Skip to main content
Journal cover image

Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.

Publication ,  Journal Article
Tabarestani, TQ; Levine, N; Sachs, E; Scholl, A; Colglazier, R; French, R; Al-Rohil, R; Brigman, B; Eward, W; Visgauss, J
Published in: Skeletal Radiol
December 2023

OBJECTIVE: To describe the presentation of giant cell tumors (GCT) of the bone in the pediatric population to (1) improve the differential diagnosis of pediatric bone tumors and (2) identify the origin of GCT. Understanding the origin of bone tumors assists in establishing appropriate diagnoses and recommending treatment options. This is particularly important in children, where evaluating the need for invasive procedures is balanced with the desire to avoid overtreatment. GCT have historically been considered epiphyseal lesions with potential metaphyseal extension. Therefore, GCT may be inappropriately excluded from the differential diagnosis of metaphyseal lesions in the skeletally immature. MATERIALS AND METHODS: We identified 14 patients from 1981 to 2021 at a single institution who had histologic confirmation of GCT and were less than 18 years old at diagnosis. Patient characteristics, tumor location, surgical treatment, and local recurrence rates were collected. RESULTS AND CONCLUSIONS: Ten (71%) patients were female. Eleven (78.6%) were epiphysiometaphyseal (1 epiphyseal, 4 metaphyseal, 6 epiphysiometaphyseal). Five patients had an open adjacent physis, of which three (60%) had tumors confined solely to the metaphysis. Of the five patients with open physis, four (80%) developed local recurrence while only one patient (11%) with a closed physis had local recurrence (p value = 0.0023). Our results illustrate that for the skeletally immature, GCT can (and in our results more commonly did) occur in the metaphyseal location. These findings suggest that GCT should be included in the differential diagnosis of primary metaphyseal-only lesions in the skeletally immature.

Duke Scholars

Published In

Skeletal Radiol

DOI

EISSN

1432-2161

Publication Date

December 2023

Volume

52

Issue

12

Start / End Page

2399 / 2408

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Male
  • Humans
  • Growth Plate
  • Giant Cell Tumor of Bone
  • Female
  • Epiphyses
  • Child
  • Bone Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tabarestani, T. Q., Levine, N., Sachs, E., Scholl, A., Colglazier, R., French, R., … Visgauss, J. (2023). Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients. Skeletal Radiol, 52(12), 2399–2408. https://doi.org/10.1007/s00256-023-04359-8
Tabarestani, Troy Q., Nicole Levine, Elizabeth Sachs, Ashley Scholl, Roy Colglazier, Robert French, Rami Al-Rohil, Brian Brigman, William Eward, and Julia Visgauss. “Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.Skeletal Radiol 52, no. 12 (December 2023): 2399–2408. https://doi.org/10.1007/s00256-023-04359-8.
Tabarestani, Troy Q., et al. “Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.Skeletal Radiol, vol. 52, no. 12, Dec. 2023, pp. 2399–408. Pubmed, doi:10.1007/s00256-023-04359-8.
Tabarestani TQ, Levine N, Sachs E, Scholl A, Colglazier R, French R, Al-Rohil R, Brigman B, Eward W, Visgauss J. Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients. Skeletal Radiol. 2023 Dec;52(12):2399–2408.
Journal cover image

Published In

Skeletal Radiol

DOI

EISSN

1432-2161

Publication Date

December 2023

Volume

52

Issue

12

Start / End Page

2399 / 2408

Location

Germany

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Male
  • Humans
  • Growth Plate
  • Giant Cell Tumor of Bone
  • Female
  • Epiphyses
  • Child
  • Bone Neoplasms