Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Radiation Oncology, Duke University 2000 - 2004
  • Intern, Internal Medicine, Greater Baltimore Medical Center 1999 - 2000
  • M.D., Johns Hopkins University 1999
  • M.S., Massachusetts Institute of Technology 1995
  • B.S., Massachusetts Institute of Technology 1994
• 

  Duke Appointment History

  • Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2018
  • Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2007
  • Associate in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2004 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Leung, Nicole, Adela R. Cardones, and Nicole Larrier. “Long-term improvement of recalcitrant Darier disease with photon and electron beam radiation therapy..” Jaad Case Reports 4, no. 10 (November 14, 2018): 1062–64. https://doi.org/10.1016/j.jdcr.2018.08.017.
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    • Leung, Nicole, Adela R. Cardones, and Nicole Larrier. “Long-term improvement of recalcitrant Hailey-Hailey disease with electron beam radiation therapy: Case report and review..” Practical Radiation Oncology 8, no. 5 (September 2018): e259–61. https://doi.org/10.1016/j.prro.2018.02.011.
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    • Lee, Andrew R., Dilraj S. Grewal, Thomas J. Cummings, Laura B. Enyedi, Nicole A. Larrier, and Prithvi Mruthyunjaya. “Multifocal iris melanoma in a 2-year-old managed with I-125 plaque brachytherapy..” Journal of Aapos : The Official Publication of the American Association for Pediatric Ophthalmology and Strabismus 21, no. 5 (October 2017): 410–12. https://doi.org/10.1016/j.jaapos.2017.03.014.
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    • Larrier, Nicole A., Brian G. Czito, and David G. Kirsch. “Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy..” Surgical Oncology Clinics of North America 25, no. 4 (October 2016): 841–60. https://doi.org/10.1016/j.soc.2016.05.012.
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    • Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer..” Science Translational Medicine 8, no. 320 (January 2016). https://doi.org/10.1126/scitranslmed.aad0293.
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    • Larrier, N. “Genitourinary,” September 3, 2015, 283–96. https://doi.org/10.1007/978-3-319-16435-9_15.
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    • Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas..” Surgical Oncology Clinics of North America 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
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    • Craciunescu, Oana I., Beverly A. Steffey, Chris R. Kelsey, Nicole A. Larrier, Cathy J. Paarz-Largay, Robert G. Prosnitz, Nelson Chao, et al. “Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial..” International Journal of Radiation Oncology, Biology, Physics 79, no. 4 (March 2011): 1248–55. https://doi.org/10.1016/j.ijrobp.2010.05.036.
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    • McMahon, Ryan L., Nicole A. Larrier, and Q Jackie Wu. “An image-guided technique for planning and verification of supine craniospinal irradiation..” Journal of Applied Clinical Medical Physics 12, no. 2 (January 31, 2011). https://doi.org/10.1120/jacmp.v12i2.3310.
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    • McMahon, R. L., N. A. Larrier, and Q. J. Wu. “An image-guided technique for planning and verification of supine craniospinal irradiation.” Journal of Applied Clinical Medical Physics 12, no. 2 (January 1, 2011): 184–90. https://doi.org/10.1120/jacmp.v12i2.3310.
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    • Nelson, John W., David S. Yoo, John H. Sampson, Robert E. Isaacs, Nicole A. Larrier, Lawrence B. Marks, Fang-Fang Yin, Q Jackie Wu, Zhiheng Wang, and John P. Kirkpatrick. “Stereotactic body radiotherapy for lesions of the spine and paraspinal regions..” International Journal of Radiation Oncology, Biology, Physics 73, no. 5 (April 2009): 1369–75. https://doi.org/10.1016/j.ijrobp.2008.06.1949.
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    • Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma..” Current Treatment Options in Oncology 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.
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    • Gururangan, Sridharan, Jeanne Krauser, Melody A. Watral, Tim Driscoll, Nicole Larrier, David A. Reardon, Jeremy N. Rich, et al. “Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma..” Neuro Oncology 10, no. 5 (October 2008): 745–51. https://doi.org/10.1215/15228517-2008-044.
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    • Miles, Edward F., Nicole A. Larrier, Christopher R. Kelsey, Jessica L. Hubbs, Jinli Ma, Sua Yoo, and Lawrence B. Marks. “Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience..” International Journal of Radiation Oncology, Biology, Physics 71, no. 4 (July 2008): 1143–50. https://doi.org/10.1016/j.ijrobp.2007.11.011.
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    • Yin, Fang-Fang, Zhiheng Wang, Sua Yoo, Q Jackie Wu, John Kirkpatrick, Nicole Larrier, Jeffrey Meyer, Christopher G. Willett, and Lawrence B. Marks. “Integration of cone-beam CT in stereotactic body radiation therapy..” Technology in Cancer Research & Treatment 7, no. 2 (April 2008): 133–39. https://doi.org/10.1177/153303460800700206.
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    • Wang, Zhiheng, Q Jackie Wu, Lawrence B. Marks, Nicole Larrier, and Fang-Fang Yin. “Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions..” International Journal of Radiation Oncology, Biology, Physics 69, no. 5 (December 2007): 1618–24. https://doi.org/10.1016/j.ijrobp.2007.08.030.
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    • Mao, Jingfang, Zafer Kocak, Sumin Zhou, Jennifer Garst, Elizabeth S. Evans, Junan Zhang, Nicole A. Larrier, Donna R. Hollis, Rodney J. Folz, and Lawrence B. Marks. “The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response..” International Journal of Radiation Oncology, Biology, Physics 67, no. 5 (April 2007): 1360–69. https://doi.org/10.1016/j.ijrobp.2006.11.003.
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    • Larrier, Nicole A., and Lawrence B. Marks. “What radiation dose is safe in patients with non-small-cell lung cancer?.” Nature Clinical Practice. Oncology 4, no. 2 (February 2007): 80–81. https://doi.org/10.1038/ncponc0689.
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    • Anscher, Mitchell S., Jennifer Garst, Lawrence B. Marks, Nicole Larrier, Frank Dunphy, James E. Herndon, Robert Clough, et al. “Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury..” Int J Radiat Oncol Biol Phys 66, no. 2 (October 1, 2006): 477–82. https://doi.org/10.1016/j.ijrobp.2006.05.031.
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    • Mazur, Melissa A., Sridharan Gururangan, Julia A. Bridge, Thomas J. Cummings, Srinivasan Mukundan, Herbert Fuchs, Nicole Larrier, and Edward C. Halperin. “Intracranial Ewing sarcoma..” Pediatric Blood & Cancer 45, no. 6 (November 2005): 850–56. https://doi.org/10.1002/pbc.20430.
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    • Rosoff, Philip M., Nicole Larrier, and Henry E. Rice. “Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease..” Pediatric Blood & Cancer 45, no. 5 (October 2005): 728–31. https://doi.org/10.1002/pbc.20288.
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    • Anscher, Mitchell S., Liguang Chen, Zahid Rabbani, Song Kang, Nicole Larrier, Hong Huang, Thaddeus V. Samulski, et al. “Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy..” Int J Radiat Oncol Biol Phys 62, no. 1 (May 1, 2005): 255–59. https://doi.org/10.1016/j.ijrobp.2005.01.040.
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    • Chen, Liguang, David M. Brizel, Zahid N. Rabbani, Thaddeus V. Samulski, Catherine L. Farrell, Nicole Larrier, Mitchell S. Anscher, and Zeljko Vujaskovic. “The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats..” International Journal of Radiation Oncology, Biology, Physics 60, no. 5 (December 2004): 1520–29. https://doi.org/10.1016/j.ijrobp.2004.07.729.
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    • DeWeese, T. L., J. M. Shipman, N. A. Larrier, N. M. Buckley, L. R. Kidd, J. D. Groopman, R. G. Cutler, H. te Riele, and W. G. Nelson. “Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation..” Proc Natl Acad Sci U S A 95, no. 20 (September 29, 1998): 11915–20. https://doi.org/10.1073/pnas.95.20.11915.
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  • Book Sections

