Michel Bagnat
Associate Professor of Cell Biology
Current Appointments & Affiliations
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2008
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- 333B Nanaline Duke Building, Durham, NC 27710
- Duke Box 3709, Durham, NC 27710
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m.bagnat@cellbio.duke.edu
(919) 681-9268
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Bagnat Lab
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Department of Cell Biology
- Background
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Education, Training, & Certifications
- Ph.D., University of Madrid (Spain) 2002
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Duke Appointment History
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2008 - 2016
- Recognition
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In the News
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FEB 21, 2018 Duke Research Blog -
JUN 22, 2017 -
JAN 11, 2017 -
SEP 22, 2016 -
FEB 16, 2015
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- Research
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Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Genetic and Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2018 - 2022
- Investigating the role of notochord segmentation in spine morphogenesis awarded by National Institutes of Health 2018 - 2021
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Mechanisms protecting cell surface integrity in giant vacuolated cells of the notochord awarded by National Institutes of Health 2017 - 2020
- Regulation of Luminal Protein Uptake and Trafficking By Lysosome-Rich Enterocytes awarded by National Institutes of Health 2017 - 2020
- Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
- Uncovering mechanisms controlling notochord vacuole and spine morphogenesis awarded by National Institutes of Health 2013 - 2018
- Epigenetic Control of Intestinal Inflammation awarded by Kenneth Rainin Foundation 2016 - 2017
- Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
- Epigenetic control of intestinal inflammation awarded by Kenneth Rainin Foundation 2015 - 2016
- Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2013 - 2015
- Discovering New Regulators of CFTR and Fluid Secretion in Zebrafish awarded by National Institutes of Health 2009 - 2014
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Norman, J, Sorrell, EL, Hu, Y, Siripurapu, V, Garcia, J, Bagwell, J, Charbonneau, P, Lubkin, SR, and Bagnat, M. "Tissue self-organization underlies morphogenesis of the notochord." Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 373, no. 1759 (September 24, 2018). Full Text
- Wopat, S, Bagwell, J, Sumigray, KD, Dickson, AL, Huitema, LFA, Poss, KD, Schulte-Merker, S, and Bagnat, M. "Spine Patterning Is Guided by Segmentation of the Notochord Sheath." Cell Reports 22, no. 8 (February 2018): 2026-2038. Full Text
- van der Vaart, M, Svoboda, O, Weijts, BG, Espín-Palazón, R, Sapp, V, Pietri, T, Bagnat, M, Muotri, AR, and Traver, D. "Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation." Disease Models & Mechanisms 10, no. 12 (December 19, 2017): 1439-1451. Full Text
- Goudarzi, M, Tarbashevich, K, Mildner, K, Begemann, I, Garcia, J, Paksa, A, Reichman-Fried, M, Mahabaleshwar, H, Blaser, H, Hartwig, J, Zeuschner, D, Galic, M, Bagnat, M, Betz, T, and Raz, E. "Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations." Developmental cell 43, no. 5 (December 2017): 577-587.e5. Full Text
- Garcia, J, Bagwell, J, Njaine, B, Norman, J, Levic, DS, Wopat, S, Miller, SE, Liu, X, Locasale, JW, Stainier, DYR, and Bagnat, M. "Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord." Current Biology : Cb 27, no. 13 (July 2017): 1982-1989.e3. Full Text
- Smith, CJ, Wheeler, MA, Marjoram, L, Bagnat, M, Deppmann, CD, and Kucenas, S. "TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone." Plos Genetics 13, no. 4 (April 5, 2017): e1006712-null. Full Text
- Cao, J, Navis, A, Cox, BD, Dickson, AL, Gemberling, M, Karra, R, Bagnat, M, and Poss, KD. "Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration." Development (Cambridge, England) 143, no. 2 (January 2016): 232-243. Full Text
- Marjoram, L, and Bagnat, M. "Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation." Current Pathobiology Reports 3, no. 2 (June 2015): 147-153. Full Text
