-A∗32:01.

Journal Article J Allergy Clin Immunol Pract · January 2024 BACKGROUND: Intravenous vancomycin therapy can cause liver injury as well as "drug reaction with eosinophilia and systemic symptoms" (DRESS) syndrome. This study aimed to better define the clinical features and HLA associations of vancomycin-induced liver ... Full text Link to item Cite

Trial Design with Win Statistics for Multiple Time-to-Event Endpoints with Hierarchy

Journal Article Statistics in Biopharmaceutical Research · January 1, 2024 The conventional approach to the analysis of composite endpoints is time-to-first event analysis. However, this approach has been criticized because it ignores the differences in clinical severity and may end up emphasizing the less severe time-to-event. T ... Full text Cite

Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly.

Journal Article Hematology · December 2023 Anemia is common in older adults, but often unexplained. Previously, we conducted a randomized, controlled trial of intravenous (IV) iron sucrose to study its impact on the 6-minute walk test and hemoglobin in older adults with unexplained anemia and ferri ... Full text Link to item Cite

When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network.

Journal Article Am J Gastroenterol · December 1, 2023 INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy. METHODS: C ... Full text Link to item Cite

A comparison of the effect of patient-specific versus weight-based protocols to treat vaso-occlusive episodes in the emergency department.

Journal Article Acad Emerg Med · December 2023 BACKGROUND: Vaso-occlusive crises (VOCs) cause debilitating pain and are a common cause of emergency department (ED) visits, for people with sickle cell disease (SCD). Strategies for achieving optimal pain control vary widely despite evidence-based guideli ... Full text Open Access Link to item Cite

The Impact of Patient Age and Corticosteroids in Patients With Sulfonamide Hepatotoxicity.

Journal Article Am J Gastroenterol · September 1, 2023 INTRODUCTION: Sulfonamides are widely used to treat and prevent various bacterial and opportunistic infections. The aim of this study was to describe the clinical presentation and outcomes of a large cohort of patients with sulfonamide hepatotoxicity. METH ... Full text Link to item Cite

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.

Journal Article Gastroenterology · March 2023 BACKGROUND & AIMS: Drug-induced liver injury (DILI) due to amoxicillin-clavulanate (AC) has been associated with HLA-A∗02:01, HLA-DRB1∗15:01, and rs2476601, a missense variant in PTPN22. The aim of this study was to identify novel risk factors for AC-DILI ... Full text Link to item Cite

Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury.

Journal Article J Hepatol · February 2023 BACKGROUND & AIMS: Nitrofurantoin (NTF) is widely used for the treatment (short-term) and prevention (long-term) of urinary tract infections. We aimed to describe the clinical characteristics, outcomes, and HLA risk factors for NTF-induced liver injury (NT ... Full text Link to item Cite

Multiparametric Quantitative Imaging Biomarkers for Phenotype Classification: A Framework for Development and Validation.

Journal Article Acad Radiol · February 2023 This manuscript is the third in a five-part series related to statistical assessment methodology for technical performance of multi-parametric quantitative imaging biomarkers (mp-QIBs). We outline approaches and statistical methodologies for developing and ... Full text Link to item Cite

Multiparametric Quantitative Imaging in Risk Prediction: Recommendations for Data Acquisition, Technical Performance Assessment, and Model Development and Validation.

Journal Article Acad Radiol · February 2023 Combinations of multiple quantitative imaging biomarkers (QIBs) are often able to predict the likelihood of an event of interest such as death or disease recurrence more effectively than single imaging measurements can alone. The development of such multip ... Full text Link to item Cite

Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN].

Journal Article Am J Med · February 2023 BACKGROUND: Turmeric is a commonly used herbal product that has been implicated in causing liver injury. The aim of this case series is to describe the clinical, histologic, and human leukocyte antigen (HLA) associations of turmeric-associated liver injury ... Full text Link to item Cite

Clinical characteristics and HLA associations of azithromycin-induced liver injury.

Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors.

Comparison of Measures of Pain Intensity During Sickle Cell Disease Vaso-Occlusive Episodes.

Characterisation of an outbreak of acute liver injury after ingestion of plant-based food supplement.

Clinical Outcomes Among High-Risk Primary Care Patients With Diabetic Kidney Disease: Methodological Challenges and Results From the STOP-DKD Study.

Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations.

Drug-Induced Liver Injury in Pregnancy: The U.S. Drug-Induced Liver Injury Network Experience.

Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations.

HLA-B*53:01 Is a Significant Risk Factor of Liver Injury due to Phenytoin and Other Antiepileptic Drugs in African Americans.

Vancomycin-Induced Liver Injury, DRESS, and HLA-A∗32:01.

Trial Design with Win Statistics for Multiple Time-to-Event Endpoints with Hierarchy

Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly.

When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network.

A comparison of the effect of patient-specific versus weight-based protocols to treat vaso-occlusive episodes in the emergency department.

The Impact of Patient Age and Corticosteroids in Patients With Sulfonamide Hepatotoxicity.

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.

Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury.

Multiparametric Quantitative Imaging Biomarkers for Phenotype Classification: A Framework for Development and Validation.

Multiparametric Quantitative Imaging in Risk Prediction: Recommendations for Data Acquisition, Technical Performance Assessment, and Model Development and Validation.

Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN].

Multiparametric Data-driven Imaging Markers: Guidelines for Development, Application and Reporting of Model Outputs in Radiomics.

Journal Article Acad Radiol · February 2023 This paper is the fifth in a five-part series on statistical methodology for performance assessment of multi-parametric quantitative imaging biomarkers (mpQIBs) for radiomic analysis. Radiomics is the process of extracting visually imperceptible features f ... Full text Link to item Cite

Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap.

Journal Article Acad Radiol · February 2023 Multiparametric quantitative imaging biomarkers (QIBs) offer distinct advantages over single, univariate descriptors because they provide a more complete measure of complex, multidimensional biological systems. In disease, where structural and functional d ... Full text Link to item Cite

Incidence of Hepatitis E Infection in American Patients With Suspected Drug-Induced Liver Injury Is Low and Declining: The DILIN Prospective Study.

Journal Article Am J Gastroenterol · September 1, 2022 INTRODUCTION: Hepatitis E virus (HEV) infection rarely causes icteric hepatitis, yet 10%-40% of adult Americans have serological evidence of previous infection. The aim of this study was to investigate the incidence, presentation, and outcome of acute and ... Full text Link to item Cite

A revised electronic version of RUCAM for the diagnosis of DILI.

Journal Article Hepatology · July 2022 BACKGROUND AND AIMS: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish DILI Regist ... Full text Link to item Cite

Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury.

Journal Article Clin Gastroenterol Hepatol · June 2022 BACKGROUND & AIMS: Garcinia cambogia, either alone or with green tea, is commonly promoted for weight loss. Sporadic cases of liver failure from G cambogia have been reported, but its role in liver injury is controversial. METHODS: Among 1418 patients enro ... Full text Link to item Cite

Leflunomide-induced liver injury: Differences in characteristics and outcomes in Indian and US registries.

Journal Article Liver Int · June 2022 BACKGROUND: Leflunomide, a disease-modifying anti-rheumatic drug, has been associated with elevations of serum aminotransferases. Herein, we describe the clinical, laboratory features and outcomes of 17 patients with leflunomide/teriflunomide hepatotoxicit ... Full text Link to item Cite

Value of liver biopsy in the diagnosis of drug-induced liver injury.

Journal Article J Hepatol · May 2022 BACKGROUND & AIMS: The utility of liver biopsy in diagnosing or staging idiosyncratic drug-induced liver injury (DILI) is unclear. The aim of this study was to determine whether liver histology impacted causality assessment in suspected DILI using a novel ... Full text Link to item Cite

Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study.

