Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Madrid (Spain) 2002
• 

  Duke Appointment History

  • Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2008 - 2016
• Recognition
• 

  In the News

  • FEB 21, 2018

    Duke Research Blog

    How A Zebrafishs Squiggly Cartilage Transforms into a Strong Spine

  • JUN 22, 2017

    Cells In Fishs Spinal Discs Repair Themselves

  • JAN 11, 2017

    Totally Tubular! Fluid Forces That Affect the Development of Biological Tubes

  • SEP 22, 2016

    Cell Biologist Named HHMI Faculty Scholar

  • FEB 16, 2015

    Researchers Discover Molecular Trigger of Inflammatory Bowel Disease
• Research
• 

  Selected Grants

  • Cellular and Environmental Regulation of Protein Absorption and Utilization in the Early Intestine awarded by National Institutes of Health 2019 - 2022
  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
  • Genetic and Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2018 - 2022
  • Investigating the role of notochord segmentation in spine morphogenesis awarded by National Institutes of Health 2018 - 2021
  • Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Mechanisms protecting cell surface integrity in giant vacuolated cells of the notochord awarded by National Institutes of Health 2017 - 2020
  • Regulation of Luminal Protein Uptake and Trafficking By Lysosome-Rich Enterocytes awarded by National Institutes of Health 2017 - 2020
  • Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
  • Uncovering mechanisms controlling notochord vacuole and spine morphogenesis awarded by National Institutes of Health 2013 - 2018
  • Epigenetic Control of Intestinal Inflammation awarded by Kenneth Rainin Foundation 2016 - 2017
  • Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
  • Epigenetic control of intestinal inflammation awarded by Kenneth Rainin Foundation 2015 - 2016
  • Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2013 - 2015
  • Discovering New Regulators of CFTR and Fluid Secretion in Zebrafish awarded by National Institutes of Health 2009 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Norman, James, Emma L. Sorrell, Yi Hu, Vaishnavi Siripurapu, Jamie Garcia, Jennifer Bagwell, Patrick Charbonneau, Sharon R. Lubkin, and Michel Bagnat. “Tissue self-organization underlies morphogenesis of the notochord..” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 373, no. 1759 (September 24, 2018). https://doi.org/10.1098/rstb.2017.0320.
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    • Wopat, Susan, Jennifer Bagwell, Kaelyn D. Sumigray, Amy L. Dickson, Leonie F. A. Huitema, Kenneth D. Poss, Stefan Schulte-Merker, and Michel Bagnat. “Spine Patterning Is Guided by Segmentation of the Notochord Sheath..” Cell Reports 22, no. 8 (February 2018): 2026–38. https://doi.org/10.1016/j.celrep.2018.01.084.
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    • Vaart, M. van der, O. Svoboda, B. G. Weijts, R. Espín-Palazón, V. Sapp, T. Pietri, M. Bagnat, A. R. Muotri, and D. Traver. “Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation..” Disease Models & Mechanisms 10, no. 12 (December 19, 2017): 1439–51. https://doi.org/10.1242/dmm.026922.
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    • Goudarzi, Mohammad, Katsiaryna Tarbashevich, Karina Mildner, Isabell Begemann, Jamie Garcia, Azadeh Paksa, Michal Reichman-Fried, et al. “Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations..” Developmental Cell 43, no. 5 (December 2017): 577-587.e5. https://doi.org/10.1016/j.devcel.2017.10.030.
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    • Garcia, Jamie, Jennifer Bagwell, Brian Njaine, James Norman, Daniel S. Levic, Susan Wopat, Sara E. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord..” Current Biology : Cb 27, no. 13 (July 2017): 1982-1989.e3. https://doi.org/10.1016/j.cub.2017.05.035.
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    • Smith, Cody J., Michael A. Wheeler, Lindsay Marjoram, Michel Bagnat, Christopher D. Deppmann, and Sarah Kucenas. “TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone..” Plos Genetics 13, no. 4 (April 5, 2017). https://doi.org/10.1371/journal.pgen.1006712.
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    • Cao, Jingli, Adam Navis, Ben D. Cox, Amy L. Dickson, Matthew Gemberling, Ravi Karra, Michel Bagnat, and Kenneth D. Poss. “Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration..” Development (Cambridge, England) 143, no. 2 (January 2016): 232–43. https://doi.org/10.1242/dev.130534.
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    • Marjoram, Lindsay, and Michel Bagnat. “Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation..” Current Pathobiology Reports 3, no. 2 (June 2015): 147–53. https://doi.org/10.1007/s40139-015-0079-x.
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    • Navis, Adam, and Michel Bagnat. “Developing pressures: fluid forces driving morphogenesis..” Current Opinion in Genetics & Development 32 (June 2015): 24–30. https://doi.org/10.1016/j.gde.2015.01.010.
