Brian Eugene Brigman | Scholars@Duke

Brian Eugene Brigman
Professor of Orthopaedic Surgery

Current Appointments & Affiliations

Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2020
Professor in Pediatrics, Pediatrics, Clinical Science Departments 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

1578 White Zone Ds, Durham, NC 27710
Box 3312 Med Ctr, Durham, NC 27710
brigm003@mc.duke.edu (919) 681-6982

Background
Education, Training, & Certifications
- Fellow, Orthopaedic Oncology, Boston University 2000 - 2001
- Resident, Orthopaedic Surgery, University of Nebraska - Lincoln 1995 - 2000
- Intern, Surgery, University of Nebraska - Lincoln 1994 - 1995
- M.D., University of North Carolina - Chapel Hill 1994
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2010 - 2020
- Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2011 - 2020
- Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2010 - 2011
- Assistant Professor of Surgery, Orthopaedic Surgery, Clinical Science Departments 2001 - 2010
- Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 2009 - 2010
- Instructor, Temporary in the Department of Surgery, Orthopaedic Surgery, Clinical Science Departments 2001
Recognition
In the News
- SEP 5, 2019 Duke Cancer Institute
  
  A Distance Runner Triumphs Over Sarcoma, By Walking
Research
Selected Grants
- A Prospective Observational Study of Intraoperative Angiography for Predicting Wound Complications in Irradiated Soft Tissue Sarcoma of the Extremities awarded by Piedmont Orthopedic Foundation 2020 - 2021
- Fresh Tissue Lab Agreement awarded by DePuy Synthes Companies 2019
- Protocol Number: 14-03-PATHOLHUM-02 awarded by IlluminOss Medical, Inc. 2015 - 2018
- Engineered imaging nanoparticles for real-time detection of cancer in the tumor bed awarded by Lumicell Diagnostics 2013 - 2015
External Relationships
- Daiichi Sankyo Co., Ltd
- Musculoskeletal Transplant Foundation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Abar, Bijan, Junheng Gao, Amanda N. Fletcher, Elizbeth Sachs, Andrew H. Wong, Alexander L. Lazarides, Chinedu Okafor, et al. “Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.” J Orthop Res, May 8, 2023. https://doi.org/10.1002/jor.25597.
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  - Tabarestani, Troy Q., Nicole Levine, Elizabeth Sachs, Ashley Scholl, Roy Colglazier, Robert French, Rami Al-Rohil, Brian Brigman, William Eward, and Julia Visgauss. “Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.” Skeletal Radiol, May 8, 2023. https://doi.org/10.1007/s00256-023-04359-8.
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  - Sag, Alan A., Richard F. Riedel, William C. Eward, Julia D. Visgauss, and Brian E. Brigman. “Hydropneumodissection-Assisted Cryoablation of Recurrent Sarcoma Adjacent to the Sciatic Nerve as a Limb-Sparing Alternative to Hindquarter Amputation.” J Vasc Interv Radiol 34, no. 5 (May 2023): 923-926.e1. https://doi.org/10.1016/j.jvir.2022.12.469.
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  - Azoury, Saïd C., Ronnie L. Shammas, Sammy Othman, Amanda Sergesketter, Brian E. Brigman, Jie C. Nguyen, Alexandre Arkader, et al. “Outcomes following Free Fibula Physeal Transfer for Pediatric Proximal Humerus Reconstruction: An International Multi-Institutional Study.” Plastic and Reconstructive Surgery 151, no. 4 (April 2023): 805–13. https://doi.org/10.1097/prs.0000000000010001.
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  - Sag, Alan A., William A. L. Sperduto, William Eward, James Ronald, Haley Davis, Xiaoyin Sara Jiang, David S. Enterline, et al. “Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.” J Vasc Interv Radiol 33, no. 12 (December 2022): 1594–1600. https://doi.org/10.1016/j.jvir.2022.08.019.
