Scholars@Duke
William Curtis Eward

William Curtis Eward

Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery
Orthopaedic Surgery
william.eward@duke.edu
Box 3312 DUMC, Durham, NC 27710
Dept. of Orthopaedic Surgery, Durham, NC 27710
Office hours

Selected Publications

Cell-cycle phase progression analysis identifies three unique phenotypes in soft tissue sarcoma.

Journal Article BMC Cancer · October 17, 2024 PURPOSE: Loddo et al. (Br J Cancer 100:959-70, 2009) established the prognostic significance of cell cycle markers and "Cell-Cycle Phenotypes" in breast carcinoma. This study aims to 1) identify prognostic cell-cycle markers in sarcoma, and 2) assess the p ... Full text Link to item Cite

Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations.

Journal Article Cancer Epidemiol · October 2024 BACKGROUND: Canine and human osteosarcoma are similar in clinical presentation and tumor genomics. Giant breed dogs experience elevated osteosarcoma incidence, and taller stature remains a consistent risk factor for human osteosarcoma. Whether evolutionari ... Full text Link to item Cite

Machine learning approaches in non-contact autofluorescence spectrum classification.

Journal Article PLOS Digit Health · October 2024 Manual surgical resection of soft tissue sarcoma tissue can involve many challenges, including the critical need for precise determination of tumor boundary with normal tissue and limitations of current surgical instrumentation, in addition to standard ris ... Full text Link to item Cite

Locking plate augmentation of polymethylmethacrylate-filled distal femoral defects: A biomechanical study.

Journal Article J Orthop Res · September 1, 2024 Benign, locally aggressive tumors of the distal femur are typically treated with intralesional curettage and polymethylmethacrylate (PMMA) cementation. However, it is not known whether plate fixation should be added to biomechanically augment these PMMA-fi ... Full text Link to item Cite

Exploring versatile applications of a vacuum-assisted bone harvester in orthopedic surgery.

Journal Article BMC Musculoskelet Disord · August 31, 2024 BACKGROUND: Orthopedic procedures often require removing bone or pathological tissue, with traditional methods involving instruments like curettes and rongeurs. However, these methods can be time-consuming and lead to increased blood loss. To mitigate thes ... Full text Link to item Cite

Assessing extremely negative online patient reviews and complaints of musculoskeletal oncology surgeons in the United States: a retrospective analysis.

Journal Article J Orthop Surg Res · July 23, 2024 INTRODUCTION: Physician-review websites (PRWs) are commonly used by patients while searching for a surgeon. There is no current literature investigating the factors that contribute to online one-star reviews of musculoskeletal oncology surgeons. This retro ... Full text Link to item Cite

Relapsing malignant phyllodes tumour presenting as isolated acrometastases.

Journal Article BMJ Case Rep · July 3, 2024 Malignant phyllodes tumours (PTs) are aggressive neoplasms with high rates of local recurrence and distant metastasis. With no known effective chemotherapy and no approved targeted therapy in the setting of metastatic disease, prognosis is limited with an ... Full text Link to item Cite

The Known and Unknown: Investigating the Carcinogenic Potential of Plastic Additives.

Journal Article Environ Sci Technol · June 18, 2024 Microplastics are routinely ingested and inhaled by humans and other organisms. Despite the frequency of plastic exposure, little is known about its health consequences. Of particular concern are plastic additives─chemical compounds that are intentionally ... Full text Link to item Cite

Psoralen: a narrative review of current and future therapeutic uses.

Journal Article J Cancer Res Clin Oncol · March 15, 2024 Psoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves. Psoralens penetrate the phospholipid cellular membranes and insert themse ... Full text Link to item Cite

ATRX and Its Prognostic Significance in Soft Tissue Sarcoma.

Journal Article Sarcoma · 2024 PURPOSE: Recently, the association between ATRX and a more aggressive sarcoma phenotype has been shown. We performed a retrospective study of sarcomas from an individual institution to evaluate ATRX as a prognosticator in soft tissue sarcoma. Experimental ... Full text Link to item Cite

From Evolutionary Biology to Bedside and Beyond: A View of Comparative Oncology throughout the Translational Pipeline

Chapter · January 1, 2024 Cancer is observed in nearly all multicellular species. While this disease of multicellular life has no doubt impacted the lives of countless organisms, from dinosaurs to humans, there also exists an opportunity to deepen our understanding of cancer by stu ... Full text Cite

Tripod Fixation of Periacetabular Metastatic Lesions Using the IlluminOss Device.

Journal Article JBJS Essent Surg Tech · 2024 BACKGROUND: Percutaneous tripod fixation of periacetabular lesions is performed at our institution for patients with metastatic bone disease and a need for quick return to systemic therapy. We have begun to use the IlluminOss Photodynamic Bone Stabilizatio ... Full text Link to item Cite

Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.

