Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Detection of pancreatic tumors, image quality, and radiation dose during the pancreatic parenchymal phase: effect of a low-tube-voltage, high-tube-current CT technique--preliminary results.

Publication ,  Journal Article
Marin, D; Nelson, RC; Barnhart, H; Schindera, ST; Ho, LM; Jaffe, TA; Yoshizumi, TT; Youngblood, R; Samei, E
Published in: Radiology
August 2010

PURPOSE: To intraindividually compare a low-tube-voltage (80 kVp), high-tube-current (675 mA) computed tomographic (CT) technique with a high-tube-voltage (140 kVp) CT protocol for the detection of pancreatic tumors, image quality, and radiation dose during the pancreatic parenchymal phase. MATERIALS AND METHODS: This prospective, single-center, HIPAA-compliant study was approved by the institutional review board, and written informed consent was obtained. Twenty-seven patients (nine men, 18 women; mean age, 64 years) with 23 solitary pancreatic tumors underwent dual-energy CT. Two imaging protocols were used: 140 kVp and 385 mA (protocol A) and 80 kVp and 675 mA (protocol B). For both protocols, the following variables were compared during the pancreatic parenchymal phase: contrast enhancement for the aorta, the pancreas, and the portal vein; pancreas-to-tumor contrast-to-noise ratio (CNR); noise; and effective dose. Two blinded, independent readers qualitatively scored the two data sets for tumor detection and image quality. Random-effect analysis of variance tests were used to compare differences between the two protocols. RESULTS: Compared with protocol A, protocol B yielded significantly higher contrast enhancement for the aorta (508.6 HU vs 221.5 HU, respectively), pancreas (151.2 HU vs 67.0 HU), and portal vein (189.7 HU vs 87.3 HU), along with a greater pancreas-to-tumor CNR (8.1 vs 5.9) (P < .001 for all comparisons). No statistically significant difference in tumor detection was observed between the two protocols. Although standard deviation of image noise increased with protocol B (11.5 HU vs 18.6 HU), this protocol significantly reduced the effective dose (from 18.5 to 5.1 mSv; P < .001). CONCLUSION: A low-tube-voltage, high-tube-current CT technique has the potential to improve the enhancement of the pancreas and peripancreatic vasculature, improve tumor conspicuity, and reduce patient radiation dose during the pancreatic parenchymal phase.

Duke Scholars

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

August 2010

Volume

256

Issue

2

Start / End Page

450 / 459

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiation Protection
  • Radiation Dosage
  • Pilot Projects
  • Pancreatic Neoplasms
  • Pancreas
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Marin, D., Nelson, R. C., Barnhart, H., Schindera, S. T., Ho, L. M., Jaffe, T. A., … Samei, E. (2010). Detection of pancreatic tumors, image quality, and radiation dose during the pancreatic parenchymal phase: effect of a low-tube-voltage, high-tube-current CT technique--preliminary results. Radiology, 256(2), 450–459. https://doi.org/10.1148/radiol.10091819
Marin, Daniele, Rendon C. Nelson, Huiman Barnhart, Sebastian T. Schindera, Lisa M. Ho, Tracy A. Jaffe, Terry T. Yoshizumi, Richard Youngblood, and Ehsan Samei. “Detection of pancreatic tumors, image quality, and radiation dose during the pancreatic parenchymal phase: effect of a low-tube-voltage, high-tube-current CT technique--preliminary results.Radiology 256, no. 2 (August 2010): 450–59. https://doi.org/10.1148/radiol.10091819.
Marin D, Nelson RC, Barnhart H, Schindera ST, Ho LM, Jaffe TA, Yoshizumi TT, Youngblood R, Samei E. Detection of pancreatic tumors, image quality, and radiation dose during the pancreatic parenchymal phase: effect of a low-tube-voltage, high-tube-current CT technique--preliminary results. Radiology. 2010 Aug;256(2):450–459.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

August 2010

Volume

256

Issue

2

Start / End Page

450 / 459

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiation Protection
  • Radiation Dosage
  • Pilot Projects
  • Pancreatic Neoplasms
  • Pancreas
  • Nuclear Medicine & Medical Imaging
  • Middle Aged