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  - Byers, Isabelle S., Nicholas A. Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojevic, Ping Fan, et al. “Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.” Antimicrob Agents Chemother 66, no. 10 (October 18, 2022): e0014022. https://doi.org/10.1128/aac.00140-22.
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  - Lazarides, Alexander L., Eliana B. Saltzman, Julia D. Visgauss, Suhail K. Mithani, William C. Eward, and Brian E. Brigman. “Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.” J Orthop Res 40, no. 10 (October 2022): 2382–90. https://doi.org/10.1002/jor.25270.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Niall Cochrane, Junheng Gao, Sin-Ho Jung, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.” J Surg Oncol 126, no. 2 (August 2022): 356–64. https://doi.org/10.1002/jso.26864.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Corrigendum to 'Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?' [The Journal of Arthroplasty 37 (2022) 232-237].” J Arthroplasty 37, no. 6 (June 2022): 1212. https://doi.org/10.1016/j.arth.2022.01.041.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1392–1408. https://doi.org/10.1245/s10434-021-10802-8.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1411–12. https://doi.org/10.1245/s10434-021-10892-4.
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  - Lazarides, Alexander L., Etienne M. Flamant, Mark C. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?” J Arthroplasty 37, no. 2 (February 2022): 232–37. https://doi.org/10.1016/j.arth.2021.10.019.
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  - Lazarides, Alexander L., Jason A. Somarelli, Brian E. Brigman, Julia D. Visgauss, and William C. Eward. “ASO Author Reflections: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma.” Ann Surg Oncol 29, no. 2 (February 2022): 1409–10. https://doi.org/10.1245/s10434-021-10904-3.
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  - Rao, Sneha R., Alexander L. Lazarides, Bruce L. Leckey, Whitney O. Lane, Julia D. Visgauss, Jason A. Somarelli, David G. Kirsch, et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.” Cancer Med 11, no. 1 (January 2022): 194–206. https://doi.org/10.1002/cam4.4428.
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  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia Dawn Visgauss, Jason A. Somarelli, Dan Blazer, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma-A National Cancer Database Study.” Ann Surg Oncol 28, no. Suppl 3 (December 2021): 449–50. https://doi.org/10.1245/s10434-021-10131-w.
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  - Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.” Ann Surg Oncol 28, no. 12 (November 2021): 7961–72. https://doi.org/10.1245/s10434-021-10099-7.
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  - Ferlauto, Harrison R., John R. Wickman, Alexander L. Lazarides, Stephanie Hendren, Julia D. Visgauss, Brian E. Brigman, Oke A. Anakwenze, Christopher S. Klifto, and William C. Eward. “Reverse total shoulder arthroplasty for oncologic reconstruction of the proximal humerus: a systematic review.” J Shoulder Elbow Surg 30, no. 11 (November 2021): e647–58. https://doi.org/10.1016/j.jse.2021.06.004.
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  - Bostrom, Mathias P. G., Kadriye O. Lewis, and Gavin Berger. “The Role of Electronic Learning in Orthopaedic Graduate Medical Training: A Consensus From Leaders in Orthopaedic Training Programs.” Journal of the American Academy of Orthopaedic Surgeons 29, no. 8 (April 15, 2021): 317–25. https://doi.org/10.5435/jaaos-d-20-00821.
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  - Schneider, Patricia, Diane Heels-Ansdell, Lehana Thabane, Michelle Ghert, and Michelle PARITY Investigators. “Prophylactic Antibiotic Regimens In Tumor Surgery (PARITY): a multi-center randomized controlled study comparing alternative antibiotic regimens in patients undergoing tumor resections with endoprosthetic replacements-a statistical analysis plan.” Trials 22, no. 1 (March 22, 2021): 223. https://doi.org/10.1186/s13063-021-05147-2.
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  - Cullen, Mark M., Ebubechi Okwumabua, Etienne M. Flamant, Harrison R. Ferlauto, Brian E. Brigman, and William C. Eward. “Humeral Shaft Fracture With Placement of an Intramedullary Nail Through an Unrecognized Sarcoma.” J Am Acad Orthop Surg Glob Res Rev 5, no. 2 (February 19, 2021). https://doi.org/10.5435/JAAOSGlobal-D-20-00142.