- Navis, A, and Bagnat, M. "Developing pressures: fluid forces driving morphogenesis." Current Opinion in Genetics & Development 32 (June 2015): 24-30. (Review) Full Text
- Navis, A, and Bagnat, M. "Loss of cftr function leads to pancreatic destruction in larval zebrafish." Developmental Biology 399, no. 2 (March 15, 2015): 237-248. Full Text
- Marjoram, L, Alvers, A, Deerhake, ME, Bagwell, J, Mankiewicz, J, Cocchiaro, JL, Beerman, RW, Willer, J, Sumigray, KD, Katsanis, N, Tobin, DM, Rawls, JF, Goll, MG, and Bagnat, M. "Epigenetic control of intestinal barrier function and inflammation in zebrafish." Proceedings of the National Academy of Sciences of the United States of America 112, no. 9 (March 2015): 2770-2775. Full Text
- Navis, A, and Bagnat, M. "Loss of cftr function leads to pancreatic destruction in larval zebrafish." Developmental biology 399, no. 2 (March 2015): 237-248. Full Text
- Rodríguez-Fraticelli, AE, Bagwell, J, Bosch-Fortea, M, Boncompain, G, Reglero-Real, N, García-León, MJ, Andrés, G, Toribio, ML, Alonso, MA, Millán, J, Perez, F, Bagnat, M, and Martín-Belmonte, F. "Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs." Nature Cell Biology 17, no. 3 (March 2015): 241-250. Full Text
- Alvers, AL, Ryan, S, Scherz, PJ, Huisken, J, and Bagnat, M. "Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling." Development (Cambridge, England) 141, no. 5 (March 2014): 1110-1119. Full Text
- Gray, RS, Wilm, TP, Smith, J, Bagnat, M, Dale, RM, Topczewski, J, Johnson, SL, and Solnica-Krezel, L. "Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations." Dev Biol 386, no. 1 (February 1, 2014): 72-85. Full Text Link to Item
- Gray, RS, Wilm, TP, Smith, J, Bagnat, M, Dale, RM, Topczewski, J, Johnson, SL, and Solnica-Krezel, L. "Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations." Developmental Biology 386, no. 1 (February 1, 2014): 72-85. Full Text
- Antonny, B, Audhya, J, l Bagnat, M, von Blume, J, Briggs, JAG, Giraudo, C, Kaeser, PS, Miller, E, Reinisch, K, Sbalzarini, IF, Schuldiner, M, Shen, J, Takamori, S, Verstreken, P, and Walther, T. "Directing traffic into the future." Developmental cell 27, no. 5 (December 2013): 480-484. Full Text
- Ryan, S, Willer, J, Marjoram, L, Bagwell, J, Mankiewicz, J, Leshchiner, I, Goessling, W, Bagnat, M, and Katsanis, N. "Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish." Development (Cambridge, England) 140, no. 21 (November 2013): 4445-4451. Full Text
- Ellis, K, Hoffman, BD, and Bagnat, M. "The vacuole within: how cellular organization dictates notochord function." Bioarchitecture 3, no. 3 (May 2013): 64-68. (Review) Full Text
- Navis, A, Marjoram, L, and Bagnat, M. "Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish." Development 140, no. 8 (April 2013): 1703-1712. Full Text Link to Item
- Ellis, K, Bagwell, J, and Bagnat, M. "Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis." The Journal of Cell Biology 200, no. 5 (March 2013): 667-679. Full Text
- Marjoram, LT, and Bagnat, M. "IDENTIFICATION OF CFTR AND FLUID SECRETION REGULATORS IN ZEBRAFISH." PEDIATRIC PULMONOLOGY 47 (September 2012): 282-282. Link to Item
- Navis, A, and Bagnat, M. "CFTR IS REQUIRED DURING DEVELOPMENT OF THE ZEBRAFISH LIVER AND PANCREAS." PEDIATRIC PULMONOLOGY 47 (September 2012): 288-288. Link to Item
- Cheung, ID, Bagnat, M, Ma, TP, Datta, A, Evason, K, Moore, JC, Lawson, ND, Mostov, KE, Moens, CB, and Stainier, DYR. "Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b." Dev Biol 361, no. 1 (January 1, 2012): 68-78. Full Text Link to Item
- Kanther, M, Sun, X, Mühlbauer, M, Mackey, LC, Flynn, EJ, Bagnat, M, Jobin, C, and Rawls, JF. "Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract." Gastroenterology 141, no. 1 (July 2011): 197-207. Full Text
- Bagnat, M, Navis, A, Herbstreith, S, Brand-Arzamendi, K, Curado, S, Gabriel, S, Mostov, K, Huisken, J, and Stainier, DYR. "Erratum: Cse1l is a negative regulator of CFTR-dependent fluid secretion (Current Biology (2010) 20 (1840-1845))." Current Biology 20, no. 23 (December 7, 2010): 2157-null. Full Text
- Bagnat, M, Navis, A, Herbstreith, S, Brand-Arzamendi, K, Curado, S, Gabriel, S, Mostov, K, Huisken, J, and Stainier, DYR. "Cse1l is a negative regulator of CFTR-dependent fluid secretion." Current Biology : Cb 20, no. 20 (October 7, 2010): 1840-1845. Full Text
- Bagnat, M, Huisken, J, Herbstreith, S, Brand-Arzamendi, K, Curado, S, and Satinier, DY. "IDENTIFICATION OF THREE CFTR REGULATORS USING FORWARD GENETICS IN ZEBRAFISH." PEDIATRIC PULMONOLOGY (2009): 226-226. Link to Item
