William Curtis Eward | Scholars@Duke

William Curtis Eward
Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery

I am an Orthopaedic Oncologist, with dual clinical degrees (MD and DVM). I treat complex sarcomas in people and animals. My laboratory studies comparative oncology - discoveries we can make about cancer by analyses across different species.

Office Hours

Although I am always happy for people to drop by, my office hours vary by week. Please email me at w.eward@alumni.duke.edu.

Current Appointments & Affiliations

Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2022
Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2019
Associate Professor of Pathology, Pathology, Clinical Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

Box 3312 DUMC, Durham, NC 27710
Dept. of Orthopaedic Surgery, Durham, NC 27710
william.eward@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- M.D., University of Vermont, College of Medicine 2006
Previous Appointments & Affiliations
- Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2012 - 2019
Recognition
In the News
- JAN 13, 2020 Duke Cancer Institute
  
  What Cancer Researchers Are Learning in Helping Our Best Friends
- APR 1, 2016 JAMA: The Journal of the American Medical Association
  
  Researchers turn to canine clinical trials to advance cancer therapies
- DEC 13, 2015 Duke Today
  
  Cancer Treatments from Our Best Friends
- OCT 14, 2013 News & Observer
  
  Tar Heel of the Week: Dr. Will Eward fights cancer -- for canines and humans
Awards & Honors
- Hyundai Hope on Wheels. Hyundai Hope on Wheels. 2017
Research
Selected Grants
- SCH: Overcoming the Intraoperative Data Desert: Biophotonics, Advanced Sensing, and Control for Automated Surgery awarded by National Institutes of Health 2020 - 2024
- Phase 1 Study of X-PACT (X-ray Psoralen Activated Cancer Therapy) awarded by Immunolight, LLC 2021 - 2024
- Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids awarded by Hyundai Hope on Wheels 2021 - 2023
- Development and validation of anti-canine reagents to enable pre-clinical development of novel therapeutics awarded by AvantGen, Inc. 2020 - 2023
- Investigating the abscopal effect of Immunolight in murine models of melanoma and soft tissue sarcoma in vivo. awarded by Immunolight, LLC 2021 - 2023
- Identifying novel CRM1 inhibitor combination therapies to treat sarcomas awarded by Karyopharm Therapeutics 2021 - 2023
- Development of an Agent Based Statistical Model to Estimate the Economic Impact of Perioperative Orthopaedic Surgery Complication in the United States awarded by Piedmont Orthopedic Foundation 2022
- Utilizing intranasal immunization to induce a cytotoxic T lymphocyte response and reduce metastatic burden in the lung awarded by National Institutes of Health 2020 - 2021
- Fresh Tissue Lab awarded by Integrum, Inc 2021
- A Prospective Observational Study of Intraoperative Angiography for Predicting Wound Complications in Irradiated Soft Tissue Sarcoma of the Extremities awarded by Piedmont Orthopedic Foundation 2020 - 2021
- Bortezomib: A novel treatment to improve outcomes in dogs with osteosarcoma awarded by Orthopaedic Research and Education Foundation 2018 - 2019
- Intraoperative detection and ablation of microscopic residual cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2016
- Engineered imaging nanoparticles for real-time detection of cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2015
- Intraoperative detection and ablation of microscopic residual cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2014
External Relationships
- restor3D
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bray, Jonathan, Will Eward, and Matthew Breen. “Evaluating the relevance of surgical margins. Part one: The problems with current methodology.” Vet Comp Oncol 21, no. 1 (March 2023): 1–11. https://doi.org/10.1111/vco.12865.
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  - Bray, Jonathan, Will Eward, and Matthew Breen. “Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk.” Vet Comp Oncol, February 6, 2023. https://doi.org/10.1111/vco.12881.
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  - Karasik, R., N. E. Lauer, A. E. Baker, N. E. Lisi, J. A. Somarelli, W. C. Eward, K. Fürst, and M. M. Dunphy-Daly. “Inequitable distribution of plastic benefits and burdens on economies and public health.” Frontiers in Marine Science 9 (January 10, 2023). https://doi.org/10.3389/fmars.2022.1017247.
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  - Sag, Alan A., Richard F. Riedel, William C. Eward, Julia D. Visgauss, and Brian E. Brigman. “Hydropneumodissection-Assisted Cryoablation of Recurrent Sarcoma Adjacent to the Sciatic Nerve as a Limb-Sparing Alternative to Hindquarter Amputation.” J Vasc Interv Radiol, December 27, 2022. https://doi.org/10.1016/j.jvir.2022.12.469.
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  - Sag, Alan A., William A. L. Sperduto, William Eward, James Ronald, Haley Davis, Xiaoyin Sara Jiang, David S. Enterline, et al. “Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.” J Vasc Interv Radiol 33, no. 12 (December 2022): 1594–1600. https://doi.org/10.1016/j.jvir.2022.08.019.
