Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature.
Publication
, Journal Article
Ahmad, J; Odin, JA; Hayashi, PH; Fontana, RJ; Conjeevaram, H; Avula, B; Khan, IA; Barnhart, H; Vuppalanchi, R; Navarro, VJ ...
Published in: Drug Alcohol Depend
January 1, 2021
BACKGROUND: Kratom is a botanical product used as an opium substitute with abuse potential. METHODS: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort. RESULTS: Eleven cases of liver injury attributed to kratom were identified with a recent increase. The majority were male with median age 40 years. All were symptomatic and developed jaundice with a median latency of 14 days. The liver injury pattern was variable, most required hospitalization and all eventually recovered. Biochemical analysis revealed active kratom ingredients. CONCLUSION: Kratom can cause severe liver injury with jaundice.
Duke Scholars
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Published In
Drug Alcohol Depend
DOI
EISSN
1879-0046
Publication Date
January 1, 2021
Volume
218
Start / End Page
108426
Location
Ireland
Related Subject Headings
- United States
- Substance Abuse
- Prospective Studies
- Mitragyna
- Male
- Humans
- Female
- Chemical and Drug Induced Liver Injury
- Analgesics, Opioid
- Adult
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Ahmad, J., Odin, J. A., Hayashi, P. H., Fontana, R. J., Conjeevaram, H., Avula, B., … Drug-Induced Liver Injury Network, . (2021). Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend, 218, 108426. https://doi.org/10.1016/j.drugalcdep.2020.108426
Ahmad, Jawad, Joseph A. Odin, Paul H. Hayashi, Robert J. Fontana, Hari Conjeevaram, Bharathi Avula, Ikhlas A. Khan, et al. “Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature.” Drug Alcohol Depend 218 (January 1, 2021): 108426. https://doi.org/10.1016/j.drugalcdep.2020.108426.
Ahmad J, Odin JA, Hayashi PH, Fontana RJ, Conjeevaram H, Avula B, et al. Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend. 2021 Jan 1;218:108426.
Ahmad, Jawad, et al. “Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature.” Drug Alcohol Depend, vol. 218, Jan. 2021, p. 108426. Pubmed, doi:10.1016/j.drugalcdep.2020.108426.
Ahmad J, Odin JA, Hayashi PH, Fontana RJ, Conjeevaram H, Avula B, Khan IA, Barnhart H, Vuppalanchi R, Navarro VJ, Drug-Induced Liver Injury Network. Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend. 2021 Jan 1;218:108426.
Published In
Drug Alcohol Depend
DOI
EISSN
1879-0046
Publication Date
January 1, 2021
Volume
218
Start / End Page
108426
Location
Ireland
Related Subject Headings
- United States
- Substance Abuse
- Prospective Studies
- Mitragyna
- Male
- Humans
- Female
- Chemical and Drug Induced Liver Injury
- Analgesics, Opioid
- Adult