Brian Eugene Brigman | Scholars@Duke

Brian Eugene Brigman
Associate Professor of Orthopaedic Surgery

Current Appointments and Affiliations

Associate Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2011
Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2010
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

1578 White Zone Ds, Durham, NC 27710
Box 3312 Med Ctr, Durham, NC 27710
brigm003@mc.duke.edu (919) 681-6982

Background
Education, Training, and Certifications
- Fellow, Orthopaedic Oncology, Boston University 2000 - 2001
- Resident, Orthopaedic Surgery, University of Nebraska at Lincoln 1995 - 2000
- Intern, Surgery, University of Nebraska at Lincoln 1994 - 1995
- M.D., University of North Carolina at Chapel Hill 1994
Research
Selected Grants
- Protocol Number: 14-03-PATHOLHUM-02 awarded by IlluminOss Medical, Inc. 2015 - 2018
- missing activity
Publications and Artistic Works
Selected Publications
- Conference Papers
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, E, Greenup, RA, Mosca, PJ, Cahill, J, Mito, JK, Cuneo, KC, Larrier, N, O'Reilly, E, Spasojevic, I, Riedel, RF, Eward, WC, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery." February 2015. Link to Item
  - Whitley, MJ, Cardona, DM, Blazer, DG, Hwang, SE, Mosca, PJ, Cahill, J, Ferrer, JM, Strasfeld, DB, Mlto, JK, Cuneo, KC, Lanier, N, Williams, O, Spasojevic, I, Riedel, RF, Eward, W, Lee, WD, Griffith, LG, Bawendi, M, Kirsch, DG, and Brigman, BE. "A phase I study of the safety and activation of a cathepsin-activalable fluorescent cancer-specific probe LUM015." May 20, 2014. Link to Item
- Journal Articles
  - Shammas, RL, Avashia, YJ, Farjat, AE, Catanzano, AA, Levin, LS, Eward, WC, Brigman, BE, and Erdmann, D. "Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications." Plastic and reconstructive surgery. Global open 5, no. 5 (May 25, 2017): e1352-. Full Text
  - Grimm, NL, Tainter, DM, Eward, WC, and Brigman, BE. "Tumors of the Epiphyses." JBJS reviews 5, no. 5 (May 23, 2017): e4-. Full Text
  - Henderson, ER, Keeney, BJ, Pala, E, Funovics, PT, Eward, WC, Groundland, JS, Ehrlichman, LK, Puchner, SSE, Brigman, BE, Ready, JE, Temple, HT, Ruggieri, P, Windhager, R, Letson, GD, and Hornicek, FJ. "The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique." The bone & joint journal 99-B, no. 4 (April 2017): 531-537. Full Text
  - Biermann, JS, Chow, W, Reed, DR, Lucas, D, Adkins, DR, Agulnik, M, Benjamin, RS, Brigman, B, Budd, GT, Curry, WT, Didwania, A, Fabbri, N, Hornicek, FJ, Kuechle, JB, Lindskog, D, Mayerson, J, McGarry, SV, Million, L, Morris, CD, Movva, S, O'Donnell, RJ, Randall, RL, Rose, P, Santana, VM, Satcher, RL, Schwartz, H, Siegel, HJ, Thornton, K, Villalobos, V, Bergman, MA, and Scavone, JL. "Bone cancer, version 2.2017 featured updates to the NCCN guidelines." JNCCN Journal of the National Comprehensive Cancer Network 15, no. 2 (February 1, 2017): 155-167.
  - Snouwaert, JN, Nguyen, M, Repenning, PW, Dye, R, Livingston, EW, Kovarova, M, Moy, SS, Brigman, BE, Bateman, TA, Ting, JP-Y, and Koller, BH. "An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice." Cell reports 17, no. 11 (December 2016): 3077-3088. Full Text
  - Lazarides, AL, Scott, EJ, Cardona, DM, Blazer, DG, Brigman, BE, and Eward, WC. "Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature." Journal of gastrointestinal cancer 47, no. 3 (September 2016): 331-335. (Review) Full Text