Journal Article J Hepatol · April 2022 BACKGROUND & AIMS: Antiepileptic drugs (AEDs) are a common cause of drug-induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other ... Full text Link to item Cite

Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles.

Journal Article Liver Int · August 2021 BACKGROUND/AIMS: Allopurinol can cause HLA class I-associated life-threatening severe skin reactions. However, HLA risk and association with clinical features in allopurinol hepatotoxicity are unknown. METHODS: Eleven of 17 patients with suspected allopuri ... Full text Link to item Cite

HLA-B*35:01 and Green Tea-Induced Liver Injury.

Journal Article Hepatology · June 2021 BACKGROUND AND AIMS: Herbal supplements, and particularly multi-ingredient products, have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. The ... Full text Link to item Cite

Differences in NT-proBNP Response and Prognosis in Men and Women With Heart Failure With Reduced Ejection Fraction.

Journal Article J Am Heart Assoc · May 18, 2021 Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a prognostic biomarker in heart failure (HF) with reduced ejection fraction. However, it is unclear whether there is a sex difference in NT-proBNP response and whether the therapeutic goal ... Full text Link to item Cite

Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE).

Journal Article Contemp Clin Trials · February 2021 OBJECTIVES: Painful vaso-occlusive episodes (VOE) are the most common reason for emergency department (ED) visits experienced by patients with sickle cell disease (SCD). The National Heart, Lung and Blood Institute (NHLBI) evidence-based recommendations fo ... Full text Link to item Cite

Human Leukocyte Antigen B14:01 and B35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.

Journal Article Hepatology · January 2021 BACKGROUND AND AIMS: Trimethoprim (TMP)-sulfamethoxazole (SMX) is an important cause of idiosyncratic drug-induced liver injury (DILI), but its genetic risk factors are not well understood. This study investigated the relationship between variants in the h ... Full text Link to item Cite

Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature.

Journal Article Drug Alcohol Depend · January 1, 2021 BACKGROUND: Kratom is a botanical product used as an opium substitute with abuse potential. METHODS: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort. RESULTS: Eleven cases of liver injury attributed to kratom were id ... Full text Link to item Cite

Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Journal Article Nat Commun · April 28, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Significant Medical Comorbidities Are Associated With Lower Causality Scores in Patients Presenting With Suspected Drug-Induced Liver Injury.

Journal Article Clin Transl Gastroenterol · April 2020 INTRODUCTION: Drug-induced liver injury (DILI) is a diagnosis of exclusion, and it can be challenging to adjudicate when there are multiple comorbidities and concomitant medications. In this study, we tested the hypothesis that comorbidity burden impacts t ... Full text Link to item Cite

Development and Validation of a Model Consisting of Comorbidity Burden to Calculate Risk of Death Within 6 Months for Patients With Suspected Drug-Induced Liver Injury.

Journal Article Gastroenterology · November 2019 BACKGROUND & AIMS: Patients with drug-induced liver injury (DILI) frequently have comorbid conditions, but the effects of non-liver comorbidities on outcomes are not well understood. We investigated the association between comorbidity burden and outcomes o ... Full text Link to item Cite

Incident anaemia in older adults with heart failure: rate, aetiology, and association with outcomes.

Journal Article Eur Heart J Qual Care Clin Outcomes · October 1, 2019 AIMS: Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anaemia of the elderly in heart failure (HF). Thus, we aimed to determine the incidence of anaemia, to characterize diagnostic testing patterns for potentially ... Full text Link to item Cite

Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury.

Journal Article Dig Dis Sci · September 2019 BACKGROUND AND AIMS: The aims were to review the diagnosis, testing and presentation of acute hepatitis C (HCV) in patients initially diagnosed to have drug-induced liver injury (DILI) enrolled in the US DILI Network. METHODS: All patients with suspected D ... Full text Link to item Cite

Antimicrobials and Antiepileptics Are the Leading Causes of Idiosyncratic Drug-induced Liver Injury in American Children.

