Overview
Statistical methodology for immunological laboratory techniques (flow cytometry, CFSE analysis, receptor-ligand binding and signaling kinetics)
Informatics of the immune system (reference and application ontologies, meta-programming, text mining and machine learning)
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
·
2022 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Research Professor of Statistical Science
·
2022 - Present
Statistical Science,
Trinity College of Arts & Sciences
Research Professor of Mathematics
·
2025 - Present
Mathematics,
Trinity College of Arts & Sciences
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Single-cell and spatial detection of senescent cells using DeepScence.
Journal Article Cell Genom · December 10, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item CiteIgG and Fc Receptor Genetic Variation Associates With Functional Antibody Responses in a DNA and Protein Candidate HIV Vaccine Trial.
Journal Article J Acquir Immune Defic Syndr · December 1, 2025 BACKGROUND: The HVTN108 trial evaluated the safety and immunogenicity of a DNA prime, adjuvanted protein boost HIV vaccine in the United States and South Africa. The underlying factors influencing individual variation in vaccine responsiveness are unknown. ... Full text Link to item CiteA rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes.
Journal Article Commun Biol · November 24, 2025 Congenital cytomegalovirus (cCMV) is the leading infectious cause of birth defects worldwide, yet immune determinants of protection to inform maternal vaccine design remain elusive due to the lack of a translational animal model. Here, we characterized the ... Full text Link to item CiteRecent Grants
Interdisciplinary Research Training Program in AIDS
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2030Center for Multiscale Immune Systems Modeling
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029View All Grants
Education, Training & Certifications
University College London (United Kingdom) ·
2002
Ph.D.
University College London (United Kingdom) ·
1998
M.S.
University of London (United Kingdom) ·
1997
B.S.
National University of Singapore (Singapore) ·
1991
M.B.B.S.