Journal Article J Orthop Res · December 2023 There is increasing evidence that perioperative factors, including type of anesthesia, may be an important consideration regarding oncological disease progression. Previous studies have suggested that regional anesthesia can improve oncological outcomes by ... Full text Link to item Cite

Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.

Journal Article Skeletal Radiol · December 2023 OBJECTIVE: To describe the presentation of giant cell tumors (GCT) of the bone in the pediatric population to (1) improve the differential diagnosis of pediatric bone tumors and (2) identify the origin of GCT. Understanding the origin of bone tumors assist ... Full text Link to item Cite

Surgical Site Infection in Patients Managed with an Endoprosthesis for the Treatment of Cancer: Evaluation of Patient, Disease, and Index Surgical Factors.

Journal Article J Bone Joint Surg Am · July 19, 2023 BACKGROUND: Surgical site infection (SSI) after segmental endoprosthetic reconstruction in patients treated for oncologic conditions remains both a devastating and a common complication. The goal of the present study was to identify variables associated wi ... Full text Link to item Cite

Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus.

Journal Article J Clin Invest · July 3, 2023 ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas. However, the role of ATRX in tumor development and response to cancer therapies remains poorly understood. Here, we developed a p ... Full text Link to item Cite

Tumor necrosis is an underappreciated histopathologic factor in the grading of chondrosarcoma.

Journal Article BMC Cancer · June 23, 2023 BACKGROUND: Cartilaginous neoplasms can be challenging to grade; there is a need to create an evidence-based rubric for grading. The goal of this study was to identify histopathologic features of chondrosarcoma that were associated with 5-year survival and ... Full text Link to item Cite

Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk.

Journal Article Veterinary and comparative oncology · June 2023 Due to the complex nature of tumour biology and the integration between host tissues and molecular processes of the tumour cells, a continued reliance on the status of the microscopic cellular margin should not remain our only determinant of the success of ... Full text Cite

Evaluating the relevance of surgical margins. Part one: The problems with current methodology.

Journal Article Vet Comp Oncol · March 2023 The goal of cancer surgery is to achieve a "clean" microscopic resection, with no residual tumour remaining in the wound. To achieve that goal, the surgeon typically incorporates a measured buffer of grossly normal tissue about the entire circumference of ... Full text Link to item Cite

Inequitable distribution of plastic benefits and burdens on economies and public health

Journal Article Frontiers in Marine Science · January 10, 2023 Plastic heterogeneously affects social systems – notably human health and local and global economies. Here we discuss illustrative examples of the benefits and burdens of each stage of the plastic lifecycle (e.g., macroplastic production, consumption, recy ... Full text Cite

Bone Sarcomas

Chapter · January 1, 2023 This chapter provides answers to practice-based questions with case studies covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of bone sarcomas. Bone sarcomas are rare, mesenchymal neop ... Full text Cite

Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.

Journal Article J Vasc Interv Radiol · December 2022 PURPOSE: To measure the ablation zone temperature and nontarget tissue temperature during radiofrequency (RF) ablation in bone containing metal instrumentation versus no metal instrumentation (control group). MATERIALS AND METHODS: Ex vivo experiments were ... Full text Link to item Cite

A transdisciplinary approach to reducing global plastic pollution

Journal Article Frontiers in Marine Science · October 28, 2022 Full text Cite

Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.

Journal Article Antimicrob Agents Chemother · October 18, 2022 In orthopedic oncology, the implant of a megaprosthetic device is standard of care after large-scale tumor resection involving segmental removal of bone. Infection remains the leading cause of implant failure, often resulting in major morbidity. Perioperat ... Full text Link to item Cite

Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.

Journal Article J Orthop Res · October 2022 For soft tissue sarcoma patients receiving preoperative radiation therapy, wound complications are common and potentially devastating. The purpose of this study was to assess the feasibility of intraoperative indocyanine green fluorescent angiography (ICGA ... Full text Link to item Cite

Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.

Journal Article JCI Insight · September 8, 2022 Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypi ... Full text Link to item Cite

Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.

Journal Article J Surg Oncol · August 2022 BACKGROUND: Little is known about the drivers of readmission in patients undergoing Orthopaedic oncologic resection. The goal of this study was to identify factors independently associated with 90-day readmission for patients undergoing oncologic resection ... Full text Link to item Cite

Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.

Journal Article Ann Surg Oncol · February 2022 BACKGROUND: Limited data are available to inform the risk of readmission and short-term mortality in musculoskeletal oncology. The goal of this study was to identify factors independently associated with 30-day readmission and 90-day mortality following su ... Full text Link to item Cite

Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?

Journal Article The Journal of arthroplasty · February 2022 BackgroundOrthopedic oncology patients are particularly susceptible to increased readmission rates and poor surgical outcomes, yet little is known about readmission rates. The goal of this study is to identify factors independently associated with ... Full text Cite

Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.