Journal Article J Pediatr Gastroenterol Nutr · August 2019 OBJECTIVES: The aim of this study was to provide an overview of the presenting features, etiologies, and outcomes of children enrolled in the Drug-induced Liver Injury Network (DILIN) prospective and retrospective studies. METHODS: Consecutive definite, hi ... Full text Link to item Cite

Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors.

Journal Article Aliment Pharmacol Ther · May 2019 BACKGROUND: Bodybuilding supplements can cause a profound cholestatic syndrome. AIM: To describe the drug-Induced liver injury network's experience with liver injury due to bodybuilding supplements. METHODS: Liver injury pattern, severity and outcomes, pot ... Full text Link to item Cite

Sclerosing Cholangitis-Like Changes on Magnetic Resonance Cholangiography in Patients With Drug Induced Liver Injury.

Journal Article Clin Gastroenterol Hepatol · March 2019 Drug-induced liver injury can lead to changes of the biliary tree that resemble sclerosing cholangitis. These changes can be seen on magnetic resonance cholangiopancreatography. Idiosyncratic drug-induced liver injury (DILI) has a variable presentation inc ... Full text Link to item Cite

NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.

Journal Article JACC Heart Fail · February 2019 OBJECTIVES: This study aims to assess the association between biomarker-guided therapy and left ventricular (LV) remodeling. BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF), it is unclear if lowering natriuretic peptides r ... Full text Link to item Cite

Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury

Journal Article Hepatology Communications · January 1, 2019 With the application of genetic testing to contemporary medical diagnostics and practice, it has become apparent that the phenotypes of many disorders are modulated by host genetic factors. The aim of the current study was to determine whether selected sin ... Full text Cite

Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Journal Article PLoS One · 2019 [This corrects the article DOI: 10.1371/journal.pone.0206389.]. ... Full text Link to item Cite

The Impact of a Rigorous Quality Program on 3D Echocardiography Data Quality in an International Multisite Randomized Trial.

Conference JACC Cardiovasc Imaging · December 2018 Full text Link to item Cite

The role of HLA-A*33:01 in patients with cholestatic hepatitis attributed to terbinafine.

Journal Article J Hepatol · December 2018 BACKGROUND & AIMS: Terbinafine is an antifungal agent that has been associated with rare instances of hepatotoxicity. In this study we aimed to describe the presenting features and outcomes of patients with terbinafine hepatotoxicity and to investigate the ... Full text Link to item Cite

Working With Statisticians in Clinical Research.

Journal Article Stroke · November 2018 Full text Link to item Cite

Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study: Protocol and baseline characteristics of a randomized controlled trial.

Journal Article Contemp Clin Trials · June 2018 UNLABELLED: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the United States. Multiple risk factors contribute to DKD development, yet few interventions target more than a single DKD risk factor at a time. This man ... Full text Open Access Link to item Cite

Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology.

Journal Article J Am Soc Echocardiogr · March 2018 BACKGROUND: As the potential for cancer therapy-related cardiac dysfunction is increasingly recognized, there is a need for the standardization of echocardiographic measurements and cut points to guide treatment. The aim of this study was to determine the ... Full text Link to item Cite

Ambulatory blood pressure in the dash diet trial: Effects of race and albuminuria.

Journal Article J Clin Hypertens (Greenwich) · February 2018 We evaluated whether low-grade albuminuria or black race modulates ambulatory blood pressure (BP) or nocturnal BP response to the DASH diet. Among 202 adults enrolled in the DASH multicenter trial who were fed the DASH or control diet for 8 weeks, reductio ... Full text Link to item Cite

Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

Journal Article PLoS One · 2018 Changes in levels of cytokines and chemokines have been proposed as possible biomarkers of tissue injury, including liver injury due to drugs. Recently, in acute drug-induced liver injury (DILI), we showed that 19 of 27 immune analytes were differentially ... Full text Open Access Link to item Cite

Predictors and Outcomes of Reverse Remodeling in Heart Failure With Reduced Ejection Fraction

Conference CIRCULATION · 2018 Cite

Racial differences in nocturnal dipping status in diabetic kidney disease: Results from the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) study.

