Thomas Lawrence Holland | Scholars@Duke

Thomas Lawrence Holland
Assistant Professor of Medicine

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2016
Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2015

Contact Information

Duke Box 102359, Durham, NC 27710
Room 163 Hanes House, Trent Drive, Durham, NC 27710
(919) 681-8263

Background
Education, Training, & Certifications
- Fellow, Infectious Diseases, Duke University School of Medicine 2008 - 2010
- Resident, Internal Medicine, Duke University School of Medicine 2005 - 2008
- M.D., Wake Forest University 2005
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2016
- Clinical Associate in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2011
Recognition
In the News
- SEP 26, 2018 Duke Health News
  
  New Way of Determining Treatment for Staph Infections Cuts Antibiotic Use
Research
Selected Grants
- CEC Activities for BPR-CS-009 Ceftobiprole medocaril - WO2 2018 - 2021
- CEC Activities for BPR-CS-009 Ceftobiprole medocaril 2017 - 2020
- Increasing the Quality and Efficiency of Clinical Trials (R18) awarded by Food and Drug Administration 2014 - 2019
- Bacteremia Modification 14 awarded by National Institutes of Health 2009 - 2017
- Mod 11 for Option 3 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
- Modification No 13 Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
- ACHN-490-007 Trial 2016 - 2017
- Modification No. 8 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2016
- Modification No. 5 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2015
- Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lodise, Thomas P., Susan L. Rosenkranz, Matthew Finnemeyer, Scott Evans, Matthew Sims, Marcus J. Zervos, C Buddy Creech, et al. “The Emperor's New Clothes: Prospective Observational Evaluation of the Association between Initial Vancomycin Exposure and Failure Rates among Adult Hospitalized Patients with MRSA Bloodstream Infections (PROVIDE)..” Clin Infect Dis, June 3, 2019. https://doi.org/10.1093/cid/ciz460.
    Full Text Link to Item
  - Evans, Scott R., Dean Follmann, Ying Liu, Thomas Holland, Sarah B. Doernberg, Nadine Rouphael, Toshimitsu Hamasaki, et al. “Sequential, Multiple-Assignment, Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)..” Clin Infect Dis 68, no. 11 (May 17, 2019): 1961–67. https://doi.org/10.1093/cid/ciy912.
    Full Text Link to Item
  - Turner, Nicholas A., Batu K. Sharma-Kuinkel, Stacey A. Maskarinec, Emily M. Eichenberger, Pratik P. Shah, Manuela Carugati, Thomas L. Holland, and Vance G. Fowler. “Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research..” Nat Rev Microbiol 17, no. 4 (April 2019): 203–18. https://doi.org/10.1038/s41579-018-0147-4.
    Full Text Open Access Copy Link to Item
  - Holland, Thomas L., Henry F. Chambers, Helen W. Boucher, G Ralph Corey, Rebecca Coleman, Bibiana Castaneda-Ruiz, and Vance G. Fowler. “Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults..” Clin Infect Dis 68, no. 5 (February 15, 2019): 865–72. https://doi.org/10.1093/cid/ciy774.
    Full Text Link to Item
  - Huang, David B., Sophie Magnet, Stefania De Angelis, Thomas L. Holland, Thomas M. File, Matthew Dryden, G Ralph Corey, Antoni Torres, and Mark H. Wilcox. “Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe..” Diagn Microbiol Infect Dis 93, no. 2 (February 2019): 154–58. https://doi.org/10.1016/j.diagmicrobio.2018.09.002.
    Full Text Link to Item
  - Radovanovic, Dejan, Giovanni Sotgiu, Mateja Jankovic, Padukudru Anand Mahesh, Pedro Jorge Marcos, Mohamed I. Abdalla, Marta Francesca Di Pasquale, et al. “An international perspective on hospitalized patients with viral community-acquired pneumonia..” Eur J Intern Med 60 (February 2019): 54–70. https://doi.org/10.1016/j.ejim.2018.10.020.
