Brian Eugene Brigman | Scholars@Duke

Brian Eugene Brigman
Associate Professor of Orthopaedic Surgery

Current Appointments & Affiliations

Associate Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2011
Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2010
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2012

Contact Information

1578 White Zone Ds, Durham, NC 27710
Box 3312 Med Ctr, Durham, NC 27710
brigm003@mc.duke.edu (919) 681-6982

Background
Education, Training, & Certifications
- Fellow, Orthopaedic Oncology, Boston University 2000 - 2001
- Resident, Orthopaedic Surgery, University of Nebraska at Lincoln 1995 - 2000
- Intern, Surgery, University of Nebraska at Lincoln 1994 - 1995
- M.D., University of North Carolina at Chapel Hill 1994
Duke Appointment History
- Associate Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2010 - 2011
- Assistant Professor of Surgery, Orthopaedics, Orthopaedics 2001 - 2010
- Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 2009 - 2010
- Instructor, Temporary in the Department of Surgery, Orthopaedics, Orthopaedics 2001
Recognition
In the News
- SEP 5, 2019 Duke Cancer Institute
  
  A Distance Runner Triumphs Over Sarcoma, By Walking
Research
Selected Grants
External Relationships
- Daiichi Sankyo Co., Ltd
- Musculoskeletal Transplant Foundation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, March 20, 2020. https://doi.org/10.1007/s00415-020-09797-1.
    Full Text Link to Item
  - Kerr, David L., Brian L. Dial, Alexander L. Lazarides, Anthony A. Catanzano, Whitney O. Lane, Dan G. Blazer, Brian E. Brigman, Sergio Mendoza-Lattes, William C. Eward, and Melissa E. Erickson. “Epidemiologic and survival trends in adult primary bone tumors of the spine.” Spine J 19, no. 12 (December 2019): 1941–49. https://doi.org/10.1016/j.spinee.2019.07.003.
    Full Text Link to Item
  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
    Full Text Open Access Copy Link to Item
  - Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.
    Full Text Link to Item
  - Kontogeorgakos, Vasileios A., William C. Eward, and Brian E. Brigman. “Microsurgery in musculoskeletal oncology.” Eur J Orthop Surg Traumatol 29, no. 2 (February 2019): 271–78. https://doi.org/10.1007/s00590-019-02373-y.
    Full Text Link to Item
  - Catanzano, Anthony A., David L. Kerr, Alexander L. Lazarides, Brian L. Dial, Whitney O. Lane, Dan G. Blazer, Nicole A. Larrier, David G. Kirsch, Brian E. Brigman, and William C. Eward. “Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.” Sarcoma 2019 (2019): 4878512. https://doi.org/10.1155/2019/4878512.
    Full Text Link to Item
  - Suresh, Visakha, Junheng Gao, Sin-Ho Jung, Brian Brigman, William Eward, and Detlev Erdmann. “The Role of Reconstructive Surgery After Skeletal and Soft Tissue Sarcoma Resection.” Ann Plast Surg 80, no. 6S Suppl 6 (June 2018): S372–76. https://doi.org/10.1097/SAP.0000000000001419.
    Full Text Link to Item
  - Lazarides, Alexander L., Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.” Bmc Cancer 18, no. 1 (April 27, 2018): 488. https://doi.org/10.1186/s12885-018-4397-3.
    Full Text Link to Item
  - Matson, Andrew P., Joseph J. Kavolus, William A. Byrd, Fraser J. Leversedge, and Brian E. Brigman. “Influence of Trainee Experience on Choice of Orthopaedic Subspecialty Fellowship.” J Am Acad Orthop Surg 26, no. 3 (February 1, 2018): e62–67. https://doi.org/10.5435/JAAOS-D-16-00701.
    Full Text Link to Item
  - Kavolus, Joseph J., Andrew P. Matson, William A. Byrd, and Brian E. Brigman. “Factors Influencing Orthopedic Surgery Residents' Choice of Subspecialty Fellowship.” Orthopedics 40, no. 5 (September 2017): e820–24. https://doi.org/10.3928/01477447-20170619-01.
