Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Madrid (Spain) 2002
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2008 - 2016
• Recognition
• 

  In the News

  • JUL 20, 2020

    Graduate Student’s Mutant Zebrafish Reveals Evolutionary History

  • SEP 3, 2019

    Duke Research

    An Alternative Path to Nutrition

  • FEB 21, 2018

    Duke Research Blog

    How A Zebrafishs Squiggly Cartilage Transforms into a Strong Spine

  • JUN 22, 2017

    Cells In Fishs Spinal Discs Repair Themselves

  • JAN 11, 2017

    Totally Tubular! Fluid Forces That Affect the Development of Biological Tubes

  • SEP 22, 2016

    Cell Biologist Named HHMI Faculty Scholar

  • FEB 16, 2015

    Researchers Discover Molecular Trigger of Inflammatory Bowel Disease
• 

  Awards & Honors

  • HHMI Faculty Scholar. Howard Hughes Medical Institute. 2016
• Research
• 

  Selected Grants

  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
  • Cellular and Environmental Regulation of Protein Absorption and Utilization in the Early Intestine awarded by National Institutes of Health 2019 - 2022
  • Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
  • Genetic and Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2018 - 2022
  • Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
  • Investigating the role of notochord segmentation in spine morphogenesis awarded by National Institutes of Health 2018 - 2021
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Mechanisms protecting cell surface integrity in giant vacuolated cells of the notochord awarded by National Institutes of Health 2017 - 2020
  • Regulation of Luminal Protein Uptake and Trafficking By Lysosome-Rich Enterocytes awarded by National Institutes of Health 2017 - 2020
  • Regulation of the Epicardial Injury Response During Heart Regeneration in Zebrafish awarded by National Institutes of Health 2016 - 2019
  • Uncovering mechanisms controlling notochord vacuole and spine morphogenesis awarded by National Institutes of Health 2013 - 2018
  • Epigenetic Control of Intestinal Inflammation awarded by Kenneth Rainin Foundation 2016 - 2017
  • Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
  • Epigenetic control of intestinal inflammation awarded by Kenneth Rainin Foundation 2015 - 2016
  • Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2013 - 2015
  • Discovering New Regulators of CFTR and Fluid Secretion in Zebrafish awarded by National Institutes of Health 2009 - 2014
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Levic, Daniel S., Naoya Yamaguchi, Siyao Wang, Holger Knaut, and Michel Bagnat. “Knock-in tagging in zebrafish facilitated by insertion into non-coding regions.” Development 148, no. 19 (October 1, 2021). https://doi.org/10.1242/dev.199994.
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    • Levic, Daniel S., and Michel Bagnat. “Self-organization of apical membrane protein sorting in epithelial cells.” Febs J, April 17, 2021. https://doi.org/10.1111/febs.15882.
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    • Hachimi, Mariam, Catalina Grabowski, Silvia Campanario, Gonzalo Herranz, Gabriel Baonza, Juan M. Serrador, Sergio Gomez-Lopez, et al. “Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis.” Curr Biol 31, no. 4 (February 22, 2021): 696-706.e9. https://doi.org/10.1016/j.cub.2020.11.010.
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    • Bagnat, Michel, and Ryan S. Gray. “Development of a straight vertebrate body axis.” Development 147, no. 21 (October 6, 2020). https://doi.org/10.1242/dev.175794.
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    • Peskin, Brianna, Katrin Henke, Nicolás Cumplido, Stephen Treaster, Matthew P. Harris, Michel Bagnat, and Gloria Arratia. “Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine.” Curr Biol 30, no. 14 (July 20, 2020): 2805-2814.e3. https://doi.org/10.1016/j.cub.2020.05.037.
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    • Levic, Daniel S., Sean Ryan, Lindsay Marjoram, Jamie Honeycutt, Jennifer Bagwell, and Michel Bagnat. “Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish.” J Cell Biol 219, no. 4 (April 6, 2020). https://doi.org/10.1083/jcb.201908225.