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    • Navis, A., and M. Bagnat. “Loss of cftr function leads to pancreatic destruction in larval zebrafish.” Developmental Biology 399, no. 2 (March 15, 2015): 237–48. https://doi.org/10.1016/j.ydbio.2014.12.034.
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    • Marjoram, Lindsay, Ashley Alvers, M Elizabeth Deerhake, Jennifer Bagwell, Jamie Mankiewicz, Jordan L. Cocchiaro, Rebecca W. Beerman, et al. “Epigenetic control of intestinal barrier function and inflammation in zebrafish..” Proceedings of the National Academy of Sciences of the United States of America 112, no. 9 (March 2015): 2770–75. https://doi.org/10.1073/pnas.1424089112.
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    • Navis, Adam, and Michel Bagnat. “Loss of cftr function leads to pancreatic destruction in larval zebrafish..” Developmental Biology 399, no. 2 (March 2015): 237–48. https://doi.org/10.1016/j.ydbio.2014.12.034.
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    • Rodríguez-Fraticelli, Alejo E., Jennifer Bagwell, Minerva Bosch-Fortea, Gaelle Boncompain, Natalia Reglero-Real, Maria J. García-León, Germán Andrés, et al. “Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs..” Nature Cell Biology 17, no. 3 (March 2015): 241–50. https://doi.org/10.1038/ncb3106.
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    • Alvers, Ashley L., Sean Ryan, Paul J. Scherz, Jan Huisken, and Michel Bagnat. “Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling..” Development (Cambridge, England) 141, no. 5 (March 2014): 1110–19. https://doi.org/10.1242/dev.100313.
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    • Gray, R. S., T. P. Wilm, J. Smith, M. Bagnat, R. M. Dale, J. Topczewski, S. L. Johnson, and L. Solnica-Krezel. “Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.” Developmental Biology 386, no. 1 (February 1, 2014): 72–85. https://doi.org/10.1016/j.ydbio.2013.11.028.
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    • Gray, Ryan S., Thomas P. Wilm, Jeff Smith, Michel Bagnat, Rodney M. Dale, Jacek Topczewski, Stephen L. Johnson, and Lilianna Solnica-Krezel. “Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations..” Developmental Biology 386, no. 1 (February 2014): 72–85. https://doi.org/10.1016/j.ydbio.2013.11.028.
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    • Antonny, Bruno, Jon Audhya, Michel l Bagnat, Julia von Blume, John A. G. Briggs, Claudio Giraudo, Pascal S. Kaeser, et al. “Directing traffic into the future..” Developmental Cell 27, no. 5 (December 2013): 480–84. https://doi.org/10.1016/j.devcel.2013.11.017.
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    • Ryan, Sean, Jason Willer, Lindsay Marjoram, Jennifer Bagwell, Jamie Mankiewicz, Ignaty Leshchiner, Wolfram Goessling, Michel Bagnat, and Nicholas Katsanis. “Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish..” Development (Cambridge, England) 140, no. 21 (November 2013): 4445–51. https://doi.org/10.1242/dev.101170.
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    • Ellis, Kathryn, Brenton D. Hoffman, and Michel Bagnat. “The vacuole within: how cellular organization dictates notochord function..” Bioarchitecture 3, no. 3 (May 2013): 64–68. https://doi.org/10.4161/bioa.25503.
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    • Navis, Adam, Lindsay Marjoram, and Michel Bagnat. “Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish..” Development (Cambridge, England) 140, no. 8 (April 2013): 1703–12. https://doi.org/10.1242/dev.091819.
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    • Ellis, Kathryn, Jennifer Bagwell, and Michel Bagnat. “Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis..” The Journal of Cell Biology 200, no. 5 (March 2013): 667–79. https://doi.org/10.1083/jcb.201212095.
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    • Marjoram, L. T., and M. Bagnat. “IDENTIFICATION OF CFTR AND FLUID SECRETION REGULATORS IN ZEBRAFISH.” Pediatric Pulmonology 47 (September 1, 2012): 282–282.
       Link to Item
    • Navis, A., and M. Bagnat. “CFTR IS REQUIRED DURING DEVELOPMENT OF THE ZEBRAFISH LIVER AND PANCREAS.” Pediatric Pulmonology 47 (September 1, 2012): 288–288.
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    • Cheung, Isla D., Michel Bagnat, Taylur P. Ma, Anirban Datta, Kimberley Evason, John C. Moore, Nathan D. Lawson, Keith E. Mostov, Cecilia B. Moens, and Didier Y. R. Stainier. “Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b..” Developmental Biology 361, no. 1 (January 2012): 68–78. https://doi.org/10.1016/j.ydbio.2011.10.004.
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    • Kanther, Michelle, Xiaolun Sun, Marcus Mühlbauer, Lantz C. Mackey, Edward J. Flynn, Michel Bagnat, Christian Jobin, and John F. Rawls. “Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract..” Gastroenterology 141, no. 1 (July 2011): 197–207. https://doi.org/10.1053/j.gastro.2011.03.042.