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  - Diana, Z., R. Karasik, G. B. Merrill, M. Morrison, K. A. Corcoran, D. Vermeer, E. Hepler-Smith, et al. “A transdisciplinary approach to reducing global plastic pollution.” Frontiers in Marine Science 9 (October 28, 2022). https://doi.org/10.3389/fmars.2022.1032381.
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  - Byers, Isabelle S., Nicholas A. Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojevic, Ping Fan, et al. “Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.” Antimicrob Agents Chemother 66, no. 10 (October 18, 2022): e0014022. https://doi.org/10.1128/aac.00140-22.
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  - Lazarides, Alexander L., Eliana B. Saltzman, Julia D. Visgauss, Suhail K. Mithani, William C. Eward, and Brian E. Brigman. “Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.” J Orthop Res 40, no. 10 (October 2022): 2382–90. https://doi.org/10.1002/jor.25270.
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  - Bartholf DeWitt, Suzanne, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E. J. Martz, Maryam Zand, Vardhman Kumar, et al. “Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.” Jci Insight 7, no. 17 (September 8, 2022). https://doi.org/10.1172/jci.insight.151583.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Niall Cochrane, Junheng Gao, Sin-Ho Jung, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.” J Surg Oncol 126, no. 2 (August 2022): 356–64. https://doi.org/10.1002/jso.26864.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Corrigendum to 'Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?' [The Journal of Arthroplasty 37 (2022) 232-237].” J Arthroplasty 37, no. 6 (June 2022): 1212. https://doi.org/10.1016/j.arth.2022.01.041.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1392–1408. https://doi.org/10.1245/s10434-021-10802-8.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1411–12. https://doi.org/10.1245/s10434-021-10892-4.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark C. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?” J Arthroplasty 37, no. 2 (February 2022): 232–37. https://doi.org/10.1016/j.arth.2021.10.019.
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  - Lazarides, Alexander L., Jason A. Somarelli, Brian E. Brigman, Julia D. Visgauss, and William C. Eward. “ASO Author Reflections: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma.” Ann Surg Oncol 29, no. 2 (February 2022): 1409–10. https://doi.org/10.1245/s10434-021-10904-3.
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  - Gunady, Ella F., Kathryn E. Ware, Sarah Hoskinson Plumlee, Nicolas Devos, David Corcoran, Joseph Prinz, Hrvoje Misetic, et al. “Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study.” Evol Med Public Health 10, no. 1 (2022): 221–30. https://doi.org/10.1093/emph/eoac016.
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  - Rao, Sneha R., Alexander L. Lazarides, Bruce L. Leckey, Whitney O. Lane, Julia D. Visgauss, Jason A. Somarelli, David G. Kirsch, et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.” Cancer Med 11, no. 1 (January 2022): 194–206. https://doi.org/10.1002/cam4.4428.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia Dawn Visgauss, Jason A. Somarelli, Dan Blazer, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma-A National Cancer Database Study.” Ann Surg Oncol 28, no. Suppl 3 (December 2021): 449–50. https://doi.org/10.1245/s10434-021-10131-w.
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  - Gilpin, Anna, Yuze Zeng, Jiaul Hoque, Ji Hyun Ryu, Yong Yang, Stefan Zauscher, William Eward, and Shyni Varghese. “Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.” Adv Healthc Mater 10, no. 23 (December 2021): e2100777. https://doi.org/10.1002/adhm.202100777.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.” Ann Surg Oncol 28, no. 12 (November 2021): 7961–72. https://doi.org/10.1245/s10434-021-10099-7.
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  - Ferlauto, Harrison R., John R. Wickman, Alexander L. Lazarides, Stephanie Hendren, Julia D. Visgauss, Brian E. Brigman, Oke A. Anakwenze, Christopher S. Klifto, and William C. Eward. “Reverse total shoulder arthroplasty for oncologic reconstruction of the proximal humerus: a systematic review.” J Shoulder Elbow Surg 30, no. 11 (November 2021): e647–58. https://doi.org/10.1016/j.jse.2021.06.004.
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  - Visgauss, Julia D., Alexander Lazarides, Brendan Dickson, Diana Cardona, Maya Sheth, Suzanne Bartholf DeWitt, Jason A. Somarelli, and William C. Eward. “Treatment of Chondroblastoma with Denosumab: A Case Report with a Correlative Analysis of Effect on the RANK Signaling Pathway.” Jbjs Case Connect 11, no. 2 (May 17, 2021). https://doi.org/10.2106/JBJS.CC.20.00178.
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  - Cullen, Mark M., Ebubechi Okwumabua, Etienne M. Flamant, Harrison R. Ferlauto, Brian E. Brigman, and William C. Eward. “Humeral Shaft Fracture With Placement of an Intramedullary Nail Through an Unrecognized Sarcoma.” J Am Acad Orthop Surg Glob Res Rev 5, no. 2 (February 19, 2021). https://doi.org/10.5435/JAAOSGlobal-D-20-00142.