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    • Ye, Lihua, Olaf Mueller, Jennifer Bagwell, Michel Bagnat, Rodger A. Liddle, and John F. Rawls. “High fat diet induces microbiota-dependent silencing of enteroendocrine cells.” Elife 8 (December 3, 2019). https://doi.org/10.7554/eLife.48479.
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    • Park, Jieun, Daniel S. Levic, Kaelyn D. Sumigray, Jennifer Bagwell, Oznur Eroglu, Carina L. Block, Cagla Eroglu, et al. “Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut.” Dev Cell 51, no. 1 (October 7, 2019): 7-20.e6. https://doi.org/10.1016/j.devcel.2019.08.001.
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    • Hachimi, Mariam, Silvia Campanario, Sergio Gomez-Lopez, Maria D. Barea, Gabriel Baonza, Minerva Bosch-Fortea, Alejo E. Rodriguez-Fraticelli, et al. “The Smoothelin-Like 2, Cortactin and Coronin-1B Network Controls the Apical Actin Cortex During Epithelial Morphogenesis,” March 29, 2019.
    • Norman, James, Emma L. Sorrell, Yi Hu, Vaishnavi Siripurapu, Jamie Garcia, Jennifer Bagwell, Patrick Charbonneau, Sharon R. Lubkin, and Michel Bagnat. “Tissue self-organization underlies morphogenesis of the notochord.” Philos Trans R Soc Lond B Biol Sci 373, no. 1759 (September 24, 2018). https://doi.org/10.1098/rstb.2017.0320.
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    • Wopat, Susan, Jennifer Bagwell, Kaelyn D. Sumigray, Amy L. Dickson, Leonie F. A. Huitema, Kenneth D. Poss, Stefan Schulte-Merker, and Michel Bagnat. “Spine Patterning Is Guided by Segmentation of the Notochord Sheath.” Cell Rep 22, no. 8 (February 20, 2018): 2026–38. https://doi.org/10.1016/j.celrep.2018.01.084.
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    • Vaart, M. van der, O. Svoboda, B. G. Weijts, R. Espín-Palazón, V. Sapp, T. Pietri, M. Bagnat, A. R. Muotri, and D. Traver. “Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.” Dis Model Mech 10, no. 12 (December 19, 2017): 1439–51. https://doi.org/10.1242/dmm.026922.
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    • Goudarzi, Mohammad, Katsiaryna Tarbashevich, Karina Mildner, Isabell Begemann, Jamie Garcia, Azadeh Paksa, Michal Reichman-Fried, et al. “Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.” Dev Cell 43, no. 5 (December 4, 2017): 577-587.e5. https://doi.org/10.1016/j.devcel.2017.10.030.
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    • Garcia, Jamie, Jennifer Bagwell, Brian Njaine, James Norman, Daniel S. Levic, Susan Wopat, Sara E. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.” Curr Biol 27, no. 13 (July 10, 2017): 1982-1989.e3. https://doi.org/10.1016/j.cub.2017.05.035.
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    • Smith, Cody J., Michael A. Wheeler, Lindsay Marjoram, Michel Bagnat, Christopher D. Deppmann, and Sarah Kucenas. “TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone.” Plos Genet 13, no. 4 (April 2017): e1006712. https://doi.org/10.1371/journal.pgen.1006712.
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    • Cao, Jingli, Adam Navis, Ben D. Cox, Amy L. Dickson, Matthew Gemberling, Ravi Karra, Michel Bagnat, and Kenneth D. Poss. “Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.” Development 143, no. 2 (January 15, 2016): 232–43. https://doi.org/10.1242/dev.130534.
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    • Marjoram, Lindsay, and Michel Bagnat. “Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation.” Curr Pathobiol Rep 3, no. 2 (June 1, 2015): 147–53. https://doi.org/10.1007/s40139-015-0079-x.
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    • Navis, Adam, and Michel Bagnat. “Developing pressures: fluid forces driving morphogenesis.” Curr Opin Genet Dev 32 (June 2015): 24–30. https://doi.org/10.1016/j.gde.2015.01.010.
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    • Navis, Adam, and Michel Bagnat. “Loss of cftr function leads to pancreatic destruction in larval zebrafish.” Dev Biol 399, no. 2 (March 15, 2015): 237–48. https://doi.org/10.1016/j.ydbio.2014.12.034.