  - Bartholf DeWitt, S, Eward, WC, Eward, CA, Lazarides, AL, Whitley, MJ, Ferrer, JM, Brigman, BE, Kirsch, DG, and Berg, J. "A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs." Veterinary surgery : VS 45, no. 6 (August 2016): 715-722. Full Text
  - Martinez, SJ, Moreno, CC, Vinson, EN, Dodd, LG, and Brigman, BE. "Angiomatoid fibrous histiocytoma: novel MR imaging findings." Skeletal radiology 45, no. 5 (May 2016): 661-670. Full Text
  - Neumann, JA, Garrigues, GE, Brigman, BE, and Eward, WC. "Synovial Chondromatosis." JBJS reviews 4, no. 5 (May 2016). Full Text
  - Dodd, RD, Sachdeva, M, Mito, JK, Eward, WC, Brigman, BE, Ma, Y, Dodd, L, Kim, Y, Lev, D, and Kirsch, DG. "Myogenic transcription factors regulate pro-metastatic miR-182." Oncogene 35, no. 14 (April 2016): 1868-1875. Full Text
  - Lazarides, AL, Whitley, MJ, Strasfeld, DB, Cardona, DM, Ferrer, JM, Mueller, JL, Fu, HL, Bartholf DeWitt, S, Brigman, BE, Ramanujam, N, Kirsch, DG, and Eward, WC. "A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma." Theranostics 6, no. 2 (January 2016): 155-166. Full Text Open Access Copy
  - Rosenthal, EL, Warram, JM, de Boer, E, Basilion, JP, Biel, MA, Bogyo, M, Bouvet, M, Brigman, BE, Colson, YL, DeMeester, SR, Gurtner, GC, Ishizawa, T, Jacobs, PM, Keereweer, S, Liao, JC, Nguyen, QT, Olson, JM, Paulsen, KD, Rieves, D, Sumer, BD, Tweedle, MF, Vahrmeijer, AL, Weichert, JP, Wilson, BC, Zenn, MR, Zinn, KR, and van Dam, GM. "Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report." Journal of nuclear medicine : official publication, Society of Nuclear Medicine 57, no. 1 (January 2016): 144-150. Full Text
  - Visgauss, JD, Eward, WC, and Brigman, BE. "Innovations in Intraoperative Tumor Visualization." The Orthopedic clinics of North America 47, no. 1 (January 2016): 253-264. (Review) Full Text
  - Whitley, MJ, Cardona, DM, Lazarides, AL, Spasojevic, I, Ferrer, JM, Cahill, J, Lee, C-L, Snuderl, M, Blazer, DG, Hwang, ES, Greenup, RA, Mosca, PJ, Mito, JK, Cuneo, KC, Larrier, NA, O'Reilly, EK, Riedel, RF, Eward, WC, Strasfeld, DB, Fukumura, D, Jain, RK, Lee, WD, Griffith, LG, Bawendi, MG, Kirsch, DG, and Brigman, BE. "A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer." Science translational medicine 8, no. 320 (January 2016): 320ra4-. Full Text
  - Hou, C-H, Lazarides, AL, Speicher, PJ, Nussbaum, DP, Blazer, DG, Kirsch, DG, Brigman, BE, and Eward, WC. "The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival." Annals of surgical oncology 22, no. 9 (September 2015): 2831-2838. Full Text
  - Lazarides, AL, Eward, WC, Green, K, Cardona, DM, Brigman, BE, and Taylor, DC. "Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy." The American journal of sports medicine 43, no. 8 (August 2015): 1935-1940. Full Text
  - Vikingstad, EM, de Ridder, GG, Glisson, RR, Cardona, DM, DiPalma, D, Eward, WC, Brigman, BE, Nelson, RC, and Kim, CY. "Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model." Journal of vascular and interventional radiology : JVIR 26, no. 8 (August 2015): 1221-1228.e1. Full Text
  - Lazarides, AL, Eward, WC, Speicher, PJ, Hou, C-H, Nussbaum, DP, Green, C, Blazer, DG, Kirsch, DG, and Brigman, BE. "The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review." Sarcoma 2015 (January 2015): 186581-. Full Text
  - Eward, WC, DeWitt, SB, Brigman, BE, Kontogeorgakos, V, and Lagoo, AS. "Extranodal Castleman disease of the extremities: a case report and review of the literature." Skeletal radiology 43, no. 11 (November 2014): 1627-1631. (Review) Full Text
