Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow, Infectious Diseases, Duke University School of Medicine 2008 - 2010
  • Resident, Internal Medicine, Duke University School of Medicine 2005 - 2008
  • M.D., Wake Forest University 2005
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2016
  • Clinical Associate in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2011
• Recognition
• 

  In the News

  • SEP 26, 2018

    Duke Health News

    New Way of Determining Treatment for Staph Infections Cuts Antibiotic Use
• Research
• 

  Selected Grants

  • CEC Activities for BPR-CS-009 Ceftobiprole medocaril - WO2 awarded by Basilea Pharmaceutica 2018 - 2021
  • CEC Activities for BPR-CS-009 Ceftobiprole medocaril awarded by Basilea Pharmaceutica 2017 - 2020
  • Increasing the Quality and Efficiency of Clinical Trials (R18) awarded by Food and Drug Administration 2014 - 2019
  • Bacteremia Modification 14 awarded by National Institutes of Health 2009 - 2017
  • Mod 11 for Option 3 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
  • Modification No 13 Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2017
  • ACHN-490-007 Trial awarded by Achaogen, Inc 2016 - 2017
  • Modification No. 8 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2016
  • Modification No. 5 - Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2015
  • Staphylococcal Bacteremia Study awarded by National Institutes of Health 2009 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Turner, NA, Sharma-Kuinkel, BK, Maskarinec, SA, Eichenberger, EM, Shah, PP, Carugati, M, Holland, TL, and Fowler, VG. "Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research." Nature Reviews. Microbiology (February 8, 2019). (Review)  Full Text  Open Access Copy
    • Holland, TL, Chambers, HF, Boucher, HW, Corey, GR, Coleman, R, Castaneda-Ruiz, B, and Fowler, VG. "Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 68, no. 5 (February 2019): 865-872.  Full Text
    • Huang, DB, Magnet, S, De Angelis, S, Holland, TL, File, TM, Dryden, M, Corey, GR, Torres, A, and Wilcox, MH. "Surveillance of iclaprim activity: in vitro susceptibility of Gram-positive skin infection pathogens collected from 2015 to 2016 from North America and Europe." Diagnostic Microbiology and Infectious Disease 93, no. 2 (February 2019): 154-158.  Full Text
    • Radovanovic, D, Sotgiu, G, Jankovic, M, Mahesh, PA, Marcos, PJ, Abdalla, MI, Di Pasquale, MF, Gramegna, A, Terraneo, S, Blasi, F, Santus, P, Aliberti, S, Reyes, LF, Restrepo, MI, and GLIMP Study Group, . "An international perspective on hospitalized patients with viral community-acquired pneumonia." European Journal of Internal Medicine 60 (February 2019): 54-70.  Full Text
    • Evans, SR, Follmann, D, Liu, Y, Holland, T, Doernberg, SB, Rouphael, N, Hamasaki, T, Jiang, Y, Lok, JJ, Tran, TTT, Harris, AD, Fowler, VG, Boucher, H, Kreiswirth, BN, Bonomo, RA, van Duin, D, Paterson, DL, and Chambers, H. "Sequential Multiple Assignment Randomized Trials for COMparing Personalized Antibiotic StrategieS (SMART-COMPASS)." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America (October 23, 2018).  Full Text
    • Doernberg, SB, Tran, TTT, Tong, SYC, Paul, M, Yahav, D, Davis, JS, Leibovici, L, Boucher, HW, Corey, GR, Cosgrove, SE, Chambers, HF, Fowler, VG, Evans, SR, Holland, TL, and Antibacterial Resistance Leadership Group, . "Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America (October 12, 2018).  Full Text