- Bagnat, M, Cheung, ID, Mostov, KE, and Stainier, DYR. "Genetic control of single lumen formation in the zebrafish gut." Nature Cell Biology 9, no. 8 (August 2007): 954-960. Full Text
- Proszynski, TJ, Klemm, R, Bagnat, M, Gaus, K, and Simons, K. "Plasma membrane polarization during mating in yeast cells." The Journal of Cell Biology 173, no. 6 (June 12, 2006): 861-866. Full Text
- Proszynski, TJ, Klemm, RW, Gravert, M, Hsu, PP, Gloor, Y, Wagner, J, Kozak, K, Grabner, H, Walzer, K, Bagnat, M, Simons, K, and Walch-Solimena, C. "A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast." Proc Natl Acad Sci U S A 102, no. 50 (December 13, 2005): 17981-17986. Full Text Link to Item
- Proszynski, TJ, Simons, K, and Bagnat, M. "O-glycosylation as a sorting determinant for cell surface delivery in yeast." Molecular Biology of the Cell 15, no. 4 (April 2004): 1533-1543. Full Text
- BAGNAT, M. "Cell surface polarization during yeast mating." Proc. Natl. Acad. Sci. USA 99 (2004): 14183-14188. Full Text
- Lommel, M, Bagnat, M, and Strahl, S. "Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants." Molecular and Cellular Biology 24, no. 1 (January 2004): 46-57. Full Text
- Balguerie, A, Bagnat, M, Bonneu, M, Aigle, M, and Breton, AM. "Rvs161p and sphingolipids are required for actin repolarization following salt stress." Eukaryotic Cell 1, no. 6 (December 2002): 1021-1031. Full Text
- Bagnat, M, and Simons, K. "Cell surface polarization during yeast mating." Proc Natl Acad Sci U S A 99, no. 22 (October 29, 2002): 14183-14188. Full Text Link to Item
- Bagnat, M, and Simons, K. "Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae." Biological Chemistry 383, no. 10 (October 2002): 1475-1480. Full Text
- Bagnat, M, Chang, A, and Simons, K. "Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast." Molecular Biology of the Cell 12, no. 12 (December 2001): 4129-4138. Full Text
- BAGNAT, M. "Plasma membrane proton ATPase Pmalp requires raft association for surface delivery in yeast." Mol. Biol. Cell. 12 (2001): 4129-4138.
- Bagnat, M. "Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast." Proceedings of the National Academy of Sciences 97, no. 7 (March 28, 2000): 3254-3259. Full Text
- Bagnat, M, Keränen, S, Shevchenko, A, and Simons, K. "Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast." Proceedings of the National Academy of Sciences of the United States of America 97, no. 7 (March 2000): 3254-3259. Full Text
- Moreno, FJ, Bagnat, M, Lim, F, and Avila, J. "OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding." Eur J Biochem 262, no. 2 (June 1999): 557-562. Link to Item
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Book Sections
- Bagnat, M, and Navis, A. "Apicobasal polarity and lumen formation during development." In Cell Polarity 2: Role in Development and Disease, 67-93. January 1, 2015. Full Text
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Conference Papers
- Trinh, LA, Koo, E, Trivedi, V, Bagnat, M, and Fraser, SE. "Molecular asymmetries in actin dynamics drive left-right organogenesis." April 2016. Link to Item
- Trinh, LA, Koo, E, Trivedi, V, Bagnat, M, and Fraser, SE. "Molecular asymmetries in actin dynamics drive left-right organogenesis." April 2016. Link to Item
- Trinh, LA, Koo, E, Trivedi, V, Bagnat, M, and Fraser, SE. "Molecular asymmetries in actin dynamics drive left-right organogenesis." April 2016. Link to Item
- Cocchiaro, JL, Navis, A, Bagnat, M, and Rawls, JF. "Zebrafish as a model to analyze macromolecule absorption in intestinal enterocytes." April 2013. Link to Item
- Bagnat, M. "USING ZEBRAFISH GENETICS TO UNDERSTAND CFTR FUNCTION & REGULATION DURING DEVELOPMENT." September 2012. Link to Item
- Alvers, A, and Bagnat, M. "Investigating the process of single lumen formation in the zebrafish gut." 2011. Link to Item
- Bagnat, M. "A FORWARD GENETICS APPROACH FOR FISHING NEW REGULATORS OF CFTR AND FLUID SECRETION." 2011. Link to Item
- Navis, A, and Bagnat, M. "CFTR FUNCTIONS DURING ZEBRAFISH ORGANOGENESIS." 2011. Link to Item
- Navis, A, and Bagnat, M. "USING ZEBRAFISH TO STUDY THE ROLE OF CFTR IN ORGANOGENESIS." 2009. Link to Item
- Bagnat, M, and Stainier, DY. "Genetic control of CFTR function in zebrafish." 2007. Link to Item
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- Teaching & Mentoring
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Recent Courses
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