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  - Kahokehr, Arman A., William R. Boysen, Michael H. Schild, Brent D. Nosé, Jiaoti Huang, Will Eward, and Andrew C. Peterson. “Urinary Pubic Symphysis Fistula Leads to Histopathologic Osteomyelitis in Prostate Cancer Survivors.” Urology 148 (February 2021): 297–301. https://doi.org/10.1016/j.urology.2020.07.038.
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  - Dayanidhi, D. L., B. C. Thomas, J. S. Osterberg, M. Vuong, G. Vargas, S. K. Kwartler, E. Schmaltz, et al. “Exploring the Diversity of the Marine Environment for New Anti-cancer Compounds.” Frontiers in Marine Science 7 (January 21, 2021). https://doi.org/10.3389/fmars.2020.614766.
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  - Allen, Tyler A., Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, et al. “A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation.” Front Oncol 11 (2021): 641187. https://doi.org/10.3389/fonc.2021.641187.
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  - Blawas, Ashley M., Kathryn E. Ware, Emma Schmaltz, Larry Zheng, Jacob Spruance, Austin S. Allen, Nicole West, et al. “An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.” Evol Med Public Health 9, no. 1 (2021): 420–30. https://doi.org/10.1093/emph/eoab036.
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  - Lazarides, Alexander L., Harrison R. Ferlauto, Zachary D. C. Burke, Anthony M. Griffin, Bruce D. Leckey, Nicholas M. Bernthal, Jay S. Wunder, et al. “The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors.” Sarcoma 2021 (2021): 4740924. https://doi.org/10.1155/2021/4740924.
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  - Elliott, Sean P. “Re: Magnetic Resonance Imaging Features of Pubic Symphysis Urinary Fistula with Pubic Bone Osteomyelitis in the Treated Prostate Cancer Patient.” J Urol 204, no. 6 (December 2020): 1372–73. https://doi.org/10.1097/JU.0000000000001279.01.
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  - Somarelli, Jason A., Gabrielle Rupprecht, Erdem Altunel, Etienne M. Flamant, Sneha Rao, Dharshan Sivaraj, Alexander L. Lazarides, et al. “A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma.” Cancers (Basel) 12, no. 11 (November 11, 2020). https://doi.org/10.3390/cancers12113335.
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  - Evans, Daniel R., Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.” Bmc Cancer 20, no. 1 (October 14, 2020): 995. https://doi.org/10.1186/s12885-020-07502-z.
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  - Lazarides, Alexander L., Marcelo Cerullo, Dimitrios Moris, Brian E. Brigman, Dan G. Blazer, and William C. Eward. “Defining a textbook surgical outcome for patients undergoing surgical resection of intermediate and high-grade soft tissue sarcomas of the extremities.” J Surg Oncol 122, no. 5 (October 2020): 884–96. https://doi.org/10.1002/jso.26087.
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  - Dodd, Rebecca D., Amanda Scherer, Wesley Huang, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Kathleen A. Ashcraft, et al. “Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.” Clin Cancer Res 26, no. 18 (September 15, 2020): 5036–47. https://doi.org/10.1158/1078-0432.CCR-19-2597.
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  - Nosé, Brent D., William R. Boysen, Arman A. Kahokehr, Brian M. Inouye, William C. Eward, Edward F. Hendershot, and Andrew C. Peterson. “Extirpative Cultures Reveal Infectious Pubic Bone Osteomyelitis in Prostate Cancer Survivors With Urinary-Pubic Symphysis Fistulae (UPF).” Urology 142 (August 2020): 221–25. https://doi.org/10.1016/j.urology.2020.04.095.
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  - Lazarides, Alexander L., David L. Kerr, Brian L. Dial, John R. Steele, Whitney O. Lane, Dan G. Blazer, Brian E. Brigman, Sergio Mendoza-Lattes, Melissa M. Erickson, and William C. Eward. “Does facility volume influence survival in patients with primary malignant bone tumors of the vertebral column? A comparative cohort study.” Spine J 20, no. 7 (July 2020): 1106–13. https://doi.org/10.1016/j.spinee.2020.02.020.
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  - Reddy, Gireesh B., David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham, and William C. Eward. “Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.” Mol Cancer Ther 19, no. 7 (July 2020): 1448–61. https://doi.org/10.1158/1535-7163.MCT-19-0689.
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  - Dial, Brian L., David L. Kerr, Alexander L. Lazarides, Anthony A. Catanzano, Cindy L. Green, Thomas Risoli, Dan G. Blazer, et al. “The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.” Spine (Phila Pa 1976) 45, no. 12 (June 15, 2020): E742–51. https://doi.org/10.1097/BRS.0000000000003406.
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  - Tuohy, Joanne L., Jason A. Somarelli, Luke B. Borst, William C. Eward, B Duncan X. Lascelles, and Jonathan E. Fogle. “Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.” Vet Comp Oncol 18, no. 1 (March 2020): 64–75. https://doi.org/10.1111/vco.12529.