    Full Text
  - Grimm, Nathan L., David M. Tainter, William C. Eward, and Brian E. Brigman. “Tumors of the Epiphyses.” Jbjs Reviews 5, no. 5 (May 2017): e4. https://doi.org/10.2106/jbjs.rvw.16.00080.
    Full Text
  - Shammas, Ronnie L., Yash J. Avashia, Alfredo E. Farjat, Anthony A. Catanzano, L Scott Levin, William C. Eward, Brian E. Brigman, and Detlev Erdmann. “Vascularized Fibula-Based Physis Transfer: A Follow-Up Study of Longitudinal Bone Growth and Complications.” Plast Reconstr Surg Glob Open 5, no. 5 (May 2017): e1352. https://doi.org/10.1097/GOX.0000000000001352.
    Full Text Link to Item
  - Henderson, E. R., B. J. Keeney, E. Pala, P. T. Funovics, W. C. Eward, J. S. Groundland, L. K. Ehrlichman, et al. “The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.” Bone Joint J 99-B, no. 4 (April 2017): 531–37. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-0960.R1.
    Full Text Link to Item
  - Biermann, J Sybil, Warren Chow, Damon R. Reed, David Lucas, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, et al. “NCCN Guidelines Insights: Bone Cancer, Version 2.2017.” J Natl Compr Canc Netw 15, no. 2 (February 2017): 155–67. https://doi.org/10.6004/jnccn.2017.0017.
    Full Text Link to Item
  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
    Full Text Open Access Copy Link to Item
  - Snouwaert, John N., MyTrang Nguyen, Peter W. Repenning, Rebecca Dye, Eric W. Livingston, Martina Kovarova, Sheryl S. Moy, et al. “An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.” Cell Rep 17, no. 11 (December 13, 2016): 3077–88. https://doi.org/10.1016/j.celrep.2016.11.052.
    Full Text Link to Item
  - Lazarides, Alexander L., Elizabeth J. Scott, Diana M. Cardona, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature.” J Gastrointest Cancer 47, no. 3 (September 2016): 331–35. https://doi.org/10.1007/s12029-015-9749-5.
    Full Text Link to Item
  - Bartholf DeWitt, Suzanne, William C. Eward, Cindy A. Eward, Alexander L. Lazarides, Melodi Javid Whitley, Jorge M. Ferrer, Brian E. Brigman, David G. Kirsch, and John Berg. “A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs.” Vet Surg 45, no. 6 (August 2016): 715–22. https://doi.org/10.1111/vsu.12487.
    Full Text Link to Item
  - Neumann, Julie A., Grant E. Garrigues, Brian E. Brigman, and William C. Eward. “Synovial Chondromatosis.” Jbjs Rev 4, no. 5 (May 10, 2016). https://doi.org/10.2106/JBJS.RVW.O.00054.
    Full Text Link to Item
  - Martinez, Salutario J., Courtney Coursey Moreno, Emily N. Vinson, Leslie G. Dodd, and Brian E. Brigman. “Angiomatoid fibrous histiocytoma: novel MR imaging findings.” Skeletal Radiol 45, no. 5 (May 2016): 661–70. https://doi.org/10.1007/s00256-016-2344-4.
    Full Text Link to Item
  - Dodd, R. D., M. Sachdeva, J. K. Mito, W. C. Eward, B. E. Brigman, Y. Ma, L. Dodd, Y. Kim, D. Lev, and D. G. Kirsch. “Myogenic transcription factors regulate pro-metastatic miR-182.” Oncogene 35, no. 14 (April 7, 2016): 1868–75. https://doi.org/10.1038/onc.2015.252.
    Full Text Link to Item
  - Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
    Full Text Link to Item
  - Lazarides, Alexander L., Melodi J. Whitley, David B. Strasfeld, Diana M. Cardona, Jorge M. Ferrer, Jenna L. Mueller, Henry L. Fu, et al. “A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.” Theranostics 6, no. 2 (2016): 155–66. https://doi.org/10.7150/thno.13536.
    Full Text Open Access Copy Link to Item
  - Rosenthal, Eben L., Jason M. Warram, Esther de Boer, James P. Basilion, Merrill A. Biel, Matthew Bogyo, Michael Bouvet, et al. “Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report.” J Nucl Med 57, no. 1 (January 2016): 144–50. https://doi.org/10.2967/jnumed.115.158915.