  - Ledford, CK, Zelenski, NA, Cardona, DM, Brigman, BE, and Eward, WC. "The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?." Clin Orthop Relat Res 471, no. 11 (November 2013): 3618-3625. Full Text Link to Item
  - Erdmann, D, Garcia, RM, Blueschke, G, Brigman, BE, and Levin, LS. "Vascularized fibula-based physis transfer for pediatric proximal humerus reconstruction." Plast Reconstr Surg 132, no. 2 (August 2013): 281e-287e. Full Text Link to Item
  - Mata, BA, Eward, WC, and Brigman, BE. "Pancarpal synovial and tenosynovial chondromatosis in a 65-year-old man: a highly unusual presentation of a common condition." Am J Orthop (Belle Mead NJ) 42, no. 8 (August 2013): E60-E63. (Review) Link to Item
  - Larrier, NA, Kirsch, DG, Riedel, RF, Levinson, H, Eward, WC, and Brigman, BE. "Practical radiation oncology for extremity sarcomas." Surg Oncol Clin N Am 22, no. 3 (July 2013): 433-443. (Review) Full Text Link to Item
  - Cuneo, KC, Mito, JK, Javid, MP, Ferrer, JM, Kim, Y, Lee, WD, Bawendi, MG, Brigman, BE, and Kirsch, DG. "Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents." Int J Radiat Oncol Biol Phys 86, no. 1 (May 1, 2013): 136-142. Full Text Link to Item
  - Eward, WC, Mito, JK, Eward, CA, Carter, JE, Ferrer, JM, Kirsch, DG, and Brigman, BE. "A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs." Clin Orthop Relat Res 471, no. 3 (March 2013): 834-842. Full Text Link to Item
  - Biermann, JS, Adkins, DR, Agulnik, M, Benjamin, RS, Brigman, B, Butrynski, JE, Cheong, D, Chow, W, Curry, WT, Frassica, DA, Frassica, FJ, Hande, KR, Hornicek, FJ, Jones, RL, Mayerson, J, McGarry, SV, McGrath, B, Morris, CD, O'donnell, RJ, Randall, RL, Santana, VM, Satcher, RL, Siegel, HJ, Mehren, MV, Bergman, MA, and Sundar, H. "Bone Cancer: Clinical practice guidelines in oncology." JNCCN Journal of the National Comprehensive Cancer Network 11, no. 6 (2013): 688-723.
  - Mito, JK, Min, HD, Ma, Y, Carter, JE, Brigman, BE, Dodd, L, Dankort, D, McMahon, M, and Kirsch, DG. "Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma." J Pathol 229, no. 1 (January 2013): 132-140. Full Text Link to Item
  - Mito, JK, Min, HD, Ma, Y, Carter, JE, Brigman, BE, Dodd, L, Dankort, D, McMahon, M, and Kirsch, DG. "Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma." Journal of Pathology 229, no. 1 (2013): 132-140. Full Text
  - Zelenski, N, Brigman, BE, Levin, LS, Erdmann, D, and Eward, WC. "The vascularized fibular graft in the pediatric upper extremity: a durable, biological solution to large oncologic defects." Sarcoma 2013 (2013): 321201-. Full Text Link to Item
  - Mito, JK, Ferrer, JM, Brigman, BE, Lee, C-L, Dodd, RD, Eward, WC, Marshall, LF, Cuneo, KC, Carter, JE, Ramasunder, S, Kim, Y, Lee, WD, Griffith, LG, Bawendi, MG, and Kirsch, DG. "Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging." Cancer 118, no. 21 (November 1, 2012): 5320-5330. Full Text Link to Item
  - Vasileios, KA, Eward, WC, and Brigman, BE. "Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities." Arch Orthop Trauma Surg 132, no. 7 (July 2012): 955-961. Full Text Link to Item
  - Radkowski, CA, Dodd, LG, Johnson, JL, Harrelson, JM, and Brigman, BE. "Leiomyosarcoma of the somatic soft tissues." J Surg Orthop Adv 21, no. 2 (2012): 96-101. Link to Item
