Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1998
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
  • Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2017 - 2020
  • Assistant Research Professor of Cell Biology, Cell Biology, Basic Science Departments 2012 - 2017
• Research
• 

  Selected Grants

  • SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
  • Structural and biophysical studies on natural SARS-CoV-2 variants awarded by National Institutes of Health 2022 - 2027
  • Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 awarded by National Institutes of Health 2021 - 2026
  • Protein Production Facility awarded by Bill and Melinda Gates Foundation 2022 - 2026
  • Novel Immunogens to Elicit Broadly Cross-reactive Antibodies That Target the Hemagglutinin Head Trimer Interface awarded by National Institutes of Health 2021 - 2025
  • HIV-1 vaccine-elicited antibodies target envelope glycans awarded by National Institutes of Health 2015 - 2025
  • Antigen recognition and activation of B-cell receptors of HIV-1 broadly neutralizing antibodies awarded by National Institutes of Health 2019 - 2024
  • Structures of initial CD4 engagement with pre-fusion, closed HIV-1 Envelope trimer and early CD4-induced conformational changes required for infection awarded by National Institutes of Health 2019 - 2024
  • Neonatal Immunity to novel TF SHIVs awarded by National Institutes of Health 2018 - 2023
  • SHIV/HIV Env-Antibody Coevolution as a Guide to Iterative Vaccine Design awarded by University of Pennsylvania 2017 - 2023
  • SHIV/HIV Env-antibody coevolution as a molecular guide to V3 glycan targeted vaccine design awarded by University of Pennsylvania 2022 - 2023
  • Immunogen Design of HIV Sequential Envelopes Derived from SHIV-infected Macaques awarded by University of Pennsylvania 2017 - 2023
  • Coronavirus Vaccine Design awarded by State of North Carolina 2020 - 2021
  • Studying the effect on HIV-1 Env structure and immune response to HIV-1 infection in mucosal fluids using Negative Stain Electron Microscopy awarded by Fred Hutchinson Cancer Research Center 2018 - 2019
  • Structural Dynamics of Stretch Activation in Muscle awarded by National Institutes of Health 2012 - 2018
  • Myofibrillar Structure of Striated Muscle awarded by National Institutes of Health 2012 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Arakelian, Claudia, Anthony Warrington, Hanspeter Winkler, R. J. Perz-Edwards, Michael K. Reedy, and Kenneth A. Taylor. “Myosin S2 origins track evolution of strong binding on actin by azimuthal rolling of motor domain.” Biophys J 108, no. 6 (March 24, 2015): 1495–1502. https://doi.org/10.1016/j.bpj.2014.12.059.
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    • Wu, Shenping, Jun Liu, Mary C. Reedy, Robert J. Perz-Edwards, Richard T. Tregear, Hanspeter Winkler, Clara Franzini-Armstrong, et al. “Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation.” Plos One 7, no. 6 (2012): e39422. https://doi.org/10.1371/journal.pone.0039422.
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    • Perz-Edwards, R. J., and M. K. Reedy. “Erratum: Electron microscopy and x-ray diffraction evidence for two Z-band structural states (Biophysical Journal (2011) 101:(709-717)).” Biophysical Journal 101, no. 5 (September 7, 2011): 1285. https://doi.org/10.1016/j.bpj.2011.08.010.
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    • Perz-Edwards, Robert J., and Michael K. Reedy. “Electron microscopy and x-ray diffraction evidence for two Z-band structural states.” Biophys J 101, no. 3 (August 3, 2011): 709–17. https://doi.org/10.1016/j.bpj.2011.06.024.
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    • Perz-Edwards, Robert J. “The basketweave form of the Z-band is expanded relative to the small-square form.” J Muscle Res Cell Motil 31, no. 5–6 (March 2011): 307–8. https://doi.org/10.1007/s10974-010-9234-5.
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    • Perz-Edwards, Robert J., Thomas C. Irving, Bruce A. J. Baumann, David Gore, Daniel C. Hutchinson, Uroš Kržič, Rebecca L. Porter, Andrew B. Ward, and Michael K. Reedy. “X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle.” Proc Natl Acad Sci U S A 108, no. 1 (January 4, 2011): 120–25. https://doi.org/10.1073/pnas.1014599107.
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    • Bekyarova, T. I., M. C. Reedy, B. A. J. Baumann, R. T. Tregear, A. Ward, U. Krzic, K. M. Prince, et al. “Reverse actin sliding triggers strong myosin binding that moves tropomyosin.” Proc Natl Acad Sci U S A 105, no. 30 (July 29, 2008): 10372–77. https://doi.org/10.1073/pnas.0709877105.
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