Journal Article Cancer Med · January 2022 INTRODUCTION: Current standard of care for most intermediate and high-grade soft-tissue sarcomas (STS) includes limb-preserving surgical resection with either neoadjuvant radiation therapy (NRT) or adjuvant radiation therapy. To date, there have been a few ... Full text Link to item Cite

Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study.

Journal Article Evol Med Public Health · 2022 BACKGROUND AND OBJECTIVES: Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma in prosimians may point to possi ... Full text Link to item Cite

Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.

Journal Article Adv Healthc Mater · December 2021 Convergent advances in the field of soft matter, macromolecular chemistry, and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed ... Full text Link to item Cite

Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.

Journal Article Ann Surg Oncol · November 2021 BACKGROUND: There are limited data to inform risk of readmission and short-term mortality in musculoskeletal oncology. The goal of this study was to identify factors independently associated with 30-day readmission and 90-day mortality following surgical r ... Full text Link to item Cite

Reverse total shoulder arthroplasty for oncologic reconstruction of the proximal humerus: a systematic review.

Journal Article J Shoulder Elbow Surg · November 2021 BACKGROUND: In recent years, there has been growing interest in the use of reverse total shoulder arthroplasty (rTSA) for reconstruction of the proximal humerus after oncologic resection. However, the indications and outcomes of oncologic rTSA remain uncle ... Full text Link to item Cite

Treatment of Chondroblastoma with Denosumab: A Case Report with a Correlative Analysis of Effect on the RANK Signaling Pathway.

Journal Article JBJS Case Connect · May 17, 2021 CASE: A 15-year-old boy with chondroblastoma of the right hemipelvis presented with significant periacetabular bone destruction. Neoadjuvant denosumab treatment facilitated initial joint preserving surgery. Unfortunately, he experienced 2 local recurrences ... Full text Link to item Cite

Humeral Shaft Fracture With Placement of an Intramedullary Nail Through an Unrecognized Sarcoma.

Journal Article J Am Acad Orthop Surg Glob Res Rev · February 19, 2021 CASE: A 72-year-old man underwent intramedullary nailing of a humeral diaphysis fracture with passage through an unrecognized pathologic fracture. Four months later, a biopsy of a soft-tissue mass in the arm revealed pleomorphic undifferentiated sarcoma. O ... Full text Link to item Cite

Urinary Pubic Symphysis Fistula Leads to Histopathologic Osteomyelitis in Prostate Cancer Survivors.

Journal Article Urology · February 2021 OBJECTIVE: To assess the histologic findings in the pubic bone resected during extirpative surgery for urinary pubic symphysis fistula (UPF). The concurrent presence of osteomyelitis and the need for bone resection at time of extirpative surgery for UPF ha ... Full text Open Access Link to item Cite

Exploring the Diversity of the Marine Environment for New Anti-cancer Compounds

Journal Article Frontiers in Marine Science · January 21, 2021 Marine ecosystems contain over 80% of the world’s biodiversity, and many of these organisms have evolved unique adaptations enabling survival in diverse and challenging environments. The biodiversity within the world’s oceans is a virtually untapped resour ... Full text Cite

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation.

Journal Article Frontiers in oncology · January 2021 Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study these ... Full text Cite

The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors.

Journal Article Sarcoma · 2021 BACKGROUND: Unlike other soft tissue sarcomas, atypical lipomatous tumors (ALTs) are thought to have a low propensity for metastasis. Despite this, a standard of care for pulmonary metastasis (PM) surveillance has not been established. This study aimed to ... Full text Link to item Cite

An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.

Journal Article Evol Med Public Health · 2021 BACKGROUND AND OBJECTIVES: Ischemic events, such as ischemic heart disease and stroke, are the number one cause of death globally. Ischemia prevents blood, carrying essential nutrients and oxygen, from reaching tissues, leading to cell and tissue death, an ... Full text Link to item Cite

A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma.

Journal Article Cancers (Basel) · November 11, 2020 BACKGROUND: Osteosarcoma is a rare but aggressive bone cancer that occurs primarily in children. Like other rare cancers, treatment advances for osteosarcoma have stagnated, with little improvement in survival for the past several decades. Developing new t ... Full text Link to item Cite

Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.

Journal Article BMC Cancer · October 14, 2020 BACKGROUND: Historically, amputation was the primary surgical treatment for osteosarcoma of the extremities; however, with advancements in surgical techniques and chemotherapies limb salvage has replaced amputation as the dominant treatment paradigm. This ... Full text Link to item Cite

Defining a textbook surgical outcome for patients undergoing surgical resection of intermediate and high-grade soft tissue sarcomas of the extremities.