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    • Marjoram, Lindsay, Ashley Alvers, M Elizabeth Deerhake, Jennifer Bagwell, Jamie Mankiewicz, Jordan L. Cocchiaro, Rebecca W. Beerman, et al. “Epigenetic control of intestinal barrier function and inflammation in zebrafish.” Proc Natl Acad Sci U S A 112, no. 9 (March 3, 2015): 2770–75. https://doi.org/10.1073/pnas.1424089112.
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    • Rodríguez-Fraticelli, Alejo E., Jennifer Bagwell, Minerva Bosch-Fortea, Gaelle Boncompain, Natalia Reglero-Real, Maria J. García-León, Germán Andrés, et al. “Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.” Nat Cell Biol 17, no. 3 (March 2015): 241–50. https://doi.org/10.1038/ncb3106.
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    • Alvers, Ashley L., Sean Ryan, Paul J. Scherz, Jan Huisken, and Michel Bagnat. “Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling.” Development 141, no. 5 (March 2014): 1110–19. https://doi.org/10.1242/dev.100313.
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    • Gray, Ryan S., Thomas P. Wilm, Jeff Smith, Michel Bagnat, Rodney M. Dale, Jacek Topczewski, Stephen L. Johnson, and Lilianna Solnica-Krezel. “Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations.” Dev Biol 386, no. 1 (February 1, 2014): 72–85. https://doi.org/10.1016/j.ydbio.2013.11.028.
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    • Antonny, Bruno, Jon Audhya, Michel l Bagnat, Julia von Blume, John A. G. Briggs, Claudio Giraudo, Pascal S. Kaeser, et al. “Directing traffic into the future.” Developmental Cell 27, no. 5 (December 2013): 480–84. https://doi.org/10.1016/j.devcel.2013.11.017.
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    • Ryan, Sean, Jason Willer, Lindsay Marjoram, Jennifer Bagwell, Jamie Mankiewicz, Ignaty Leshchiner, Wolfram Goessling, Michel Bagnat, and Nicholas Katsanis. “Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish.” Development 140, no. 21 (November 2013): 4445–51. https://doi.org/10.1242/dev.101170.
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    • Ellis, Kathryn, Brenton D. Hoffman, and Michel Bagnat. “The vacuole within: how cellular organization dictates notochord function.” Bioarchitecture 3, no. 3 (May 2013): 64–68. https://doi.org/10.4161/bioa.25503.
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    • Navis, Adam, Lindsay Marjoram, and Michel Bagnat. “Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.” Development 140, no. 8 (April 2013): 1703–12. https://doi.org/10.1242/dev.091819.
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    • Ellis, Kathryn, Jennifer Bagwell, and Michel Bagnat. “Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis.” J Cell Biol 200, no. 5 (March 4, 2013): 667–79. https://doi.org/10.1083/jcb.201212095.
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    • Marjoram, L. T., and M. Bagnat. “IDENTIFICATION OF CFTR AND FLUID SECRETION REGULATORS IN ZEBRAFISH.” Pediatric Pulmonology 47 (September 1, 2012): 282–282.
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    • Navis, A., and M. Bagnat. “CFTR IS REQUIRED DURING DEVELOPMENT OF THE ZEBRAFISH LIVER AND PANCREAS.” Pediatric Pulmonology 47 (September 1, 2012): 288–288.
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    • Cheung, Isla D., Michel Bagnat, Taylur P. Ma, Anirban Datta, Kimberley Evason, John C. Moore, Nathan D. Lawson, Keith E. Mostov, Cecilia B. Moens, and Didier Y. R. Stainier. “Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.” Dev Biol 361, no. 1 (January 1, 2012): 68–78. https://doi.org/10.1016/j.ydbio.2011.10.004.
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    • Kanther, Michelle, Xiaolun Sun, Marcus Mühlbauer, Lantz C. Mackey, Edward J. Flynn, Michel Bagnat, Christian Jobin, and John F. Rawls. “Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract.” Gastroenterology 141, no. 1 (July 2011): 197–207. https://doi.org/10.1053/j.gastro.2011.03.042.