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  - Somarelli, Jason A., Amy M. Boddy, Heather L. Gardner, Suzanne Bartholf DeWitt, Joanne Tuohy, Kate Megquier, Maya U. Sheth, et al. “Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life.” Mol Biol Evol 37, no. 1 (January 1, 2020): 11–17. https://doi.org/10.1093/molbev/msz254.
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  - Rao, Sneha R., Jason A. Somarelli, Erdem Altunel, Laura E. Selmic, Mark Byrum, Maya U. Sheth, Serene Cheng, et al. “From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.” Front Oncol 10 (2020): 117. https://doi.org/10.3389/fonc.2020.00117.
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  - Zhang, Chenan, Helen M. Hansen, Eleanor C. Semmes, Julio Gonzalez-Maya, Libby Morimoto, Qingyi Wei, William C. Eward, et al. “Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.” Bone 130 (January 2020): 115070. https://doi.org/10.1016/j.bone.2019.115070.
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  - Kerr, David L., Brian L. Dial, Alexander L. Lazarides, Anthony A. Catanzano, Whitney O. Lane, Dan G. Blazer, Brian E. Brigman, Sergio Mendoza-Lattes, William C. Eward, and Melissa E. Erickson. “Epidemiologic and survival trends in adult primary bone tumors of the spine.” Spine J 19, no. 12 (December 2019): 1941–49. https://doi.org/10.1016/j.spinee.2019.07.003.
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  - Sheth, M. U., S. K. Kwartler, E. R. Schmaltz, S. M. Hoskinson, E. J. Martz, M. M. Dunphy-Daly, T. F. Schultz, A. J. Read, W. C. Eward, and J. A. Somarelli. “Bioengineering a Future Free of Marine Plastic Waste.” Frontiers in Marine Science 6 (October 11, 2019). https://doi.org/10.3389/fmars.2019.00624.
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  - Jolly, Mohit Kumar, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, et al. “E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.” Mol Cancer Res 17, no. 6 (June 2019): 1391–1402. https://doi.org/10.1158/1541-7786.MCR-18-0763.
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  - Sexton, Stephanie J., Garjae Lavien, Nicholas Said, William Eward, Andrew C. Peterson, and Rajan T. Gupta. “Magnetic resonance imaging features of pubic symphysis urinary fistula with pubic bone osteomyelitis in the treated prostate cancer patient.” Abdom Radiol (Ny) 44, no. 4 (April 2019): 1453–60. https://doi.org/10.1007/s00261-018-1827-2.
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  - Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.
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  - Xu, Shengnan, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, et al. “An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.” J Clin Med 8, no. 2 (February 7, 2019). https://doi.org/10.3390/jcm8020205.
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  - Kontogeorgakos, Vasileios A., William C. Eward, and Brian E. Brigman. “Microsurgery in musculoskeletal oncology.” Eur J Orthop Surg Traumatol 29, no. 2 (February 2019): 271–78. https://doi.org/10.1007/s00590-019-02373-y.
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  - Batich, Kristen A., Richard F. Riedel, John P. Kirkpatrick, Betty C. Tong, William C. Eward, Char Loo Tan, Patricia D. Pittman, Roger E. McLendon, and Katherine B. Peters. “Recurrent Extradural Myxopapillary Ependymoma With Oligometastatic Spread.” Front Oncol 9 (2019): 1322. https://doi.org/10.3389/fonc.2019.01322.
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  - Catanzano, Anthony A., David L. Kerr, Alexander L. Lazarides, Brian L. Dial, Whitney O. Lane, Dan G. Blazer, Nicole A. Larrier, David G. Kirsch, Brian E. Brigman, and William C. Eward. “Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.” Sarcoma 2019 (2019): 4878512. https://doi.org/10.1155/2019/4878512.
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  - Zhang, Chenan, Libby M. Morimoto, Adam J. de Smith, Helen M. Hansen, Julio Gonzalez-Maya, Alyson A. Endicott, Ivan V. Smirnov, et al. “Genetic determinants of childhood and adult height associated with osteosarcoma risk.” Cancer 124, no. 18 (September 15, 2018): 3742–52. https://doi.org/10.1002/cncr.31645.
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  - O’Connor, S. M., S. E. Wobker, D. M. Cardona, W. Eward, R. J. Esther, and L. G. Dodd. “Iatrogenic lesions of soft tissue and bone.” Semin Diagn Pathol 35, no. 4 (July 2018): 208–17. https://doi.org/10.1053/j.semdp.2017.09.003.
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  - Suresh, Visakha, Junheng Gao, Sin-Ho Jung, Brian Brigman, William Eward, and Detlev Erdmann. “The Role of Reconstructive Surgery After Skeletal and Soft Tissue Sarcoma Resection.” Ann Plast Surg 80, no. 6S Suppl 6 (June 2018): S372–76. https://doi.org/10.1097/SAP.0000000000001419.