    Full Text Link to Item
  - Visgauss, Julia D., William C. Eward, and Brian E. Brigman. “Innovations in Intraoperative Tumor Visualization.” Orthop Clin North Am 47, no. 1 (January 2016): 253–64. https://doi.org/10.1016/j.ocl.2015.08.023.
    Full Text Link to Item
  - Hou, Chun-Han, Alexander L. Lazarides, Paul J. Speicher, Daniel P. Nussbaum, Daniel G. Blazer, David G. Kirsch, Brian E. Brigman, and William C. Eward. “The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.” Ann Surg Oncol 22, no. 9 (September 2015): 2831–38. https://doi.org/10.1245/s10434-015-4639-4.
    Full Text Link to Item
  - Lazarides, Alexander L., William C. Eward, Kimberly Green, Diana M. Cardona, Brian E. Brigman, and Dean C. Taylor. “Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy.” The American Journal of Sports Medicine 43, no. 8 (August 2015): 1935–40. https://doi.org/10.1177/0363546515584040.
    Full Text
  - Vikingstad, Eric M., Gustaaf G. de Ridder, Richard R. Glisson, Diana M. Cardona, Devon DiPalma, William C. Eward, Brian E. Brigman, Rendon C. Nelson, and Charles Y. Kim. “Comparison of Acute Histologic and Biomechanical Effects of Radiofrequency Ablation and Cryoablation on Periarticular Structures in a Swine Model.” J Vasc Interv Radiol 26, no. 8 (August 2015): 1221-1228.e1. https://doi.org/10.1016/j.jvir.2015.04.013.
    Full Text Link to Item
  - Lazarides, Alexander L., William C. Eward, Paul J. Speicher, Chun-Han Hou, Daniel P. Nussbaum, Cindy Green, Dan G. Blazer, David G. Kirsch, and Brian E. Brigman. “The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.” Sarcoma 2015 (2015): 186581. https://doi.org/10.1155/2015/186581.
    Full Text Link to Item
  - Eward, William C., Suzanne B. DeWitt, Brian E. Brigman, Vasilios Kontogeorgakos, and Anand S. Lagoo. “Extranodal Castleman disease of the extremities: a case report and review of the literature.” Skeletal Radiol 43, no. 11 (November 2014): 1627–31. https://doi.org/10.1007/s00256-014-1945-z.
    Full Text Link to Item
  - Ledford, Cameron K., Nicole A. Zelenski, Diana M. Cardona, Brian E. Brigman, and William C. Eward. “The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed?” Clin Orthop Relat Res 471, no. 11 (November 2013): 3618–25. https://doi.org/10.1007/s11999-013-3178-1.
    Full Text Link to Item
  - Erdmann, Detlev, Ryan M. Garcia, Gert Blueschke, Brian E. Brigman, and L Scott Levin. “Vascularized fibula-based physis transfer for pediatric proximal humerus reconstruction.” Plast Reconstr Surg 132, no. 2 (August 2013): 281e-287e. https://doi.org/10.1097/PRS.0b013e31829589fb.
    Full Text Link to Item
  - Mata, Brian A., William C. Eward, and Brian E. Brigman. “Pancarpal synovial and tenosynovial chondromatosis in a 65-year-old man: a highly unusual presentation of a common condition.” Am J Orthop (Belle Mead Nj) 42, no. 8 (August 2013): E60–63.
    Link to Item
  - Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surgical Oncology Clinics of North America 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
    Full Text
  - Biermann, J Sybil, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, Brian Brigman, James E. Butrynski, David Cheong, et al. “Bone cancer.” J Natl Compr Canc Netw 11, no. 6 (June 1, 2013): 688–723. https://doi.org/10.6004/jnccn.2013.0088.
    Full Text Link to Item
  - Cuneo, Kyle C., Jeffrey K. Mito, Melodi P. Javid, Jorge M. Ferrer, Yongbaek Kim, W David Lee, Moungi G. Bawendi, Brian E. Brigman, and David G. Kirsch. “Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents.” Int J Radiat Oncol Biol Phys 86, no. 1 (May 1, 2013): 136–42. https://doi.org/10.1016/j.ijrobp.2012.12.007.