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    • Bagnat, M., A. Navis, S. Herbstreith, K. Brand-Arzamendi, S. Curado, S. Gabriel, K. Mostov, J. Huisken, and D. Y. R. Stainier. “Erratum: Cse1l is a negative regulator of CFTR-dependent fluid secretion (Current Biology (2010) 20 (1840-1845)).” Current Biology 20, no. 23 (December 7, 2010): 2157. https://doi.org/10.1016/j.cub.2010.11.031.
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    • Bagnat, Michel, Adam Navis, Sara Herbstreith, Koroboshka Brand-Arzamendi, Silvia Curado, Sherif Gabriel, Keith Mostov, Jan Huisken, and Didier Y. R. Stainier. “Cse1l is a negative regulator of CFTR-dependent fluid secretion.” Curr Biol 20, no. 20 (October 26, 2010): 1840–45. https://doi.org/10.1016/j.cub.2010.09.012.
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    • Bagnat, M., J. Huisken, S. Herbstreith, K. Brand-Arzamendi, S. Curado, and D. Y. Satinier. “IDENTIFICATION OF THREE CFTR REGULATORS USING FORWARD GENETICS IN ZEBRAFISH.” Pediatric Pulmonology, January 1, 2009, 226–226.
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    • Bagnat, Michel, Isla D. Cheung, Keith E. Mostov, and Didier Y. R. Stainier. “Genetic control of single lumen formation in the zebrafish gut.” Nat Cell Biol 9, no. 8 (August 2007): 954–60. https://doi.org/10.1038/ncb1621.
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    • Proszynski, Tomasz J., Robin Klemm, Michel Bagnat, Katharina Gaus, and Kai Simons. “Plasma membrane polarization during mating in yeast cells.” J Cell Biol 173, no. 6 (June 19, 2006): 861–66. https://doi.org/10.1083/jcb.200602007.
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    • Proszynski, Tomasz J., Robin W. Klemm, Maike Gravert, Peggy P. Hsu, Yvonne Gloor, Jan Wagner, Karol Kozak, et al. “A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast.” Proc Natl Acad Sci U S A 102, no. 50 (December 13, 2005): 17981–86. https://doi.org/10.1073/pnas.0509107102.
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    • Proszynski, Tomasz J., Kai Simons, and Michel Bagnat. “O-glycosylation as a sorting determinant for cell surface delivery in yeast.” Mol Biol Cell 15, no. 4 (April 2004): 1533–43. https://doi.org/10.1091/mbc.e03-07-0511.
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    • Lommel, Mark, Michel Bagnat, and Sabine Strahl. “Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants.” Mol Cell Biol 24, no. 1 (January 2004): 46–57. https://doi.org/10.1128/MCB.24.1.46-57.2004.
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    • Balguerie, Axelle, Michel Bagnat, Marc Bonneu, Michel Aigle, and Annick M. Breton. “Rvs161p and sphingolipids are required for actin repolarization following salt stress.” Eukaryot Cell 1, no. 6 (December 2002): 1021–31. https://doi.org/10.1128/EC.1.6.1021-1031.2002.
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    • Bagnat, Michel, and Kai Simons. “Cell surface polarization during yeast mating.” Proc Natl Acad Sci U S A 99, no. 22 (October 29, 2002): 14183–88. https://doi.org/10.1073/pnas.172517799.
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    • Bagnat, Michel, and Kai Simons. “Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae.” Biol Chem 383, no. 10 (October 2002): 1475–80. https://doi.org/10.1515/BC.2002.169.
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    • Bagnat, M., A. Chang, and K. Simons. “Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast.” Mol Biol Cell 12, no. 12 (December 2001): 4129–38. https://doi.org/10.1091/mbc.12.12.4129.
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    • BAGNAT, M. “Plasma membrane proton ATPase Pmalp requires raft association for surface delivery in yeast.” Mol. Biol. Cell. 12 (2001): 4129–38.
    • Bagnat, M., S. Keränen, A. Shevchenko, and K. Simons. “Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast.” Proc Natl Acad Sci U S A 97, no. 7 (March 28, 2000): 3254–59. https://doi.org/10.1073/pnas.060034697.
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    • Moreno, F. J., M. Bagnat, F. Lim, and J. Avila. “OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding.” Eur J Biochem 262, no. 2 (June 1999): 557–62. https://doi.org/10.1046/j.1432-1327.1999.00408.x.
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  • Book Sections