  - Kokosis, G, Stolberg-Stolberg, J, Eward, WC, Richard, MJ, Hollenbeck, ST, Levinson, H, Brigman, BE, and Erdmann, D. "[Femur reconstruction using combined autologous fibula transfer and humeral allograft]." Chirurg 82, no. 12 (December 2011): 1120-1123. Full Text Link to Item
  - Lin, F-H, Chang, JB, and Brigman, BE. "Role of mitogen-activated protein kinase in osteoblast differentiation." J Orthop Res 29, no. 2 (February 2011): 204-210. Full Text Link to Item
  - Mito, JK, Dodd, RD, Brigman, BE, Li, Z, Eward, WC, Mukherjee, S, and Kirsch, D. "Dissecting molecular mechanisms of metastasis in a primary mouse model of soft tissue sarcoma." CLINICAL & EXPERIMENTAL METASTASIS 28, no. 2 (February 2011): 166-167. Link to Item
  - Cuneo, KC, Mito, JK, Brigman, BE, Ferrer, JM, Lee, C, Eward, WC, Carter, JE, and Kirsch, DG. "Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model." INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 81, no. 2 (2011): S729-S730. Link to Item
  - Viens, NA, Watters, TS, Vinson, EN, and Brigman, BE. "Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis." Clin Orthop Relat Res 468, no. 11 (November 2010): 3126-3131. (Review) Full Text Link to Item
  - Kontogeorgakos, VA, Martinez, S, Dodd, L, and Brigman, BE. "Extremity soft tissue sarcomas presented as hematomas." Arch Orthop Trauma Surg 130, no. 10 (October 2010): 1209-1214. Full Text Link to Item
  - Lin, F-H, Chang, JB, McGuire, MH, Yee, JA, and Brigman, BE. "Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro." J Orthop Res 28, no. 7 (July 2010): 958-964. Full Text Link to Item
  - Eward, WC, Kontogeorgakos, V, Levin, LS, and Brigman, BE. "Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection." Clin Orthop Relat Res 468, no. 2 (February 2010): 590-598. Full Text Link to Item
  - Biermann, JS, Adkins, DR, Benjamin, RS, Brigman, B, Chow, W, III, EUC, Frassica, DA, Frassica, FJ, George, S, Hande, KR, Hornicek, FJ, Letson, GD, Mayerson, J, McGarry, SV, McGrath, B, Morris, CD, O'Donnell, RJ, Randall, RL, Santana, VM, Satcher, RL, Siegel, HJ, Somaiah, N, and Yasko, AW. "Bone cancer." JNCCN Journal of the National Comprehensive Cancer Network 8, no. 6 (2010): 688-712.
  - Gaskill, T, Payne, D, and Brigman, B. "Cryptococcal abscess imitating a soft-tissue sarcoma in an immunocompetent host: A case report." Journal of Bone and Joint Surgery - Series A 92, no. 9 (2010): 1890-1893. Full Text
  - Mito, JK, Riedel, RF, Dodd, L, Lahat, G, Lazar, AJ, Dodd, RD, Stangenberg, L, Eward, WC, Hornicek, FJ, Yoon, SS, Brigman, BE, Jacks, T, Lev, D, Mukherjee, S, and Kirsch, DG. "Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. (Published online)" PLoS One 4, no. 11 (November 30, 2009): e8075-. Full Text Link to Item
  - Riedel, RF, Larrier, N, Dodd, L, Kirsch, D, Martinez, S, and Brigman, BE. "The clinical management of chondrosarcoma." Curr Treat Options Oncol 10, no. 1-2 (April 2009): 94-106. (Review) Full Text Link to Item
  - Kontogeorgakos, VA, Xenakis, T, Papachristou, D, Korompilias, A, Kanellopoulos, A, Beris, A, and Brigman, B. "Cortical desmoid and the four clinical scenarios." Archives of Orthopaedic and Trauma Surgery 129, no. 6 (2009): 779-785. Full Text
  - Narváez, JA, Martinez, S, Dodd, LG, and Brigman, BE. "Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases." AJR Am J Roentgenol 188, no. 5 (May 2007): 1302-1305. Full Text Link to Item