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  - Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.
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  - Lazarides, Alexander L., Harrison R. Ferlauto, Zachary D. C. Burke, Anthony M. Griffin, Bruce D. Leckey, Nicholas M. Bernthal, Jay S. Wunder, et al. “The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors.” Sarcoma 2021 (January 2021): 4740924. https://doi.org/10.1155/2021/4740924.
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  - VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.
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  - Evans, Daniel R., Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.” Bmc Cancer 20, no. 1 (October 14, 2020): 995. https://doi.org/10.1186/s12885-020-07502-z.
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  - Lazarides, Alexander L., Marcelo Cerullo, Dimitrios Moris, Brian E. Brigman, Dan G. Blazer, and William C. Eward. “Defining a textbook surgical outcome for patients undergoing surgical resection of intermediate and high-grade soft tissue sarcomas of the extremities.” J Surg Oncol 122, no. 5 (October 2020): 884–96. https://doi.org/10.1002/jso.26087.
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  - Lazarides, Alexander L., David L. Kerr, Brian L. Dial, John R. Steele, Whitney O. Lane, Dan G. Blazer, Brian E. Brigman, Sergio Mendoza-Lattes, Melissa M. Erickson, and William C. Eward. “Does facility volume influence survival in patients with primary malignant bone tumors of the vertebral column? A comparative cohort study.” Spine J 20, no. 7 (July 2020): 1106–13. https://doi.org/10.1016/j.spinee.2020.02.020.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - Reddy, Gireesh B., David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham, and William C. Eward. “Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.” Molecular Cancer Therapeutics 19, no. 7 (July 2020): 1448–61. https://doi.org/10.1158/1535-7163.mct-19-0689.
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  - Dial, Brian L., David L. Kerr, Alexander L. Lazarides, Anthony A. Catanzano, Cindy L. Green, Thomas Risoli, Dan G. Blazer, et al. “The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.” Spine (Phila Pa 1976) 45, no. 12 (June 15, 2020): E742–51. https://doi.org/10.1097/BRS.0000000000003406.
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  - VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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  - Kerr, David L., Brian L. Dial, Alexander L. Lazarides, Anthony A. Catanzano, Whitney O. Lane, Dan G. Blazer, Brian E. Brigman, Sergio Mendoza-Lattes, William C. Eward, and Melissa E. Erickson. “Epidemiologic and survival trends in adult primary bone tumors of the spine.” Spine J 19, no. 12 (December 2019): 1941–49. https://doi.org/10.1016/j.spinee.2019.07.003.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.
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  - Kontogeorgakos, Vasileios A., William C. Eward, and Brian E. Brigman. “Microsurgery in musculoskeletal oncology.” Eur J Orthop Surg Traumatol 29, no. 2 (February 2019): 271–78. https://doi.org/10.1007/s00590-019-02373-y.
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  - Catanzano, Anthony A., David L. Kerr, Alexander L. Lazarides, Brian L. Dial, Whitney O. Lane, Dan G. Blazer, Nicole A. Larrier, David G. Kirsch, Brian E. Brigman, and William C. Eward. “Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.” Sarcoma 2019 (2019): 4878512. https://doi.org/10.1155/2019/4878512.
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  - Shea, Phelan, Nathan N. O’Hara, Sheila A. Sprague, Mohit Bhandari, Brad A. Petrisor, Kyle J. Jeray, Min Zhan, Gerard P. Slobogean, Raymond A. Pensy, and Raymond A. Fluid Lavage in Open Wounds Investigators. “Wound Surface Area as a Risk Factor for Flap Complications among Patients with Open Fractures.” Plast Reconstr Surg 142, no. 1 (July 2018): 228–36. https://doi.org/10.1097/PRS.0000000000004418.
