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Thomas Lawrence Holland

Thomas Lawrence Holland

Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 163 Hanes House, Trent Drive, Durham, NC 27710

Current Appointments & Affiliations

Professor of Medicine · 2024 - Present Medicine, Infectious Diseases, Medicine
Membership in the Duke Clinical Research Institute · 2015 - Present Duke Clinical Research Institute, Institutes and Centers

In the News

Published October 4, 2023
Drug Found Effective in Fighting Deadly Infections
Published July 11, 2022
Monoclonal Antibody Treatment Reduced Deaths in Hospitalized COVID Patients
Published September 26, 2018
New Way of Determining Treatment for Staph Infections Cuts Antibiotic Use

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Recent Publications

Impact of obesity on clinical outcomes in patients treated with ceftobiprole: results from Phase 3 clinical trials.

Journal Article The Journal of antimicrobial chemotherapy · March 2025 BackgroundCeftobiprole was non-inferior to comparators for the treatment of Staphylococcus aureus bloodstream infection (bacteraemia) (SAB), acute bacterial skin and skin structure infection (ABSSSI), and community-acquired bacterial pneumonia (CA ... Full text Cite

Long-term outcomes of passive immunotherapy for COVID-19: a pooled analysis of a large multinational platform randomized clinical trial.

Journal Article Clin Microbiol Infect · February 6, 2025 OBJECTIVES: Passive immunotherapy, including monoclonal antibodies and neutralizing proteins, was used for the treatment of patients with COVID-19 during the pandemic. Accelerating COVID-19 Therapeutic Interventions and Vaccines-Therapeutics for Inpatients ... Full text Link to item Cite

Oral Versus Intravenous Antibiotic Therapy for Staphylococcus aureus Bacteremia or Endocarditis: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.

Journal Article Clin Infect Dis · February 5, 2025 BACKGROUND: We conducted a systematic review of randomized, controlled trials (RCTs) to generate more precise estimates of the efficacy and safety of oral versus intravenous antibiotic therapy for Staphylococcus aureus bacteremia or endocarditis. METHODS: ... Full text Link to item Cite
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Recent Grants

Invasive Candidiasis

Clinical TrialPrincipal Investigator · Awarded by Basilea Pharmaceutica · 2024 - 2028

Antibacterial Resistance Leadership Group (ARLG)

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2013 - 2026

HR-BV 3

Clinical TrialPrincipal Investigator · Awarded by Biomeme, Inc. · 2023 - 2024

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Education, Training & Certifications

Wake Forest University · 2005 M.D.