Benjamin Aaron Alman
James R. Urbaniak, M.D., Distinguished Professor of Orthopedic Surgery
Current Appointments & Affiliations
- James R. Urbaniak, M.D., Distinguished Professor of Orthopedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2013
- Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2013
- Chair of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2013
- Professor in Cell Biology, Cell Biology, Basic Science Departments 2014
- Professor in Pediatrics, Pediatrics, Clinical Science Departments 2014
- Professor in the Department of Pathology, Pathology, Clinical Science Departments 2015
- Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2020
- Professor in Neurosurgery, Neurosurgery, Clinical Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013
- Co-Director of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Background
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Education, Training, & Certifications
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Previous Appointments & Affiliations
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018 - 2021
- Consulting Professor in the Department of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2013
- Recognition
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In the News
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JAN 22, 2020 Duke Health News -
DEC 5, 2018 Duke Health News -
AUG 8, 2016 STAT -
AUG 8, 2016 STAT -
JUL 15, 2016 Duke Today -
JUL 15, 2016 -
MAY 20, 2015 Duke Today -
MAY 20, 2015 -
FEB 17, 2015 Duke Today -
FEB 17, 2015
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Awards & Honors
- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing awarded by National Institutes of Health 2021 - 2026
- Molecular Etiology of Enchondromatosis awarded by National Institutes of Health 2014 - 2026
- Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma awarded by National Institutes of Health 2021 - 2026
- The role of macrophage subpopulations in the rejuvenation of fracture repair awarded by National Institutes of Health 2021 - 2025
- Genetic approaches to skin regeneration in zebrafish awarded by National Institutes of Health 2020 - 2025
- Investigating the role of LCP1 in metastatic progression of chondrosarcoma awarded by The Musculoskeletal Tumor Society 2022 - 2023
- Exercise Induced Muscle Secreted Factors That Modify Osteoarthritis (OA) Severity awarded by National Institutes of Health 2021 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Cabinet Radiation Therapy System for Small Animals awarded by North Carolina Biotechnology Center 2022 - 2023
- Exercise-induced recovery of intervertebral disc health awarded by National Institutes of Health 2020 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Rejuvenating fracture repair: The role of the macrophage and Beta-catenin awarded by National Institutes of Health 2016 - 2022
- Stable Isotope Resolved Metabolomics to Interrogate the Interactions between Stroma and Desmoid Tumors awarded by Desmoid Tumor Research Foundation, Inc. 2018 - 2021
- Targeting Tumor Initiating Cell in Undifferentiated Pleomorphic Sarcoma awarded by National Institutes of Health 2016 - 2020
- IPA - Janet Prvu Bettger awarded by Durham Veterans Affairs Medical Center 2018 - 2019
- Collaboration for a Cure: Identifying new Therapeutic Targets for Desmoid Tumors awarded by Desmoid Tumor Research Foundation, Inc. 2013 - 2019
- A Genetically Targeted Mouse Model of Desmoid Tumors awarded by Desmoid Tumor Research Foundation, Inc. 2017 - 2018
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Bartholf DeWitt, Suzanne, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E. J. Martz, Maryam Zand, Vardhman Kumar, et al. “Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.” Jci Insight 7, no. 17 (September 8, 2022). https://doi.org/10.1172/jci.insight.151583.Full Text Link to Item
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Ito, Kan, Yoshihiro Nishida, Shunsuke Hamada, Koki Shimizu, Tomohisa Sakai, Bisei Ohkawara, Benjamin A. Alman, et al. “Efficacy of auranofin as an inhibitor of desmoid progression.” Sci Rep 12, no. 1 (July 13, 2022): 11918. https://doi.org/10.1038/s41598-022-15756-9.Full Text Link to Item
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Schut, Anne-Rose W., Anne L. M. Vriends, Andrea Sacchetti, Milea J. M. Timbergen, Benjamin A. Alman, Mushriq Al-Jazrawe, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer, and Erik A. C. Wiemer. “In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition.” Eur J Surg Oncol 48, no. 7 (July 2022): 1527–35. https://doi.org/10.1016/j.ejso.2022.02.020.Full Text Link to Item
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Obremskey, William, Ben Alman, Thomas Parker Vail, Michael Suk, and George Russell. “How to Assess Quality in an Increasingly Diverse Health-Care System: AOA Critical Issues Symposium.” J Bone Joint Surg Am 104, no. 12 (June 15, 2022): e51. https://doi.org/10.2106/JBJS.21.00307.Full Text Link to Item
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Zhang, Hongyuan, Vijitha Puviindran, Puviindran Nadesan, Xiruo Ding, Leyao Shen, Yuning J. Tang, Hidetoshi Tsushima, et al. “Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations.” J Bone Miner Res 37, no. 5 (May 2022): 983–96. https://doi.org/10.1002/jbmr.4532.Full Text Link to Item
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Yahara, Yasuhito, Tuyet Nguyen, Koji Ishikawa, Katsuhiko Kamei, and Benjamin A. Alman. “The origins and roles of osteoclasts in bone development, homeostasis and repair.” Development (Cambridge, England) 149, no. 8 (April 2022): dev199908. https://doi.org/10.1242/dev.199908.Full Text
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Naert, Thomas, Dieter Tulkens, Tom Van Nieuwenhuysen, Joanna Przybyl, Suzan Demuynck, Matt van de Rijn, Mushriq Al-Jazrawe, et al. “CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.” Proc Natl Acad Sci U S A 118, no. 47 (November 23, 2021). https://doi.org/10.1073/pnas.2115116118.Full Text Link to Item
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Tang, Yuning Jackie, Vijitha Puviindran, Yu Xiang, Yasuhito Yahara, Hongyuan Zhang, Puviindran Nadesan, Yarui Diao, David G. Kirsch, and Benjamin A. Alman. “Tumor-propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma.” Jci Insight 6, no. 22 (November 22, 2021). https://doi.org/10.1172/jci.insight.148768.Full Text Link to Item
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Rickert, Kathleen D., Paolo Arrigoni, Camille R. Guzel, Helena F. Barber, Benjamin A. Alman, and Robert K. Lark. “Growth Modulation by Stimulating the Growth Plate: A Pilot Study.” Ultrasound Med Biol 47, no. 8 (August 2021): 2339–45. https://doi.org/10.1016/j.ultrasmedbio.2021.03.036.Full Text Link to Item
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Pathmanapan, Sinthu, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder, and Benjamin A. Alman. “Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes.” Cancer Metab 9, no. 1 (March 24, 2021): 13. https://doi.org/10.1186/s40170-021-00247-8.Full Text Link to Item
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Zhang, Hongyuan, and Benjamin A. Alman. “Enchondromatosis and Growth Plate Development.” Curr Osteoporos Rep 19, no. 1 (February 2021): 40–49. https://doi.org/10.1007/s11914-020-00639-7.Full Text Link to Item
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Kavolus, Joseph J., Alexander L. Lazarides, Christina Moore, Thorsten M. Seyler, Samuel S. Wellman, David E. Attarian, Michael P. Bolognesi, and Benjamin A. Alman. “The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures.” J Arthroplasty 36, no. 1 (January 2021): 236-241.e3. https://doi.org/10.1016/j.arth.2020.07.054.Full Text Link to Item
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Yahara, Yasuhito, Xinyi Ma, Liam Gracia, and Benjamin A. Alman. “Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair.” Front Cell Dev Biol 9 (2021): 622035. https://doi.org/10.3389/fcell.2021.622035.Full Text Link to Item
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Obremskey, William T., Sanford E. Emery, and Benjamin A. Alman. “Challenges and Solutions to Academic Orthopaedics in Current Health-Care Economics: AOA Critical Issues.” J Bone Joint Surg Am 102, no. 9 (May 6, 2020): e38. https://doi.org/10.2106/JBJS.19.01054.Full Text Link to Item
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Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A. Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.” Elife 9 (April 17, 2020). https://doi.org/10.7554/eLife.51756.Full Text Link to Item
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Desmoid Tumor Working Group, Myung-Joong. “The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients.” Eur J Cancer 127 (March 2020): 96–107. https://doi.org/10.1016/j.ejca.2019.11.013.Full Text Link to Item
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Lark, Robert K., Brian L. Dial, and Benjamin A. Alman. “Complications After Pediatric Hip Fractures: Evaluation and Management.” J Am Acad Orthop Surg 28, no. 1 (January 1, 2020): 10–19. https://doi.org/10.5435/JAAOS-D-17-00689.Full Text Link to Item
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Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.Full Text Link to Item
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Tang, Yuning J., Jianguo Huang, Hidetoshi Tsushima, Ga I. Ban, Hongyuan Zhang, Kristianne M. Oristian, Vijitha Puviindran, et al. “Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.” Cell Rep 28, no. 11 (September 10, 2019): 2837-2850.e5. https://doi.org/10.1016/j.celrep.2019.08.029.Full Text Link to Item
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Kwak, Yoon Hae, Tomasa Barrientos, Bridgette Furman, Hazel Zhang, Vijitha Puviindran, Hattie Cutcliffe, Jonas Herfarth, Eugene Nwankwo, and Benjamin A. Alman. “Pharmacologic targeting of β-catenin improves fracture healing in old mice.” Sci Rep 9, no. 1 (June 21, 2019): 9005. https://doi.org/10.1038/s41598-019-45339-0.Full Text Link to Item
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Zhang, Hongyuan, Qingxia Wei, Hidetoshi Tsushima, Vijitha Puviindran, Yuning J. Tang, Sinthu Pathmanapan, Raymond Poon, et al. “Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.” Jci Insight 5, no. 11 (April 30, 2019). https://doi.org/10.1172/jci.insight.127232.Full Text Link to Item
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Ali, Shabana Amanda, Ben Niu, Kathryn S. E. Cheah, and Benjamin Alman. “Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes.” Plos One 14, no. 1 (2019): e0211333. https://doi.org/10.1371/journal.pone.0211333.Full Text Link to Item
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Vi, Linda, Gurpreet S. Baht, Erik J. Soderblom, Heather Whetstone, Qingxia Wei, Bridgette Furman, Vijitha Puviindran, et al. “Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.” Nat Commun 9, no. 1 (December 5, 2018): 5191. https://doi.org/10.1038/s41467-018-07666-0.Full Text Open Access Copy Link to Item
