Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Infectious Diseases, Duke University School of Medicine 2008 - 2010
  • Resident, Internal Medicine, Duke University School of Medicine 2005 - 2008
  • M.D., Wake Forest University 2005
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2019 - 2020
  • Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016 - 2019
  • Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2016
  • Clinical Associate in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2011
• Recognition
• 

  In the News

  • JUL 11, 2022

    Duke Health News

    Monoclonal Antibody Treatment Reduced Deaths in Hospitalized COVID Patients

  • SEP 26, 2018

    Duke Health News

    New Way of Determining Treatment for Staph Infections Cuts Antibiotic Use
• Research
• 

  Selected Grants

  • Antibacterial Resistance Leadership Group (ARLG) awarded by National Institutes of Health 2013 - 2026
  • EPCTU - Task Area A - Admin and Overall awarded by National Institutes of Health 2022 - 2023
  • CEC Activities for BPR-CS-009 Ceftobiprole medocaril - WO2 awarded by Basilea Pharmaceutica 2018 - 2022
  • CEC Activities for BPR-CS-009 Ceftobiprole medocaril awarded by Basilea Pharmaceutica 2017 - 2022
  • Vaccine Trial_LOI awarded by Universitair Medisch Centrum Utrecht 2019 - 2021
  • Bacteremia Modification 14 awarded by National Institutes of Health 2009 - 2017
  • Mod 11 for Option 3 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
  • Modification No 13 Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
  • ACHN-490-007 Trial awarded by Achaogen, Inc 2016 - 2017
  • Modification No. 8 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2016
  • Modification No. 5 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2015
  • A Phase III Multi-Center, Randomized, Open-label, Comparative Study to Assess the Efficacy of a Treatment Algorithm to Reduce the Use of Vancomycin in Patients with Intravenous Catheter-Associated Bloodstream Infections (BSI) due to Staphylococci awarded by National Institutes of Health 2009 - 2012
• 

  External Relationships

  • Aridis Pharmaceuticals
  • Basilea Inc.
  • Genentech, Inc (Roche Holding)
  • Motif Biosciences
  • Roivant Sciences
  • UpToDate, Inc
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chastre, Jean, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, et al. “Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.” Crit Care 26, no. 1 (November 15, 2022): 355. https://doi.org/10.1186/s13054-022-04204-9.
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    • Holland, Thomas L., Arnold S. Bayer, and Vance G. Fowler. “Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management.” Clin Infect Dis 75, no. 9 (October 29, 2022): 1668–74. https://doi.org/10.1093/cid/ciac364.
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    • ACTIV-3–Therapeutics for Inpatients with COVID-19 (TICO) Study Group, Nicholas A. “Tixagevimab-cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial.” Lancet Respir Med 10, no. 10 (October 2022): 972–84. https://doi.org/10.1016/S2213-2600(22)00215-6.
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    • Howard-Anderson, Jessica, Toshimitsu Hamasaki, Weixiao Dai, Deborah Collyar, Daniel Rubin, Sumathi Nambiar, Tori Kinamon, et al. “Improving Traditional Registrational Trial Endpoints: Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Complicated Urinary Tract Infection Clinical Trials.” Clin Infect Dis, August 29, 2022. https://doi.org/10.1093/cid/ciac692.
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    • Bergin, Stephen P., Sara B. Calvert, John Farley, Jie-Lena Sun, Karen Chiswell, Willem Dieperink, Jan Kluytmans, et al. “PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.” Open Forum Infect Dis 9, no. 7 (July 2022): ofac231. https://doi.org/10.1093/ofid/ofac231.
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    • Turner, Nicholas A., Allan Xu, Smitha Zaharoff, Thomas L. Holland, and Thomas P. Lodise. “Determination of plasma protein binding of dalbavancin.” J Antimicrob Chemother 77, no. 7 (June 29, 2022): 1899–1902. https://doi.org/10.1093/jac/dkac131.
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    • Howard-Anderson, Jessica, Weixiao Dai, Dafna Yahav, Toshimitsu Hamasaki, Adi Turjeman, Fidi Koppel, Erica Franceschini, et al. “A Desirability of Outcome Ranking Analysis of a Randomized Clinical Trial Comparing Seven Versus Fourteen Days of Antibiotics for Uncomplicated Gram-Negative Bloodstream Infection.” Open Forum Infect Dis 9, no. 6 (June 2022): ofac140. https://doi.org/10.1093/ofid/ofac140.
