Scholars@Duke publication: Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Publication , Journal Article

Mito, JK; Riedel, RF; Dodd, L; Lahat, G; Lazar, AJ; Dodd, RD; Stangenberg, L; Eward, WC; Hornicek, FJ; Yoon, SS; Brigman, BE; Jacks, T ...

Published in: PLoS One

November 30, 2009

Published version (DOI) Link to item

Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.

Duke Scholars

Author Richard Francis Riedel Medicine, Medical Oncology

Author William Curtis Eward Orthopaedic Surgery

Author Brian Eugene Brigman Orthopaedic Surgery

Published In

PLoS One

DOI

10.1371/journal.pone.0008075

EISSN

1932-6203

Publication Date

November 30, 2009

Volume

Issue

Start / End Page

e8075

Location

United States

Related Subject Headings

Species Specificity
Soft Tissue Neoplasms
Sarcoma
Neoplasm Metastasis
Microarray Analysis
Mice
Humans
Histiocytoma, Malignant Fibrous
Genotype
Genomics

Citation

APA

Chicago

ICMJE

MLA

NLM

Mito, J. K., Riedel, R. F., Dodd, L., Lahat, G., Lazar, A. J., Dodd, R. D., … Kirsch, D. G. (2009). Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One, 4(11), e8075. https://doi.org/10.1371/journal.pone.0008075

Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” PLoS One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.

Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, et al. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One. 2009 Nov 30;4(11):e8075.

Mito, Jeffrey K., et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” PLoS One, vol. 4, no. 11, Nov. 2009, p. e8075. Pubmed, doi:10.1371/journal.pone.0008075.

Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One. 2009 Nov 30;4(11):e8075.

Published In

PLoS One

DOI

10.1371/journal.pone.0008075

EISSN

1932-6203

Publication Date

November 30, 2009

Volume

Issue

Start / End Page

e8075

Location

United States

Related Subject Headings

Species Specificity
Soft Tissue Neoplasms
Sarcoma
Neoplasm Metastasis
Microarray Analysis
Mice
Humans
Histiocytoma, Malignant Fibrous
Genotype
Genomics