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Nousiainen, Markku T., Polina Mironova, Melissa Hynes, Susan Glover Takahashi, Richard Reznick, William Kraemer, Benjamin Alman, Peter Ferguson, and Peter CBC Planning Committee. “Eight-year outcomes of a competency-based residency training program in orthopedic surgery.” Med Teach 40, no. 10 (October 2018): 1042–54. https://doi.org/10.1080/0142159X.2017.1421751.Full Text Link to Item
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Apkon, Susan D., Ben Alman, David J. Birnkrant, Robert Fitch, Robert Lark, William Mackenzie, Norbert Weidner, and Michael Sussman. “Orthopedic and Surgical Management of the Patient With Duchenne Muscular Dystrophy.” Pediatrics 142, no. Suppl 2 (October 2018): S82–89. https://doi.org/10.1542/peds.2018-0333J.Full Text Link to Item
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Tsushima, Hidetoshi, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, and Benjamin A. Alman. “Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.” Development 145, no. 13 (July 9, 2018). https://doi.org/10.1242/dev.162396.Full Text Link to Item
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Birnkrant, David J., Katharine Bushby, Carla M. Bann, Benjamin A. Alman, Susan D. Apkon, Angela Blackwell, Laura E. Case, et al. “Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management.” Lancet Neurol 17, no. 4 (April 2018): 347–61. https://doi.org/10.1016/S1474-4422(18)30025-5.Full Text Link to Item
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Baht, Gurpreet S., Linda Vi, and Benjamin A. Alman. “The Role of the Immune Cells in Fracture Healing.” Curr Osteoporos Rep 16, no. 2 (April 2018): 138–45. https://doi.org/10.1007/s11914-018-0423-2.Full Text Link to Item
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Hsu, Shu-Hsuan Claire, Puviindran Nadesan, Vijitha Puviindran, William B. Stallcup, David G. Kirsch, and Benjamin A. Alman. “Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.” J Biol Chem 293, no. 7 (February 16, 2018): 2466–75. https://doi.org/10.1074/jbc.M117.805051.Full Text Link to Item
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Mercier, Kelly A., Mushriq Al-Jazrawe, Raymond Poon, Zachery Acuff, and Benjamin Alman. “A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates.” Sci Rep 8, no. 1 (January 12, 2018): 584. https://doi.org/10.1038/s41598-017-18921-7.Full Text Open Access Copy Link to Item
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Giampietro, Philip F., Olivier Pourquie, Cathy Raggio, Shiro Ikegawa, Peter D. Turnpenny, Ryan Gray, Sally L. Dunwoodie, et al. “Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.” Am J Med Genet A 176, no. 1 (January 2018): 253–56. https://doi.org/10.1002/ajmg.a.38550.Full Text Link to Item
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Scales, Charles D. “Editorial Comment.” Urology 106 (August 2017): 37. https://doi.org/10.1016/j.urology.2017.03.055.Full Text Link to Item
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Alman, Benjamin A., James J. Purtill, Vincent D. Pellegrini, and Peter Scoles. “The Fourth Year of Medical School: Time for Reassessment: AOA Critical Issues.” J Bone Joint Surg Am 99, no. 13 (July 5, 2017): e72. https://doi.org/10.2106/JBJS.16.01094.Full Text Link to Item
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Baht, Gurpreet S., Puviindran Nadesan, David Silkstone, and Benjamin A. Alman. “Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.” Bone 98 (May 2017): 31–36. https://doi.org/10.1016/j.bone.2017.02.012.Full Text Link to Item
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MacParland, Sonya A., Kim M. Tsoi, Ben Ouyang, Xue-Zhong Ma, Justin Manuel, Ali Fawaz, Mario A. Ostrowski, et al. “Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.” Acs Nano 11, no. 3 (March 2017): 2428–43. https://doi.org/10.1021/acsnano.6b06245.Full Text
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Tsoi, Kim M., Sonya A. MacParland, Xue-Zhong Ma, Vinzent N. Spetzler, Juan Echeverri, Ben Ouyang, Saleh M. Fadel, et al. “Mechanism of hard-nanomaterial clearance by the liver.” Nat Mater 15, no. 11 (November 2016): 1212–21. https://doi.org/10.1038/nmat4718.Full Text Link to Item
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Ghadakzadeh, Saber, Peter Kannu, Heather Whetstone, Andrew Howard, and Benjamin A. Alman. “β-Catenin modulation in neurofibromatosis type 1 bone repair: therapeutic implications.” Faseb J 30, no. 9 (September 2016): 3227–37. https://doi.org/10.1096/fj.201500190RR.Full Text Link to Item
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Sato, Shingo, Yuning J. Tang, Qingxia Wei, Makoto Hirata, Angela Weng, Ilkyu Han, Atsushi Okawa, et al. “Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.” Cell Rep 16, no. 4 (July 26, 2016): 917–27. https://doi.org/10.1016/j.celrep.2016.06.058.Full Text Link to Item
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Rockel, Jason S., Chunying Yu, Heather Whetstone, April M. Craft, Katherine Reilly, Henry Ma, Hidetoshi Tsushima, et al. “Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.” J Clin Invest 126, no. 5 (May 2, 2016): 1649–63. https://doi.org/10.1172/JCI80205.Full Text Link to Item
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Nousiainen, Markku T., Sydney A. McQueen, Peter Ferguson, Benjamin Alman, William Kraemer, Oleg Safir, Richard Reznick, and Ranil Sonnadara. “Simulation for Teaching Orthopaedic Residents in a Competency-based Curriculum: Do the Benefits Justify the Increased Costs?” Clin Orthop Relat Res 474, no. 4 (April 2016): 935–44. https://doi.org/10.1007/s11999-015-4512-6.Full Text Link to Item
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Ng, Adeline H., Sidney Omelon, Fabio Variola, Bedilu Allo, Thomas L. Willett, Benjamin A. Alman, and Marc D. Grynpas. “Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix.” J Bone Miner Res 31, no. 2 (February 2016): 369–79. https://doi.org/10.1002/jbmr.2702.Full Text Link to Item
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Ali, Shabana Amanda, Mushriq Al-Jazrawe, Henry Ma, Heather Whetstone, Raymond Poon, Sarah Farr, Mark Naples, Khosrow Adeli, and Benjamin A. Alman. “Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.” Arthritis Rheumatol 68, no. 1 (January 2016): 127–37. https://doi.org/10.1002/art.39337.Full Text Link to Item
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Gray, Mary J., Peter Kannu, Swarkar Sharma, Christine Neyt, Dongping Zhang, Nandina Paria, Philip B. Daniel, et al. “Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.” Am J Hum Genet 97, no. 6 (December 3, 2015): 837–47. https://doi.org/10.1016/j.ajhg.2015.11.001.Full Text Link to Item
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Stinson, Jennifer N., Lindsay A. Jibb, Cynthia Nguyen, Paul C. Nathan, Anne Marie Maloney, L Lee Dupuis, J Ted Gerstle, et al. “Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer.” Pain 156, no. 12 (December 2015): 2607–15. https://doi.org/10.1097/j.pain.0000000000000385.Full Text Link to Item
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Wei, Qingxia, Yuning J. Tang, Veronique Voisin, Shingo Sato, Makoto Hirata, Heather Whetstone, Ilkyu Han, et al. “Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.” Oncotarget 6, no. 37 (November 24, 2015): 40283–94. https://doi.org/10.18632/oncotarget.5375.Full Text Link to Item
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Ng, Adeline H., Gurpreet S. Baht, Benjamin A. Alman, and Marc D. Grynpas. “Bone Marrow Stress Decreases Osteogenic Progenitors.” Calcif Tissue Int 97, no. 5 (November 2015): 476–86. https://doi.org/10.1007/s00223-015-0032-3.Full Text Link to Item
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Alman, Benjamin A. “The role of hedgehog signalling in skeletal health and disease.” Nat Rev Rheumatol 11, no. 9 (September 2015): 552–60. https://doi.org/10.1038/nrrheum.2015.84.Full Text Link to Item
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Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (August 26, 2015): 7761. https://doi.org/10.1038/ncomms8761.Full Text Link to Item
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Craft, April M., Jason S. Rockel, Yulia Nartiss, Rita A. Kandel, Benjamin A. Alman, and Gordon M. Keller. “Generation of articular chondrocytes from human pluripotent stem cells.” Nat Biotechnol 33, no. 6 (June 2015): 638–45. https://doi.org/10.1038/nbt.3210.Full Text Link to Item
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Vi, Linda, Gurpreet S. Baht, Heather Whetstone, Adeline Ng, Qingxia Wei, Raymond Poon, Sivakami Mylvaganam, Marc Grynpas, and Benjamin A. Alman. “Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.” J Bone Miner Res 30, no. 6 (June 2015): 1090–1102. https://doi.org/10.1002/jbmr.2422.Full Text Link to Item
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Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (May 19, 2015): 7131. https://doi.org/10.1038/ncomms8131.Full Text Link to Item
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Hirata, Makoto, Masato Sasaki, Rob A. Cairns, Satoshi Inoue, Vijitha Puviindran, Wanda Y. Li, Bryan E. Snow, et al. “Mutant IDH is sufficient to initiate enchondromatosis in mice.” Proc Natl Acad Sci U S A 112, no. 9 (March 3, 2015): 2829–34. https://doi.org/10.1073/pnas.1424400112.Full Text Link to Item
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Al-Jazrawe, Mushriq, Magdalene Au, and Benjamin Alman. “Optimal therapy for desmoid tumors: current options and challenges for the future.” Expert Rev Anticancer Ther 15, no. 12 (2015): 1443–58. https://doi.org/10.1586/14737140.2015.1096203.Full Text Link to Item
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Hoogenes, Jen, Polina Mironova, Oleg Safir, Sydney A. McQueen, Hesham Abdelbary, Michael Drexler, Markku Nousiainen, et al. “Student-led learning: a new teaching paradigm for surgical skills.” Am J Surg 209, no. 1 (January 2015): 107–14. https://doi.org/10.1016/j.amjsurg.2014.08.037.Full Text Link to Item
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Zhukova, Nataliya, Vijay Ramaswamy, Marc Remke, Dianna C. Martin, Pedro Castelo-Branco, Cindy H. Zhang, Michael Fraser, et al. “WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.” Acta Neuropathol Commun 2 (December 24, 2014): 174. https://doi.org/10.1186/s40478-014-0174-y.Full Text Link to Item
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Bernick, Joshua, Yufa Wang, Ian A. Sigal, Benjamin A. Alman, Cari M. Whyne, and Diane Nam. “Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents.” J Bone Joint Surg Am 96, no. 23 (December 3, 2014): 1990–98. https://doi.org/10.2106/JBJS.N.00057.Full Text Link to Item
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Gordon, Jonathan A. R., Jennifer W. Lisle, Benjamin A. Alman, and Jane B. Lian. “Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.” J Cell Physiol 229, no. 12 (December 2014): 1884–86. https://doi.org/10.1002/jcp.24692.Full Text Link to Item
