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Brian Eugene Brigman

Professor of Orthopaedic Surgery
Orthopaedic Surgery
Box 3312 Med Ctr, Durham, NC
1578 White Zone DS, Durham, NC

Current Appointments & Affiliations


Professor of Orthopaedic Surgery · 2020 - Present Orthopaedic Surgery, Clinical Science Departments
Professor in Pediatrics · 2020 - Present Pediatrics, Clinical Science Departments
Member of the Duke Cancer Institute · 2012 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published September 5, 2019
A Distance Runner Triumphs Over Sarcoma, By Walking

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Recent Publications


Novel niclosamide stearate prodrug therapeutic shows potential efficacy against naturally occurring canine osteosarcoma in a clinical feasibility study.

Journal Article Am J Vet Res · January 1, 2026 OBJECTIVE: To manufacture and characterize a modified niclosamide stearate (NS) prodrug therapeutic (mNSPT) for use in a small clinical trial in a metastatic canine osteosarcoma (OS) model. ANIMALS: 10 dogs that presented for treatment of nondetectable met ... Full text Link to item Cite

The impact of preoperative bone mineral density on outcomes following lower extremity megaprosthetic reconstruction for oncologic resections.

Journal Article Bone · January 2026 BACKGROUND: While megaprosthetic reconstructions have been instrumental in restoring patients' functional abilities, surgeons remain cautious of revision risk. This is the first study to assess the impacts of preoperative bone mineral density (BMD) on outc ... Full text Link to item Cite

The Price of Prophylactic Fixation of the Humerus: A Nationwide Analysis of Negotiated Payor Rates.

Journal Article J Surg Oncol · December 29, 2025 BACKGROUND: Metastatic disease in the humerus presents with severe pain, compromised upper extremity function, and impending or completed pathologic fractures. Prophylactic fixation can improve quality of life, yet little is known about the variability in ... Full text Link to item Cite
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Recent Grants


Fresh Tissue Lab Agreement

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by DePuy Synthes Companies · 2019 - 2019

Protocol Number: 14-03-PATHOLHUM-02

Clinical TrialPrincipal Investigator · Awarded by IlluminOss Medical, Inc. · 2015 - 2018

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 1994 M.D.