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    • Bagnat, M., A. Navis, S. Herbstreith, K. Brand-Arzamendi, S. Curado, S. Gabriel, K. Mostov, J. Huisken, and D. Y. R. Stainier. “Erratum: Cse1l is a negative regulator of CFTR-dependent fluid secretion (Current Biology (2010) 20 (1840-1845)).” Current Biology 20, no. 23 (December 7, 2010). https://doi.org/10.1016/j.cub.2010.11.031.
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    • Bagnat, Michel, Adam Navis, Sara Herbstreith, Koroboshka Brand-Arzamendi, Silvia Curado, Sherif Gabriel, Keith Mostov, Jan Huisken, and Didier Y. R. Stainier. “Cse1l is a negative regulator of CFTR-dependent fluid secretion..” Current Biology : Cb 20, no. 20 (October 7, 2010): 1840–45. https://doi.org/10.1016/j.cub.2010.09.012.
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    • Bagnat, M., J. Huisken, S. Herbstreith, K. Brand-Arzamendi, S. Curado, and D. Y. Satinier. “IDENTIFICATION OF THREE CFTR REGULATORS USING FORWARD GENETICS IN ZEBRAFISH.” Pediatric Pulmonology, January 1, 2009, 226–226.
       Link to Item
    • Bagnat, Michel, Isla D. Cheung, Keith E. Mostov, and Didier Y. R. Stainier. “Genetic control of single lumen formation in the zebrafish gut..” Nature Cell Biology 9, no. 8 (August 2007): 954–60. https://doi.org/10.1038/ncb1621.
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    • Proszynski, TJ, Klemm, R, Bagnat, M, Gaus, K, and Simons, K. "Plasma membrane polarization during mating in yeast cells." The Journal of Cell Biology 173, no. 6 (June 12, 2006): 861-866.  Full Text
    • Proszynski, Tomasz J., Robin W. Klemm, Maike Gravert, Peggy P. Hsu, Yvonne Gloor, Jan Wagner, Karol Kozak, et al. “A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast..” Proceedings of the National Academy of Sciences of the United States of America 102, no. 50 (December 5, 2005): 17981–86. https://doi.org/10.1073/pnas.0509107102.
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    • Proszynski, Tomasz J., Kai Simons, and Michel Bagnat. “O-glycosylation as a sorting determinant for cell surface delivery in yeast..” Molecular Biology of the Cell 15, no. 4 (April 2004): 1533–43. https://doi.org/10.1091/mbc.E03-07-0511.
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    • BAGNAT, M. “Cell surface polarization during yeast mating.” Proc. Natl. Acad. Sci. Usa 99 (2004): 14183–88. https://doi.org/10.1073/pnas.172517799.
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    • Lommel, Mark, Michel Bagnat, and Sabine Strahl. “Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants..” Molecular and Cellular Biology 24, no. 1 (January 2004): 46–57. https://doi.org/10.1128/MCB.24.1.46-57.2004.
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    • Balguerie, Axelle, Michel Bagnat, Marc Bonneu, Michel Aigle, and Annick M. Breton. “Rvs161p and sphingolipids are required for actin repolarization following salt stress..” Eukaryotic Cell 1, no. 6 (December 2002): 1021–31. https://doi.org/10.1128/EC.1.6.1021-1031.2002.
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    • Bagnat, Michel, and Kai Simons. “Cell surface polarization during yeast mating..” Proceedings of the National Academy of Sciences of the United States of America 99, no. 22 (October 8, 2002): 14183–88. https://doi.org/10.1073/pnas.172517799.
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    • Bagnat, Michel, and Kai Simons. “Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae..” Biological Chemistry 383, no. 10 (October 2002): 1475–80. https://doi.org/10.1515/bc.2002.169.
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    • Bagnat, M., A. Chang, and K. Simons. “Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast..” Molecular Biology of the Cell 12, no. 12 (December 2001): 4129–38. https://doi.org/10.1091/mbc.12.12.4129.
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    • BAGNAT, M. “Plasma membrane proton ATPase Pmalp requires raft association for surface delivery in yeast.” Mol. Biol. Cell. 12 (2001): 4129–38.
    • Bagnat, M. “Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast.” Proceedings of the National Academy of Sciences 97, no. 7 (March 28, 2000): 3254–59. https://doi.org/10.1073/pnas.060034697.
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    • Bagnat, M., S. Keränen, A. Shevchenko, and K. Simons. “Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast..” Proceedings of the National Academy of Sciences of the United States of America 97, no. 7 (March 2000): 3254–59. https://doi.org/10.1073/pnas.060034697.
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    • Moreno, F. J., M. Bagnat, F. Lim, and J. Avila. “OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding..” European Journal of Biochemistry 262, no. 2 (June 1999): 557–62. https://doi.org/10.1046/j.1432-1327.1999.00408.x.
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  • Book Sections