    • Holland, TL, Raad, I, Boucher, HW, Anderson, DJ, Cosgrove, SE, Aycock, PS, Baddley, JW, Chaftari, A-M, Chow, S-C, Chu, VH, Carugati, M, Cook, P, Corey, GR, Crowley, AL, Daly, J, Gu, J, Hachem, R, Horton, J, Jenkins, TC, Levine, D, Miro, JM, Pericas, JM, Riska, P, Rubin, Z, Rupp, ME, Schrank, J, Sims, M, Wray, D, Zervos, M, Fowler, VG, and Staphylococcal Bacteremia Investigators, . "Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial." Jama 320, no. 12 (September 2018): 1249-1258.  Full Text
    • Huang, DB, Corey, GR, Holland, TL, Lodise, T, O'Riordan, W, Wilcox, MH, File, TM, Dryden, M, Balser, B, Desplats, E, and Torres, A. "Pooled analysis of the phase 3 REVIVE trials: randomised, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin-structure infections." International Journal of Antimicrobial Agents 52, no. 2 (August 2018): 233-240.  Full Text
    • Restrepo, MI, Babu, BL, Reyes, LF, Chalmers, JD, Soni, NJ, Sibila, O, Faverio, P, Cilloniz, C, Rodriguez-Cintron, W, Aliberti, S, Aruj, PK, Attorri, S, Barimboim, E, Caeiro, JP, Garzón, MI, Cambursano, VH, Ceccato, A, Chertcoff, J, Lascar, F, Di Tulio, F, Díaz, AC, de Vedia, L, Ganaha, MC, Lambert, S, Lopardo, G, Luna, CM, Malberti, AG, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, PG, Stagnaro, JP, Shah, S, Lötsch, F, Thalhammer, F, Anseeuw, K, Francois, CA, Van Braeckel, E, Vincent, JL, Djimon, MZ, Bashi, J, Dodo, R, Nouér, SA, Chipev, P, Encheva, M, Miteva, D, Petkova, D, Dodo Balkissou, A, Pefura Yone, EW, Mbatchou Ngahane, BH, Shen, N, Xu, JF, Bustamante Rico, CA, Buitrago, R, Pereira Paternina, FJ, Kayembe Ntumba, JM, Carevic, VV, Jakopovic, M, Jankovic, M, Matkovic, Z, Mitrecic, I, Bouchy Jacobsson, ML, Bro Christensen, A, Heitmann Bødtger, UC, Niels Meyer, C, Vestergaard Jensen, A, Baunbæk-Knudsen, G, Petersen, PT, Andersen, S, Abd El-Wahhab, IE, Elsayed Morsy, N, Shafiek, H, Sobh, E, Abdella Abdulsemed, K, Bertrand, F, Brun-Buisson, C, de Montmollin, E, Fartoukh, M, Messika, J, Tattevin, P, Khoury, A, Ebruke, B, Dreher, M, Kolditz, M, Meisinger, M, Pletz, MW, Hagel, S, Rupp, J, Schaberg, T, Spielmanns, M, Creutz, P, Suttorp, N, Siaw-Lartey, B, Dimakou, K, and Papapetrou, D. "Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: A multinational point prevalence study of hospitalised patients." European Respiratory Journal 52, no. 2 (August 1, 2018).  Full Text
    • Holland, TL, O'Riordan, W, McManus, A, Shin, E, Borghei, A, File, TM, Wilcox, MH, Torres, A, Dryden, M, Lodise, T, Oguri, T, Corey, GR, McLeroth, P, Shukla, R, and Huang, DB. "A Phase 3, Randomized, Double-Blind, Multicenter Study To Evaluate the Safety and Efficacy of Intravenous Iclaprim versus Vancomycin for Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed To Be Due to Gram-Positive Pathogens (REVIVE-2 Study)." Antimicrobial Agents and Chemotherapy 62, no. 5 (May 2018).  Full Text
    • Huang, DB, O'Riordan, W, Overcash, JS, Heller, B, Amin, F, File, TM, Wilcox, MH, Torres, A, Dryden, M, Holland, TL, McLeroth, P, Shukla, R, and Corey, GR. "A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Vs Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positive Pathogens: REVIVE-1." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 66, no. 8 (April 2018): 1222-1229.  Full Text
    • Holland, TL, and Fowler, VG. "Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST." Lancet (London, England) 391, no. 10121 (February 2018): 634-636.  Full Text
    • Huang, DB, Strader, CD, MacDonald, JS, VanArendonk, M, Peck, R, and Holland, T. "An updated review of iclaprim: A potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria." Open Forum Infectious Diseases 5, no. 2 (February 1, 2018). (Review)  Full Text