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  - Suresh, Visakha, Junheng Gao, Sin-Ho Jung, Brian Brigman, William Eward, and Detlev Erdmann. “The Role of Reconstructive Surgery After Skeletal and Soft Tissue Sarcoma Resection.” Ann Plast Surg 80, no. 6S Suppl 6 (June 2018): S372–76. https://doi.org/10.1097/SAP.0000000000001419.
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  - Lazarides, Alexander L., Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.” Bmc Cancer 18, no. 1 (April 27, 2018): 488. https://doi.org/10.1186/s12885-018-4397-3.
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  - Matson, Andrew P., Joseph J. Kavolus, William A. Byrd, Fraser J. Leversedge, and Brian E. Brigman. “Influence of Trainee Experience on Choice of Orthopaedic Subspecialty Fellowship.” J Am Acad Orthop Surg 26, no. 3 (February 1, 2018): e62–67. https://doi.org/10.5435/JAAOS-D-16-00701.
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  - Ryan, Sean, Julia Visgauss, David Kerr, Joshua Helmkamp, Nicholas Said, Emily Vinson, Patrick O’Donnell, et al. “The Value of MRI in Distinguishing Subtypes of Lipomatous Extremity Tumors Needs Reassessment in the Era of MDM2 and CDK4 Testing.” Sarcoma 2018 (2018): 1901896. https://doi.org/10.1155/2018/1901896.
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  - Scott, Elizabeth, Mitchell R. Klement, Brian E. Brigman, and William C. Eward. “Beyond Mirels: Factors Influencing Surgical Outcome of Metastasis to the Extremities in the Modern Era.” J Surg Orthop Adv 27, no. 3 (2018): 178–86.
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  - Kavolus, Joseph J., Andrew P. Matson, William A. Byrd, and Brian E. Brigman. “Factors Influencing Orthopedic Surgery Residents' Choice of Subspecialty Fellowship.” Orthopedics 40, no. 5 (September 1, 2017): e820–24. https://doi.org/10.3928/01477447-20170619-01.
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  - Grimm, Nathan L., David M. Tainter, William C. Eward, and Brian E. Brigman. “Tumors of the Epiphyses.” Jbjs Rev 5, no. 5 (May 2017): e4. https://doi.org/10.2106/JBJS.RVW.16.00080.
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  - Shammas, Ronnie L., Yash J. Avashia, Alfredo E. Farjat, Anthony A. Catanzano, L Scott Levin, William C. Eward, Brian E. Brigman, and Detlev Erdmann. “Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications.” Plast Reconstr Surg Glob Open 5, no. 5 (May 2017): e1352. https://doi.org/10.1097/GOX.0000000000001352.
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  - Henderson, E. R., B. J. Keeney, E. Pala, P. T. Funovics, W. C. Eward, J. S. Groundland, L. K. Ehrlichman, et al. “The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.” Bone Joint J 99-B, no. 4 (April 2017): 531–37. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-0960.R1.
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  - Biermann, J Sybil, Warren Chow, Damon R. Reed, David Lucas, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, et al. “NCCN Guidelines Insights: Bone Cancer, Version 2.2017.” J Natl Compr Canc Netw 15, no. 2 (February 2017): 155–67. https://doi.org/10.6004/jnccn.2017.0017.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Snouwaert, John N., MyTrang Nguyen, Peter W. Repenning, Rebecca Dye, Eric W. Livingston, Martina Kovarova, Sheryl S. Moy, et al. “An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.” Cell Rep 17, no. 11 (December 13, 2016): 3077–88. https://doi.org/10.1016/j.celrep.2016.11.052.
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  - Lazarides, Alexander L., Elizabeth J. Scott, Diana M. Cardona, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature.” J Gastrointest Cancer 47, no. 3 (September 2016): 331–35. https://doi.org/10.1007/s12029-015-9749-5.
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  - Bartholf DeWitt, Suzanne, William C. Eward, Cindy A. Eward, Alexander L. Lazarides, Melodi Javid Whitley, Jorge M. Ferrer, Brian E. Brigman, David G. Kirsch, and John Berg. “A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.” Vet Surg 45, no. 6 (August 2016): 715–22. https://doi.org/10.1111/vsu.12487.
