Current Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Duke Human Vaccine Institute,
Medicine
Member of the Duke Human Vaccine Institute
·
2017 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Myosin S2 origins track evolution of strong binding on actin by azimuthal rolling of motor domain.
Journal Article Biophys J · March 24, 2015 Myosin crystal structures have given rise to the swinging lever arm hypothesis, which predicts a large axial tilt of the lever arm domain during the actin-attached working stroke. Previous work imaging the working stroke in actively contracting, fast-froze ... Full text Link to item CiteStructural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation.
Journal Article PLoS One · 2012 The application of rapidly applied length steps to actively contracting muscle is a classic method for synchronizing the response of myosin cross-bridges so that the average response of the ensemble can be measured. Alternatively, electron tomography (ET) ... Full text Link to item CiteErratum: Electron microscopy and x-ray diffraction evidence for two Z-band structural states (Biophysical Journal (2011) 101:(709-717))
Journal Article Biophysical Journal · September 7, 2011 Full text CiteRecent Grants
Neonatal Immunity to novel TF SHIVs
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2029SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens
ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027SHIV/HIV Env-Antibody Coevolution as a Guide to Iterative Vaccine Design
ResearchCollaborator · Awarded by University of Pennsylvania · 2017 - 2027View All Grants
Education, Training & Certifications
Duke University ·
1998
Ph.D.