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  - Lazarides, Alexander L., Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.” Bmc Cancer 18, no. 1 (April 27, 2018): 488. https://doi.org/10.1186/s12885-018-4397-3.
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  - Ryan, Sean, Julia Visgauss, David Kerr, Joshua Helmkamp, Nicholas Said, Emily Vinson, Patrick O’Donnell, et al. “The Value of MRI in Distinguishing Subtypes of Lipomatous Extremity Tumors Needs Reassessment in the Era of MDM2 and CDK4 Testing.” Sarcoma 2018 (2018): 1901896. https://doi.org/10.1155/2018/1901896.
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  - Scott, Elizabeth, Mitchell R. Klement, Brian E. Brigman, and William C. Eward. “Beyond Mirels: Factors Influencing Surgical Outcome of Metastasis to the Extremities in the Modern Era.” J Surg Orthop Adv 27, no. 3 (2018): 178–86.
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  - Eward, William C., Alexander L. Lazarides, Anthony M. Griffin, Patrick W. O’Donnell, Amir Sternheim, Anne O’Neill, Stefan O. Hofer, Peter C. Ferguson, and Jay S. Wunder. “Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction following Resection.” Plast Reconstr Surg Glob Open 5, no. 11 (November 2017): e1553. https://doi.org/10.1097/GOX.0000000000001553.
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  - Dodd, Rebecca D., Chang-Lung Lee, Tess Overton, Wesley Huang, William C. Eward, Lixia Luo, Yan Ma, et al. “NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.” Cancer Res 77, no. 16 (August 15, 2017): 4486–97. https://doi.org/10.1158/0008-5472.CAN-16-2643.
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  - Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.” Nat Commun 8 (July 10, 2017): 15999. https://doi.org/10.1038/ncomms15999.
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  - Grimm, Nathan L., David M. Tainter, William C. Eward, and Brian E. Brigman. “Tumors of the Epiphyses.” Jbjs Rev 5, no. 5 (May 2017): e4. https://doi.org/10.2106/JBJS.RVW.16.00080.
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  - Shammas, Ronnie L., Yash J. Avashia, Alfredo E. Farjat, Anthony A. Catanzano, L Scott Levin, William C. Eward, Brian E. Brigman, and Detlev Erdmann. “Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications.” Plast Reconstr Surg Glob Open 5, no. 5 (May 2017): e1352. https://doi.org/10.1097/GOX.0000000000001352.
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  - Ware, Kathryn E., Shivee Gilja, Shenghan Xu, Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, et al. “Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.” J Vis Exp, no. 122 (April 7, 2017). https://doi.org/10.3791/55520.
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  - Henderson, E. R., B. J. Keeney, E. Pala, P. T. Funovics, W. C. Eward, J. S. Groundland, L. K. Ehrlichman, et al. “The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.” Bone Joint J 99-B, no. 4 (April 2017): 531–37. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-0960.R1.
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  - Ryan, Sean, William Eward, Brian Brigman, and Robert Zura. “Chronic Osteomyelitis of the Distal Femur Treated with Resection and Delayed Endoprosthetic Reconstruction: A Report of Three Cases.” Case Rep Orthop 2017 (2017): 5141032. https://doi.org/10.1155/2017/5141032.
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  - Somarelli, Jason A., Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J. Hish, Shivee Gilja, et al. “Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.” Mol Cell Biol 36, no. 19 (October 1, 2016): 2503–13. https://doi.org/10.1128/MCB.00373-16.
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  - Lazarides, Alexander L., Elizabeth J. Scott, Diana M. Cardona, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature.” J Gastrointest Cancer 47, no. 3 (September 2016): 331–35. https://doi.org/10.1007/s12029-015-9749-5.
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  - Bartholf DeWitt, Suzanne, William C. Eward, Cindy A. Eward, Alexander L. Lazarides, Melodi Javid Whitley, Jorge M. Ferrer, Brian E. Brigman, David G. Kirsch, and John Berg. “A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.” Vet Surg 45, no. 6 (August 2016): 715–22. https://doi.org/10.1111/vsu.12487.
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  - Neumann, Julie A., Grant E. Garrigues, Brian E. Brigman, and William C. Eward. “Synovial Chondromatosis.” Jbjs Rev 4, no. 5 (May 10, 2016). https://doi.org/10.2106/JBJS.RVW.O.00054.
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  - Dodd, R. D., M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, and D. G. Kirsch. “Myogenic transcription factors regulate pro-metastatic miR-182.” Oncogene 35, no. 14 (April 7, 2016): 1868–75. https://doi.org/10.1038/onc.2015.252.
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  - Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
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  - Lazarides, Alexander L., Melodi J. Whitley, David B. Strasfeld, Diana M. Cardona, Jorge M. Ferrer, Jenna L. Mueller, Henry L. Fu, et al. “A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.” Theranostics 6, no. 2 (2016): 155–66. https://doi.org/10.7150/thno.13536.