Journal Article J Surg Oncol · October 2020 BACKGROUND: Quality measures for the surgical management soft tissue sarcoma of the extremity are limited. The purpose of this study was to define a textbook surgical outcome (TO) for soft tissue sarcoma of the extremities (STS-E) and to examine its associ ... Full text Link to item Cite

Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.

Journal Article Clin Cancer Res · September 15, 2020 PURPOSE: Nanoparticle-encapsulated drug formulations can improve responses to conventional chemotherapy by increasing drug retention within the tumor and by promoting a more effective antitumor immune response than free drug. New drug delivery modalities a ... Full text Link to item Cite

Extirpative Cultures Reveal Infectious Pubic Bone Osteomyelitis in Prostate Cancer Survivors With Urinary-Pubic Symphysis Fistulae (UPF).

Journal Article Urology · August 2020 OBJECTIVE: To examine the infectious features of patients with urinary pubic symphysis fistula (UPF) and their association with osteomyelitis. METHODS: We conducted a review of our quality improvement database for 36 patients with UPF undergoing bone resec ... Full text Open Access Link to item Cite

Does facility volume influence survival in patients with primary malignant bone tumors of the vertebral column? A comparative cohort study.

Journal Article Spine J · July 2020 BACKGROUND CONTEXT: Facility volume has been correlated with survival in many cancers. This relationship has not been established in primary malignant bone tumors of the vertebral column (BTVC). PURPOSE: To investigate whether facility patient volume is as ... Full text Open Access Link to item Cite

Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.

Journal Article Mol Cancer Ther · July 2020 Therapeutic advances for osteosarcoma have stagnated over the past several decades, leading to an unmet clinical need for patients. The purpose of this study was to develop a novel therapy for osteosarcoma by reformulating and validating niclosamide, an es ... Full text Open Access Link to item Cite

The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.

Journal Article Spine (Phila Pa 1976) · June 15, 2020 STUDY DESIGN: Retrospective review. OBJECTIVE: To determine if adjuvant radiation therapy (RT) improves overall survival (OS) following surgical resection of chordomas. SUMMARY OF BACKGROUND DATA: The role of RT for the treatment of chordomas remains incom ... Full text Link to item Cite

Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.

Journal Article Vet Comp Oncol · March 2020 Since William Coley utilized bacterial immunotherapy to treat sarcomas in the late 19th century, an association between infection and improved survival has been reported for human and canine osteosarcoma patients. One of the reasons for this improved survi ... Full text Link to item Cite

Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.

Journal Article Bone · January 2020 Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in subject ... Full text Link to item Cite

Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life.

Journal Article Mol Biol Evol · January 1, 2020 Despite a considerable expenditure of time and resources and significant advances in experimental models of disease, cancer research continues to suffer from extremely low success rates in translating preclinical discoveries into clinical practice. The con ... Full text Link to item Cite

From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.

Journal Article Front Oncol · 2020 Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for rare cancers, su ... Full text Link to item Cite

Epidemiologic and survival trends in adult primary bone tumors of the spine.

Journal Article Spine J · December 2019 BACKGROUND CONTEXT: Malignant primary spinal tumors are rare making it difficult to perform large studies comparing epidemiologic, survival, and treatment trends. We investigated the largest registry of primary bone tumors, the National Cancer Database (NC ... Full text Open Access Link to item Cite

Bioengineering a Future Free of Marine Plastic Waste

Journal Article Frontiers in Marine Science · October 11, 2019 Plastic waste has reached epidemic proportions worldwide, and the production of plastic continues to rise steadily. Plastic represents a diverse array of commonly used synthetic polymers that are extremely useful as durable, economically beneficial alterna ... Full text Cite

E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.

Journal Article Mol Cancer Res · June 2019 CDH1 (also known as E-cadherin), an epithelial-specific cell-cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, and mediating intracellular signaling. Downregulation of E-cadherin is a hallmar ... Full text Link to item Cite

Magnetic resonance imaging features of pubic symphysis urinary fistula with pubic bone osteomyelitis in the treated prostate cancer patient.

Journal Article Abdom Radiol (NY) · April 2019 INTRODUCTION: Pubic bone osteomyelitis with pubic symphysis urinary fistula represents a debilitating complication of radiation and ablative treatments for prostate cancer. The definitive radiographic diagnosis of this clinical entity is not described. In ... Full text Link to item Cite

Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?

Journal Article Clin Orthop Relat Res · April 2019 BACKGROUND: For many cancer types, survival is improved when patients receive management at treatment centers that encounter high numbers of patients annually. This correlation may be more important with less common malignancies such as sarcoma. Existing e ... Full text Link to item Cite

An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.

Journal Article J Clin Med · February 7, 2019 The evolution of therapeutic resistance is a major cause of death for cancer patients. The development of therapy resistance is shaped by the ecological dynamics within the tumor microenvironment and the selective pressure of the host immune system. These ... Full text Link to item Cite

Microsurgery in musculoskeletal oncology.