    • Stergiopoulos, S, Calvert, SB, Brown, CA, Awatin, J, Tenaerts, P, Holland, TL, DiMasi, JA, and Getz, KA. "Cost Drivers of a Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia Phase 3 Clinical Trial." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 66, no. 1 (January 2018): 72-80.  Full Text
    • Neuss, MJ, and Holland, TL. "Digital ischaemia after intra-arterial drug injection." Bmj Case Reports 2017 (September 25, 2017).  Full Text
    • Clifton, DC, Clement, ME, Holland, TL, Cox, GM, Dicks, KV, and Stout, JE. "Suboptimal HIV Testing Among Patients Admitted With Pneumonia: A Missed Opportunity." AIDS education and prevention : official publication of the International Society for AIDS Education 29, no. 4 (August 2017): 377-388.  Full Text
    • Doernberg, SB, Lodise, TP, Thaden, JT, Munita, JM, Cosgrove, SE, Arias, CA, Boucher, HW, Corey, GR, Lowy, FD, Murray, B, Miller, LG, Holland, TL, and Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG), . "Gram-Positive Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 64, no. suppl_1 (March 2017): S24-S29. (Review)  Full Text
    • Bergin, SP, Holland, TL, Fowler, VG, and Tong, SYC. "Bacteremia, Sepsis, and Infective Endocarditis Associated with Staphylococcus aureus." Current Topics in Microbiology and Immunology 409 (January 2017): 263-296.  Full Text
    • Masika, WG, O'Meara, WP, Holland, TL, and Armstrong, J. "Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya." Plos One 12, no. 3 (January 2017): e0174199-null.  Full Text  Open Access Copy
    • Holland, TL, Mikita, S, Bloom, D, Roberts, J, McCall, J, Collyar, D, Santiago, J, Tiernan, R, and Toerner, J. "Patient and physician attitudes regarding risk and benefit in streamlined development programmes for antibacterial drugs: a qualitative analysis." Bmj Open 6, no. 11 (November 10, 2016): e013561-null.  Full Text
    • Lumsden, RH, Akwanalo, C, Chepkwony, S, Kithei, A, Omollo, V, Holland, TL, Bloomfield, GS, and O'Meara, WP. "Clinical and geographic patterns of rheumatic heart disease in outpatients attending cardiology clinic in western Kenya." International Journal of Cardiology 223 (November 2016): 228-235.  Full Text
    • Deck, DH, Jordan, JM, Holland, TL, Fan, W, Wikler, MA, Sulham, KA, and Ralph Corey, G. "Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting." Infectious diseases and therapy 5, no. 3 (September 2016): 353-361.  Full Text
    • Deck, DH, Jordan, JM, Holland, TL, Fan, W, Wikler, MA, Sulham, KA, and Ralph Corey, G. "Erratum to: Single-Dose Oritavancin Treatment of Acute Bacterial Skin and Skin Structure Infections: SOLO Trial Efficacy by Eron Severity and Management Setting." Infectious diseases and therapy 5, no. 3 (September 2016): 363-365.  Full Text
    • Holland, TL, Baddour, LM, Bayer, AS, Hoen, B, Miro, JM, and Fowler, VG. "Infective endocarditis." Nature Reviews. Disease Primers 2 (September 2016): 16059-null. (Review)  Full Text
    • Knirsch, C, Alemayehu, D, Botgros, R, Comic-Savic, S, Friedland, D, Holland, TL, Merchant, K, Noel, GJ, Pelfrene, E, Reith, C, Santiago, J, Tiernan, R, Tenearts, P, Goldsack, JC, and Fowler, VG. "Improving Conduct and Feasibility of Clinical Trials to Evaluate Antibacterial Drugs to Treat Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia: Recommendations of the Clinical Trials Transformation Initiative Antibacterial Drug Development Project Team." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 63 Suppl 2 (August 2016): S29-S36.  Full Text
    • Maina, AN, Farris, CM, Odhiambo, A, Jiang, J, Laktabai, J, Armstrong, J, Holland, T, Richards, AL, and O'Meara, WP. "Q Fever, Scrub Typhus, and Rickettsial Diseases in Children, Kenya, 2011-2012." Emerging Infectious Diseases 22, no. 5 (May 2016): 883-886.  Full Text  Open Access Copy