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    • Mourad, Ahmad, Thomas L. Holland, and Nicholas A. Turner. “Antiplatelet Therapy in Staphylococcus aureus Bacteremia: No Time Like the Past?” Antimicrobial Agents and Chemotherapy 66, no. 6 (June 2022): e0036522. https://doi.org/10.1128/aac.00365-22.
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    • Turner, Nicholas A., Smitha Zaharoff, Heather King, Scott Evans, Toshimitsu Hamasaki, Thomas Lodise, Varduhi Ghazaryan, et al. “Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial.” Trials 23, no. 1 (May 16, 2022): 407. https://doi.org/10.1186/s13063-022-06370-1.
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    • Robbins-Juarez, Shelief, Rachel Tobin, Michelle M. Schneider, Adela Rambi G. Cardones, Thomas L. Holland, and Stephen A. Telloni. “Severe Retiform Purpura Associated With COVID-19 Infection.” Annals of Internal Medicine: Clinical Cases 1, no. 2 (April 1, 2022). https://doi.org/10.7326/aimcc.2022.0006.
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    • ACTIV-3/TICO Bamlanivimab Study Group, James D., Jens D. Lundgren, Birgit Grund, Christina E. Barkauskas, Thomas L. Holland, Robert L. Gottlieb, Uriel Sandkovsky, et al. “Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial.” Ann Intern Med 175, no. 2 (February 2022): 234–43. https://doi.org/10.7326/M21-3507.
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    • King, Heather A., Sarah B. Doernberg, Kiran Grover, Julie Miller, Megan Oakes, Tsai-Wei Wang, Molly McFatrich, et al. “Patients' Experiences With Staphylococcus aureus and Gram-Negative Bacterial Bloodstream Infections: Results From Cognitive Interviews to Inform Assessment of Health-Related Quality of Life.” Open Forum Infect Dis 9, no. 2 (February 2022): ofab622. https://doi.org/10.1093/ofid/ofab622.
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    • Lodise, Thomas P., Marc Scheetz, Joseph J. Carreno, Henry Chambers, Vance Fowler, and Thomas L. Holland. “Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.” Open Forum Infect Dis 9, no. 2 (February 2022): ofab651. https://doi.org/10.1093/ofid/ofab651.
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    • Scheetz, Marc H., Gwendolyn M. Pais, Thomas P. Lodise, Steven Y. C. Tong, Joshua S. Davis, J Nicholas O’Donnell, Jiajun Liu, et al. “Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.” Antimicrob Agents Chemother 65, no. 10 (September 17, 2021): e0106021. https://doi.org/10.1128/AAC.01060-21.
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    • Carugati, Manuela, S. Aliberti, G. Sotgiu, F. Blasi, A. Gori, R. Menendez, M. Encheva, et al. “Correction to: Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study.” Eur J Clin Microbiol Infect Dis 40, no. 9 (September 2021): 2051. https://doi.org/10.1007/s10096-021-04295-2.
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    • Chambers, Henry F., Scott R. Evans, Robin Patel, Heather R. Cross, Anthony D. Harris, Yohei Doi, Helen W. Boucher, et al. “Antibacterial Resistance Leadership Group 2.0: Back to Business.” Clin Infect Dis 73, no. 4 (August 16, 2021): 730–39. https://doi.org/10.1093/cid/ciab141.
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    • King, Heather A., Sarah B. Doernberg, Julie Miller, Kiran Grover, Megan Oakes, Felicia Ruffin, Sarah Gonzales, et al. “Patients' Experiences With Staphylococcus aureus and Gram-negative Bacterial Bloodstream Infections: A Qualitative Descriptive Study and Concept Elicitation Phase To Inform Measurement of Patient-reported Quality of Life.” Clin Infect Dis 73, no. 2 (July 15, 2021): 237–47. https://doi.org/10.1093/cid/ciaa611.
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    • Moehring, Rebekah W., and Thomas L. Holland. “Compiling Observational Research During a Pandemic: A Necessary Bridge.” Clin Infect Dis 72, no. 11 (June 1, 2021): e750–52. https://doi.org/10.1093/cid/ciaa1705.