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  - Neumann, Julie A., Grant E. Garrigues, Brian E. Brigman, and William C. Eward. “Synovial Chondromatosis.” Jbjs Rev 4, no. 5 (May 10, 2016). https://doi.org/10.2106/JBJS.RVW.O.00054.
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  - Martinez, Salutario J., Courtney Coursey Moreno, Emily N. Vinson, Leslie G. Dodd, and Brian E. Brigman. “Angiomatoid fibrous histiocytoma: novel MR imaging findings.” Skeletal Radiol 45, no. 5 (May 2016): 661–70. https://doi.org/10.1007/s00256-016-2344-4.
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  - Dodd, R. D., M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, and D. G. Kirsch. “Myogenic transcription factors regulate pro-metastatic miR-182.” Oncogene 35, no. 14 (April 7, 2016): 1868–75. https://doi.org/10.1038/onc.2015.252.
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  - Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
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  - Lazarides, Alexander L., Melodi J. Whitley, David B. Strasfeld, Diana M. Cardona, Jorge M. Ferrer, Jenna L. Mueller, Henry L. Fu, et al. “A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.” Theranostics 6, no. 2 (2016): 155–66. https://doi.org/10.7150/thno.13536.
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  - Rosenthal, Eben L., Jason M. Warram, Esther de Boer, James P. Basilion, Merrill A. Biel, Matthew Bogyo, Michael Bouvet, et al. “Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report.” J Nucl Med 57, no. 1 (January 2016): 144–50. https://doi.org/10.2967/jnumed.115.158915.
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  - Visgauss, Julia D., William C. Eward, and Brian E. Brigman. “Innovations in Intraoperative Tumor Visualization.” Orthop Clin North Am 47, no. 1 (January 2016): 253–64. https://doi.org/10.1016/j.ocl.2015.08.023.
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  - Hou, Chun-Han, Alexander L. Lazarides, Paul J. Speicher, Daniel P. Nussbaum, Daniel G. Blazer, David G. Kirsch, Brian E. Brigman, and William C. Eward. “The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.” Ann Surg Oncol 22, no. 9 (September 2015): 2831–38. https://doi.org/10.1245/s10434-015-4639-4.
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  - Lazarides, Alexander L., William C. Eward, Kimberly Green, Diana M. Cardona, Brian E. Brigman, and Dean C. Taylor. “Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy.” Am J Sports Med 43, no. 8 (August 2015): 1935–40. https://doi.org/10.1177/0363546515584040.
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  - Vikingstad, Eric M., Gustaaf G. de Ridder, Richard R. Glisson, Diana M. Cardona, Devon DiPalma, William C. Eward, Brian E. Brigman, Rendon C. Nelson, and Charles Y. Kim. “Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model.” J Vasc Interv Radiol 26, no. 8 (August 2015): 1221-1228.e1. https://doi.org/10.1016/j.jvir.2015.04.013.
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  - Lazarides, Alexander L., William C. Eward, Paul J. Speicher, Chun-Han Hou, Daniel P. Nussbaum, Cindy Green, Dan G. Blazer, David G. Kirsch, and Brian E. Brigman. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.” Sarcoma 2015 (2015): 186581. https://doi.org/10.1155/2015/186581.
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  - Eward, William C., Suzanne B. DeWitt, Brian E. Brigman, Vasilios Kontogeorgakos, and Anand S. Lagoo. “Extranodal Castleman disease of the extremities: a case report and review of the literature.” Skeletal Radiol 43, no. 11 (November 2014): 1627–31. https://doi.org/10.1007/s00256-014-1945-z.
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  - Ledford, Cameron K., Nicole A. Zelenski, Diana M. Cardona, Brian E. Brigman, and William C. Eward. “The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?” Clin Orthop Relat Res 471, no. 11 (November 2013): 3618–25. https://doi.org/10.1007/s11999-013-3178-1.
