Bone Sarcomas
This chapter provides answers to practice-based questions with case studies covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of bone sarcomas. Bone sarcomas are rare, mesenchymal neoplasms that primarily originate in bone and account for less than 1% of all cancers. Multimodal therapeutic approaches are key to improving outcomes for patients and treatment paradigms have been well established for both osteosarcoma and Ewing sarcoma over the years. Local control for bone sarcomas can be addressed with surgery and/or radiation therapy, depending on histological subtype. An understanding of the underlying biology that leads to the pathogenesis of disease has resulted in advances, particularly in giant cell tumor of bone. Bone sarcomas continue to remain an area of significant unmet medical need..