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    • Pericàs, Juan M., Jaume Llopis, Maria Jesús Jiménez-Exposito, Wissam M. Kourany, Benito Almirante, Giampiero Carosi, Emanuele Durante-Mangoni, et al. “Infective Endocarditis in Patients on Chronic Hemodialysis.” J Am Coll Cardiol 77, no. 13 (April 6, 2021): 1629–40. https://doi.org/10.1016/j.jacc.2021.02.014.
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    • ACTIV-3/TICO LY-CoV555 Study Group, James D., Jens D. Lundgren, Birgit Grund, Christina E. Barkauskas, Thomas L. Holland, Robert L. Gottlieb, Uriel Sandkovsky, et al. “A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.” N Engl J Med 384, no. 10 (March 11, 2021): 905–14. https://doi.org/10.1056/NEJMoa2033130.
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    • Holland, Thomas L. “Evidence-Based Guidelines Should Be Used To Inform COVID-19 Management.” Antimicrob Agents Chemother 65, no. 3 (February 17, 2021). https://doi.org/10.1128/AAC.02501-20.
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    • Marin-Corral, Judith, Sergi Pascual-Guardia, Francesco Amati, Stefano Aliberti, Joan R. Masclans, Nilam Soni, Alejandro Rodriguez, et al. “Aspiration Risk Factors, Microbiology, and Empiric Antibiotics for Patients Hospitalized With Community-Acquired Pneumonia.” Chest 159, no. 1 (January 2021): 58–72. https://doi.org/10.1016/j.chest.2020.06.079.
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    • Bergin, Stephen P., Adrian Coles, Sara B. Calvert, John Farley, John H. Powers, Marcus J. Zervos, Matthew Sims, et al. “PROPHETIC: Prospective Identification of Pneumonia in Hospitalized Patients in the ICU.” Chest 158, no. 6 (December 2020): 2370–80. https://doi.org/10.1016/j.chest.2020.06.034.
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    • Beigel, John H., Kay M. Tomashek, Lori E. Dodd, Aneesh K. Mehta, Barry S. Zingman, Andre C. Kalil, Elizabeth Hohmann, et al. “Remdesivir for the Treatment of Covid-19 - Final Report.” N Engl J Med 383, no. 19 (November 5, 2020): 1813–26. https://doi.org/10.1056/NEJMoa2007764.
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    • Holland, Thomas L., and Joshua S. Davis. “Combination Therapy for MRSA Bacteremia: To ß or Not to ß?” Clin Infect Dis 71, no. 1 (June 24, 2020): 11–13. https://doi.org/10.1093/cid/ciz750.
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    • Holland, Thomas L. “Early Oral Antibiotic Switch for Staphylococcus aureus Bacteremia: Many Are Called, but Few Are Chosen.” Antimicrob Agents Chemother 64, no. 7 (June 23, 2020). https://doi.org/10.1128/AAC.00317-20.
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    • Corneli, Amy, Sara B. Calvert, John H. Powers, Teresa Swezey, Deborah Collyar, Brian Perry, John J. Farley, et al. “Consensus on Language for Advance Informed Consent in Health Care-Associated Pneumonia Clinical Trials Using a Delphi Process.” Jama Netw Open 3, no. 5 (May 1, 2020): e205435. https://doi.org/10.1001/jamanetworkopen.2020.5435.
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    • Eichenberger, E. M., V. G. Fowler, and T. L. Holland. “Duration of antibiotic therapy for Staphylococcus aureus bacteraemia: the long and the short of it.” Clin Microbiol Infect 26, no. 5 (May 2020): 536–38. https://doi.org/10.1016/j.cmi.2020.01.003.
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    • Shelburne, S. A., R. W. Dib, B. T. Endres, R. Reitzel, X. Li, A. Kalia, P. Sahasrabhojane, et al. “Whole-genome sequencing of Staphylococcus epidermidis bloodstream isolates from a prospective clinical trial reveals that complicated bacteraemia is caused by a limited number of closely related sequence types.” Clin Microbiol Infect 26, no. 5 (May 2020): 646.e1-646.e8. https://doi.org/10.1016/j.cmi.2019.10.008.
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    • Villafuerte, David, Stefano Aliberti, Nilam J. Soni, Paola Faverio, Pedro J. Marcos, Richard G. Wunderink, Alejandro Rodriguez, et al. “Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community-acquired pneumonia.” Respirology 25, no. 5 (May 2020): 543–51. https://doi.org/10.1111/resp.13663.