    Full Text Link to Item
  - Eward, William C., Jeffrey K. Mito, Cindy A. Eward, Jessica E. Carter, Jorge M. Ferrer, David G. Kirsch, and Brian E. Brigman. “A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs.” Clin Orthop Relat Res 471, no. 3 (March 2013): 834–42. https://doi.org/10.1007/s11999-012-2560-8.
    Full Text Link to Item
  - Mito, Jeffrey K., Hooney D. Min, Yan Ma, Jessica E. Carter, Brian E. Brigman, Leslie Dodd, David Dankort, Martin McMahon, and David G. Kirsch. “Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.” J Pathol 229, no. 1 (January 2013): 132–40. https://doi.org/10.1002/path.4099.
    Full Text Link to Item
  - Zelenski, Nicki, Brian E. Brigman, L Scott Levin, Detlev Erdmann, and William C. Eward. “The vascularized fibular graft in the pediatric upper extremity: a durable, biological solution to large oncologic defects.” Sarcoma 2013 (2013): 321201. https://doi.org/10.1155/2013/321201.
    Full Text Link to Item
  - Mito, Jeffrey K., Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, et al. “Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.” Cancer 118, no. 21 (November 1, 2012): 5320–30. https://doi.org/10.1002/cncr.27458.
    Full Text Link to Item
  - Vasileios, Kontogeorgakos A., William C. Eward, and Brian E. Brigman. “Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities.” Arch Orthop Trauma Surg 132, no. 7 (July 2012): 955–61. https://doi.org/10.1007/s00402-012-1510-y.
    Full Text Link to Item
  - Radkowski, Christopher A., Leslie G. Dodd, Jeffrey L. Johnson, John M. Harrelson, and Brian E. Brigman. “Leiomyosarcoma of the somatic soft tissues.” J Surg Orthop Adv 21, no. 2 (2012): 96–101. https://doi.org/10.3113/jsoa.2012.0096.
    Full Text Link to Item
  - Kokosis, G., J. Stolberg-Stolberg, W. C. Eward, M. J. Richard, S. T. Hollenbeck, H. Levinson, B. E. Brigman, and D. Erdmann. “[Femur reconstruction using combined autologous fibula transfer and humeral allograft].” Chirurg 82, no. 12 (December 2011): 1120–23. https://doi.org/10.1007/s00104-011-2165-x.
    Full Text Link to Item
  - Cuneo, K. C., J. K. Mito, B. E. Brigman, J. M. Ferrer, C. Lee, W. C. Eward, J. E. Carter, and D. G. Kirsch. “Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S729–30. https://doi.org/10.1016/j.ijrobp.2011.06.1300.
    Full Text
  - Lin, Fu-Hsiung, Jessica B. Chang, and Brian E. Brigman. “Role of mitogen-activated protein kinase in osteoblast differentiation.” J Orthop Res 29, no. 2 (February 2011): 204–10. https://doi.org/10.1002/jor.21222.
    Full Text Link to Item
  - Mito, Jeffrey K., Rebecca D. Dodd, Brian E. Brigman, Zhizhong Li, William C. Eward, Sayan Mukherjee, and David Kirsch. “Dissecting molecular mechanisms of metastasis in a primary mouse model of soft tissue sarcoma.” Clinical & Experimental Metastasis 28, no. 2 (February 1, 2011): 166–67.
    Link to Item
  - Viens, Nicholas A., Tyler Steven Watters, Emily N. Vinson, and Brian E. Brigman. “Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis.” Clin Orthop Relat Res 468, no. 11 (November 2010): 3126–31. https://doi.org/10.1007/s11999-010-1257-0.
    Full Text Link to Item
  - Kontogeorgakos, Vasileios A., Salutario Martinez, Leslie Dodd, and Brian E. Brigman. “Extremity soft tissue sarcomas presented as hematomas.” Arch Orthop Trauma Surg 130, no. 10 (October 2010): 1209–14. https://doi.org/10.1007/s00402-009-0987-5.
    Full Text Link to Item
  - Gaskill, Trevor, Diane Payne, and Brian Brigman. “Cryptococcal abscess imitating a soft-tissue sarcoma in an immunocompetent host: a case report.” J Bone Joint Surg Am 92, no. 9 (August 4, 2010): 1890–93. https://doi.org/10.2106/JBJS.I.01091.