Journal Article J Clin Hypertens (Greenwich) · December 2017 While racial variation in ambulatory blood pressure (BP) is known, patterns of diurnal dipping in the context of diabetic kidney disease have not been well defined. The authors sought to determine the association of race with nocturnal dipping status among ... Full text Open Access Link to item Cite

Identification and Characterization of Fenofibrate-Induced Liver Injury.

Journal Article Dig Dis Sci · December 2017 BACKGROUND: Fenofibrate is a commonly used hypolipidemic associated with rare instances of hepatotoxicity, and routine liver biochemistry monitoring is recommended. AIMS: The aim of this study is to describe the presenting clinical features, liver histopat ... Full text Link to item Cite

Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.

Journal Article Circ Heart Fail · December 2017 BACKGROUND: Mitochondrial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in heart failure management. Elamipretide is a novel tetrapeptide that increases mitochondrial energy; however, its safety, tolerability, and ... Full text Link to item Cite

Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.

Journal Article Liver Int · November 2017 BACKGROUND & AIM: Gender and menopause may contribute to type and severity of drug-induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of menopause] ... Full text Link to item Cite

Death and liver transplantation within 2 years of onset of drug-induced liver injury.

Journal Article Hepatology · October 2017 UNLABELLED: Drug-induced liver injury (DILI) is an important cause of death and indication for liver transplantation (fatality). The role of DILI in these fatalities is poorly characterized, particularly when fatalities occur >26 weeks after DILI onset. We ... Full text Link to item Cite

Testing for Hepatitis C Virus RNA is Recommended in Patients with Suspected Drug Induced Liver Injury (DILI)

Conference HEPATOLOGY · October 1, 2017 Link to item Cite

Minocycline and anti-epileptics are the leading causes of DILI in Children

Conference HEPATOLOGY · October 1, 2017 Link to item Cite

Idiosyncratic Drug Induced Liver Injury in African-Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians.

Journal Article Am J Gastroenterol · September 2017 OBJECTIVES: Idiosyncratic drug induced liver injury (DILI) is a rare but potentially serious liver disorder and a major cause of significant liver injury. Limited data exist on racial differences in DILI incidence, presentation, and course. METHODS: We com ... Full text Link to item Cite

Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗35:02 as a risk factor.

Conference J Hepatol · July 2017 BACKGROUND & AIMS: Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline drug-induced liver injury (DILI) in a well-phenotyped ... Full text Link to item Cite

Comparison of Associations of Reduced Estimated Glomerular Filtration Rate With Stroke Outcomes Between Hypertension and No Hypertension.

Journal Article Stroke · June 2017 BACKGROUND AND PURPOSE: We compared the association of low estimated glomerular filtration rate (eGFR) with stroke outcomes among patients with hypertension and without hypertension. METHODS: We used the China stroke registry to identify patients on discha ... Full text Link to item Cite

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Journal Article Gastroenterology · April 2017 BACKGROUND & AIMS: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS: We performed a GWAS of 862 persons w ... Full text Link to item Cite

Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements.

Journal Article Hepatology · April 2017 UNLABELLED: Bile duct loss during the course of drug-induced liver injury is uncommon, but can be an indication of vanishing bile duct syndrome (VBDS). In this work, we assess the frequency, causes, clinical features, and outcomes of cases of drug-induced ... Full text Link to item Cite

Methods for assessing the reliability of quality of life based on SF-36.