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    • Lodise, Thomas P., Susan L. Rosenkranz, Matthew Finnemeyer, Scott Evans, Matthew Sims, Marcus J. Zervos, C Buddy Creech, et al. “The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE).” Clin Infect Dis 70, no. 8 (April 10, 2020): 1536–45. https://doi.org/10.1093/cid/ciz460.
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    • Noviello, Stephanie, G Ralph Corey, Thomas L. Holland, Thomas Lodise, William O’Riordan, Mark H. Wilcox, Thomas M. File, et al. “A pooled analysis of patients with wound infections in the Phase 3 REVIVE trials: randomized, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin structure infections.” J Med Microbiol 69, no. 4 (April 2020): 625–30. https://doi.org/10.1099/jmm.0.001177.
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    • Hamed, Kamal, Marc Engelhardt, Mark E. Jones, Mikael Saulay, Thomas L. Holland, Harald Seifert, and Vance G. Fowler. “Ceftobiprole versus daptomycin in Staphylococcus aureus bacteremia: a novel protocol for a double-blind, Phase III trial.” Future Microbiol 15, no. 1 (January 2020): 35–48. https://doi.org/10.2217/fmb-2019-0332.
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    • Aliberti, Stefano, Grayden S. Cook, Bettina L. Babu, Luis F. Reyes, Alejandro H Rodriguez, Francisco Sanz, Nilam J. Soni, et al. “International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia.” J Infect 79, no. 4 (October 2019): 300–311. https://doi.org/10.1016/j.jinf.2019.07.004.
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    • Evans, Scott R., Dean Follmann, Ying Liu, Thomas Holland, Sarah B. Doernberg, Nadine Rouphael, Toshimitsu Hamasaki, et al. “Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS).” Clin Infect Dis 68, no. 11 (May 17, 2019): 1961–67. https://doi.org/10.1093/cid/ciy912.
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    • Doernberg, Sarah B., Thuy Tien Tram Tran, Steven Y. C. Tong, Mical Paul, Dafna Yahav, Joshua S. Davis, Leonard Leibovici, et al. “Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection.” Clin Infect Dis 68, no. 10 (May 2, 2019): 1691–98. https://doi.org/10.1093/cid/ciy766.
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    • Di Pasquale, Marta Francesca, Giovanni Sotgiu, Andrea Gramegna, Dejan Radovanovic, Silvia Terraneo, Luis F. Reyes, Jan Rupp, et al. “Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients.” Clin Infect Dis 68, no. 9 (April 24, 2019): 1482–93. https://doi.org/10.1093/cid/ciy723.
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    • Turner, Nicholas A., Batu K. Sharma-Kuinkel, Stacey A. Maskarinec, Emily M. Eichenberger, Pratik P. Shah, Manuela Carugati, Thomas L. Holland, and Vance G. Fowler. “Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.” Nat Rev Microbiol 17, no. 4 (April 2019): 203–18. https://doi.org/10.1038/s41579-018-0147-4.
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    • Holland, Thomas L., Henry F. Chambers, Helen W. Boucher, G Ralph Corey, Rebecca Coleman, Bibiana Castaneda-Ruiz, and Vance G. Fowler. “Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults.” Clin Infect Dis 68, no. 5 (February 15, 2019): 865–72. https://doi.org/10.1093/cid/ciy774.
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    • Huang, David B., Sophie Magnet, Stefania De Angelis, Thomas L. Holland, Thomas M. File, Matthew Dryden, G Ralph Corey, Antoni Torres, and Mark H. Wilcox. “Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe.” Diagn Microbiol Infect Dis 93, no. 2 (February 2019): 154–58. https://doi.org/10.1016/j.diagmicrobio.2018.09.002.
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    • Radovanovic, Dejan, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I. Abdalla, Marta Francesca Di Pasquale, et al. “An international perspective on hospitalized patients with viral community-acquired pneumonia.” Eur J Intern Med 60 (February 2019): 54–70. https://doi.org/10.1016/j.ejim.2018.10.020.