    • Lane, S, Johnston, K, Sulham, KA, Syed, I, Pollack, CV, Holland, T, and Nathwani, D. "Identification of Patient Characteristics Influencing Setting of Care Decisions for Patients With Acute Bacterial Skin and Skin Structure Infections: Results of a Discrete Choice Experiment." Clinical Therapeutics 38, no. 3 (March 2016): 531-544.  Full Text
    • Tong, SYC, Davis, JS, Eichenberger, E, Holland, TL, and Fowler, VG. "Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management." Clinical Microbiology Reviews 28, no. 3 (July 2015): 603-661. (Review)  Full Text
    • Bostwick, AD, Zhang, C, Manninen, K, Touchberry, J, Greene, SR, and Holland, TL. "Bacteremia Caused by Kerstersia gyiorum." Journal of Clinical Microbiology 53, no. 6 (June 2015): 1965-1967.  Full Text
    • O'Meara, WP, Mott, JA, Laktabai, J, Wamburu, K, Fields, B, Armstrong, J, Taylor, SM, MacIntyre, C, Sen, R, Menya, D, Pan, W, Nicholson, BP, Woods, CW, and Holland, TL. "Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis." The American Journal of Tropical Medicine and Hygiene 92, no. 5 (May 2015): 1030-1037.  Full Text
    • Arnold, CJ, Johnson, M, Bayer, AS, Bradley, S, Giannitsioti, E, Miró, JM, Tornos, P, Tattevin, P, Strahilevitz, J, Spelman, D, Athan, E, Nacinovich, F, Fortes, CQ, Lamas, C, Barsic, B, Fernández-Hidalgo, N, Muñoz, P, and Chu, VH. "Candida infective endocarditis: an observational cohort study with a focus on therapy." Antimicrobial Agents and Chemotherapy 59, no. 4 (April 2015): 2365-2373.  Full Text
    • Chirouze, C, Alla, F, Fowler, VG, Sexton, DJ, Corey, GR, Chu, VH, Wang, A, Erpelding, M-L, Durante-Mangoni, E, Fernández-Hidalgo, N, Giannitsioti, E, Hannan, MM, Lejko-Zupanc, T, Miró, JM, Muñoz, P, Murdoch, DR, Tattevin, P, Tribouilloy, C, Hoen, B, and ICE Prospective Investigators, . "Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 60, no. 5 (March 2015): 741-749.  Full Text
    • Delahaye, F, Chu, VH, Altclas, J, Barsic, B, Delahaye, A, Freiberger, T, Gordon, DL, Hannan, MM, Hoen, B, Kanj, SS, Lejko-Zupanc, T, Mestres, CA, Pachirat, O, Pappas, P, Lamas, C, Selton-Suty, C, Tan, R, Tattevin, P, Wang, A, and International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators, . "One-year outcome following biological or mechanical valve replacement for infective endocarditis." International Journal of Cardiology 178 (January 2015): 117-123.  Full Text
    • Holland, TL, and Fowler, VG. "Diagnosing endocarditis in patients with Staphylococcus aureus bacteremia--reply." JAMA 313, no. 4 (January 2015): 420-421. (Letter)  Full Text
    • Bloomfield, GS, Hogan, JW, Keter, A, Holland, TL, Sang, E, Kimaiyo, S, and Velazquez, EJ. "Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records." Bmc Infectious Diseases 14, no. 1 (December 2014).  Full Text
    • Holland, T, Fowler, VG, and Shelburne, SA. "Invasive gram-positive bacterial infection in cancer patients." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 59 Suppl 5 (November 2014): S331-S334. (Review)  Full Text
    • Holland, TL, Arnold, C, and Fowler, VG. "Clinical management of Staphylococcus aureus bacteremia: a review." Jama 312, no. 13 (October 2014): 1330-1341. (Review)  Full Text
    • Bloomfield, GS, Hogan, JW, Keter, A, Holland, TL, Sang, E, Kimaiyo, S, and Velazquez, EJ. "Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records." Bmc Infectious Diseases 14 (May 22, 2014): 284-null.  Full Text  Open Access Copy