    Full Text Link to Item
  - Corneli, Amy, Brian Perry, Deborah Collyar, John H. Powers, John J. Farley, Sara B. Calvert, Jonas Santiago, et al. “Assessment of the Perceived Acceptability of an Early Enrollment Strategy Using Advance Consent in Health Care-Associated Pneumonia..” Jama Netw Open 1, no. 8 (December 7, 2018). https://doi.org/10.1001/jamanetworkopen.2018.5816.
    Full Text Link to Item
  - Doernberg, Sarah B., Thuy Tien Tram Tran, Steven Y. C. Tong, Mical Paul, Dafna Yahav, Joshua S. Davis, Leonard Leibovici, et al. “Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection..” Clin Infect Dis, October 12, 2018. https://doi.org/10.1093/cid/ciy766.
    Full Text Link to Item
  - Holland, Thomas L., Issam Raad, Helen W. Boucher, Deverick J. Anderson, Sara E. Cosgrove, P Suzanne Aycock, John W. Baddley, et al. “Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial..” Jama 320, no. 12 (September 25, 2018): 1249–58. https://doi.org/10.1001/jama.2018.13155.
    Full Text Link to Item
  - Huang, David B., G Ralph Corey, Thomas L. Holland, Thomas Lodise, William O’Riordan, Mark H. Wilcox, Thomas M. File, et al. “Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections..” Int J Antimicrob Agents 52, no. 2 (August 2018): 233–40. https://doi.org/10.1016/j.ijantimicag.2018.05.012.
    Full Text Link to Item
  - Restrepo, Marcos I., Bettina L. Babu, Luis F. Reyes, James D. Chalmers, Nilam J. Soni, Oriol Sibila, Paola Faverio, et al. “Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients..” Eur Respir J 52, no. 2 (August 2018). https://doi.org/10.1183/13993003.01190-2017.
    Full Text Link to Item
  - Holland, Thomas L., William O’Riordan, Alison McManus, Elliot Shin, Ali Borghei, Thomas M. File, Mark H. Wilcox, et al. “A Phase 3, Randomized, Double-Blind, Multicenter Study To Evaluate the Safety and Efficacy of Intravenous Iclaprim versus Vancomycin for Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed To Be Due to Gram-Positive Pathogens (REVIVE-2 Study)..” Antimicrob Agents Chemother 62, no. 5 (May 2018). https://doi.org/10.1128/AAC.02580-17.
    Full Text Link to Item
  - Huang, David B., William O’Riordan, J Scott Overcash, Barry Heller, Faisal Amin, Thomas M. File, Mark H. Wilcox, et al. “A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Vs Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positive Pathogens: REVIVE-1..” Clin Infect Dis 66, no. 8 (April 3, 2018): 1222–29. https://doi.org/10.1093/cid/cix987.
    Full Text Link to Item
  - Holland, Thomas L., and Vance G. Fowler. “Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST..” Lancet 391, no. 10121 (February 17, 2018): 634–36. https://doi.org/10.1016/S0140-6736(17)33294-4.
    Full Text Link to Item
  - Huang, D. B., C. D. Strader, J. S. MacDonald, M. VanArendonk, R. Peck, and T. Holland. “An updated review of iclaprim: A potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria.” Open Forum Infectious Diseases 5, no. 2 (February 1, 2018). https://doi.org/10.1093/ofid/ofy003.
    Full Text
  - Stergiopoulos, Stella, Sara B. Calvert, Carrie A. Brown, Josephine Awatin, Pamela Tenaerts, Thomas L. Holland, Joseph A. DiMasi, and Kenneth A. Getz. “Cost Drivers of a Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia Phase 3 Clinical Trial..” Clin Infect Dis 66, no. 1 (January 6, 2018): 72–80. https://doi.org/10.1093/cid/cix726.
    Full Text Link to Item
  - Neuss, Michael James, and Thomas Lawrence Holland. “Digital ischaemia after intra-arterial drug injection..” Bmj Case Rep 2017 (September 25, 2017). https://doi.org/10.1136/bcr-2017-222141.
    Full Text Link to Item
  - Clifton, Dana C., Meredith E. Clement, Thomas L. Holland, Gary M. Cox, Kristen V. Dicks, and Jason E. Stout. “Suboptimal HIV Testing Among Patients Admitted With Pneumonia: A Missed Opportunity..” Aids Educ Prev 29, no. 4 (August 2017): 377–88. https://doi.org/10.1521/aeap.2017.29.4.377.