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    • Corneli, Amy, Brian Perry, Deborah Collyar, John H. Powers, John J. Farley, Sara B. Calvert, Jonas Santiago, et al. “Assessment of the Perceived Acceptability of an Early Enrollment Strategy Using Advance Consent in Health Care-Associated Pneumonia.” Jama Netw Open 1, no. 8 (December 7, 2018): e185816. https://doi.org/10.1001/jamanetworkopen.2018.5816.
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    • Carugati, Manuela, Stefano Aliberti, Luis Felipe Reyes, Ricardo Franco Sadud, Muhammad Irfan, Cristina Prat, Nilam J. Soni, et al. “Microbiological testing of adults hospitalised with community-acquired pneumonia: an international study.” Erj Open Res 4, no. 4 (October 2018). https://doi.org/10.1183/23120541.00096-2018.
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    • Holland, Thomas L., Issam Raad, Helen W. Boucher, Deverick J. Anderson, Sara E. Cosgrove, P Suzanne Aycock, John W. Baddley, et al. “Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.” Jama 320, no. 12 (September 25, 2018): 1249–58. https://doi.org/10.1001/jama.2018.13155.
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    • Restrepo, Marcos I., Bettina L. Babu, Luis F. Reyes, James D. Chalmers, Nilam J. Soni, Oriol Sibila, Paola Faverio, et al. “Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients.” Eur Respir J 52, no. 2 (August 2018). https://doi.org/10.1183/13993003.01190-2017.
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    • Huang, David B., G Ralph Corey, Thomas L. Holland, Thomas Lodise, William O’Riordan, Mark H. Wilcox, Thomas M. File, et al. “Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections.” Int J Antimicrob Agents 52, no. 2 (August 2018): 233–40. https://doi.org/10.1016/j.ijantimicag.2018.05.012.
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    • Holland, Thomas L., William O’Riordan, Alison McManus, Elliot Shin, Ali Borghei, Thomas M. File, Mark H. Wilcox, et al. “A Phase 3, Randomized, Double-Blind, Multicenter Study To Evaluate the Safety and Efficacy of Intravenous Iclaprim versus Vancomycin for Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed To Be Due to Gram-Positive Pathogens (REVIVE-2 Study).” Antimicrob Agents Chemother 62, no. 5 (May 2018). https://doi.org/10.1128/AAC.02580-17.
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    • Huang, David B., William O’Riordan, J Scott Overcash, Barry Heller, Faisal Amin, Thomas M. File, Mark H. Wilcox, et al. “A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Vs Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positive Pathogens: REVIVE-1.” Clin Infect Dis 66, no. 8 (April 3, 2018): 1222–29. https://doi.org/10.1093/cid/cix987.
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    • Holland, Thomas L., and Vance G. Fowler. “Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST.” Lancet 391, no. 10121 (February 17, 2018): 634–36. https://doi.org/10.1016/S0140-6736(17)33294-4.
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    • Huang, David B., Catherine D. Strader, James S. MacDonald, Mark VanArendonk, Richard Peck, and Thomas Holland. “An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria.” Open Forum Infect Dis 5, no. 2 (February 2018): ofy003. https://doi.org/10.1093/ofid/ofy003.
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    • Stergiopoulos, Stella, Sara B. Calvert, Carrie A. Brown, Josephine Awatin, Pamela Tenaerts, Thomas L. Holland, Joseph A. DiMasi, and Kenneth A. Getz. “Cost Drivers of a Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia Phase 3 Clinical Trial.” Clin Infect Dis 66, no. 1 (January 6, 2018): 72–80. https://doi.org/10.1093/cid/cix726.
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    • Boggan, J., M. R. Ruopp, T. L. Holland, M. J. Stillwagon, J. A. Govert, and J. G. Bae. “Missing the mark: inaccuracy of administrative data in identification of hospitalized patients with pneumonia and results of a systematic clinical reclassification process on readmission rates.” Journal of Hospital Administration 6, no. 6 (November 20, 2017): 35–41. https://doi.org/10.5430/jha.v6n6p35.
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    • Neuss, Michael James, and Thomas Lawrence Holland. “Digital ischaemia after intra-arterial drug injection.” Bmj Case Rep 2017 (September 25, 2017). https://doi.org/10.1136/bcr-2017-222141.