  - Biermann, JS, Adkins, D, Benjamin, R, Brigman, B, Chow, W, III, EUC, Frassica, D, Frassica, FJ, George, S, Healey, JH, Jr, RH, Letson, GD, Mayerson, J, McGarry, SV, O'Donnell, RJ, Patt, J, Randall, RL, Santana, V, Satcher, RL, Schmidt, RG, Siegel, HJ, Wong, MK, and Yasko, AW. "Bone cancer: Clinical Practice Guidelines in Oncology™." JNCCN Journal of the National Comprehensive Cancer Network 5, no. 4 (2007): 420-437.
  - Lang, JE, Dodd, L, Martinez, S, and Brigman, BE. "Case reports: acral myxoinflammatory fibroblastic sarcoma: a report of five cases and literature review." Clin Orthop Relat Res 445 (April 2006): 254-260. (Review) Full Text Link to Item
  - Toomayan, GA, Robertson, F, Major, NM, and Brigman, BE. "Upper extremity compartmental anatomy: clinical relevance to radiologists." Skeletal Radiol 35, no. 4 (April 2006): 195-201. (Review) Full Text Link to Item
  - Carothers, JT, Brigman, BE, Lawson, RD, and Rizzo, M. "Stacking of a dermal regeneration template for reconstruction of a soft-tissue defect after tumor excision from the palm of the hand: a case report." J Hand Surg Am 30, no. 6 (November 2005): 1322-1326. Full Text Link to Item
  - Biermann, JS, Baker, LH, Benjamin, R, Brigman, B, Chow, W, III, EUC, Frassica, D, Frassica, FJ, George, S, Healey, JH, Heck, R, Letson, GD, Mayerson, J, Neff, J, O'Donnell, RJ, Randall, RL, Santana, V, Satcher, RL, Schmidt, RG, Siegel, HJ, Wong, MK, and Yasko, AW. "Bone cancer: Clinical practice guidelines." JNCCN Journal of the National Comprehensive Cancer Network 3, no. 2 (2005): 124-140.
  - Dodd, LG, Major, N, and Brigman, B. "Malignant giant cell tumor of soft parts." Skeletal Radiol 33, no. 5 (May 2004): 295-299. Full Text Link to Item
  - Brigman, BE, Hornicek, FJ, Gebhardt, MC, and Mankin, HJ. "Allografts about the Knee in Young Patients with High-Grade Sarcoma." Clin Orthop Relat Res , no. 421 (April 2004): 232-239. Link to Item
  - Brigman, BE, Kumagai, SG, and McGuire, MH. "Rotationplasty after failed limb-sparing tumor surgery: a report of two cases." Clin Orthop Relat Res , no. 415 (October 2003): 254-260. Full Text Link to Item
  - Hau, MA, Fox, EJ, Cates, JM, Brigman, BE, and Mankin, HJ. "Jaffe-Campanacci syndrome. A case report and review of the literature." The Journal of bone and joint surgery. American volume 84-A, no. 4 (April 2002): 634-638. (Academic Article)
  - Tsuzaki, M, Brigman, BE, Yamamoto, J, Lawrence, WT, Simmons, JG, Mohapatra, NK, Lund, PK, Wyk, JV, Hannafin, JA, Bhargava, MM, and Banes, AJ. "Insulin-like growth factor-I is expressed by avian flexor tendon cells." Journal of Orthopaedic Research 18, no. 4 (2000): 546-556.
  - Banes, AJ, Tsuzaki, M, Hu, P, Brigman, B, Brown, T, Almekinders, L, Lawrence, WT, and Fischer, T. "PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro." Journal of Biomechanics 28, no. 12 (1995): 1505-1513. Full Text
  - Banes, AJ, Tsuzaki, M, Yamamoto, J, Fischer, T, Brigman, B, Brown, T, and Miller, L. "Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals." Biochemistry and cell biology = Biochimie et biologie cellulaire 73, no. 7-8 (1995): 349-365.
  - Brigman, BE, Hu, P, Yin, H, Tsuzaki, M, Lawrence, WT, and Banes, AJ. "Fibronectin in the tendon-synovial complex: Quantitation in vivo and in vitro by ELISA and relative mRNA levels by polymerase chain reaction and northern blot." Journal of Orthopaedic Research 12, no. 2 (1994): 253-261.

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Education, Training, and Certifications

Selected Grants

Selected Publications

Conference Papers

Journal Articles