Journal Article Eur J Orthop Surg Traumatol · February 2019 Sarcomas are rare mesenchymal bone and soft tissue tumors of the musculoskeletal system. In the past, the primary treatment modality was amputation of the involved limb and the 5-year survival was very low for high-grade tumors. During the last three decad ... Full text Link to item Cite

Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.

Journal Article Sarcoma · 2019 BACKGROUND: Although chondrosarcomas (CS) are mostly considered radioresistant, advancements in radiotherapy have brought attention to its use in these patients. Using the largest registry of primary bone tumors, the National Cancer Database (NCDB), we sou ... Full text Link to item Cite

Recurrent Extradural Myxopapillary Ependymoma With Oligometastatic Spread.

Journal Article Front Oncol · 2019 Myxopapillary ependymomas are a slow-growing, grade I type glial tumor in the lumbosacral region. More rarely, they can present as extradural, subcutaneous sacrococcygeal, or perisacral masses, and it is under these circumstances that they are more likely ... Full text Link to item Cite

Genetic determinants of childhood and adult height associated with osteosarcoma risk.

Journal Article Cancer · September 15, 2018 BACKGROUND: Although increased height has been associated with osteosarcoma risk in previous epidemiologic studies, to the authors' knowledge the relative contribution of stature during different developmental timepoints remains unclear. Furthermore, the q ... Full text Open Access Link to item Cite

New Techniques for Diagnosis and Treatment of Musculoskeletal Tumors: Methods of Intraoperative Margin Detection

Conference Techniques in Orthopaedics · September 1, 2018 Although frozen section analysis remains the standard for intraoperative margin detection for some cancers, there are critical limitations with using this method in the treatment of musculoskeletal tumors. Extensive work has been done to develop more accur ... Full text Cite

Iatrogenic lesions of soft tissue and bone.

Journal Article Semin Diagn Pathol · July 2018 Full text Link to item Cite

The Role of Reconstructive Surgery After Skeletal and Soft Tissue Sarcoma Resection.

Journal Article Ann Plast Surg · June 2018 BACKGROUND: Skeletal and soft tissue reconstruction after sarcoma resection remains challenging. The use of advanced reconstructive techniques has been shown to improve function and increase rates of limb salvage. This study aims to analyze the utilization ... Full text Link to item Cite

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.

Journal Article BMC Cancer · April 27, 2018 BACKGROUND: In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival in soft tissue sarcoma (STS). We i ... Full text Link to item Cite

The Value of MRI in Distinguishing Subtypes of Lipomatous Extremity Tumors Needs Reassessment in the Era of MDM2 and CDK4 Testing.

Journal Article Sarcoma · 2018 INTRODUCTION: Extremity lipomas and well-differentiated liposarcomas (WDLs) are difficult to distinguish on MR imaging. We sought to evaluate the accuracy of MRI interpretation using MDM2 amplification, via fluorescence in-situ hybridization (FISH), as the ... Full text Link to item Cite

Beyond Mirels: Factors Influencing Surgical Outcome of Metastasis to the Extremities in the Modern Era.

Journal Article J Surg Orthop Adv · 2018 Mirels scoring system for determining prophylactic stabilization need of skeletal metastases includes a limited number of variables and does not differentiate between procedure types. This study sought to identify additional variables associated with surgi ... Link to item Cite

Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction following Resection.

Journal Article Plast Reconstr Surg Glob Open · November 2017 OBJECTIVE: Soft-tissue sarcomas are most frequently located deep within myofascial compartments. Superficial soft-tissue sarcomas (S-STS) are relatively less common and may be managed differently than deep sarcomas because generous resection margins are of ... Full text Link to item Cite

NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.

Journal Article Cancer Res · August 15, 2017 Haploinsufficiency in the tumor suppressor NF1 contributes to the pathobiology of neurofibromatosis type 1, but a related role has not been established in malignant peripheral nerve sheath tumors (MPNST) where NF1 mutations also occur. Patients with NF1-as ... Full text Link to item Cite

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.

Journal Article Nat Commun · July 10, 2017 Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how th ... Full text Link to item Cite

Abstract 2810: Using CRISPR/Cas9 to generate primary soft tissue sarcoma in genetically engineered and wild-type mice

Conference Cancer Research · July 1, 2017 AbstractGenetically engineered mouse models (GEMMs) that employ site-specific recombinase (SSR) technology are important tools for pre-clinical studies, but this approach is costly and time-consuming. Here, ... Full text Cite

Tumors of the Epiphyses.

Journal Article JBJS Rev · May 2017 Full text Link to item Cite

Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications.