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    • Clifton, Dana C., Meredith E. Clement, Thomas L. Holland, Gary M. Cox, Kristen V. Dicks, and Jason E. Stout. “Suboptimal HIV Testing Among Patients Admitted With Pneumonia: A Missed Opportunity.” Aids Educ Prev 29, no. 4 (August 2017): 377–88. https://doi.org/10.1521/aeap.2017.29.4.377.
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    • Doernberg, Sarah B., Thomas P. Lodise, Joshua T. Thaden, Jose M. Munita, Sara E. Cosgrove, Cesar A. Arias, Helen W. Boucher, et al. “Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.” Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 64, no. suppl_1 (March 2017): S24–29. https://doi.org/10.1093/cid/ciw828.
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    • Bergin, Stephen P., Thomas L. Holland, Vance G. Fowler, and Steven Y. C. Tong. “Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus.” Curr Top Microbiol Immunol 409 (2017): 263–96. https://doi.org/10.1007/82_2015_5001.
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    • Masika, Wechuli Geoffrey, Wendy Prudhomme O’Meara, Thomas L. Holland, and Janice Armstrong. “Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya.” Plos One 12, no. 3 (2017): e0174199. https://doi.org/10.1371/journal.pone.0174199.
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    • Aliberti, Stefano, Luis F. Reyes, Paola Faverio, Giovanni Sotgiu, Simone Dore, Alejandro H. Rodriguez, Nilam J. Soni, Marcos I. Restrepo, and Marcos I. GLIMP investigators. “Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study.” Lancet Infect Dis 16, no. 12 (December 2016): 1364–76. https://doi.org/10.1016/S1473-3099(16)30267-5.
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    • Lumsden, Rebecca H., Constantine Akwanalo, Stella Chepkwony, Anne Kithei, Vincent Omollo, Thomas L. Holland, Gerald S. Bloomfield, and Wendy P. O’Meara. “Clinical and geographic patterns of rheumatic heart disease in outpatients attending cardiology clinic in western Kenya.” Int J Cardiol 223 (November 15, 2016): 228–35. https://doi.org/10.1016/j.ijcard.2016.08.069.
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    • Holland, Thomas L., Stephen Mikita, Diane Bloom, Jamie Roberts, Jonathan McCall, Deborah Collyar, Jonas Santiago, Rosemary Tiernan, and Joseph Toerner. “Patient and physician attitudes regarding risk and benefit in streamlined development programmes for antibacterial drugs: a qualitative analysis.” Bmj Open 6, no. 11 (November 10, 2016): e013561. https://doi.org/10.1136/bmjopen-2016-013561.
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    • Deck, Daniel H., Jennifer M. Jordan, Thomas L. Holland, Weihong Fan, Matthew A. Wikler, Katherine A. Sulham, and G. Ralph Corey. “Erratum to: Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting.” Infect Dis Ther 5, no. 3 (September 2016): 363–65. https://doi.org/10.1007/s40121-016-0127-9.
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    • Deck, Daniel H., Jennifer M. Jordan, Thomas L. Holland, Weihong Fan, Matthew A. Wikler, Katherine A. Sulham, and G. Ralph Corey. “Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting.” Infect Dis Ther 5, no. 3 (September 2016): 353–61. https://doi.org/10.1007/s40121-016-0119-9.
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    • Holland, Thomas L., Larry M. Baddour, Arnold S. Bayer, Bruno Hoen, Jose M. Miro, and Vance G. Fowler. “Infective endocarditis.” Nat Rev Dis Primers 2 (September 1, 2016): 16059. https://doi.org/10.1038/nrdp.2016.59.
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    • Knirsch, Charles, Demissie Alemayehu, Radu Botgros, Sabrina Comic-Savic, David Friedland, Thomas L. Holland, Kunal Merchant, et al. “Improving Conduct and Feasibility of Clinical Trials to Evaluate Antibacterial Drugs to Treat Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia: Recommendations of the Clinical Trials Transformation Initiative Antibacterial Drug Development Project Team.” Clin Infect Dis 63 Suppl 2 (August 15, 2016): S29–36. https://doi.org/10.1093/cid/ciw258.
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    • Maina, Alice N., Christina M. Farris, Antony Odhiambo, Ju Jiang, Jeremiah Laktabai, Janice Armstrong, Thomas Holland, Allen L. Richards, and Wendy P. O’Meara. “Q Fever, Scrub Typhus, and Rickettsial Diseases in Children, Kenya, 2011-2012.” Emerg Infect Dis 22, no. 5 (May 2016): 883–86. https://doi.org/10.3201/eid2205.150953.