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  - Erdmann, Detlev, Ryan M. Garcia, Gert Blueschke, Brian E. Brigman, and L Scott Levin. “Vascularized fibula-based physis transfer for pediatric proximal humerus reconstruction.” Plast Reconstr Surg 132, no. 2 (August 2013): 281e-287e. https://doi.org/10.1097/PRS.0b013e31829589fb.
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  - Mata, Brian A., William C. Eward, and Brian E. Brigman. “Pancarpal synovial and tenosynovial chondromatosis in a 65-year-old man: a highly unusual presentation of a common condition.” Am J Orthop (Belle Mead Nj) 42, no. 8 (August 2013): E60–63.
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  - Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
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  - Biermann, J Sybil, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, Brian Brigman, James E. Butrynski, David Cheong, et al. “Bone cancer.” J Natl Compr Canc Netw 11, no. 6 (June 1, 2013): 688–723. https://doi.org/10.6004/jnccn.2013.0088.
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  - Cuneo, Kyle C., Jeffrey K. Mito, Melodi P. Javid, Jorge M. Ferrer, Yongbaek Kim, W David Lee, Moungi G. Bawendi, Brian E. Brigman, and David G. Kirsch. “Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents.” Int J Radiat Oncol Biol Phys 86, no. 1 (May 1, 2013): 136–42. https://doi.org/10.1016/j.ijrobp.2012.12.007.
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  - Eward, William C., Jeffrey K. Mito, Cindy A. Eward, Jessica E. Carter, Jorge M. Ferrer, David G. Kirsch, and Brian E. Brigman. “A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.” Clin Orthop Relat Res 471, no. 3 (March 2013): 834–42. https://doi.org/10.1007/s11999-012-2560-8.
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  - Mito, Jeffrey K., Hooney D. Min, Yan Ma, Jessica E. Carter, Brian E. Brigman, Leslie Dodd, David Dankort, Martin McMahon, and David G. Kirsch. “Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.” J Pathol 229, no. 1 (January 2013): 132–40. https://doi.org/10.1002/path.4099.
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  - Zelenski, Nicki, Brian E. Brigman, L Scott Levin, Detlev Erdmann, and William C. Eward. “The vascularized fibular graft in the pediatric upper extremity: a durable, biological solution to large oncologic defects.” Sarcoma 2013 (2013): 321201. https://doi.org/10.1155/2013/321201.
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  - Mito, Jeffrey K., Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, et al. “Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.” Cancer 118, no. 21 (November 1, 2012): 5320–30. https://doi.org/10.1002/cncr.27458.
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  - Vasileios, Kontogeorgakos A., William C. Eward, and Brian E. Brigman. “Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities.” Arch Orthop Trauma Surg 132, no. 7 (July 2012): 955–61. https://doi.org/10.1007/s00402-012-1510-y.
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  - Radkowski, Christopher A., Leslie G. Dodd, Jeffrey L. Johnson, John M. Harrelson, and Brian E. Brigman. “Leiomyosarcoma of the somatic soft tissues.” J Surg Orthop Adv 21, no. 2 (2012): 96–101. https://doi.org/10.3113/jsoa.2012.0096.
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  - Kokosis, G., J. Stolberg-Stolberg, W. C. Eward, M. J. Richard, S. T. Hollenbeck, H. Levinson, B. E. Brigman, and D. Erdmann. “[Femur reconstruction using combined autologous fibula transfer and humeral allograft].” Chirurg 82, no. 12 (December 2011): 1120–23. https://doi.org/10.1007/s00104-011-2165-x.
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  - Cuneo, K. C., J. K. Mito, B. E. Brigman, J. M. Ferrer, C. Lee, W. C. Eward, J. E. Carter, and D. G. Kirsch. “Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S729–30. https://doi.org/10.1016/j.ijrobp.2011.06.1300.
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  - Lin, Fu-Hsiung, Jessica B. Chang, and Brian E. Brigman. “Role of mitogen-activated protein kinase in osteoblast differentiation.” J Orthop Res 29, no. 2 (February 2011): 204–10. https://doi.org/10.1002/jor.21222.