    • Bagnat, M., and A. Navis. “Apicobasal polarity and lumen formation during development.” In Cell Polarity 2: Role in Development and Disease, 67–93, 2015. https://doi.org/10.1007/978-3-319-14466-5_3.
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  • Conference Papers

    • Laselva, O., M. Bagnat, and C. E. Bear. “STUDYING THE DISTINCT SENSITIVITIES OF CFTR MODULATORS USING ZEBRAFISH-CFTR.” In Pediatric Pulmonology, 52:S225–S225. WILEY, 2017.
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    • Garcia, J. N., J. Bagwell, B. Njaine, J. Norman, D. Levic, S. Wopat, S. Miller, et al. “Sheath Cell Invasion and Trans-differentiation Repair Mechanical Damage Caused by Loss of Caveolae in the Zebrafish Notochord.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
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    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.
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    • Trinh, Le A., Eun Koo, Vikas Trivedi, Michel Bagnat, and Scott E. Fraser. “Molecular asymmetries in actin dynamics drive left-right organogenesis.” In Faseb Journal, Vol. 30, 2016.
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    • Cocchiaro, Jordan L., Adam Navis, Michel Bagnat, and John F. Rawls. “Zebrafish as a model to analyze macromolecule absorption in intestinal enterocytes.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
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    • Bagnat, Michel. “USING ZEBRAFISH GENETICS TO UNDERSTAND CFTR FUNCTION & REGULATION DURING DEVELOPMENT.” In Pediatric Pulmonology, 47:140–41. WILEY-BLACKWELL, 2012.
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    • Alvers, A., and M. Bagnat. “Investigating the process of single lumen formation in the zebrafish gut.” In Molecular Biology of the Cell, Vol. 22. AMER SOC CELL BIOLOGY, 2011.
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    • Bagnat, M. “A FORWARD GENETICS APPROACH FOR FISHING NEW REGULATORS OF CFTR AND FLUID SECRETION.” In Pediatric Pulmonology, 270–270. WILEY-BLACKWELL, 2011.
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    • Navis, A., and M. Bagnat. “CFTR FUNCTIONS DURING ZEBRAFISH ORGANOGENESIS.” In Pediatric Pulmonology, 274–75. WILEY-BLACKWELL, 2011.
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    • Navis, A., and M. Bagnat. “USING ZEBRAFISH TO STUDY THE ROLE OF CFTR IN ORGANOGENESIS.” In Pediatric Pulmonology, 284–85. WILEY-LISS, 2009.
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    • Bagnat, M., and D. Y. Stainier. “Genetic control of CFTR function in zebrafish.” In Pediatric Pulmonology, 280–280. WILEY-LISS, 2007.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOLOGY 791T: Tutorial 2022
  • CELLBIO 493: Research Independent Study 2022
  • CMB 720: Modern Techniques in Cell and Molecular Biology 2022
  • CELLBIO 493: Research Independent Study 2021
  • CELLBIO 493: Research Independent Study 2020

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