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Ng, Adeline H., Thomas L. Willett, Benjamin A. Alman, and Marc D. Grynpas. “Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD).” Bone 68 (November 2014): 57–66. https://doi.org/10.1016/j.bone.2014.07.037.Full Text Link to Item
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Klingberg, Franco, Melissa L. Chow, Anne Koehler, Stellar Boo, Lara Buscemi, Thomas M. Quinn, Mercedes Costell, Benjamin A. Alman, Elisabeth Genot, and Boris Hinz. “Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.” J Cell Biol 207, no. 2 (October 27, 2014): 283–97. https://doi.org/10.1083/jcb.201402006.Full Text Link to Item
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Amini-Nik, Saeid, Elizabeth Cambridge, Winston Yu, Anne Guo, Heather Whetstone, Puviindran Nadesan, Raymond Poon, Boris Hinz, and Benjamin A. Alman. “β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.” J Clin Invest 124, no. 6 (June 2014): 2599–2610. https://doi.org/10.1172/JCI62059.Full Text Link to Item
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Campbell, Veronica T., Puviindran Nadesan, S Amanda Ali, Chang Ye Yale Wang, Heather Whetstone, Raymond Poon, Qingxia Wei, et al. “Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.” Mol Cancer Ther 13, no. 5 (May 2014): 1259–69. https://doi.org/10.1158/1535-7163.MCT-13-0731.Full Text Link to Item
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Baht, Gurpreet S., David Silkstone, Puviindran Nadesan, Heather Whetstone, and Benjamin A. Alman. “Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.” J Orthop Res 32, no. 4 (April 2014): 581–86. https://doi.org/10.1002/jor.22562.Full Text Link to Item
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Knight, Dominique M., Cristina Alves, Benjamin Alman, and Andrew Howard. “Percutaneous screw fixation promotes healing of lateral condyle nonunion in children.” J Pediatr Orthop 34, no. 2 (March 2014): 155–60. https://doi.org/10.1097/BPO.0000000000000077.Full Text Link to Item
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Lo, Winnie W., Jay S. Wunder, Brendan C. Dickson, Veronica Campbell, Karen McGovern, Benjamin A. Alman, and Irene L. Andrulis. “Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma.” Cancer 120, no. 4 (February 15, 2014): 537–47. https://doi.org/10.1002/cncr.28439.Full Text Link to Item
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Alman, B., and C. Evans. “On the shoulders of giants: The future of the Journal of Orthopaedic Research.” Journal of Orthopaedic Research 32, no. 9 (January 1, 2014): 1095–96. https://doi.org/10.1002/jor.22689.Full Text
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Lundine, Kristopher M., Stephen J. Lewis, Zaid Al-Aubaidi, Benjamin Alman, and Andrew W. Howard. “Patient outcomes in the operative and nonoperative management of high-grade spondylolisthesis in children.” J Pediatr Orthop 34, no. 5 (2014): 483–89. https://doi.org/10.1097/BPO.0000000000000133.Full Text Link to Item
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Sonnadara, Ranil R., Carween Mui, Sydney McQueen, Polina Mironova, Markku Nousiainen, Oleg Safir, William Kraemer, Peter Ferguson, Benjamin Alman, and Richard Reznick. “Reflections on competency-based education and training for surgical residents.” J Surg Educ 71, no. 1 (2014): 151–58. https://doi.org/10.1016/j.jsurg.2013.06.020.Full Text Link to Item
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Sonnadara, Ranil R., Carween Mui, Sydney McQueen, Polina Mironova, Markku Nousiainen, Oleg Safir, William Kraemer, Peter Ferguson, Benjamin Alman, and Richard Reznick. “Letter to the editor response.” J Surg Educ 71, no. 5 (2014): 652–53. https://doi.org/10.1016/j.jsurg.2014.05.018.Full Text Link to Item
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Ho, L., S. A. Ali, M. Al-Jazrawe, R. Kandel, J. S. Wunder, and B. A. Alman. “Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.” Oncogene 32, no. 47 (November 21, 2013): 5388–96. https://doi.org/10.1038/onc.2012.588.Full Text Link to Item
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Ferguson, Peter C., William Kraemer, Markku Nousiainen, Oleg Safir, Ranil Sonnadara, Benjamin Alman, and Richard Reznick. “Three-year experience with an innovative, modular competency-based curriculum for orthopaedic training.” J Bone Joint Surg Am 95, no. 21 (November 6, 2013): e166. https://doi.org/10.2106/JBJS.M.00314.Full Text Link to Item
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Sonnadara, R., S. McQueen, P. Mironova, O. Safir, M. Nousiainen, P. Ferguson, B. Alman, W. Kraemer, and R. Reznick. “Reflections on current methods for evaluating skills during joint replacement surgery: a scoping review.” Bone Joint J 95-B, no. 11 (November 2013): 1445–49. https://doi.org/10.1302/0301-620X.95B11.30732.Full Text Link to Item
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Sonnadara, Ranil R., Shawn Garbedian, Oleg Safir, Carween Mui, Polina Mironova, Markku Nousiainen, Peter Ferguson, Benjamin Alman, William Kraemer, and Richard Reznick. “Toronto orthopaedic boot camp III: examining the efficacy of student-regulated learning during an intensive, laboratory-based surgical skills course.” Surgery 154, no. 1 (July 2013): 29–33. https://doi.org/10.1016/j.surg.2013.05.003.Full Text Link to Item
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Ghanbari-Azarnier, Ronak, Shingo Sato, Qingxia Wei, Mushriq Al-Jazrawe, and Benjamin A. Alman. “Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.” Neoplasia 15, no. 7 (July 2013): 712–19. https://doi.org/10.1593/neo.13452.Full Text Link to Item
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Lebel, David E., John A. Corston, Laura C. McAdam, W Douglas Biggar, and Benjamin A. Alman. “Glucocorticoid treatment for the prevention of scoliosis in children with Duchenne muscular dystrophy: long-term follow-up.” J Bone Joint Surg Am 95, no. 12 (June 19, 2013): 1057–61. https://doi.org/10.2106/JBJS.L.01577.Full Text Link to Item
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Craft, April M., Nazish Ahmed, Jason S. Rockel, Gurpreet S. Baht, Benjamin A. Alman, Rita A. Kandel, Agamemnon E. Grigoriadis, and Gordon M. Keller. “Specification of chondrocytes and cartilage tissues from embryonic stem cells.” Development 140, no. 12 (June 2013): 2597–2610. https://doi.org/10.1242/dev.087890.Full Text Link to Item
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Bielefeld, Kirsten A., Saeid Amini-Nik, and Benjamin A. Alman. “Cutaneous wound healing: recruiting developmental pathways for regeneration.” Cell Mol Life Sci 70, no. 12 (June 2013): 2059–81. https://doi.org/10.1007/s00018-012-1152-9.Full Text Link to Item
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Tsoi, Kim M., Qin Dai, Benjamin A. Alman, and Warren C. W. Chan. “Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies.” Acc Chem Res 46, no. 3 (March 19, 2013): 662–71. https://doi.org/10.1021/ar300040z.Full Text Link to Item
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Stinson, Jennifer N., Lindsay A. Jibb, Cynthia Nguyen, Paul C. Nathan, Anne Marie Maloney, L Lee Dupuis, J Ted Gerstle, et al. “Development and testing of a multidimensional iPhone pain assessment application for adolescents with cancer.” J Med Internet Res 15, no. 3 (March 8, 2013): e51. https://doi.org/10.2196/jmir.2350.Full Text Link to Item
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Camp, Mark W., David A. Mattingly, Allan E. Gross, Markku T. Nousiainen, Benjamin A. Alman, and Martin F. McKneally. “Patients' views on surgeons' financial conflicts of interest.” J Bone Joint Surg Am 95, no. 2 (January 16, 2013): e91-8. https://doi.org/10.2106/JBJS.L.00270.Full Text Link to Item
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Alman, Benjamin A., Peter Ferguson, William Kraemer, Markku T. Nousiainen, and Richard K. Reznick. “Competency-based education: a new model for teaching orthopaedics.” Instr Course Lect 62 (2013): 565–69.Link to Item
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Ho, L., S. A. Ali, M. Al-Jazrawe, R. Kandel, J. S. Wunder, and B. A. Alman. “Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.” Oncogene 32, no. 47 (January 1, 2013): 5388–96. https://doi.org/10.1038/onc.2012.588.Full Text
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Buckwalter, Joseph A., Tim Wright, Laurntiu Mogoanta, and Benjamin Alman. “Plagiarism: an assault on the integrity of scientific research.” J Orthop Res 30, no. 12 (December 2012): 1867–68. https://doi.org/10.1002/jor.22198.Full Text Link to Item
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Hsu, Shu-Hsuan C., Xiaoyun Zhang, Steven Cheng, Jay S. Wunder, Chi-Chung Hui, and Benjamin A. Alman. “Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate.” J Biol Chem 287, no. 43 (October 19, 2012): 36222–28. https://doi.org/10.1074/jbc.M112.382275.Full Text Link to Item
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Ali, Shabana Amanda, and Benjamin Alman. “RNA extraction from human articular cartilage by chondrocyte isolation.” Anal Biochem 429, no. 1 (October 1, 2012): 39–41. https://doi.org/10.1016/j.ab.2012.06.028.Full Text Link to Item
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Zolkipli, Zarazuela, Mary Sherlock, William D. Biggar, Glenn Taylor, Jamie S. Hutchison, Arie Peliowski, Benjamin A. Alman, Simon C. Ling, and Ingrid Tein. “Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks.” Eur J Paediatr Neurol 16, no. 5 (September 2012): 549–53. https://doi.org/10.1016/j.ejpn.2012.01.004.Full Text Link to Item
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Alves, C., M. Steele, U. Narayanan, A. Howard, B. Alman, and J. G. Wright. “Open reduction and internal fixation of unstable slipped capital femoral epiphysis by means of surgical dislocation does not decrease the rate of avascular necrosis: A preliminary study.” Journal of Children’S Orthopaedics 6, no. 4 (August 1, 2012): 277–83. https://doi.org/10.1007/s11832-012-0423-1.Full Text
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Black, Kevin P., Benjamin A. Alman, William N. Levine, Steven P. Nestler, and Stephen J. Pinney. “Orthopaedic resident education--it's a whole new game: "If I'm going to be a spine surgeon, why do I need to learn how to reconstruct an anterior cruciate ligament?": AOA critical issues.” J Bone Joint Surg Am 94, no. 13 (July 3, 2012): e96. https://doi.org/10.2106/JBJS.K.01214.Full Text Link to Item
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Sonnadara, Ranil R., Shawn Garbedian, Oleg Safir, Markku Nousiainen, Benjamin Alman, Peter Ferguson, William Kraemer, and Richard Reznick. “Orthopaedic Boot Camp II: examining the retention rates of an intensive surgical skills course.” Surgery 151, no. 6 (June 2012): 803–7. https://doi.org/10.1016/j.surg.2012.03.017.Full Text Link to Item
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McAdam, L. C., A. L. Mayo, B. A. Alman, and W. D. Biggar. “The Canadian experience with long term deflazacort treatment in Duchenne muscular dystrophy.” Acta Myologica 31, no. MAY (May 1, 2012): 16–20.