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  - Mito, Jeffrey K., Rebecca D. Dodd, Brian E. Brigman, Zhizhong Li, William C. Eward, Sayan Mukherjee, and David Kirsch. “Dissecting molecular mechanisms of metastasis in a primary mouse model of soft tissue sarcoma.” Clinical & Experimental Metastasis 28, no. 2 (February 1, 2011): 166–67.
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  - Viens, Nicholas A., Tyler Steven Watters, Emily N. Vinson, and Brian E. Brigman. “Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis.” Clin Orthop Relat Res 468, no. 11 (November 2010): 3126–31. https://doi.org/10.1007/s11999-010-1257-0.
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  - Kontogeorgakos, Vasileios A., Salutario Martinez, Leslie Dodd, and Brian E. Brigman. “Extremity soft tissue sarcomas presented as hematomas.” Arch Orthop Trauma Surg 130, no. 10 (October 2010): 1209–14. https://doi.org/10.1007/s00402-009-0987-5.
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  - Gaskill, Trevor, Diane Payne, and Brian Brigman. “Cryptococcal abscess imitating a soft-tissue sarcoma in an immunocompetent host: a case report.” J Bone Joint Surg Am 92, no. 9 (August 4, 2010): 1890–93. https://doi.org/10.2106/JBJS.I.01091.
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  - Lin, Fu-Hsiumg, Jessica B. Chang, Michael H. McGuire, John A. Yee, and Brian E. Brigman. “Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro.” J Orthop Res 28, no. 7 (July 2010): 958–64. https://doi.org/10.1002/jor.21099.
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  - Biermann, J Sybil, Douglas R. Adkins, Robert S. Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah A. Frassica, et al. “Bone cancer.” J Natl Compr Canc Netw 8, no. 6 (June 2010): 688–712. https://doi.org/10.6004/jnccn.2010.0051.
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  - Eward, William C., Vasileios Kontogeorgakos, Lawrence Scott Levin, and Brian E. Brigman. “Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection.” Clin Orthop Relat Res 468, no. 2 (February 2010): 590–98. https://doi.org/10.1007/s11999-009-1053-x.
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  - Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” Plos One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.
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  - Kontogeorgakos, Vasilelos A., Theodore Xenakis, Dionysios Papachristou, Anastasios Korompilias, Anastasios Kanellopoulos, Alexander Beris, and Brian Brigman. “Cortical desmoid and the four clinical scenarios.” Arch Orthop Trauma Surg 129, no. 6 (June 2009): 779–85. https://doi.org/10.1007/s00402-008-0687-6.
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  - Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma.” Curr Treat Options Oncol 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.
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  - Narváez, José Antonio, Salutario Martinez, Leslie G. Dodd, and Brian E. Brigman. “Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases.” Ajr Am J Roentgenol 188, no. 5 (May 2007): 1302–5. https://doi.org/10.2214/AJR.05.0141.
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  - Biermann, J Sybil, Douglas Adkins, Robert Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah Frassica, et al. “Bone cancer.” J Natl Compr Canc Netw 5, no. 4 (April 2007): 420–37. https://doi.org/10.6004/jnccn.2007.0037.
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  - Lang, Jason E., Leslie Dodd, Salutario Martinez, and Brian E. Brigman. “Case reports: acral myxoinflammatory fibroblastic sarcoma: a report of five cases and literature review.” Clin Orthop Relat Res 445 (April 2006): 254–60. https://doi.org/10.1097/01.blo.0000201158.67443.a2.
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  - Toomayan, Glen A., Fabienne Robertson, Nancy M. Major, and Brian E. Brigman. “Upper extremity compartmental anatomy: clinical relevance to radiologists.” Skeletal Radiol 35, no. 4 (April 2006): 195–201. https://doi.org/10.1007/s00256-005-0063-3.