Journal Article Stat Med · December 30, 2016 The 36-Item Short Form Health Survey (SF-36) has been widely used to measure quality of life. Reliability has been traditionally assessed by intraclass correlation coefficient (ICC), which is equivalent to Cronbach's alpha theoretically. However, it is a s ... Full text Link to item Cite

Choice of agreement indices for assessing and improving measurement reproducibility in a core laboratory setting.

Journal Article Stat Methods Med Res · December 2016 Clinical core laboratories, such as Echocardiography core laboratories, are increasingly used in clinical studies with imaging outcomes as primary, secondary, or surrogate endpoints. While many factors contribute to the quality of measurements of imaging v ... Full text Link to item Cite

Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.

Journal Article J Am Soc Echocardiogr · December 2016 BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twe ... Full text Open Access Link to item Cite

A Novel Computerized Drug Induced Liver Injury Causality Assessment Tool (DILI-CAT)

Conference HEPATOLOGY · October 1, 2016 Link to item Cite

Drug Induced Liver Injury Associated with Sclerosing Cholangitis Like Changes on Magnetic Resonance Cholangiography Imaging

Conference HEPATOLOGY · October 1, 2016 Link to item Cite

Idiosyncratic drug induced liver injury in African Americans: Causes, Clinical Features and Outcomes

Conference HEPATOLOGY · October 1, 2016 Link to item Cite

Assessing agreement with relative area under the coverage probability curve.

Journal Article Stat Med · August 15, 2016 There has been substantial statistical literature in the last several decades on assessing agreement, and coverage probability approach was selected as a preferred index for assessing and improving measurement agreement in a core laboratory setting. With t ... Full text Link to item Cite

Amoxicillin-Clavulanate-Induced Liver Injury.

Journal Article Dig Dis Sci · August 2016 BACKGROUND AND AIMS: Amoxicillin-clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry. Here, we examined a large cohort of AC-DILI cases and compared features of AC-DILI to those of ... Full text Link to item Cite

Short-term effects of the DASH diet in adults with moderate chronic kidney disease: a pilot feeding study.

Journal Article Clin Kidney J · August 2016 BACKGROUND: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) for adults with normal kidney function, evidence is lacking regarding its safety and efficacy in chronic kidney disease (CKD). We aimed to test the effe ... Full text Open Access Link to item Cite

Echocardiographic agreement in the diagnostic evaluation for infective endocarditis.

Journal Article Int J Cardiovasc Imaging · July 2016 Echocardiography is essential for the diagnosis and management of infective endocarditis (IE). However, the reproducibility for the echocardiographic assessment of variables relevant to IE is unknown. Objectives of this study were: (1) To define the reprod ... Full text Link to item Cite

Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims.

Journal Article Acad Radiol · April 2016 A major initiative of the Quantitative Imaging Biomarker Alliance is to develop standards-based documents called "Profiles," which describe one or more technical performance claims for a given imaging modality. The term "actor" denotes any entity (device, ... Full text Open Access Link to item Cite

A simulation study of nonparametric total deviation index as a measure of agreement based on quantile regression.

Journal Article J Biopharm Stat · 2016 Total deviation index (TDI) captures a prespecified quantile of the absolute deviation of paired observations from raters, observers, methods, assays, instruments, etc. We compare the performance of TDI using nonparametric quantile regression to the TDI as ... Full text Link to item Cite

The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis.

Journal Article Clin Cases Miner Bone Metab · 2016 OBJECTIVES: To evaluate whether lumbar vertebral body density CT attenuation values measured in Hounsfield Units (HUs) on routine Computed Tomography (CT) examinations can be reliably measured with limited variability, and to evaluate for a correlation bet ... Full text Link to item Cite

Numeric score-based conditional and overall change-in-status indices for ordered categorical data.

Journal Article Stat Med · November 30, 2015 Planned interventions and/or natural conditions often effect change on an ordinal categorical outcome (e.g., symptom severity). In such scenarios, it is sometimes desirable to assign a priori scores to observed changes in status, typically giving higher we ... Full text Link to item Cite