Journal Article Plast Reconstr Surg Glob Open · May 2017 BACKGROUND: The vascularized free fibula epiphyseal transfer provides an option for the preservation of limb lengthening after resection of the proximal humerus in pediatric sarcoma patients. The purpose of this study was to provide a long-term follow-up o ... Full text Open Access Link to item Cite

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.

Journal Article J Vis Exp · April 7, 2017 Phenotypic plasticity refers to a phenomenon in which cells transiently gain traits of another lineage. During carcinoma progression, phenotypic plasticity drives invasion, dissemination and metastasis. Indeed, while most of the studies of phenotypic plast ... Full text Link to item Cite

The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.

Journal Article Bone Joint J · April 2017 AIMS: Instability of the hip is the most common mode of failure after reconstruction with a proximal femoral arthroplasty (PFA) using an endoprosthesis after excision of a tumour. Small studies report improved stability with capsular repair of the hip and ... Full text Link to item Cite

Chronic Osteomyelitis of the Distal Femur Treated with Resection and Delayed Endoprosthetic Reconstruction: A Report of Three Cases.

Journal Article Case Rep Orthop · 2017 Chronic osteomyelitis involving the distal femur often results in amputation or arthrodesis. This article presents three cases of chronic osteomyelitis treated with a staged approach culminating in endoprosthetic reconstruction. Stage one involved resectio ... Full text Link to item Cite

Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.

Journal Article Mol Cell Biol · October 1, 2016 Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). I ... Full text Open Access Link to item Cite

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.

Journal Article Vet Surg · August 2016 OBJECTIVE: To assess the ability of a novel imaging system designed for intraoperative detection of residual cancer in tumor beds to distinguish neoplastic from normal tissue in dogs undergoing resection of soft tissue sarcoma (STS) and mast cell tumor (MC ... Full text Link to item Cite

Synovial Chondromatosis.

Journal Article JBJS Rev · May 10, 2016 Synovial chondromatosis is a rare, benign condition of unknown etiology in which the synovium undergoes metaplasia leading to cartilaginous nodules that ultimately break free, mineralize, and even ossify. The most commonly involved joint is the knee. Patie ... Full text Link to item Cite

Myogenic transcription factors regulate pro-metastatic miR-182.

Journal Article Oncogene · April 7, 2016 Approximately 30% of patients with soft-tissue sarcoma die from pulmonary metastases. The mechanisms that drive sarcoma metastasis are not well understood. Recently, we identified miR-182 as a driver of sarcoma metastasis in a primary mouse model of soft-t ... Full text Link to item Cite

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Journal Article Sci Transl Med · January 6, 2016 Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcision, a ... Full text Link to item Cite

Innovations in Intraoperative Tumor Visualization.

Journal Article Orthop Clin North Am · January 2016 In the surgical management of solid tumors, adequacy of tumor resection has implications for local recurrence and survival. The standard method of intraoperative identification of tumor margin is frozen section pathologic analysis, which is time-consuming ... Full text Link to item Cite

A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.

Journal Article Theranostics · 2016 The treatment of soft tissue sarcoma (STS) generally involves tumor excision with a wide margin. Although advances in fluorescence imaging make real-time detection of cancer possible, removal is limited by the precision of the human eye and hand. Here, we ... Full text Open Access Link to item Cite

The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.

Journal Article Ann Surg Oncol · September 2015 BACKGROUND: It is a consensus that radiation therapy (RT) should be applied for all large, deep, high-grade soft tissue sarcomas (STS). Therefore, we investigated the National Cancer Database (NCDB) to study how these guidelines are being followed, to dete ... Full text Link to item Cite

Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model.

Journal Article J Vasc Interv Radiol · August 2015 PURPOSE: To compare the acute effects of radiofrequency (RF) ablation and cryoablation on the structural integrity of nontarget periarticular tissues that may be placed at risk during percutaneous bone ablation. MATERIALS AND METHODS: RF ablation and cryoa ... Full text Link to item Cite

Abstract SY36-03: Intraoperative molecular imaging with protease-activated fluorescent imaging agents

Conference Cancer Research · August 1, 2015 AbstractIntra-operative detection of residual cancer in the tumor bed can be used to decrease the risk of a positive surgical margin, reduce the rate of re-excision, and tailor adjuvant therapy. LUM015 is a ... Full text Cite

Impact of liposomal bupivacaine administration on postoperative pain in patients undergoing total knee replacement.

Journal Article Pharmacotherapy · May 2015 STUDY OBJECTIVE: To determine whether liposomal bupivacaine, a long-acting anesthetic indicated for single-dose wound infiltration to produce postoperative analgesia, has an impact on postoperative pain in patients undergoing total knee arthroplasties (TKA ... Full text Link to item Cite

The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.

Journal Article Sarcoma · 2015 Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB ... Full text Link to item Cite

Extranodal Castleman disease of the extremities: a case report and review of the literature.