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McAdam, Laura C., Amanda L. Mayo, Benjamin A. Alman, and W Douglas Biggar. “The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy.” Acta Myol 31, no. 1 (May 2012): 16–20.Link to Item
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Sparrow, Duncan B., Gavin Chapman, Allanceson J. Smith, Muhammad Z. Mattar, Joelene A. Major, Victoria C. O’Reilly, Yumiko Saga, et al. “A mechanism for gene-environment interaction in the etiology of congenital scoliosis.” Cell 149, no. 2 (April 13, 2012): 295–306. https://doi.org/10.1016/j.cell.2012.02.054.Full Text Link to Item
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Wang, Chang Ye Yale, Qingxia Wei, Ilkyu Han, Shingo Sato, Ronak Ghanbari-Azarnier, Heather Whetstone, Raymond Poon, et al. “Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas.” Cancer Res 72, no. 4 (February 15, 2012): 1013–22. https://doi.org/10.1158/0008-5472.CAN-11-2531.Full Text Link to Item
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Poon, Raymond, Helen Hong, Xin Wei, James Pan, and Benjamin A. Alman. “A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.” Plos One 7, no. 5 (2012): e37940. https://doi.org/10.1371/journal.pone.0037940.Full Text Link to Item
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Maezawa, Yoshiro, Matthew Binnie, Chengjin Li, Paul Thorner, Chi-Chung Hui, Benjamin Alman, Makoto Mark Taketo, and Susan E. Quaggin. “A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.” Plos One 7, no. 7 (2012): e40547. https://doi.org/10.1371/journal.pone.0040547.Full Text Link to Item
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Nam, Diane, Elaine Mau, Yufa Wang, David Wright, David Silkstone, Heather Whetstone, Cari Whyne, and Benjamin Alman. “T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair.” Plos One 7, no. 6 (2012): e40044. https://doi.org/10.1371/journal.pone.0040044.Full Text Link to Item
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Alman, Benjamin A., Simon P. Kelley, and Diane Nam. “Heal thyself: using endogenous regeneration to repair bone.” Tissue Eng Part B Rev 17, no. 6 (December 2011): 431–36. https://doi.org/10.1089/ten.TEB.2011.0189.Full Text Link to Item
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Fattah, A., T. Cypel, E. J. Donner, F. Wang, B. A. Alman, and R. M. Zuker. “The first successful lower extremity transplantation: 6-year follow-up and implications for cortical plasticity.” Am J Transplant 11, no. 12 (December 2011): 2762–67. https://doi.org/10.1111/j.1600-6143.2011.03782.x.Full Text Link to Item
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Atesok, Kivanc I., Benjamin A. Alman, Emil H. Schemitsch, Amos Peyser, and Henry Mankin. “Osteoid osteoma and osteoblastoma.” J Am Acad Orthop Surg 19, no. 11 (November 2011): 678–89. https://doi.org/10.5435/00124635-201111000-00004.Full Text Link to Item
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“Correction: Aggressive Fibromatosis (Desmoid Tumor) Is Derived from Mesenchymal Progenitor Cells.” Cancer Research 71, no. 18 (September 15, 2011): 6084–6084. https://doi.org/10.1158/0008-5472.can-11-2654.Full Text
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Amini-Nik, Saeid, Dylan Glancy, Corey Boimer, Heather Whetstone, Charles Keller, and Benjamin A. Alman. “Pax7 expressing cells contribute to dermal wound repair, regulating scar size through a β-catenin mediated process.” Stem Cells 29, no. 9 (September 2011): 1371–79. https://doi.org/10.1002/stem.688.Full Text Link to Item
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Hsu, Shu-Hsuan C., Xiaoyun Zhang, Chunying Yu, Zhu Juan Li, Jay S. Wunder, Chi-Chung Hui, and Benjamin A. Alman. “Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.” Development 138, no. 17 (September 2011): 3791–3801. https://doi.org/10.1242/dev.069492.Full Text Link to Item
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Bielefeld, Kirsten A., Saeid Amini-Nik, Heather Whetstone, Raymond Poon, Andrew Youn, Jian Wang, and Benjamin A. Alman. “Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.” J Biol Chem 286, no. 31 (August 5, 2011): 27687–97. https://doi.org/10.1074/jbc.M111.261677.Full Text Link to Item
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Rockel, Jason S., and Benjamin A. Alman. “Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases.” J Orthop Res 29, no. 6 (June 2011): 810–15. https://doi.org/10.1002/jor.21372.Full Text Link to Item
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Sonnadara, Ranil R., Aaron Van Vliet, Oleg Safir, Benjamin Alman, Peter Ferguson, William Kraemer, and Richard Reznick. “Orthopedic boot camp: examining the effectiveness of an intensive surgical skills course.” Surgery 149, no. 6 (June 2011): 745–49. https://doi.org/10.1016/j.surg.2010.11.011.Full Text Link to Item
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Hong, H., P. Nadesan, R. Poon, and B. A. Alman. “Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour).” Br J Cancer 104, no. 9 (April 26, 2011): 1452–58. https://doi.org/10.1038/bjc.2011.107.Full Text Link to Item
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Robanus-Maandag, Els, Cathy Bosch, Saeid Amini-Nik, Jeroen Knijnenburg, Karoly Szuhai, Pascale Cervera, Raymond Poon, et al. “Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids.” Plos One 6, no. 9 (2011): e24354. https://doi.org/10.1371/journal.pone.0024354.Full Text Link to Item
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Alman, B. “Genetic Diagnosis of Skeletal Dysplasias,” December 1, 2010, 149–54. https://doi.org/10.1016/B978-0-12-374430-2.00013-4.Full Text
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Szauter, K. M., A. Ordas, R. M. Laxer, E. Pope, D. Wherrett, B. Alman, M. Mink, C. D. Boyd, K. Csiszar, and A. Hinek. “A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network.” Br J Dermatol 163, no. 5 (November 2010): 1102–15. https://doi.org/10.1111/j.1365-2133.2010.09911.x.Full Text Link to Item
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Wu, Colleen, Saeid Amini-Nik, Puviindran Nadesan, William L. Stanford, and Benjamin A. Alman. “Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells.” Cancer Res 70, no. 19 (October 1, 2010): 7690–98. https://doi.org/10.1158/0008-5472.CAN-10-1656.Full Text Link to Item
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Amini-Nik, Saeid, Darren Kraemer, Michael L. Cowan, Keith Gunaratne, Puviindran Nadesan, Benjamin A. Alman, and RJ Dwayne Miller. “Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery.” Plos One 5, no. 9 (September 28, 2010). https://doi.org/10.1371/journal.pone.0013053.Full Text Link to Item
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Bovée, Judith V. M. G., Pancras C. W. Hogendoorn, Jay S. Wunder, and Benjamin A. Alman. “Cartilage tumours and bone development: molecular pathology and possible therapeutic targets.” Nat Rev Cancer 10, no. 7 (July 2010): 481–88. https://doi.org/10.1038/nrc2869.Full Text Link to Item
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Alman, B., and J. Wedge. “Robert Bruce Salter, C.C., MD, FRCSC. Dec 15, 1924-May 10, 2010 (Accepted).” Journal of Children’S Orthopaedics, June 29, 2010, 1–2. https://doi.org/10.1007/s11832-010-0272-8.Full Text
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Offiah, Amaka, Benjamin Alman, Alberto S. Cornier, Philip F. Giampietro, Olivier Tassy, Angie Wade, Peter D. Turnpenny, and Peter D. ICVAS (International Consortium for Vertebral Anomalies and Scoliosis). “Pilot assessment of a radiologic classification system for segmentation defects of the vertebrae.” Am J Med Genet A 152A, no. 6 (June 2010): 1357–71. https://doi.org/10.1002/ajmg.a.33361.Full Text Link to Item
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Ho, Louisa, and Benjamin Alman. “Protecting the hedgerow: p53 and hedgehog pathway interactions.” Cell Cycle 9, no. 3 (February 1, 2010): 506–11. https://doi.org/10.4161/cc.9.3.10552.Full Text Link to Item
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Lipa, Joan E., Wei Qiu, Ning Huang, Benjamin A. Alman, and Cho Y. Pang. “Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.” Plast Reconstr Surg 125, no. 2 (February 2010): 437–45. https://doi.org/10.1097/PRS.0b013e3181c82d05.Full Text Link to Item
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Alman, B. “Overview and comparison of idiopathic, neuromuscular, and congenital forms of scoliosis,” January 1, 2010, 73–79. https://doi.org/10.1007/978-1-4419-1406-4_4.Full Text
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Lin, A. C., B. L. Seeto, J. M. Bartoszko, M. A. Khoury, H. Whetstone, L. Ho, C. Hsu, A. S. Ali, and B. A. Alman. “Erratum: Modulating hedgehog signaling can attenuate the severity of osteoarthritis (Nature Medicine (2009) 15 (1421-1425)).” Nature Medicine 16, no. 1 (January 1, 2010): 129. https://doi.org/10.1038/nm0110-129b.Full Text
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Lin, Alvin C., Brian L. Seeto, Justyna M. Bartoszko, Michael A. Khoury, Heather Whetstone, Louisa Ho, Claire Hsu, S Amanda Ali, and Benjamin A. Alman. “Modulating hedgehog signaling can attenuate the severity of osteoarthritis.” Nat Med 15, no. 12 (December 2009): 1421–25. https://doi.org/10.1038/nm.2055.Full Text Link to Item
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Ho, Louisa, Aneta Stojanovski, Heather Whetstone, Qing Xia Wei, Elaine Mau, Jay S. Wunder, and Benjamin Alman. “Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.” Cancer Cell 16, no. 2 (August 4, 2009): 126–36. https://doi.org/10.1016/j.ccr.2009.05.013.Full Text Link to Item
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Alman, Benjamin A. “Multiple hereditary exostosis and hedgehog signaling: implications for novel therapies.” J Bone Joint Surg Am 91 Suppl 4 (July 2009): 63–67. https://doi.org/10.2106/JBJS.I.00301.Full Text Link to Item
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Poon, Raymond, Saeid Amini Nik, Jessica Ahn, Laura Slade, and Benjamin A. Alman. “Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction.” Bmc Cell Biol 10 (May 11, 2009): 38. https://doi.org/10.1186/1471-2121-10-38.Full Text Link to Item
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Poon, Raymond, Catherine Li, and Benjamin A. Alman. “Beta-catenin mediates soft tissue contracture in clubfoot.” Clin Orthop Relat Res 467, no. 5 (May 2009): 1180–85. https://doi.org/10.1007/s11999-008-0692-7.Full Text Link to Item