    Full Text Link to Item
  - Doernberg, Sarah B., Thomas P. Lodise, Joshua T. Thaden, Jose M. Munita, Sara E. Cosgrove, Cesar A. Arias, Helen W. Boucher, et al. “Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group..” Clin Infect Dis 64, no. suppl_1 (March 15, 2017): S24–29. https://doi.org/10.1093/cid/ciw828.
    Full Text Link to Item
  - Bergin, Stephen P., Thomas L. Holland, Vance G. Fowler, and Steven Y. C. Tong. “Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus..” Curr Top Microbiol Immunol 409 (2017): 263–96. https://doi.org/10.1007/82_2015_5001.
    Full Text Link to Item
  - Masika, Wechuli Geoffrey, Wendy Prudhomme O’Meara, Thomas L. Holland, and Janice Armstrong. “Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya..” Plos One 12, no. 3 (2017). https://doi.org/10.1371/journal.pone.0174199.
    Full Text Open Access Copy Link to Item
  - Lumsden, Rebecca H., Constantine Akwanalo, Stella Chepkwony, Anne Kithei, Vincent Omollo, Thomas L. Holland, Gerald S. Bloomfield, and Wendy P. O’Meara. “Clinical and geographic patterns of rheumatic heart disease in outpatients attending cardiology clinic in western Kenya..” Int J Cardiol 223 (November 15, 2016): 228–35. https://doi.org/10.1016/j.ijcard.2016.08.069.
    Full Text Link to Item
  - Holland, Thomas L., Stephen Mikita, Diane Bloom, Jamie Roberts, Jonathan McCall, Deborah Collyar, Jonas Santiago, Rosemary Tiernan, and Joseph Toerner. “Patient and physician attitudes regarding risk and benefit in streamlined development programmes for antibacterial drugs: a qualitative analysis..” Bmj Open 6, no. 11 (November 10, 2016). https://doi.org/10.1136/bmjopen-2016-013561.
    Full Text Link to Item
  - Deck, Daniel H., Jennifer M. Jordan, Thomas L. Holland, Weihong Fan, Matthew A. Wikler, Katherine A. Sulham, and G. Ralph Corey. “Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting..” Infect Dis Ther 5, no. 3 (September 2016): 353–61. https://doi.org/10.1007/s40121-016-0119-9.
    Full Text Link to Item
  - Deck, Daniel H., Jennifer M. Jordan, Thomas L. Holland, Weihong Fan, Matthew A. Wikler, Katherine A. Sulham, and G. Ralph Corey. “Erratum to: Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting..” Infect Dis Ther 5, no. 3 (September 2016): 363–65. https://doi.org/10.1007/s40121-016-0127-9.
    Full Text Link to Item
  - Holland, Thomas L., Larry M. Baddour, Arnold S. Bayer, Bruno Hoen, Jose M. Miro, and Vance G. Fowler. “Infective endocarditis..” Nat Rev Dis Primers 2 (September 1, 2016). https://doi.org/10.1038/nrdp.2016.59.
    Full Text Link to Item
  - Knirsch, Charles, Demissie Alemayehu, Radu Botgros, Sabrina Comic-Savic, David Friedland, Thomas L. Holland, Kunal Merchant, et al. “Improving Conduct and Feasibility of Clinical Trials to Evaluate Antibacterial Drugs to Treat Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia: Recommendations of the Clinical Trials Transformation Initiative Antibacterial Drug Development Project Team..” Clin Infect Dis 63 Suppl 2 (August 15, 2016): S29–36. https://doi.org/10.1093/cid/ciw258.
    Full Text Link to Item
  - Maina, Alice N., Christina M. Farris, Antony Odhiambo, Ju Jiang, Jeremiah Laktabai, Janice Armstrong, Thomas Holland, Allen L. Richards, and Wendy P. O’Meara. “Q Fever, Scrub Typhus, and Rickettsial Diseases in Children, Kenya, 2011-2012..” Emerg Infect Dis 22, no. 5 (May 2016): 883–86. https://doi.org/10.3201/eid2205.150953.
