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William Curtis Eward

Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery
Orthopaedic Surgery
Box 3312 DUMC, Durham, NC 27710
Dept. of Orthopaedic Surgery, Durham, NC 27710

Overview


I am an Orthopaedic Oncologist, with dual clinical degrees (MD and DVM).  I treat complex sarcomas in people and animals.  My laboratory studies comparative oncology - discoveries we can make about cancer by analyses across different species.

Office Hours


Although I am always happy for people to drop by, my office hours vary by week.  Please email me at w.eward@alumni.duke.edu.

Current Appointments & Affiliations


Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery · 2022 - Present Orthopaedic Surgery, Clinical Science Departments
Associate Professor of Orthopaedic Surgery · 2023 - Present Orthopaedic Surgery, Clinical Science Departments
Associate Professor of Pathology · 2022 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2013 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published February 28, 2025
Bass Connections Team Tackles Microplastics
Published January 13, 2020
What Cancer Researchers Are Learning in Helping Our Best Friends
Published April 1, 2016
Researchers turn to canine clinical trials to advance cancer therapies

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Recent Publications


Hospital, regional, and policy-level variations in shoulder arthroplasty prices: a Nationwide database study.

Journal Article JSES Rev Rep Tech · February 2026 BACKGROUND: Surgical reconstruction via hemiarthroplasty, anatomic total shoulder arthroplasty (aTSA), or reverse total shoulder arthroplasty (rTSA) is a common approach for treatment of various shoulder pathologies. Little is known about variations in neg ... Full text Link to item Cite

Novel niclosamide stearate prodrug therapeutic shows potential efficacy against naturally occurring canine osteosarcoma in a clinical feasibility study.

Journal Article Am J Vet Res · January 1, 2026 OBJECTIVE: To manufacture and characterize a modified niclosamide stearate (NS) prodrug therapeutic (mNSPT) for use in a small clinical trial in a metastatic canine osteosarcoma (OS) model. ANIMALS: 10 dogs that presented for treatment of nondetectable met ... Full text Link to item Cite

The impact of preoperative bone mineral density on outcomes following lower extremity megaprosthetic reconstruction for oncologic resections.

Journal Article Bone · January 2026 BACKGROUND: While megaprosthetic reconstructions have been instrumental in restoring patients' functional abilities, surgeons remain cautious of revision risk. This is the first study to assess the impacts of preoperative bone mineral density (BMD) on outc ... Full text Link to item Cite
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Recent Grants


Does the use of the reamer-irrigator-aspirator (RIA) during prophylactic intramedullary nailing attenuate the rise of circulating tumor cells?

Clinical TrialPrincipal Investigator · Awarded by Medical Device Business Services, Inc. · 2025 - 2030

Boston Children's/UCLA/Duke Next Generation Regeneration for Osteoarthritis (BUD NextGenRegen for OA)

ResearchInvestigator · Awarded by Advanced Research Projects Agency for Health · 2024 - 2029

XPO1 and proteasome inhibition as a novel therapeutic combination in osteosarcoma

ResearchCo Investigator · Awarded by The Paula Takacs Foundation For Sarcoma Research · 2026 - 2027

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Education, Training & Certifications


University of Vermont, College of Medicine · 2006 M.D.