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  - Visgauss, Julia D., William C. Eward, and Brian E. Brigman. “Innovations in Intraoperative Tumor Visualization.” Orthop Clin North Am 47, no. 1 (January 2016): 253–64. https://doi.org/10.1016/j.ocl.2015.08.023.
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  - Barquet, A., E. Barrios, M. Garau, R. D. Zura, and W. C. Eward. “Epidemiology and Diagnosis of Ipsilateral Femoral Neck and Shaft Fractures: A Systematic Review of 1761 cases in 1758 Patients (1990-2015).” Trauma Cases and Reviews 1, no. 015 (November 14, 2015): 1–7.
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  - Hou, Chun-Han, Alexander L. Lazarides, Paul J. Speicher, Daniel P. Nussbaum, Daniel G. Blazer, David G. Kirsch, Brian E. Brigman, and William C. Eward. “The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.” Ann Surg Oncol 22, no. 9 (September 2015): 2831–38. https://doi.org/10.1245/s10434-015-4639-4.
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  - Lazarides, Alexander L., William C. Eward, Kimberly Green, Diana M. Cardona, Brian E. Brigman, and Dean C. Taylor. “Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy.” Am J Sports Med 43, no. 8 (August 2015): 1935–40. https://doi.org/10.1177/0363546515584040.
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  - Vikingstad, Eric M., Gustaaf G. de Ridder, Richard R. Glisson, Diana M. Cardona, Devon DiPalma, William C. Eward, Brian E. Brigman, Rendon C. Nelson, and Charles Y. Kim. “Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model.” J Vasc Interv Radiol 26, no. 8 (August 2015): 1221-1228.e1. https://doi.org/10.1016/j.jvir.2015.04.013.
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  - White, Sarah, Cathy Vaughan, Doug Raiff, William Eward, and Michael Bolognesi. “Impact of liposomal bupivacaine administration on postoperative pain in patients undergoing total knee replacement.” Pharmacotherapy 35, no. 5 (May 2015): 477–81. https://doi.org/10.1002/phar.1587.
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  - Lazarides, Alexander L., William C. Eward, Paul J. Speicher, Chun-Han Hou, Daniel P. Nussbaum, Cindy Green, Dan G. Blazer, David G. Kirsch, and Brian E. Brigman. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.” Sarcoma 2015 (2015): 186581. https://doi.org/10.1155/2015/186581.
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  - Eward, William C., Suzanne B. DeWitt, Brian E. Brigman, Vasilios Kontogeorgakos, and Anand S. Lagoo. “Extranodal Castleman disease of the extremities: a case report and review of the literature.” Skeletal Radiol 43, no. 11 (November 2014): 1627–31. https://doi.org/10.1007/s00256-014-1945-z.
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  - Lazarides, Alexander, Detlev Erdmann, David Powers, and William Eward. “Custom facial reconstruction for osteosarcoma of the jaw.” J Oral Maxillofac Surg 72, no. 11 (November 2014): 2375.e1-2375.10. https://doi.org/10.1016/j.joms.2014.07.018.
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  - O’Donnell, Patrick W., Anthony M. Griffin, William C. Eward, Amir Sternheim, Charles N. Catton, Peter W. Chung, Brian O’Sullivan, Peter C. Ferguson, and Jay S. Wunder. “The effect of the setting of a positive surgical margin in soft tissue sarcoma.” Cancer 120, no. 18 (September 15, 2014): 2866–75. https://doi.org/10.1002/cncr.28793.
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  - O’Donnell, Patrick W., Anthony M. Griffin, William C. Eward, Amir Sternheim, Jay S. Wunder, and Peter C. Ferguson. “Early follow-up of a custom non-fluted diaphyseal press-fit tumour prosthesis.” Int Orthop 38, no. 1 (January 2014): 123–27. https://doi.org/10.1007/s00264-013-2078-z.
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  - Ledford, Cameron K., Nicole A. Zelenski, Diana M. Cardona, Brian E. Brigman, and William C. Eward. “The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?” Clin Orthop Relat Res 471, no. 11 (November 2013): 3618–25. https://doi.org/10.1007/s11999-013-3178-1.
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  - Dodd, Rebecca D., Jeffrey K. Mito, William C. Eward, Rhea Chitalia, Mohit Sachdeva, Yan Ma, Jordi Barretina, Leslie Dodd, and David G. Kirsch. “NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.” Mol Cancer Ther 12, no. 9 (September 2013): 1906–17. https://doi.org/10.1158/1535-7163.MCT-13-0189.
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  - Sternheim, A., K. Saidi, J. Lochab, P. W. O’Donnell, W. C. Eward, A. Griffin, J. S. Wunder, and P. Ferguson. “Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure.” Bone Joint J 95-B, no. 8 (August 2013): 1144–48. https://doi.org/10.1302/0301-620X.95B8.31832.