    Full Text Link to Item
  - Lin, Fu-Hsiumg, Jessica B. Chang, Michael H. McGuire, John A. Yee, and Brian E. Brigman. “Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro.” J Orthop Res 28, no. 7 (July 2010): 958–64. https://doi.org/10.1002/jor.21099.
    Full Text Link to Item
  - Biermann, J Sybil, Douglas R. Adkins, Robert S. Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah A. Frassica, et al. “Bone cancer.” J Natl Compr Canc Netw 8, no. 6 (June 2010): 688–712. https://doi.org/10.6004/jnccn.2010.0051.
    Full Text Link to Item
  - Eward, William C., Vasileios Kontogeorgakos, Lawrence Scott Levin, and Brian E. Brigman. “Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection.” Clin Orthop Relat Res 468, no. 2 (February 2010): 590–98. https://doi.org/10.1007/s11999-009-1053-x.
    Full Text Link to Item
  - Mito, Jeffrey K., Richard F. Riedel, Leslie Dodd, Guy Lahat, Alexander J. Lazar, Rebecca D. Dodd, Lars Stangenberg, et al. “Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.” Plos One 4, no. 11 (November 30, 2009): e8075. https://doi.org/10.1371/journal.pone.0008075.
    Full Text Link to Item
  - Kontogeorgakos, Vasilelos A., Theodore Xenakis, Dionysios Papachristou, Anastasios Korompilias, Anastasios Kanellopoulos, Alexander Beris, and Brian Brigman. “Cortical desmoid and the four clinical scenarios.” Arch Orthop Trauma Surg 129, no. 6 (June 2009): 779–85. https://doi.org/10.1007/s00402-008-0687-6.
    Full Text Link to Item
  - Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma.” Curr Treat Options Oncol 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.
    Full Text Link to Item
  - Narváez, José Antonio, Salutario Martinez, Leslie G. Dodd, and Brian E. Brigman. “Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases.” Ajr Am J Roentgenol 188, no. 5 (May 2007): 1302–5. https://doi.org/10.2214/AJR.05.0141.
    Full Text Link to Item
  - Biermann, J Sybil, Douglas Adkins, Robert Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah Frassica, et al. “Bone cancer.” J Natl Compr Canc Netw 5, no. 4 (April 2007): 420–37. https://doi.org/10.6004/jnccn.2007.0037.
    Full Text Link to Item
  - Lang, Jason E., Leslie Dodd, Salutario Martinez, and Brian E. Brigman. “Case reports: acral myxoinflammatory fibroblastic sarcoma: a report of five cases and literature review.” Clin Orthop Relat Res 445 (April 2006): 254–60. https://doi.org/10.1097/01.blo.0000201158.67443.a2.
    Full Text Link to Item
  - Toomayan, Glen A., Fabienne Robertson, Nancy M. Major, and Brian E. Brigman. “Upper extremity compartmental anatomy: clinical relevance to radiologists.” Skeletal Radiol 35, no. 4 (April 2006): 195–201. https://doi.org/10.1007/s00256-005-0063-3.
    Full Text Link to Item
  - Carothers, Joshua T., Brian E. Brigman, Richard D. Lawson, and Marco Rizzo. “Stacking of a dermal regeneration template for reconstruction of a soft-tissue defect after tumor excision from the palm of the hand: a case report.” J Hand Surg Am 30, no. 6 (November 2005): 1322–26. https://doi.org/10.1016/j.jhsa.2005.08.001.
    Full Text Link to Item
  - Biermann, J Sybil, Laurence H. Baker, Robert Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad, Deborah Frassica, et al. “Bone cancer clinical practice guidelines.” J Natl Compr Canc Netw 3, no. 2 (March 2005): 124–40.
    Link to Item
  - Dodd, Leslie G., Nancy Major, and Brian Brigman. “Malignant giant cell tumor of soft parts.” Skeletal Radiol 33, no. 5 (May 2004): 295–99. https://doi.org/10.1007/s00256-003-0744-8.