    Full Text Open Access Copy Link to Item
  - Lane, Suzanne, Karissa Johnston, Katherine A. Sulham, Iqra Syed, Charles V. Pollack, Thomas Holland, and Dilip Nathwani. “Identification of Patient Characteristics Influencing Setting of Care Decisions for Patients With Acute Bacterial Skin and Skin Structure Infections: Results of a Discrete Choice Experiment..” Clin Ther 38, no. 3 (March 2016): 531–44. https://doi.org/10.1016/j.clinthera.2016.01.007.
    Full Text Link to Item
  - Tong, Steven Y. C., Joshua S. Davis, Emily Eichenberger, Thomas L. Holland, and Vance G. Fowler. “Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management..” Clin Microbiol Rev 28, no. 3 (July 2015): 603–61. https://doi.org/10.1128/CMR.00134-14.
    Full Text Link to Item
  - Bostwick, A Doran, Cecelia Zhang, Katja Manninen, Joanne Touchberry, Shermalyn R. Greene, and Thomas L. Holland. “Bacteremia Caused by Kerstersia gyiorum..” J Clin Microbiol 53, no. 6 (June 2015): 1965–67. https://doi.org/10.1128/JCM.03625-14.
    Full Text Link to Item
  - O’Meara, Wendy P., Joshua A. Mott, Jeremiah Laktabai, Kabura Wamburu, Barry Fields, Janice Armstrong, Steve M. Taylor, et al. “Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis..” Am J Trop Med Hyg 92, no. 5 (May 2015): 1030–37. https://doi.org/10.4269/ajtmh.14-0560.
    Full Text Link to Item
  - Arnold, Christopher J., Melissa Johnson, Arnold S. Bayer, Suzanne Bradley, Efthymia Giannitsioti, José M. Miró, Pilar Tornos, et al. “Candida infective endocarditis: an observational cohort study with a focus on therapy..” Antimicrob Agents Chemother 59, no. 4 (April 2015): 2365–73. https://doi.org/10.1128/AAC.04867-14.
    Full Text Link to Item
  - Chirouze, Catherine, François Alla, Vance G. Fowler, Daniel J. Sexton, G Ralph Corey, Vivian H. Chu, Andrew Wang, et al. “Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study..” Clin Infect Dis 60, no. 5 (March 1, 2015): 741–49. https://doi.org/10.1093/cid/ciu871.
    Full Text Link to Item
  - Holland, Thomas L., and Vance G. Fowler. “Diagnosing endocarditis in patients with Staphylococcus aureus bacteremia--reply..” Jama 313, no. 4 (January 27, 2015): 420–21. https://doi.org/10.1001/jama.2014.16954.
    Full Text Link to Item
  - Delahaye, F., V. H. Chu, J. Altclas, B. Barsic, A. Delahaye, T. Freiberger, D. L. Gordon, et al. “One-year outcome following biological or mechanical valve replacement for infective endocarditis..” Int J Cardiol 178 (January 15, 2015): 117–23. https://doi.org/10.1016/j.ijcard.2014.10.125.
    Full Text Link to Item
  - Chu, Vivian H., Lawrence P. Park, Eugene Athan, Francois Delahaye, Tomas Freiberger, Cristiane Lamas, Jose M. Miro, et al. “Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis..” Circulation 131, no. 2 (January 13, 2015): 131–40. https://doi.org/10.1161/CIRCULATIONAHA.114.012461.
    Full Text Link to Item
  - Holland, Thomas, Vance G. Fowler, and Samuel A. Shelburne. “Invasive gram-positive bacterial infection in cancer patients..” Clin Infect Dis 59 Suppl 5 (November 15, 2014): S331–34. https://doi.org/10.1093/cid/ciu598.
    Full Text Link to Item
  - Holland, Thomas L., Christopher Arnold, and Vance G. Fowler. “Clinical management of Staphylococcus aureus bacteremia: a review..” Jama 312, no. 13 (October 1, 2014): 1330–41. https://doi.org/10.1001/jama.2014.9743.
