Overview
The incorporation of personalized medicine to all areas of human health represents a turning point for human genetics studies, a point at which the discoveries made have real implications for clinical medicine. It is important for students to gain experience in how human genetics studies are conducted and how results of those studies may be used. As a statistical geneticist and biostatistician my research interests are focused on developing and applying statistical methods to search for genes causing common human diseases. My research programs combine development and application of statistical methods for genetic studies, with a particular emphasis on understanding the joint effects of genes and environment.
These studies I work on cover diverse areas in biomedicine but are always collaborative, with the goal of bringing robust data science and statistical methods to the project. Collaborative studies include genetic and ‘omics studies of cardiovascular disease, health effects of air pollution, genetic analysis of adherence to an exercise program, genetic analysis in evaluating colon cancer risk, genetic analysis of suicide, and systems biology analysis of Gulf War Illness.
Keywords: human genetics, genetic association, gene mapping, genetic epidemiology, statistical genetics, biostatistics, cardiovascular disease, computational biology, diabetes, aging, colon cancer, colon polyps, kidney disease, Gulf War Illness, exercise behavior, suicide
Current Appointments & Affiliations
Recent Publications
Genotype-by-sex interaction analyses for alcohol use disorder across biobanks
Journal Article Alcohol Clinical and Experimental Research · November 1, 2025 Background: Alcohol use and alcohol use disorder (AUD) are significant contributors to morbidity and mortality, with different prevalences between males and females. Despite the established genetic contribution to AUD, sex as a biological variable and the ... Full text CiteAn African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy.
Journal Article Nat Genet · November 2025 The high burden of dilated cardiomyopathy (DCM) in individuals of African descent remains incompletely explained. Here, to explore a genetic basis, we conducted a genome-wide association study in 1,802 DCM cases and 93,804 controls of African genetic ances ... Full text Link to item CiteAccelerated transcriptomic age and susceptibility to traffic-related air pollution among cardiac catheterization patients.
Journal Article Sci Total Environ · October 15, 2025 BACKGROUND: Accelerated transcriptomic and/or epigenetic age have been proposed as biomarkers of disrupted systemic health and of increased sensitivity to environmental exposures. Previously, we observed epigenetic age acceleration as a biomarker of sensit ... Full text Link to item CiteRecent Grants
Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2019 - 2029The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis
ResearchCo-Mentor · Awarded by National Institute on Aging · 2024 - 2029Accelerated Aging in Gulf War Illness: Phenotypes, Epigenetic Biomarkers and Associations with Gulf War Exposures
ResearchPrincipal Investigator · Awarded by Department of Defense · 2023 - 2027View All Grants