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Thomas Lawrence Holland

Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 163 Hanes House, Trent Drive, Durham, NC 27710

Current Appointments & Affiliations


Professor of Medicine · 2024 - Present Medicine, Infectious Diseases, Medicine
Membership in the Duke Clinical Research Institute · 2015 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published October 4, 2023
Drug Found Effective in Fighting Deadly Infections
Published July 11, 2022
Monoclonal Antibody Treatment Reduced Deaths in Hospitalized COVID Patients
Published September 26, 2018
New Way of Determining Treatment for Staph Infections Cuts Antibiotic Use

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Recent Publications


A patient-centric paradigm and tool for clinical research: the DOOR is open.

Journal Article Antimicrob Agents Chemother · January 7, 2026 Randomized clinical trials are the gold standard for evaluating the benefits and harms of interventions and yet may not provide the evidence needed to inform medical decision-making, an ultimate goal for clinical research. Commonly used design and analysis ... Full text Link to item Cite

S5530 Syphilitic Hepatitis Without Rash: A Diagnostic Challenge

Conference American Journal of Gastroenterology · October 2025 Full text Cite

Management of Staphylococcus aureus Bacteremia: A Review.

Journal Article JAMA · September 2, 2025 IMPORTANCE: Staphylococcus aureus, a gram-positive bacterium, is the leading cause of death from bacteremia worldwide, with a case fatality rate of 15% to 30% and an estimated 300 000 deaths per year. OBSERVATIONS: Staphylococcus aureus bacteremia causes m ... Full text Link to item Cite
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Recent Grants


Invasive Candidiasis

Clinical TrialPrincipal Investigator · Awarded by Basilea Pharmaceutica · 2024 - 2028

Antibacterial Resistance Leadership Group (ARLG)

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2013 - 2026

HR-BV 3

Clinical TrialPrincipal Investigator · Awarded by Biomeme, Inc. · 2023 - 2024

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Education, Training & Certifications


Wake Forest University · 2005 M.D.