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Noor, Abdul, Christian Windpassinger, Irina Vitcu, Marija Orlic, Muhammad Arshad Rafiq, Mahwish Khalid, Mahmood Nasir Malik, Muhammad Ayub, Benjamin Alman, and John B. Vincent. “Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3.” Am J Hum Genet 84, no. 4 (April 2009): 519–23. https://doi.org/10.1016/j.ajhg.2009.03.007.Full Text Link to Item
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Chen, Yan, and Benjamin A. Alman. “Wnt pathway, an essential role in bone regeneration.” J Cell Biochem 106, no. 3 (February 15, 2009): 353–62. https://doi.org/10.1002/jcb.22020.Full Text Link to Item
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Giampietro, Philip F., Sally L. Dunwoodie, Kenro Kusumi, Olivier Pourquié, Olivier Tassy, Amaka C. Offiah, Alberto S. Cornier, et al. “Progress in the understanding of the genetic etiology of vertebral segmentation disorders in humans.” Ann N Y Acad Sci 1151 (January 2009): 38–67. https://doi.org/10.1111/j.1749-6632.2008.03452.x.Full Text Link to Item
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Gurung, Ananta, Faisal Uddin, Richard P. Hill, Peter C. Ferguson, and Benjamin A. Alman. “Beta-catenin is a mediator of the response of fibroblasts to irradiation.” Am J Pathol 174, no. 1 (January 2009): 248–55. https://doi.org/10.2353/ajpath.2009.080576.Full Text Link to Item
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Yan, T., M. Angelini, B. A. Alman, I. L. Andrulis, and J. S. Wunder. “Erratum: Patched-one or smoothened gene mutations are infrequent in chondrosarcoma (Clinical Orthopaedics and Related Research DOI: 10.1007/s11999-008-0332-2).” Clinical Orthopaedics and Related Research 467, no. 12 (January 1, 2009): 3356. https://doi.org/10.1007/s11999-009-1134-x.Full Text
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Lavoie, Jean-Francois, Jeffrey A. Biernaskie, Yan Chen, Darius Bagli, Benjamin Alman, David R. Kaplan, and Freda D. Miller. “Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair.” Stem Cells Dev 18, no. 6 (2009): 893–906. https://doi.org/10.1089/scd.2008.0260.Full Text Link to Item
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Alman, Benjamin A., and Jay S. Wunder. “Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia.” Ann N Y Acad Sci 1144 (November 2008): 36–41. https://doi.org/10.1196/annals.1418.006.Full Text Link to Item
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Gevorgyan, Artur, Balram Sukhu, Benjamin A. Alman, Robert G. Bristow, Cho Y. Pang, and Christopher R. Forrest. “Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells.” Plast Reconstr Surg 122, no. 4 (October 2008): 1025–35. https://doi.org/10.1097/PRS.0b013e3181845931.Full Text Link to Item
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Giampietro, Philip F., Sally L. Dunwoodie, Kenro Kusumi, Olivier Pourquié, Olivier Tassy, Amaka C. Offiah, Alberto S. Cornier, et al. “Molecular diagnosis of vertebral segmentation disorders in humans.” Expert Opin Med Diagn 2, no. 10 (October 2008): 1107–21. https://doi.org/10.1517/17530059.2.10.1107.Full Text Link to Item
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Wu, Colleen, and Benjamin A. Alman. “Side population cells in human cancers.” Cancer Lett 268, no. 1 (September 8, 2008): 1–9. https://doi.org/10.1016/j.canlet.2008.03.048.Full Text Link to Item
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Yan, Taiqiang, Mark Angelini, Benjamin A. Alman, Irene L. Andrulis, and Jay S. Wunder. “Patched-one or smoothened gene mutations are infrequent in chondrosarcoma.” Clin Orthop Relat Res 466, no. 9 (September 2008): 2184–89. https://doi.org/10.1007/s11999-008-0332-2.Full Text Link to Item
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Silkstone, David, Helen Hong, and Benjamin A. Alman. “Beta-catenin in the race to fracture repair: in it to Wnt.” Nat Clin Pract Rheumatol 4, no. 8 (August 2008): 413–19. https://doi.org/10.1038/ncprheum0838.Full Text Link to Item
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Kolski, Hanna K., Cynthia Hawkins, Mayana Zatz, Flavia de Paula, Doug Biggar, Ben Alman, and Jiri Vajsar. “Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques.” Neuropathology 28, no. 3 (June 2008): 264–68. https://doi.org/10.1111/j.1440-1789.2007.00871.x.Full Text Link to Item
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Sato, M., M. Liu, M. Anraku, T. Ogura, G. D’Cruz, B. A. Alman, T. K. Waddell, E. Kim, L. Zhang, and S. Keshavjee. “Allograft airway fibrosis in the pulmonary milieu: a disorder of tissue remodeling.” Am J Transplant 8, no. 3 (March 2008): 517–28. https://doi.org/10.1111/j.1600-6143.2007.02106.x.Full Text Link to Item
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Goh, Y. I., S. S. Tjandra, C. Hsu, A. Gurung, R. Poon, P. Nadesan, and B. A. Alman. “IFN-β signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors (Cancer Research (August 1, 2007) 67 (7124-7131)).” Cancer Research 68, no. 3 (February 1, 2008): 956. https://doi.org/10.1158/0008-5472.CAN-68-3-COR2.Full Text
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Alman, B. A. “Skeletal dysplasias and the growth plate.” Clin Genet 73, no. 1 (January 2008): 24–30. https://doi.org/10.1111/j.1399-0004.2007.00933.x.Full Text Link to Item
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Wright, James G., Sandra Donaldson, Andrew Howard, Derek Stephens, Benjamin Alman, and Douglas Hedden. “Are surgeons' preferences for instrumentation related to patient outcomes? A randomized clinical trial of two implants for idiopathic scoliosis.” J Bone Joint Surg Am 89, no. 12 (December 2007): 2684–93. https://doi.org/10.2106/JBJS.F.00720.Full Text Link to Item
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Howard, Andrew, Sandra Donaldson, Douglas Hedden, Derek Stephens, Benjamin Alman, and James Wright. “Improvement in quality of life following surgery for adolescent idiopathic scoliosis.” Spine (Phila Pa 1976) 32, no. 24 (November 15, 2007): 2715–18. https://doi.org/10.1097/BRS.0b013e31815a51cd.Full Text Link to Item
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Mercado, Eyal, Benjamin Alman, and James G. Wright. “Does spinal fusion influence quality of life in neuromuscular scoliosis?” Spine (Phila Pa 1976) 32, no. 19 Suppl (September 1, 2007): S120–25. https://doi.org/10.1097/BRS.0b013e318134eabe.Full Text Link to Item
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Wu, Colleen, Qingxia Wei, Velani Utomo, Puviindran Nadesan, Heather Whetstone, Rita Kandel, Jay S. Wunder, and Benjamin A. Alman. “Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.” Cancer Res 67, no. 17 (September 1, 2007): 8216–22. https://doi.org/10.1158/0008-5472.CAN-07-0999.Full Text Link to Item
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Tjandra, Sean S., Claire Hsu, Y Ingrid Goh, Ananta Gurung, Raymond Poon, Puviindran Nadesan, and Benjamin A. Alman. “IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors.” Cancer Res 67, no. 15 (August 1, 2007): 7124–31. https://doi.org/10.1158/0008-5472.CAN-07-0686.Full Text Link to Item
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Wunder, Jay S., Torsten O. Nielsen, Robert G. Maki, Brian O’sullivan, and Benjamin A. Alman. “CYP3A4/5 and pharmacogenetics in patients with sarcoma - Authors' reply.” Lancet Oncol 8, no. 8 (August 2007): 668–69. https://doi.org/10.1016/S1470-2045(07)70216-4.Full Text Link to Item
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Chen, Yan, Heather C. Whetstone, Alvin C. Lin, Puviindran Nadesan, Qingxia Wei, Raymond Poon, and Benjamin A. Alman. “Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.” Plos Med 4, no. 7 (July 31, 2007): e249. https://doi.org/10.1371/journal.pmed.0040249.Full Text Link to Item
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Donaldson, Sandra, Derek Stephens, Andrew Howard, Benjamin Alman, Unni Narayanan, and James G. Wright. “Surgical decision making in adolescent idiopathic scoliosis.” Spine (Phila Pa 1976) 32, no. 14 (June 15, 2007): 1526–32. https://doi.org/10.1097/BRS.0b013e318067dc75.Full Text Link to Item
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Boutis, Kathy, Andrew R. Willan, Paul Babyn, Unni G. Narayanan, Benjamin Alman, and Suzanne Schuh. “A randomized, controlled trial of a removable brace versus casting in children with low-risk ankle fractures.” Pediatrics 119, no. 6 (June 2007): e1256–63. https://doi.org/10.1542/peds.2006-2958.Full Text Link to Item
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Wunder, Jay S., Torsten O. Nielsen, Robert G. Maki, Brian O’Sullivan, and Benjamin A. Alman. “Opportunities for improving the therapeutic ratio for patients with sarcoma.” Lancet Oncol 8, no. 6 (June 2007): 513–24. https://doi.org/10.1016/S1470-2045(07)70169-9.Full Text Link to Item
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Turnpenny, Peter D., Ben Alman, Alberto S. Cornier, Philip F. Giampietro, Amaka Offiah, Olivier Tassy, Olivier Pourquié, Kenro Kusumi, and Sally Dunwoodie. “Abnormal vertebral segmentation and the notch signaling pathway in man.” Dev Dyn 236, no. 6 (June 2007): 1456–74. https://doi.org/10.1002/dvdy.21182.Full Text Link to Item
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Baliko, Frank, Tamara Bright, Raymond Poon, Brenda Cohen, Sean E. Egan, and Benjamin A. Alman. “Inhibition of notch signaling induces neural differentiation in Ewing sarcoma.” Am J Pathol 170, no. 5 (May 2007): 1686–94. https://doi.org/10.2353/ajpath.2007.060971.Full Text Link to Item
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Mau, Elaine, Heather Whetstone, Chunying Yu, Sevan Hopyan, Jay S. Wunder, and Benjamin A. Alman. “PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.” Dev Biol 305, no. 1 (May 1, 2007): 28–39. https://doi.org/10.1016/j.ydbio.2007.01.031.Full Text Link to Item
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Li, Catherine F., Jeffrey R. MacDonald, Robert Y. Wei, Jocelyn Ray, Kimberly Lau, Christopher Kandel, Rachel Koffman, Sherilyn Bell, Stephen W. Scherer, and Benjamin A. Alman. “Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.” Bmc Genomics 8 (April 3, 2007): 92. https://doi.org/10.1186/1471-2164-8-92.Full Text Link to Item