    Full Text Link to Item
  - Bloomfield, Gerald S., Joseph W. Hogan, Alfred Keter, Thomas L. Holland, Edwin Sang, Sylvester Kimaiyo, and Eric J. Velazquez. “Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records..” Bmc Infect Dis 14 (May 22, 2014). https://doi.org/10.1186/1471-2334-14-284.
    Full Text Open Access Copy Link to Item
  - Bloomfield, G. S., J. W. Hogan, A. Keter, T. L. Holland, E. Sang, S. Kimaiyo, and E. J. Velazquez. “Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: A retrospective analysis of electronic health records.” Bmc Infectious Diseases 14, no. 1 (2014). https://doi.org/10.1186/1471-2334-14-284.
    Full Text
  - Carugati, Manuela, Arnold S. Bayer, Josè M. Miró, Lawrence P. Park, Armenio C. Guimarães, Athanasios Skoutelis, Claudio Q. Fortes, et al. “High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis..” Antimicrob Agents Chemother 57, no. 12 (December 2013): 6213–22. https://doi.org/10.1128/AAC.01563-13.
    Full Text Link to Item
  - Barsic, Bruno, Stuart Dickerman, Vladimir Krajinovic, Paul Pappas, Javier Altclas, Giampiero Carosi, José H. Casabé, et al. “Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke..” Clin Infect Dis 56, no. 2 (January 2013): 209–17. https://doi.org/10.1093/cid/cis878.
    Full Text Link to Item
  - Chambers, Stephen T., David Murdoch, Arthur Morris, David Holland, Paul Pappas, Manel Almela, Nuria Fernández-Hidalgo, et al. “HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort..” Plos One 8, no. 5 (2013). https://doi.org/10.1371/journal.pone.0063181.
    Full Text Link to Item
  - Bloomfield, Gerald S., Joseph W. Hogan, Alfred Keter, Thomas L. Holland, James Osanya, Edwin Sang, Sylvester Kimaiyo, and Eric J. Velazquez. “High Blood Pressure Increases Risk of Death Among Human Immunodeficiency Virus Seropositive Individuals in Kenya.” Circulation 126, no. 21 (November 20, 2012).
    Link to Item
  - Fowler, V., and T. Holland. “Reply to gould.” Journal of Infectious Diseases 205, no. 5 (March 1, 2012). https://doi.org/10.1093/infdis/jir847.
    Full Text
  - Holland, T. L., N. M. Thielman, and R. D. Pearson. “Chemotherapy of Bacterial, Fungal, and Viral Diseases,” December 1, 2011, 95–104. https://doi.org/10.1016/B978-0-7020-3935-5.00013-6.
    Full Text
  - Holland, Thomas L., and Vance G. Fowler. “Vancomycin minimum inhibitory concentration and outcome in patients with Staphylococcus aureus bacteremia: pearl or pellet?.” J Infect Dis 204, no. 3 (August 1, 2011): 329–31. https://doi.org/10.1093/infdis/jir275.
    Full Text Link to Item
  - Holland, Thomas L., Christopher W. Woods, and Maria Joyce. “Antibacterial susceptibility testing in the clinical laboratory..” Infect Dis Clin North Am 23, no. 4 (December 2009): 757–vii. https://doi.org/10.1016/j.idc.2009.06.001.
    Full Text Link to Item
  - Ruopp, Marcus D., Joel C. Boggan, Thomas L. Holland, Mary Jane Stillwagon, Joseph A. Govert, and Jonathan G. Bae. “Missing the Mark: Inaccuracy of administrative data in identification of hospitalized patients with pneumonia and results of a systematic clinical reclassification process on readmission rates.” Journal of Hospital Administration 6, no. 6 (n.d.): 35–35. https://doi.org/10.5430/jha.v6n6p35.
    Full Text Open Access Copy
- Conference Papers
  - Bergin, S. P., A. Coles, J. Farley, J. Santiago, S. Calvert, V. G. Fowler, and T. L. Holland. “Predicting Pneumonia: A Prospective Observational Study Of The Risk Factors For Hospital-Acquired And Ventilator-Associated Bacterial Pneumonia.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
    Link to Item
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Duke Global Health Outreach. You get what you look for: emerging infections in a malaria-endemic zone. January 2014 2014

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Outreach & Engaged Scholarship