    • Bagnat, M., and A. Navis. “Apicobasal polarity and lumen formation during development.” In Cell Polarity 2: Role in Development and Disease, 67–93, 2015. https://doi.org/10.1007/978-3-319-14466-5_3.
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  • Conference Papers

    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
       Link to Item
    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
       Link to Item
    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30, 2016.
       Link to Item
    • Cocchiaro, Jordan L., Adam Navis, Michel Bagnat, and John F. Rawls. “Zebrafish as a model to analyze macromolecule absorption in intestinal enterocytes.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
       Link to Item
    • Bagnat, Michel. “USING ZEBRAFISH GENETICS TO UNDERSTAND CFTR FUNCTION & REGULATION DURING DEVELOPMENT.” In Pediatric Pulmonology, 47:140–41. WILEY-BLACKWELL, 2012.
       Link to Item
    • Alvers, A., and M. Bagnat. “Investigating the process of single lumen formation in the zebrafish gut.” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.
       Link to Item
    • Bagnat, M. “A FORWARD GENETICS APPROACH FOR FISHING NEW REGULATORS OF CFTR AND FLUID SECRETION.” In Pediatric Pulmonology, 270–270. WILEY-BLACKWELL, 2011.
       Link to Item
    • Navis, A., and M. Bagnat. “CFTR FUNCTIONS DURING ZEBRAFISH ORGANOGENESIS.” In Pediatric Pulmonology, 274–75. WILEY-BLACKWELL, 2011.
       Link to Item
    • Navis, A., and M. Bagnat. “USING ZEBRAFISH TO STUDY THE ROLE OF CFTR IN ORGANOGENESIS.” In Pediatric Pulmonology, 284–85. WILEY-LISS, 2009.
       Link to Item
    • Bagnat, M., and D. Y. Stainier. “Genetic control of CFTR function in zebrafish.” In Pediatric Pulmonology, 280–280. WILEY-LISS, 2007.
       Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • CELLBIO 493: Research Independent Study 2019
  • CMB 710B: Cell & Molecular Biology Module II 2018

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