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Alman, Benjamin A., and William A. Horton. “Developmental biology in orthopaedics. Summary of the 2006 AAOS research symposium.” J Bone Joint Surg Am 89, no. 3 (March 2007): 668–71. https://doi.org/10.2106/JBJS.F.01609.Full Text Link to Item
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Donaldson, Sandra, Douglas Hedden, Derek Stephens, Benjamin Alman, Andrew Howard, Unni Narayanan, and James G. Wright. “Surgeon reliability in rating physical deformity in adolescent idiopathic scoliosis.” Spine (Phila Pa 1976) 32, no. 3 (February 1, 2007): 363–67. https://doi.org/10.1097/01.brs.0000253605.71168.2e.Full Text Link to Item
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Chen, Yan, Heather C. Whetstone, Andrew Youn, Puviindran Nadesan, Edwin C. Y. Chow, Alvin C. Lin, and Benjamin A. Alman. “Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.” J Biol Chem 282, no. 1 (January 5, 2007): 526–33. https://doi.org/10.1074/jbc.M602700200.Full Text Link to Item
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Janicki, J. A., and B. Alman. “Scoliosis: Review of diagnosis and treatment.” Paediatrics and Child Health 12, no. 9 (January 1, 2007): 771–76. https://doi.org/10.1093/pch/12.9.771.Full Text
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Li, Catherine F., Robert Y. Wei, Frank Baliko, Bharati Bapat, and Benjamin A. Alman. “An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients.” Fam Cancer 6, no. 1 (2007): 89–95. https://doi.org/10.1007/s10689-006-9109-5.Full Text Link to Item
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Stansberg, Christine, Audun Vik-Mo, Rita Holdhus, Harald Breilid, Boleslaw Srebro, Kjell Petersen, Hugo A. Jørgensen, Inge Jonassen, and Vidar M. Steen. “Gene expression profiles in rat brain disclose CNS signature genes and regional patterns of functional specialisation.” Bmc Genomics 8, no. 1 (2007): 94–94. https://doi.org/10.1186/1471-2164-8-94.Full Text
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Wunder, T., T. O. Nielsen, R. G. Maki, B. O’Sullivan, and B. A. Alman. “Opportunities for improving the therapeutic ratio for patients with sarcoma (vol 8, pg 513, 2007).” Lancet Oncology 8, no. 8 (2007): 670–670.Link to Item
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Smith, Patricia L., Sandra Donaldson, Douglas Hedden, Benjamin Alman, Andrew Howard, Derek Stephens, and James G. Wright. “Parents' and patients' perceptions of postoperative appearance in adolescent idiopathic scoliosis.” Spine (Phila Pa 1976) 31, no. 20 (September 15, 2006): 2367–74. https://doi.org/10.1097/01.brs.0000240204.98960.dd.Full Text Link to Item
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Zuker, Ronald M., Rick Redett, Ben Alman, John G. Coles, Norma Timoney, and Sigmund H. Ein. “First successful lower-extremity transplantation: technique and functional result.” J Reconstr Microsurg 22, no. 4 (May 2006): 239–44. https://doi.org/10.1055/s-2006-939928.Full Text Link to Item
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Cheon, Sophia S., Qingxia Wei, Ananta Gurung, Andrew Youn, Tamara Bright, Raymond Poon, Heather Whetstone, Abhijit Guha, and Benjamin A. Alman. “Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.” Faseb J 20, no. 6 (April 2006): 692–701. https://doi.org/10.1096/fj.05-4759com.Full Text Link to Item
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Biggar, W. D., V. A. Harris, L. Eliasoph, and B. Alman. “Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade.” Neuromuscul Disord 16, no. 4 (April 2006): 249–55. https://doi.org/10.1016/j.nmd.2006.01.010.Full Text Link to Item
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Tiet, Tri Dung, Sevan Hopyan, Puviindran Nadesan, Nalan Gokgoz, Raymond Poon, Alvin C. Lin, Taiqiang Yan, Irene L. Andrulis, Benjamin A. Alman, and Jay S. Wunder. “Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.” Am J Pathol 168, no. 1 (January 2006): 321–30. https://doi.org/10.2353/ajpath.2006.050001.Full Text Link to Item
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Hopyan, Sevan, Puviindran Nadesan, Chunying Yu, Jay Wunder, and Benjamin A. Alman. “Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.” J Pathol 206, no. 2 (June 2005): 143–50. https://doi.org/10.1002/path.1761.Full Text Link to Item
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Cheon, Sophia, Raymond Poon, Chunying Yu, Michael Khoury, Rob Shenker, Joel Fish, and Benjamin A. Alman. “Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds.” Lab Invest 85, no. 3 (March 2005): 416–25. https://doi.org/10.1038/labinvest.3700237.Full Text Link to Item
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Fen Li, Catherine, Christopher Kandel, Frank Baliko, Puviindran Nadesan, Nils Brünner, and Benjamin A. Alman. “Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor).” Oncogene 24, no. 9 (February 24, 2005): 1615–24. https://doi.org/10.1038/sj.onc.1208193.Full Text Link to Item
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Skaggs, David L., Lauren Friend, Benjamin Alman, Henry G. Chambers, Michael Schmitz, Brett Leake, Robert M. Kay, and John M. Flynn. “The effect of surgical delay on acute infection following 554 open fractures in children.” J Bone Joint Surg Am 87, no. 1 (January 2005): 8–12. https://doi.org/10.2106/JBJS.C.01561.Full Text Link to Item
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Alman, Benjamin A. “Duchenne muscular dystrophy and steroids: pharmacologic treatment in the absence of effective gene therapy.” J Pediatr Orthop 25, no. 4 (2005): 554–56. https://doi.org/10.1097/01.bpo.0000167368.17274.54.Full Text Link to Item
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Leitch, Khristinn Kellie, Naweed Raza, Doug Biggar, Derek Stephen, James G. Wright, and Benjamin Alman. “Should foot surgery be performed for children with Duchenne muscular dystrophy?” J Pediatr Orthop 25, no. 1 (2005): 95–97. https://doi.org/10.1097/00004694-200501000-00021.Full Text Link to Item
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Khurana, Jasvir S., Shuji Ogino, Ting Shen, Hemant Parekh, Uwe Scherbel, William Delong, Michael D. Feldman, Paul J. Zhang, Hubert J. Wolfe, and Benjamin A. Alman. “Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions.” Arch Pathol Lab Med 128, no. 11 (November 2004): 1267–69. https://doi.org/10.5858/2004-128-1267-BMPAEB.Full Text Link to Item
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Biggar, W. D., L. Politano, V. A. Harris, L. Passamano, J. Vajsar, B. Alman, A. Palladino, L. I. Comi, and G. Nigro. “Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols.” Neuromuscul Disord 14, no. 8–9 (September 2004): 476–82. https://doi.org/10.1016/j.nmd.2004.05.001.Full Text Link to Item
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Kong, Yuan, Raymond Poon, Puviindran Nadesan, Tamara Di Muccio, Riccardo Fodde, Rama Khokha, and Benjamin A. Alman. “Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.” Cancer Res 64, no. 16 (August 15, 2004): 5795–5803. https://doi.org/10.1158/0008-5472.CAN-03-3112.Full Text Link to Item
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Denys, H., O. De Wever, B. Nusgens, Y. Kong, R. Sciot, A. -. T. Le, K. Van Dam, et al. “Invasion and MMP expression profile in desmoid tumours.” Br J Cancer 90, no. 7 (April 5, 2004): 1443–49. https://doi.org/10.1038/sj.bjc.6601661.Full Text Link to Item
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Alman, Benjamin A., S Naweed Raza, and W Douglas Biggar. “Steroid treatment and the development of scoliosis in males with duchenne muscular dystrophy.” J Bone Joint Surg Am 86, no. 3 (March 2004): 519–24. https://doi.org/10.2106/00004623-200403000-00009.Full Text Link to Item
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Roposch, Andreas, Atul R. Bhaskar, Francis Lee, Sanya Adedapo, Maryline Mousny, and Benjamin A. Alman. “Orthopaedic manifestations of Brachmann-de Lange syndrome: a report of 34 patients.” J Pediatr Orthop B 13, no. 2 (March 2004): 118–22. https://doi.org/10.1097/00009957-200403000-00011.Full Text Link to Item
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Cheon, Sophia S., Puviindran Nadesan, Raymond Poon, and Benjamin A. Alman. “Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.” Exp Cell Res 293, no. 2 (February 15, 2004): 267–74. https://doi.org/10.1016/j.yexcr.2003.09.029.Full Text Link to Item
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Denys, Hannelore, Ali Jadidizadeh, Saeid Amini Nik, Kim Van Dam, Stein Aerts, Benjamin A. Alman, Jean-Jacques Cassiman, and Sabine Tejpar. “Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors.” Oncogene 23, no. 3 (January 22, 2004): 654–64. https://doi.org/10.1038/sj.onc.1207160.Full Text Link to Item
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Narayanan, Unni G., Joshua E. Hyman, Andrew M. Wainwright, Mercer Rang, and Benjamin A. Alman. “Complications of elastic stable intramedullary nail fixation of pediatric femoral fractures, and how to avoid them.” J Pediatr Orthop 24, no. 4 (2004): 363–69. https://doi.org/10.1097/00004694-200407000-00004.Full Text Link to Item
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Yu, Chunying, Anh-Thy Le, Herman Yeger, Bernard Perbal, and Benjamin A. Alman. “NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.” J Pathol 201, no. 4 (December 2003): 609–15. https://doi.org/10.1002/path.1468.Full Text Link to Item
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Tolg, Cornelia, Raymoond Poon, Riccardo Fodde, Eva Ann Turley, and Benjamin Aaron Alman. “Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).” Oncogene 22, no. 44 (October 9, 2003): 6873–82. https://doi.org/10.1038/sj.onc.1206811.Full Text Link to Item
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Howard, Jeffrey C., Vincenzo M. Varallo, Douglas C. Ross, James H. Roth, Kenneth J. Faber, Benjamin Alman, and Bing Siang Gan. “Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro.” Bmc Musculoskelet Disord 4 (July 16, 2003): 16. https://doi.org/10.1186/1471-2474-4-16.Full Text Link to Item
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Varallo, Vincenzo M., Bing Siang Gan, Shannon Seney, Douglas C. Ross, James H. Roth, Robert S. Richards, Robert M. McFarlane, Benjamin Alman, and Jeffrey C. Howard. “Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro.” Oncogene 22, no. 24 (June 12, 2003): 3680–84. https://doi.org/10.1038/sj.onc.1206415.Full Text Link to Item