Journal Article Skeletal Radiol · November 2014 Castleman disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass or, in the extranodal form of the disease, a mass located in the mediastinum or retroperitoneum. It is exceptionally uncomm ... Full text Link to item Cite

Custom facial reconstruction for osteosarcoma of the jaw.

Journal Article J Oral Maxillofac Surg · November 2014 Osteosarcoma accounts for most primary bone cancers in children and young adults. High-grade lesions are typically managed with a combination of chemotherapy and wide-margin surgical excision. Although this malignancy typically affects the metaphyseal regi ... Full text Link to item Cite

The effect of the setting of a positive surgical margin in soft tissue sarcoma.

Journal Article Cancer · September 15, 2014 BACKGROUND: The objectives of this study were to evaluate the risk of local recurrence and survival after soft tissue sarcoma (STS) resection with positive margins and to evaluate the safety of sparing adjacent critical structures. METHODS: One hundred six ... Full text Link to item Cite

Bone Sarcomas

Chapter · June 20, 2014 This chapter presents a series of case studies with questions related to bone sarcomas. The first case study is about a 17-year-old Caucasian male diagnosed with Ewing sarcoma of the left humerus. Other case studies include a 52-year-old Caucasian male wit ... Full text Cite

The vascularized fibular graft in the treatment of osteonecrosis: Data, dogma, and controversies

Chapter · January 1, 2014 In the debate about surgical treatment for osteonecrosis of the femoral head (ONFH), no topic is more frequently debated than the use of the free vascularized fi bular graft (FVFG) as a standard treatment. Pioneered by Urbaniak in 1979, the FVFG represents ... Full text Cite

Bone sarcomas

Chapter · 2014 Cite

Early follow-up of a custom non-fluted diaphyseal press-fit tumour prosthesis.

Journal Article Int Orthop · January 2014 PURPOSE: The objective of this study was to evaluate the early results of a custom non-fluted diaphyseal press-fit stem for use with the global modular replacement system (GMRS) tumour prosthesis and the early complications associated with this implant. ME ... Full text Link to item Cite

The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?

Journal Article Clin Orthop Relat Res · November 2013 BACKGROUND: Tumor-induced osteomalacia is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. Phosphaturic mesenchymal tumors represent a rare etiology of tumor-induced osteomalacia. Nonspecific symptoms of fat ... Full text Link to item Cite

NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.

Journal Article Mol Cancer Ther · September 2013 Soft-tissue sarcomas are a heterogeneous group of tumors arising from connective tissue. Recently, mutations in the neurofibromin 1 (NF1) tumor suppressor gene were identified in multiple subtypes of human soft-tissue sarcomas. To study the effect of NF1 i ... Full text Link to item Cite

Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure.

Journal Article Bone Joint J · August 2013 We investigated the clinical outcome of internal fixation for pathological fracture of the femur after primary excision of a soft-tissue sarcoma that had been treated with adjuvant radiotherapy. A review of our database identified 22 radiation-induced frac ... Full text Link to item Cite

Pancarpal synovial and tenosynovial chondromatosis in a 65-year-old man: a highly unusual presentation of a common condition.

Journal Article Am J Orthop (Belle Mead NJ) · August 2013 Synovial chondromatosis is a rare, benign, metaplastic condition in which synovial tissue becomes hyperplastic, and foci of cartilaginous metaplasia develop in the synovial membranes of joints, bursae, or tendon sheaths. Involvement is most commonly monoar ... Link to item Cite

Practical radiation oncology for extremity sarcomas.

Journal Article Surg Oncol Clin N Am · July 2013 Soft tissue sarcomas are rare cancers. They should be managed by a multidisciplinary team with experience caring for these diverse malignancies. Local control is frequently achieved with a combination of radiation therapy and surgery. This article reviews ... Full text Link to item Cite

A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.

Journal Article Clin Orthop Relat Res · March 2013 BACKGROUND: Treatment of soft tissue sarcoma (STS) includes complete tumor excision. However, in some patients, residual sarcoma cells remain in the tumor bed. We previously described a novel hand-held imaging device prototype that uses molecular imaging t ... Full text Link to item Cite

Training femoral neck screw insertion skills to surgical trainees: computer-assisted surgery versus conventional fluoroscopic technique.

Journal Article J Orthop Trauma · February 2013 BACKGROUND: : Femoral neck fractures are among the most common orthopaedic injuries impacting the health care system. Surgical management of such fractures with cannulated screws is a commonly performed procedure. The acquisition of surgical skills necessa ... Full text Link to item Cite

Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI?

Journal Article Sarcoma · 2013 Well-differentiated liposarcoma represents a radiographic diagnostic dilemma. To determine the accuracy, interrater reliability, and relationship of stranding, nodularity, and size in the MRI differentiation of lipoma and well-differentiated liposarcoma, M ... Full text Link to item Cite

The vascularized fibular graft in the pediatric upper extremity: a durable, biological solution to large oncologic defects.