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    • Lane, Suzanne, Karissa Johnston, Katherine A. Sulham, Iqra Syed, Charles V. Pollack, Thomas Holland, and Dilip Nathwani. “Identification of Patient Characteristics Influencing Setting of Care Decisions for Patients With Acute Bacterial Skin and Skin Structure Infections: Results of a Discrete Choice Experiment.” Clin Ther 38, no. 3 (March 2016): 531–44. https://doi.org/10.1016/j.clinthera.2016.01.007.
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    • Tong, Steven Y. C., Joshua S. Davis, Emily Eichenberger, Thomas L. Holland, and Vance G. Fowler. “Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.” Clin Microbiol Rev 28, no. 3 (July 2015): 603–61. https://doi.org/10.1128/CMR.00134-14.
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    • Bostwick, A Doran, Cecelia Zhang, Katja Manninen, Joanne Touchberry, Shermalyn R. Greene, and Thomas L. Holland. “Bacteremia Caused by Kerstersia gyiorum.” J Clin Microbiol 53, no. 6 (June 2015): 1965–67. https://doi.org/10.1128/JCM.03625-14.
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    • O’Meara, Wendy P., Joshua A. Mott, Jeremiah Laktabai, Kabura Wamburu, Barry Fields, Janice Armstrong, Steve M. Taylor, et al. “Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis.” Am J Trop Med Hyg 92, no. 5 (May 2015): 1030–37. https://doi.org/10.4269/ajtmh.14-0560.
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    • Arnold, Christopher J., Melissa Johnson, Arnold S. Bayer, Suzanne Bradley, Efthymia Giannitsioti, José M. Miró, Pilar Tornos, et al. “Candida infective endocarditis: an observational cohort study with a focus on therapy.” Antimicrob Agents Chemother 59, no. 4 (April 2015): 2365–73. https://doi.org/10.1128/AAC.04867-14.
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    • Chirouze, Catherine, François Alla, Vance G. Fowler, Daniel J. Sexton, G Ralph Corey, Vivian H. Chu, Andrew Wang, et al. “Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.” Clin Infect Dis 60, no. 5 (March 1, 2015): 741–49. https://doi.org/10.1093/cid/ciu871.
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    • Holland, Thomas L., and Vance G. Fowler. “Diagnosing endocarditis in patients with Staphylococcus aureus bacteremia--reply.” Jama 313, no. 4 (January 27, 2015): 420–21. https://doi.org/10.1001/jama.2014.16954.
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    • Delahaye, F., V. H. Chu, J. Altclas, B. Barsic, A. Delahaye, T. Freiberger, D. L. Gordon, et al. “One-year outcome following biological or mechanical valve replacement for infective endocarditis.” Int J Cardiol 178 (January 15, 2015): 117–23. https://doi.org/10.1016/j.ijcard.2014.10.125.
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    • Chu, Vivian H., Lawrence P. Park, Eugene Athan, Francois Delahaye, Tomas Freiberger, Cristiane Lamas, Jose M. Miro, et al. “Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.” Circulation 131, no. 2 (January 13, 2015): 131–40. https://doi.org/10.1161/CIRCULATIONAHA.114.012461.
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    • Holland, Thomas, Vance G. Fowler, and Samuel A. Shelburne. “Invasive gram-positive bacterial infection in cancer patients.” Clin Infect Dis 59 Suppl 5, no. Suppl 5 (November 15, 2014): S331–34. https://doi.org/10.1093/cid/ciu598.
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    • Holland, Thomas L., Christopher Arnold, and Vance G. Fowler. “Clinical management of Staphylococcus aureus bacteremia: a review.” Jama 312, no. 13 (October 1, 2014): 1330–41. https://doi.org/10.1001/jama.2014.9743.
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    • Bloomfield, Gerald S., Joseph W. Hogan, Alfred Keter, Thomas L. Holland, Edwin Sang, Sylvester Kimaiyo, and Eric J. Velazquez. “Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.” Bmc Infect Dis 14 (May 22, 2014): 284. https://doi.org/10.1186/1471-2334-14-284.