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Tiet, Tri Dung, and Benjamin A. Alman. “Developmental pathways in musculoskeletal neoplasia: involvement of the Indian Hedgehog-parathyroid hormone-related protein pathway.” Pediatr Res 53, no. 4 (April 2003): 539–43. https://doi.org/10.1203/01.PDR.0000054688.93486.18.Full Text Link to Item
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Alman, Benjamin A. “Genetic etiology does not supplant the need to understand orthopaedic disorders.” Clin Orthop Relat Res, no. 401 (August 2002): 2–3.Link to Item
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Alman, Benjamin A. “A classification for genetic disorders of interest to orthopaedists.” Clin Orthop Relat Res, no. 401 (August 2002): 17–26. https://doi.org/10.1097/00003086-200208000-00004.Full Text Link to Item
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Plasschaert, F., C. Craig, R. Bell, W. G. Cole, J. S. Wunder, and B. A. Alman. “Eosinophilic granuloma. A different behaviour in children than in adults.” J Bone Joint Surg Br 84, no. 6 (August 2002): 870–72. https://doi.org/10.1302/0301-620x.84b6.12585.Full Text Link to Item
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Purkiss, Sheila B., Brandon Driscoll, William G. Cole, and Benjamin Alman. “Idiopathic scoliosis in families of children with congenital scoliosis.” Clin Orthop Relat Res, no. 401 (August 2002): 27–31. https://doi.org/10.1097/00003086-200208000-00005.Full Text Link to Item
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Cheon, Sophia S., Alexander Y. L. Cheah, Stefanie Turley, Puviindran Nadesan, Raymond Poon, Hans Clevers, and Benjamin A. Alman. “beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.” Proc Natl Acad Sci U S A 99, no. 10 (May 14, 2002): 6973–78. https://doi.org/10.1073/pnas.102657399.Full Text Link to Item
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Hopyan, Sevan, Nalan Gokgoz, Raymond Poon, Robert C. Gensure, Chunying Yu, William G. Cole, Robert S. Bell, et al. “A mutant PTH/PTHrP type I receptor in enchondromatosis.” Nat Genet 30, no. 3 (March 2002): 306–10. https://doi.org/10.1038/ng844.Full Text Link to Item
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Boutis, K., L. Komar, D. Jaramillo, P. Babyn, B. Alman, B. Snyder, K. D. Mandl, and S. Schuh. “Sensitivity of a clinical examination to predict need for radiography in children with ankle injuries: a prospective study.” Lancet 358, no. 9299 (December 22, 2001): 2118–21. https://doi.org/10.1016/S0140-6736(01)07218-X.Full Text Link to Item
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Meng, X., R. Poon, X. Zhang, A. Cheah, Q. Ding, C. C. Hui, and B. Alman. “Suppressor of fused negatively regulates beta-catenin signaling.” J Biol Chem 276, no. 43 (October 26, 2001): 40113–19. https://doi.org/10.1074/jbc.M105317200.Full Text Link to Item
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Dormans, J. P., D. Spiegel, J. Meyer, N. Asada, B. A. Alman, S. G. Pill, B. Himelstein, and R. Womer. “Fibromatoses in childhood: the desmoid/fibromatosis complex.” Med Pediatr Oncol 37, no. 2 (August 2001): 126–31. https://doi.org/10.1002/mpo.1181.Full Text Link to Item
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Tejpar, S., C. Li, C. Yu, R. Poon, H. Denys, R. Sciot, E. Van Cutsem, J. J. Cassiman, and B. A. Alman. “Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).” Br J Cancer 85, no. 1 (July 6, 2001): 98–101. https://doi.org/10.1054/bjoc.2001.1857.Full Text Link to Item
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Burrow, S. R., B. Alman, and J. G. Wright. “Short stature as a screening test for endocrinopathy in slipped capital femoral epiphysis.” J Bone Joint Surg Br 83, no. 2 (March 2001): 263–68. https://doi.org/10.1302/0301-620x.83b2.10554.Full Text Link to Item
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Babyn, P. S., C. E. Wihlborg, J. K. Tjong, B. A. Alman, and P. J. Silberberg. “Local complications after limb-salvage surgery for pediatric bone tumours: a pictorial essay.” Can Assoc Radiol J 52, no. 1 (February 2001): 35–42.Link to Item
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Poon, R., R. Smits, C. Li, S. Jagmohan-Changur, M. Kong, S. Cheon, C. Yu, R. Fodde, and B. A. Alman. “Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).” Oncogene 20, no. 4 (January 25, 2001): 451–60. https://doi.org/10.1038/sj.onc.1204107.Full Text Link to Item
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Wedge, J. H., T. R. Daniels, and B. A. Alman. “Congenital clubfoot.” Current Paediatrics 11, no. 5 (January 1, 2001): 332–40. https://doi.org/10.1054/cupe.2001.0214.Full Text
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Khurana, J. S., S. Ogino, T. McHale, M. Feldman, U. Scherbel, P. Wirganowicz, P. Schultz, and B. A. Alman. “Bone morphogenetic proteins (BMPs) and its receptors (BMPR) are expressed by both bone forming and non bone forming lesions.” Bone 28, no. 5 (2001): S112–S112.Link to Item
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Li, C., Q. Nguyen, W. G. Cole, and B. A. Alman. “Potential treatment for clubfeet based on growth factor blockade.” J Pediatr Orthop 21, no. 3 (2001): 372–77.Link to Item
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Couture, J., A. Mitri, R. Lagace, R. Smits, T. Berk, H. L. Bouchard, R. Fodde, B. Alman, and B. Bapat. “A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.” Clin Genet 57, no. 3 (March 2000): 205–12. https://doi.org/10.1034/j.1399-0004.2000.570306.x.Full Text Link to Item
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Harjacek, M., S. Diaz-Cano, B. A. Alman, J. Coburn, R. Ruthazer, H. Wolfe, and A. C. Steere. “Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis.” J Rheumatol 27, no. 2 (February 2000): 497–503.Link to Item
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Kim, H. K., B. Alman, and W. G. Cole. “A shortened course of parenteral antibiotic therapy in the management of acute septic arthritis of the hip.” J Pediatr Orthop 20, no. 1 (2000): 44–47.Link to Item
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Tejpar, S., F. Nollet, C. Li, J. S. Wunder, G. Michils, P. dal Cin, E. Van Cutsem, et al. “Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor).” Oncogene 18, no. 47 (November 11, 1999): 6615–20. https://doi.org/10.1038/sj.onc.1203041.Full Text Link to Item
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Alman, B. A., and H. K. Kim. “Pelvic obliquity after fusion of the spine in Duchenne muscular dystrophy.” J Bone Joint Surg Br 81, no. 5 (September 1999): 821–24. https://doi.org/10.1302/0301-620x.81b5.9383.Full Text Link to Item
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Hopyan, S., N. Gokgoz, R. S. Bell, I. L. Andrulis, B. A. Alman, and J. S. Wunder. “Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours.” J Orthop Res 17, no. 5 (September 1999): 633–38. https://doi.org/10.1002/jor.1100170503.Full Text Link to Item
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Daniels, T. R., B. Alman, and J. H. Wedge. “Congenital clubfoot.” Current Orthopaedics 13, no. 3 (January 1, 1999): 229–36. https://doi.org/10.1016/S0268-0890(99)90008-7.Full Text
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Li, C., B. Bapat, and B. A. Alman. “Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor).” Am J Pathol 153, no. 3 (September 1998): 709–14. https://doi.org/10.1016/s0002-9440(10)65614-3.Full Text Link to Item
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Tjong, J. K., P. S. Babyn, B. A. Alman, and P. J. Silberberg. “Diagnostic imaging of post limb-salvage complications in pediatric patients with osteogenic sarcoma or Ewing's sarcoma.” Radiology 209P (1998): 365–365.Link to Item
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Alman, B. A., C. Li, M. E. Pajerski, S. Diaz-Cano, and H. J. Wolfe. “Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors).” Am J Pathol 151, no. 2 (August 1997): 329–34.Link to Item
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Gallivan, K., B. A. Alman, K. P. Moriarty, M. E. Pajerski, C. O’Donnell, and T. M. Crombleholme. “Differential collagen I gene expression in fetal fibroblasts.” J Pediatr Surg 32, no. 7 (July 1997): 1033–36. https://doi.org/10.1016/s0022-3468(97)90393-6.Full Text Link to Item
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Alman, B. A., M. E. Pajerski, S. Diaz-Cano, K. Corboy, and H. J. Wolfe. “Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder.” Diagn Mol Pathol 6, no. 2 (April 1997): 98–101. https://doi.org/10.1097/00019606-199704000-00005.Full Text Link to Item
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Alman, B. A. “Etiology and treatment of fibrous dysplasia.” Current Opinion in Orthopaedics 8, no. 5 (January 1, 1997): 25–29. https://doi.org/10.1097/00001433-199710000-00005.Full Text
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Alman, B. A., M. E. Pajerski, C. Li, S. J. DiazCano, and H. J. Wolfe. “APC mutations are present in some sporadic aggressive fibromatosis.” Laboratory Investigation 76, no. 1 (1997): 21–21.Link to Item
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Muller, E., M. Castagnaro, D. W. Yandel, H. J. Wolfe, and B. A. Alman. “Molecular genetic and immunohistochemical analysis of the tumor suppressor genes Rb and p53 in palmar and aggressive fibromatosis.” Diagn Mol Pathol 5, no. 3 (September 1996): 194–200. https://doi.org/10.1097/00019606-199609000-00008.Full Text Link to Item
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Alman, B. A., D. A. Greel, L. K. Ruby, M. J. Goldberg, and H. J. Wolfe. “Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain.” J Orthop Res 14, no. 5 (September 1996): 722–28. https://doi.org/10.1002/jor.1100140507.Full Text Link to Item
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Alman, B. A., M. Bhandari, and J. G. Wright. “Function of dislocated hips in children with lower level spina bifida.” J Bone Joint Surg Br 78, no. 2 (March 1996): 294–98.Link to Item
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Alman, B. A., M. Bhandari, and J. G. Wright. “Function of dislocated hips in children with lower level spina bifida.” The Journal of Bone and Joint Surgery. British Volume 78, no. 2 (March 1996): 294–98.