Journal Article Sarcoma · 2013 Skeletal reconstruction after large tumor resection is challenging. The free vascularized fibular graft (FVFG) offers the potential for rapid autograft incorporation as well as growing physeal transfer in pediatric patients. We retrospectively reviewed ele ... Full text Open Access Link to item Cite

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.

Journal Article Cancer · November 1, 2012 BACKGROUND: The goal of limb-sparing surgery for a soft tissue sarcoma of the extremity is to remove all malignant cells while preserving limb function. After initial surgery, microscopic residual disease in the tumor bed will cause a local recurrence in a ... Full text Link to item Cite

The vascularized fibular graft in precollapse osteonecrosis: is long-term hip preservation possible?

Journal Article Clin Orthop Relat Res · October 2012 BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a debilitating condition affecting primarily young patients. Free vascularized fibular grafting (FVFG) may provide a durable means to preserve the femoral head. When used in the precollapse stages of ... Full text Link to item Cite

Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities.

Journal Article Arch Orthop Trauma Surg · July 2012 BACKGROUND: Malignant fibrous histiocytoma (MFH) of soft tissue is one of the most common sarcoma in adulthood. However, only a few series have separately studied the clinical behavior and prognosis of this malignancy. METHODS: We retrospectively reviewed ... Full text Link to item Cite

[Femur reconstruction using combined autologous fibula transfer and humeral allograft].

Journal Article Chirurg · December 2011 Wide resection far into the femoral metaphysis may be required to treat malignant bone tumors in the pediatric and adolescent patient population. Biological reconstruction using a free, vascularized fibular graft is a well-established surgical technique. A ... Full text Link to item Cite

Dissecting molecular mechanisms of metastasis in a primary mouse model of soft tissue sarcoma

Journal Article CLINICAL & EXPERIMENTAL METASTASIS · February 1, 2011 Link to item Cite

Dissecting mechanisms of metastasis using a mouse model of cancer

Journal Article CLINICAL & EXPERIMENTAL METASTASIS · February 1, 2011 Link to item Cite

Case report: lead toxicity associated with an extra-articular retained missile 14 years after injury.

Journal Article J Surg Orthop Adv · 2011 Lead toxicity associated with extra-articular retained missiles (EARMs) is an uncommon yet potentially devastating complication of gunshot wounds. While the risk of lead toxicity with intra-articular retained missiles is well-known, EARMs are routinely per ... Link to item Cite

Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection.

Journal Article Clin Orthop Relat Res · February 2010 UNLABELLED: Skeletal reconstruction of large tumor resection defects is challenging. Free vascularized fibular transfer offers the potential for rapid autograft incorporation in limbs compromised by adjuvant chemotherapy or radiation. We retrospectively re ... Full text Link to item Cite

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Journal Article PLoS One · November 30, 2009 Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of so ... Full text Link to item Cite

Attitudes toward physician-assisted suicide among physicians in Vermont.

Journal Article J Med Ethics · July 2007 BACKGROUND: Legislation on physician-assisted suicide (PAS) is being considered in a number of states since the passage of the Oregon Death With Dignity Act in 1994. Opinion assessment surveys have historically assessed particular subsets of physicians. OB ... Full text Link to item Cite

Immunohistochemistry of the canine vomeronasal organ.

Journal Article J Anat · September 2003 The canine's olfactory acuity is legendary, but neither its main olfactory system nor its vomeronasal system has been described in much detail. We used immunohistochemistry on paraffin-embedded sections of male and female adult dog vomeronasal organ (VNO) ... Full text Link to item Cite

Shuttle mission effects on glutamate receptor expression in the developing rodent spinal cord.

Journal Article Aviat Space Environ Med · June 2003 BACKGROUND: Within the mammalian central nervous system (CNS), glutamate receptors play a fundamental role in excitatory neurotransmission and synaptic plasticity. Studies of the neonatal cerebral cortex suggests that rearing environment can influence the ... Link to item Cite

Immunohistochemistry of the canine vomeronasal organ.

Journal Article J Anat · June 2003 The canine's olfactory acuity is legendary, but neither its main olfactory system nor its vomeronasal system has been described in much detail. We used immunohistochemistry on paraffin-embedded sections of male and female adult dog vomeronasal organ (VNO) ... Full text Link to item Cite

Effects of unilaterally restricted carpal range of motion on kinematic gait analysis of the dog

Journal Article Veterinary and Comparative Orthopaedics and Traumatology · January 1, 2003 Decreased carpal range of motion is a common sequel to both disease and injury of the canine carpus; it is also encountered following therapeutic endeavours such as taping, bandaging, and arthrodesis. It was the aim of this study to define alterations of m ... Full text Cite