    • Carugati, M, Bayer, AS, Miró, JM, Park, LP, Guimarães, AC, Skoutelis, A, Fortes, CQ, Durante-Mangoni, E, Hannan, MM, Nacinovich, F, Fernández-Hidalgo, N, Grossi, P, Tan, R-S, Holland, T, Fowler, VG, Corey, RG, Chu, VH, and International Collaboration on Endocarditis, . "High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the international collaboration on endocarditis." Antimicrobial Agents and Chemotherapy 57, no. 12 (December 2013): 6213-6222.  Full Text
    • Barsic, B, Dickerman, S, Krajinovic, V, Pappas, P, Altclas, J, Carosi, G, Casabé, JH, Chu, VH, Delahaye, F, Edathodu, J, Fortes, CQ, Olaison, L, Pangercic, A, Patel, M, Rudez, I, Tamin, SS, Vincelj, J, Bayer, AS, Wang, A, and International Collaboration on Endocarditis–Prospective Cohort Study Investigators, . "Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 56, no. 2 (January 2013): 209-217.  Full Text
    • Chambers, ST, Murdoch, D, Morris, A, Holland, D, Pappas, P, Almela, M, Fernández-Hidalgo, N, Almirante, B, Bouza, E, Forno, D, del Rio, A, Hannan, MM, Harkness, J, Kanafani, ZA, Lalani, T, Lang, S, Raymond, N, Read, K, Vinogradova, T, Woods, CW, Wray, D, Corey, GR, Chu, VH, and International Collaboration on Endocarditis Prospective Cohort Study Investigators, . "HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort." Plos One 8, no. 5 (January 2013): e63181-null.  Full Text
    • Bloomfield, GS, Hogan, JW, Keter, A, Holland, TL, Osanya, J, Sang, E, Kimaiyo, S, and Velazquez, EJ. "High Blood Pressure Increases Risk of Death Among Human Immunodeficiency Virus Seropositive Individuals in Kenya." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Fowler, V, and Holland, T. "Reply to gould." Journal of Infectious Diseases 205, no. 5 (March 1, 2012): 865-null. (Letter)  Full Text
    • Holland, TL, and Fowler, VG. "Vancomycin minimum inhibitory concentration and outcome in patients with Staphylococcus aureus bacteremia: pearl or pellet?." The Journal of Infectious Diseases 204, no. 3 (August 2011): 329-331.  Full Text
    • Holland, TL, Thielman, NM, and Pearson, RD. "Chemotherapy of Bacterial, Fungal, and Viral Diseases." (2011): 95-104.  Full Text
    • Holland, TL, Woods, CW, and Joyce, M. "Antibacterial susceptibility testing in the clinical laboratory." Infect Dis Clin North Am 23, no. 4 (December 2009): 757-vii. (Review)  Full Text  Link to Item
    • Corneli, A, Perry, B, Collyar, D, Powers, JH, Farley, JJ, Calvert, SB, Santiago, J, Donnelly, HK, Swezey, T, Dombeck, CB, De Anda, C, Fowler, VG, and Holland, TL. "Assessment of the Perceived Acceptability of an Early Enrollment Strategy Using Advance Consent in Health Care–Associated Pneumonia(Published online)." Jama Network Open 1, no. 8: e185816-e185816.  Full Text
    • Ruopp, MD, Boggan, JC, Holland, TL, Stillwagon, MJ, Govert, JA, and Bae, JG. "Missing the Mark: Inaccuracy of administrative data in identification of hospitalized patients with pneumonia and results of a systematic clinical reclassification process on readmission rates(Published online)." Journal of Hospital Administration 6, no. 6: 35-35.  Full Text  Open Access Copy

  • Conference Papers

    • Bergin, SP, Coles, A, Farley, J, Santiago, J, Calvert, S, Fowler, VG, and Holland, TL. "Predicting Pneumonia: A Prospective Observational Study Of The Risk Factors For Hospital-Acquired And Ventilator-Associated Bacterial Pneumonia." International Conference of the American-Thoracic-Society (ATS). Washington, DC. May 19, 2017 - May 24, 2017.: AMER THORACIC SOC, January 1, 2017.  Link to Item
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Duke Global Health Outreach. You get what you look for: emerging infections in a malaria-endemic zone. January 2014  2014

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