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Alman, B. A., D. A. Greel, and H. J. Wolfe. “Activating mutations of Gs protein in monostotic fibrous lesions of bone.” J Orthop Res 14, no. 2 (March 1996): 311–15. https://doi.org/10.1002/jor.1100140221.Full Text Link to Item
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Crombleholme, T. M., M. D’Alton, M. Cendron, B. Alman, M. D. Goldberg, G. T. Klauber, A. Cohen, C. Heilman, M. Lewis, and B. H. Harris. “Prenatal diagnosis and the pediatric surgeon: the impact of prenatal consultation on perinatal management.” J Pediatr Surg 31, no. 1 (January 1996): 156–62. https://doi.org/10.1016/s0022-3468(96)90340-1.Full Text Link to Item
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Alman, B. A., K. Merdek, and H. J. Wolfe. “Growth factor and cytokine expression in osteolytic bone metastases.” Laboratory Investigation 74, no. 1 (1996): 3–3.Link to Item
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Alman, B. A., S. J. DiazCano, D. A. Greel, and H. J. Wolfe. “Activating Gs mutations in monostotic fibrous lesions of bone.” Laboratory Investigation 74, no. 1 (1996): 2–2.Link to Item
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Alman, B. A., J. I. Krajbich, and S. Hubbard. “Proximal femoral focal deficiency: results of rotationplasty and Syme amputation.” J Bone Joint Surg Am 77, no. 12 (December 1995): 1876–82. https://doi.org/10.2106/00004623-199512000-00012.Full Text Link to Item
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Crombleholme, T. M., K. Dirkes, T. M. Whitney, B. Alman, S. Garmel, and R. J. Connelly. “Amniotic band syndrome in fetal lambs. I: Fetoscopic release and morphometric outcome.” J Pediatr Surg 30, no. 7 (July 1995): 974–78. https://doi.org/10.1016/0022-3468(95)90324-0.Full Text Link to Item
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ALMAN, B. A., D. A. GREEL, and H. J. WOLFE. “REGULATION OF PROLIFERATION AND PLATELET-DERIVED GROWTH-FACTOR (PDGF) EXPRESSION IN PALMAR FIBROMATOSIS (DUPUYTRENS DISEASE) BY MECHANICAL STRAIN.” Laboratory Investigation 72, no. 1 (1995): A4–A4.Link to Item
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Alman, B. A., A. De Bari, and J. I. Krajbich. “Massive allografts in the treatment of osteosarcoma and Ewing sarcoma in children and adolescents.” J Bone Joint Surg Am 77, no. 1 (January 1995): 54–64. https://doi.org/10.2106/00004623-199501000-00008.Full Text Link to Item
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Alman, B. A., S. P. Naber, R. M. Terek, W. A. Jiranek, M. J. Goldberg, and H. J. Wolfe. “Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures.” J Orthop Res 13, no. 1 (January 1995): 67–77. https://doi.org/10.1002/jor.1100130111.Full Text Link to Item
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Terek, R. M., W. A. Jiranek, M. J. Goldberg, H. J. Wolfe, and B. A. Alman. “The expression of platelet-derived growth-factor gene in Dupuytren contracture.” J Bone Joint Surg Am 77, no. 1 (January 1995): 1–9. https://doi.org/10.2106/00004623-199501000-00001.Full Text Link to Item
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Gowen, G. F., R. E. Campbell, M. M. McFarland, and B. A. Alman. “Giant marginal ulcer.” Surg Endosc 8, no. 2 (February 1994): 107–10. https://doi.org/10.1007/BF00316619.Full Text Link to Item
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Levitsky, K. A., B. A. Alman, D. S. Jevsevar, and J. Morehead. “Digital nerves of the foot: anatomic variations and implications regarding the pathogenesis of interdigital neuroma.” Foot Ankle 14, no. 4 (May 1993): 208–14. https://doi.org/10.1177/107110079301400406.Full Text Link to Item
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Alman, B. A., C. L. Craig, and S. Zimbler. “Subtalar arthrodesis for stabilization of valgus hindfoot in patients with cerebral palsy.” J Pediatr Orthop 13, no. 5 (1993): 634–41.Link to Item
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Sturm, P. F., B. A. Alman, and B. L. Christie. “Femur fractures in institutionalized patients after hip spica immobilization.” J Pediatr Orthop 13, no. 2 (1993): 246–48.Link to Item
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Alman, B. A., M. J. Goldberg, S. P. Naber, T. Galanopoulous, H. N. Antoniades, and H. J. Wolfe. “Aggressive fibromatosis.” J Pediatr Orthop 12, no. 1 (January 1992): 1–10.Link to Item
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ALMAN, B. A., W. A. JIRANEK, S. P. NABER, R. M. TEREK, M. J. GOLDBERG, and H. J. WOLFE. “INAPPROPRIATE C-SIS PROTOONCOGENE EXPRESSION IN FIBROUS DYSPLASIA - AN INSITU HYBRIDIZATION AND PCR STUDY.” Laboratory Investigation 66, no. 1 (1992): A2–A2.Link to Item
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JIRANEK, W. A., B. A. ALMAN, R. M. TEREK, S. P. NABER, L. K. RUBY, M. J. GOLDBERG, and H. J. WOLFE. “INSITU HYBRIDIZATION TO LOCALIZE C-SIS PROTOONCOGENE EXPRESSION IN DUPUYTRENS FIBROMATOSIS.” Laboratory Investigation 66, no. 1 (1992): A7–A7.Link to Item
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ALMAN, B. A., S. P. NABER, M. J. GOLDBERG, and H. J. WOLFE. “DIFFERENTIAL EXPRESSION OF THE C-SIS PROTOONCOGENE IN FIBROPROLIFERATIVE LESIONS OF THE EXTREMITIES.” Laboratory Investigation 64, no. 1 (1991): A2–A2.Link to Item
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Alman, B. A., and M. J. Goldberg. “Solitary osteochondroma of the clavicle.” J Pediatr Orthop 11, no. 2 (1991): 181–83. https://doi.org/10.1097/01241398-199103000-00007.Full Text Link to Item
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Alman, B., and P. Frasca. “Fracture failure mechanisms in patients with osteogenesis imperfecta.” J Orthop Res 5, no. 1 (1987): 139–43. https://doi.org/10.1002/jor.1100050118.Full Text Link to Item
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Book Sections
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Alman, Benjamin, and Gurpreet Baht. “Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton.,” 2230:105–13, 2021. https://doi.org/10.1007/978-1-0716-1028-2_7.Full Text Link to Item
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Dial, B. L., and B. A. Alman. “The Hip in Fibrous Dysplasia.” In The Pediatric and Adolescent Hip: Essentials and Evidence, 769–83, 2019. https://doi.org/10.1007/978-3-030-12003-0_32.Full Text
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Alman, B. A. “The immature skeleton.” In Rockwood and Wilkins’ Fractures in Children: Eighth Edition, 2014.
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Alman, B. A. “The immature skeleton.” In Rockwood, Green, and Wilkins Fractures in Adults and Children: Eighth Edition, Vol. 2–2, 2014.
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Alman, B. A. “The immature skeleton.” In Rockwood & Wilkins Fractures in Children: Eighth Edition, 2014.
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Alman, B. “Desmoid tumors: Are they benign or malignant?” In Desmoid Tumors, 195–203, 2012. https://doi.org/10.1007/978-94-007-1685-8_13.Full Text
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Yassir, W. K., B. A. Alman, and M. J. Goldberg. “Defective Limb Embryology.” In Fetal and Neonatal Physiology: Third Edition, 2–2:1844–49, 2003. https://doi.org/10.1016/B978-0-7216-9654-6.50183-1.Full Text
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Conference Papers
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Sekar, M., and B. A. Alman. “Macrophage-secreted Factors that Rejuvenate Delayed Fracture Healing Characteristic of Aging.” In Journal of the American Geriatrics Society, 63:S149–S149. WILEY-BLACKWELL, 2015.Link to Item
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Ali, S. A., H. C. Whetstone, and B. A. Alman. “Hedgehog signaling regulates cholesterol homeostasis in osteoarthritis.” In Osteoarthritis and Cartilage, 22:S160–S160. Elsevier BV, 2014. https://doi.org/10.1016/j.joca.2014.02.299.Full Text
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Singh, Kaustabh, Anton Mihic, Kota Hatta, Saeid Amini-Nik, Jun Wu, Shu-Hong Li, Lu Sun, et al. “Reduced beta-catenin Expression in Mouse Cardiomyocytes Increases Matrix Metalloproteinase Activation and Apoptosis, Producing Greater Post-Infarction Ventricular Dysfunction.” In Circulation, Vol. 128, 2013.Link to Item
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Ng, A. H., B. A. Alman, and M. D. Grynpas. “Development of a mouse model of Adynamic Bone Disease (ABD).” In Bone, 48:S174–S174. Elsevier BV, 2011. https://doi.org/10.1016/j.bone.2011.03.398.Full Text
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Biggar, W. D., V. A. Harris, and B. A. Alman. “G.P.10 06 Does deflazacort treatment impact the surgical outcomes for boys with Duchenne muscular dystrophy?” In Neuromuscular Disorders, 16:719–20. Elsevier BV, 2006. https://doi.org/10.1016/j.nmd.2006.05.240.Full Text
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- Teaching & Mentoring
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Recent Courses
- ORTHO 222C: Orthopaedic Surgery Experience 2023
- ORTHO 421C: Fractures/Musculoskeletal Trauma 2023
- ORTHO 429C: Sub-Internship in Orthopaedic Surgery 2023
- ORTHO 433C: Pediatric Orthopaedics 2023
- PATHOL 793: Research Independent Study 2023
- ORTHO 222C: Orthopaedic Surgery Experience 2022
- ORTHO 429C: Sub-Internship in Orthopaedic Surgery 2022
- PATHOL 793: Research Independent Study 2022
- PATHOL 793: Research Independent Study 2021
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