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    • Bloomfield, G. S., J. W. Hogan, A. Keter, T. L. Holland, E. Sang, S. Kimaiyo, and E. J. Velazquez. “Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: A retrospective analysis of electronic health records.” Bmc Infectious Diseases 14, no. 1 (2014). https://doi.org/10.1186/1471-2334-14-284.
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    • Carugati, Manuela, Arnold S. Bayer, Josè M. Miró, Lawrence P. Park, Armenio C. Guimarães, Athanasios Skoutelis, Claudio Q. Fortes, et al. “High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis.” Antimicrob Agents Chemother 57, no. 12 (December 2013): 6213–22. https://doi.org/10.1128/AAC.01563-13.
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    • Barsic, Bruno, Stuart Dickerman, Vladimir Krajinovic, Paul Pappas, Javier Altclas, Giampiero Carosi, José H. Casabé, et al. “Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.” Clin Infect Dis 56, no. 2 (January 2013): 209–17. https://doi.org/10.1093/cid/cis878.
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    • Chambers, Stephen T., David Murdoch, Arthur Morris, David Holland, Paul Pappas, Manel Almela, Nuria Fernández-Hidalgo, et al. “HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.” Plos One 8, no. 5 (2013): e63181. https://doi.org/10.1371/journal.pone.0063181.
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    • Bloomfield, Gerald S., Joseph W. Hogan, Alfred Keter, Thomas L. Holland, James Osanya, Edwin Sang, Sylvester Kimaiyo, and Eric J. Velazquez. “High Blood Pressure Increases Risk of Death Among Human Immunodeficiency Virus Seropositive Individuals in Kenya.” Circulation 126, no. 21 (November 20, 2012).
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    • Fowler, V., and T. Holland. “Reply to gould.” Journal of Infectious Diseases 205, no. 5 (March 1, 2012): 865. https://doi.org/10.1093/infdis/jir847.
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    • Holland, T. L., N. M. Thielman, and R. D. Pearson. “Chemotherapy of Bacterial, Fungal, and Viral Diseases,” December 1, 2011, 95–104. https://doi.org/10.1016/B978-0-7020-3935-5.00013-6.
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    • Holland, Thomas L., and Vance G. Fowler. “Vancomycin minimum inhibitory concentration and outcome in patients with Staphylococcus aureus bacteremia: pearl or pellet?” J Infect Dis 204, no. 3 (August 1, 2011): 329–31. https://doi.org/10.1093/infdis/jir275.
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    • Holland, Thomas L., Christopher W. Woods, and Maria Joyce. “Antibacterial susceptibility testing in the clinical laboratory.” Infect Dis Clin North Am 23, no. 4 (December 2009): 757–vii. https://doi.org/10.1016/j.idc.2009.06.001.
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  • Book Sections

    • Holland, T. L., N. M. Thielman, and R. D. Pearson. “Chemotherapy of Bacterial, Fungal, and Viral Diseases.” In Tropical Infectious Diseases: Principles, Pathogens and Practice, 95–104, 2011. https://doi.org/10.1016/B978-0-7020-3935-5.00013-6.
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  • Conference Papers

    • Bergin, S. P., A. Coles, J. Farley, J. Santiago, S. Calvert, V. G. Fowler, and T. L. Holland. “Predicting Pneumonia: A Prospective Observational Study Of The Risk Factors For Hospital-Acquired And Ventilator-Associated Bacterial Pneumonia.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • Holland, T., S. Mikita, A. Corneli, J. Roberts, J. McCall, D. Collyar, J. Santiago, and R. Tiernan. “Streamlining Antibacterial Drug Development Programs To Address Unmet Medical Need: Patient And Provider Attitudes On A Modified Benefit-Risk Calculus.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Laktabai, Jeremiah, Wendy Omeara, Joshua Mott, Kabura Wamburu, Barry Fields, Janice Armstrong, Steve Taylor, et al. “ETIOLOGY OF PEDIATRIC FEVER IN WESTERN KENYA: A CASE-CONTROL STUDY OF FALCIPARUM MALARIA, RESPIRATORY VIRUSES, AND STREPTOCOCCAL PHARYNGITIS.” In American Journal of Tropical Medicine and Hygiene, 93:318–318. AMER SOC TROP MED & HYGIENE, 2015.
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• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Duke Global Health Outreach. You get what you look for: emerging infections in a malaria-endemic zone. January 2014  2014

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