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  - Mata, Brian A., William C. Eward, and Brian E. Brigman. “Pancarpal synovial and tenosynovial chondromatosis in a 65-year-old man: a highly unusual presentation of a common condition.” Am J Orthop (Belle Mead Nj) 42, no. 8 (August 2013): E60–63.
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  - Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
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  - Eward, William C., Jeffrey K. Mito, Cindy A. Eward, Jessica E. Carter, Jorge M. Ferrer, David G. Kirsch, and Brian E. Brigman. “A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.” Clin Orthop Relat Res 471, no. 3 (March 2013): 834–42. https://doi.org/10.1007/s11999-012-2560-8.
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  - Nousiainen, Markku T., Daniel M. Omoto, Patrick O. Zingg, Yoram A. Weil, Sami W. Mardam-Bey, and William C. Eward. “Training femoral neck screw insertion skills to surgical trainees: computer-assisted surgery versus conventional fluoroscopic technique.” J Orthop Trauma 27, no. 2 (February 2013): 87–92. https://doi.org/10.1097/BOT.0b013e3182604b49.
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  - O’Donnell, Patrick W., Anthony M. Griffin, William C. Eward, Amir Sternheim, Lawrence M. White, Jay S. Wunder, and Peter C. Ferguson. “Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI?” Sarcoma 2013 (2013): 982784. https://doi.org/10.1155/2013/982784.
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  - Zelenski, Nicki, Brian E. Brigman, L Scott Levin, Detlev Erdmann, and William C. Eward. “The vascularized fibular graft in the pediatric upper extremity: a durable, biological solution to large oncologic defects.” Sarcoma 2013 (2013): 321201. https://doi.org/10.1155/2013/321201.
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  - Mito, Jeffrey K., Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, et al. “Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.” Cancer 118, no. 21 (November 1, 2012): 5320–30. https://doi.org/10.1002/cncr.27458.
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  - Eward, William C., Craig A. Rineer, James R. Urbaniak, Marc J. Richard, and David S. Ruch. “The vascularized fibular graft in precollapse osteonecrosis: is long-term hip preservation possible?” Clin Orthop Relat Res 470, no. 10 (October 2012): 2819–26. https://doi.org/10.1007/s11999-012-2429-x.
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  - Vasileios, Kontogeorgakos A., William C. Eward, and Brian E. Brigman. “Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities.” Arch Orthop Trauma Surg 132, no. 7 (July 2012): 955–61. https://doi.org/10.1007/s00402-012-1510-y.
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  - Kokosis, G., J. Stolberg-Stolberg, W. C. Eward, M. J. Richard, S. T. Hollenbeck, H. Levinson, B. E. Brigman, and D. Erdmann. “[Femur reconstruction using combined autologous fibula transfer and humeral allograft].” Chirurg 82, no. 12 (December 2011): 1120–23. https://doi.org/10.1007/s00104-011-2165-x.
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  - Cuneo, K. C., J. K. Mito, B. E. Brigman, J. M. Ferrer, C. Lee, W. C. Eward, J. E. Carter, and D. G. Kirsch. “Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S729–30. https://doi.org/10.1016/j.ijrobp.2011.06.1300.
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  - Dodd, Rebecca D., Jeff Mito, Brian Brigman, Will Eward, Leslie Dodd, Sayan Mukherjee, and David Krisch. “Dissecting mechanisms of metastasis using a mouse model of cancer.” Clinical & Experimental Metastasis 28, no. 2 (February 1, 2011): 166–166.
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  - Mito, Jeffrey K., Rebecca D. Dodd, Brian E. Brigman, Zhizhong Li, William C. Eward, Sayan Mukherjee, and David Kirsch. “Dissecting molecular mechanisms of metastasis in a primary mouse model of soft tissue sarcoma.” Clinical & Experimental Metastasis 28, no. 2 (February 1, 2011): 166–67.
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  - Eward, William C., Dennis Darcey, Leslie G. Dodd, and Robert D. Zura. “Case report: lead toxicity associated with an extra-articular retained missile 14 years after injury.” J Surg Orthop Adv 20, no. 4 (2011): 241–46.
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  - Watters, Tyler Steven, William C. Eward, Rhett K. Hallows, Leslie G. Dodd, Samuel S. Wellman, and Michael P. Bolognesi. “Pseudotumor with superimposed periprosthetic infection following metal-on-metal total hip arthroplasty: a case report.” J Bone Joint Surg Am 92, no. 7 (July 7, 2010): 1666–69. https://doi.org/10.2106/JBJS.I.01208.
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  - Eward, William C., Vasileios Kontogeorgakos, Lawrence Scott Levin, and Brian E. Brigman. “Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection.” Clin Orthop Relat Res 468, no. 2 (February 2010): 590–98. https://doi.org/10.1007/s11999-009-1053-x.
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  - Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” Plos One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.