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  - Carothers, Joshua T., Brian E. Brigman, Richard D. Lawson, and Marco Rizzo. “Stacking of a dermal regeneration template for reconstruction of a soft-tissue defect after tumor excision from the palm of the hand: a case report.” J Hand Surg Am 30, no. 6 (November 2005): 1322–26. https://doi.org/10.1016/j.jhsa.2005.08.001.
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  - Biermann, J Sybil, Laurence H. Baker, Robert Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah Frassica, et al. “Bone cancer clinical practice guidelines.” J Natl Compr Canc Netw 3, no. 2 (March 2005): 124–40.
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  - Dodd, Leslie G., Nancy Major, and Brian Brigman. “Malignant giant cell tumor of soft parts.” Skeletal Radiol 33, no. 5 (May 2004): 295–99. https://doi.org/10.1007/s00256-003-0744-8.
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  - Brigman, Brian E., Francis J. Hornicek, Mark C. Gebhardt, and Henry J. Mankin. “Allografts about the Knee in Young Patients with High-Grade Sarcoma.” Clin Orthop Relat Res, no. 421 (April 2004): 232–39. https://doi.org/10.1097/01.blo.0000127132.12576.05.
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  - Brigman, Brian E., Steven G. Kumagai, and Michael H. McGuire. “Rotationplasty after failed limb-sparing tumor surgery: a report of two cases.” Clin Orthop Relat Res, no. 415 (October 2003): 254–60. https://doi.org/10.1097/01.blo.0000093887.12372.3d.
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  - Hau, Mohammad Anwar, Edward J. Fox, Justin M. Cates, Brian E. Brigman, and Henry J. Mankin. “Jaffe-Campanacci syndrome. A case report and review of the literature.” J Bone Joint Surg Am 84, no. 4 (April 2002): 634–38.
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  - Tsuzaki, M., B. E. Brigman, J. Yamamoto, W. T. Lawrence, J. G. Simmons, N. K. Mohapatra, P. K. Lund, et al. “Insulin-like growth factor-I is expressed by avian flexor tendon cells.” J Orthop Res 18, no. 4 (July 2000): 546–56. https://doi.org/10.1002/jor.1100180406.
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  - Banes, A. J., M. Tsuzaki, P. Hu, B. Brigman, T. Brown, L. Almekinders, W. T. Lawrence, and T. Fischer. “PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro.” J Biomech 28, no. 12 (December 1995): 1505–13. https://doi.org/10.1016/0021-9290(95)00098-4.
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  - Banes, A. J., M. Tsuzaki, J. Yamamoto, T. Fischer, B. Brigman, T. Brown, and L. Miller. “Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals.” Biochem Cell Biol 73, no. 7–8 (1995): 349–65. https://doi.org/10.1139/o95-043.
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  - Brigman, B. E., P. Hu, H. Yin, M. Tsuzaki, W. T. Lawrence, and A. J. Banes. “Fibronectin in the tendon-synovial complex: quantitation in vivo and in vitro by ELISA and relative mRNA levels by polymerase chain reaction and northern blot.” J Orthop Res 12, no. 2 (March 1994): 253–61. https://doi.org/10.1002/jor.1100120215.
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- Conference Papers
  - Catanzano, A. A., S. P. Ryan, A. L. Lazarides, B. E. Brigman, and W. C. Eward. “New Techniques for Diagnosis and Treatment of Musculoskeletal Tumors: Methods of Intraoperative Margin Detection.” In Techniques in Orthopaedics, 33:148–57, 2018. https://doi.org/10.1097/BTO.0000000000000290.
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  - Mowery, Yvonne Marie, Karla V. Ballman, Richard F. Riedel, Brian E. Brigman, Steven Attia, Christian Frederick Meyer, Scott Schuetze, et al. “SU2C-SARC032: A phase II randomized controlled trial of neoadjuvant pembrolizumab with radiotherapy and adjuvant pembrolizumab for high-risk soft tissue sarcoma.” In Journal of Clinical Oncology, 36:TPS11588–TPS11588. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.tps11588.
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  - Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.
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  - Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.
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