    Full Text Link to Item
  - Brigman, Brian E., Francis J. Hornicek, Mark C. Gebhardt, and Henry J. Mankin. “Allografts about the Knee in Young Patients with High-Grade Sarcoma.” Clin Orthop Relat Res, no. 421 (April 2004): 232–39. https://doi.org/10.1097/01.blo.0000127132.12576.05.
    Full Text Link to Item
  - Brigman, Brian E., Steven G. Kumagai, and Michael H. McGuire. “Rotationplasty after failed limb-sparing tumor surgery: a report of two cases.” Clin Orthop Relat Res, no. 415 (October 2003): 254–60. https://doi.org/10.1097/01.blo.0000093887.12372.3d.
    Full Text Link to Item
  - Hau, Mohammad Anwar, Edward J. Fox, Justin M. Cates, Brian E. Brigman, and Henry J. Mankin. “Jaffe-Campanacci syndrome. A case report and review of the literature.” J Bone Joint Surg Am 84, no. 4 (April 2002): 634–38.
    Link to Item
  - Tsuzaki, M., B. E. Brigman, J. Yamamoto, W. T. Lawrence, J. G. Simmons, N. K. Mohapatra, P. K. Lund, et al. “Insulin-like growth factor-I is expressed by avian flexor tendon cells.” J Orthop Res 18, no. 4 (July 2000): 546–56. https://doi.org/10.1002/jor.1100180406.
    Full Text Link to Item
  - Banes, A. J., M. Tsuzaki, P. Hu, B. Brigman, T. Brown, L. Almekinders, W. T. Lawrence, and T. Fischer. “PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro.” J Biomech 28, no. 12 (December 1995): 1505–13. https://doi.org/10.1016/0021-9290(95)00098-4.
    Full Text Link to Item
  - Banes, A. J., M. Tsuzaki, J. Yamamoto, T. Fischer, B. Brigman, T. Brown, and L. Miller. “Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals.” Biochem Cell Biol 73, no. 7–8 (July 1995): 349–65. https://doi.org/10.1139/o95-043.
    Full Text Link to Item
  - Brigman, B. E., P. Hu, H. Yin, M. Tsuzaki, W. T. Lawrence, and A. J. Banes. “Fibronectin in the tendon-synovial complex: quantitation in vivo and in vitro by ELISA and relative mRNA levels by polymerase chain reaction and northern blot.” J Orthop Res 12, no. 2 (March 1994): 253–61. https://doi.org/10.1002/jor.1100120215.
    Full Text Link to Item
  - Scott, Elizabeth, Mitchell R. Klement, Brian E. Brigman, and William C. Eward. “Beyond Mirels: Factors Influencing Surgical Outcome of Metastasis to the Extremities in the Modern Era.” J Surg Orthop Adv 27, no. 3 (n.d.): 178–86.
    Link to Item
- Conference Papers
  - Catanzano, A. A., S. P. Ryan, A. L. Lazarides, B. E. Brigman, and W. C. Eward. “New Techniques for Diagnosis and Treatment of Musculoskeletal Tumors: Methods of Intraoperative Margin Detection.” In Techniques in Orthopaedics, 33:148–57, 2018. https://doi.org/10.1097/BTO.0000000000000290.
    Full Text
  - Whitley, M. J., D. M. Cardona, D. G. Blazer, E. Hwang, R. A. Greenup, P. J. Mosca, J. Cahill, et al. “A Phase I Clinical Trial of LUM015: A Protease-activated Fluorescent Imaging Agent to Detect Cancer during Surgery.” In Annals of Surgical Oncology, 22:S11–12. SPRINGER, 2015.
    Link to Item
  - Whitley, Melodi Javid, Diana M. Cardona, Dan G. Blazer, Shelley E. Hwang, Paul J. Mosca, Joan Cahill, Jorge M. Ferrer, et al. “A phase I study of the safety and activation of a cathepsin-activatable fluorescent cancer-specific probe LUM015.” In Journal of Clinical Oncology, 32:TPS11135–TPS11135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps11135.
    Full Text
Teaching & Mentoring
Recent Courses
- ORTHO 432C: Musculoskeletal Oncology 2020
- ORTHO 405C: Basic Arthroscopy & Arthroplasty 2018

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Recent Courses