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  - Craig, Alexa, Beth Cronin, William Eward, James Metz, Logan Murray, Gail Rose, Eric Suess, and Maria E. Vergara. “Attitudes toward physician-assisted suicide among physicians in Vermont.” J Med Ethics 33, no. 7 (July 2007): 400–403. https://doi.org/10.1136/jme.2006.018713.
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  - Dennis, J. C., J. G. Allgier, L. S. Desouza, W. C. Eward, and E. E. Morrison. “Immunohistochemistry of the canine vomeronasal organ (vol 202, pg 329, 2003).” Journal of Anatomy 203, no. 3 (September 1, 2003): 345–345.
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  - Dennis, J. C., J. G. Allgier, L. S. Desouza, W. C. Eward, and E. E. Morrison. “Immunohistochemistry of the canine vomeronasal organ.” J Anat 203, no. 3 (September 2003): 329–38. https://doi.org/10.1046/j.1469-7580.2003.00190.x.
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  - Stegenga, S. L., W. Eward, and R. G. Kalb. “Shuttle mission effects on glutamate receptor expression in the developing rodent spinal cord.” Aviat Space Environ Med 74, no. 6 Pt 1 (June 2003): 615–21.
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  - Dennis, J. C., J. G. Allgier, L. S. Desouza, W. C. Eward, and E. E. Morrison. “Immunohistochemistry of the canine vomeronasal organ.” J Anat 202, no. 6 (June 2003): 515–24. https://doi.org/10.1046/j.1469-7580.2003.00190.x.
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  - Eward, C., R. L. Gillette, and W. Eward. “Effects of unilaterally restricted carpal range of motion on kinematic gait analysis of the dog.” Veterinary and Comparative Orthopaedics and Traumatology 16, no. 3 (January 1, 2003): 158–63. https://doi.org/10.1055/s-0038-1632771.
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  - Dial, Brian L., David L. Kerr, Alexander L. Lazarides, Anthony A. Catanzano, Cindy L. Green, Dan G. Blazer, Rory Goodwin, et al. “The Therapeutic Benefit of Radiotherapy for Chordoma Patients with Positive Surgical Margins,” n.d.
- Book Sections
  - Larrier, N., W. C. Eward, and R. F. Riedel. “Bone Sarcomas.” In Cancer Consult: Expertise for Clinical Practice, 687–95, 2014. https://doi.org/10.1002/9781118589199.ch105.
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  - Eward, W. “The vascularized fibular graft in the treatment of osteonecrosis: Data, dogma, and controversies.” In Osteonecrosis, 321–23, 2014. https://doi.org/10.1007/978-3-642-35767-1_44.
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  - Larrier, Nicole, William C. Eward, and Richard F. Riedel. “Bone sarcomas.” In CANCER CONSULT: EXPERTISE FOR CLINICAL PRACTICE, 689–95, 2014.
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- Conference Papers
  - Catanzano, A. A., S. P. Ryan, A. L. Lazarides, B. E. Brigman, and W. C. Eward. “New Techniques for Diagnosis and Treatment of Musculoskeletal Tumors: Methods of Intraoperative Margin Detection.” In Techniques in Orthopaedics, 33:148–57, 2018. https://doi.org/10.1097/BTO.0000000000000290.
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  - Dodd, Rebecca, Chang-Lung Lee, Mary Overton, Wesley Huang, William Eward, Davis Ingram, Diana Cordona, Alexander Lazar, and David Kirsch. “Modeling the tumor microenvironment in sarcoma: The impact on MPNST biology and chemotherapeutic response.” In Clinical Cancer Research, 24:31–31. AMER ASSOC CANCER RESEARCH, 2018.
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  - Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR/Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.” In Clinical Cancer Research, 24:44–45. AMER ASSOC CANCER RESEARCH, 2018.
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  - Huang, Jianguo, Mark Chen, Melodi J. Whitley, Hsuan-Cheng Kuo, Andrea Walens, Yvonne M. Mowery, David V. Mater, et al. “Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice.” In Cancer Research, 77:2810–2810. American Association for Cancer Research (AACR), 2017. https://doi.org/10.1158/1538-7445.am2017-2810.
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  - Whitley, Melodi J., Diana M. Cardona, Dan G. Blazer, Shelley Hwang, Rachel A. Greenup, Paul J. Mosca, Joan Cahill, et al. “Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents.” In Cancer Research, Vol. 75. American Association for Cancer Research (AACR), 2015. https://doi.org/10.1158/1538-7445.am2015-sy36-03.
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  - Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.
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  - Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.
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  - Rebuck, Jill A., William Eward, Marissa Slusarczyk, Benjamin Suratt, James Hebert, and Joe Petty. “LANSOPRAZOLE ATTENUATES NEUTROPHIL-MEDIATED TISSUE DAMAGE OF LIVER FOLLOWING VISCERAL ISCHEMIA-REPERFUSION INJURY IN MICE.” In Critical Care Medicine, 34:A147–A147. Ovid Technologies (Wolters Kluwer Health), 2006. https://doi.org/10.1097/00003246-200612002-00510.
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