    • Larrier, N., W. C. Eward, and R. F. Riedel. “Bone Sarcomas.” In Cancer Consult: Expertise for Clinical Practice, 687–95, 2014. https://doi.org/10.1002/9781118589199.ch105.
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  • Conference Papers

    • Craciunescu, O., J. Macfall, B. Soher, P. Stauffer, P. Maccarini, E. Jones, N. Larrier, et al. “WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update.” In Medical Physics, Vol. 36, 2009. https://doi.org/10.1118/1.3182470.
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    • Craciunescu, O., B. Steffey, S. Yoo, N. Larrier, C. Paarz‐largay, K. Sullivan, and R. Prosnitz. “TU‐EE‐A2‐05: Challenges in Limiting Kidney Dose When Delivering Total Body Irradiation (TBI) for Patients with Severe Systemic Sclerosis (SSc).” In Medical Physics, Vol. 34, 2007. https://doi.org/10.1118/1.2761426.
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    • Wang, Z., J. Nelson, S. Yoo, Q. J. wu, J. Kirkpatrick, N. Larrier, J. Meyer, C. Willett, and F. Yin. “SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions.” In Medical Physics, Vol. 34, 2007. https://doi.org/10.1118/1.2760913.
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    • Craciunescu, O., T. Raidy, D. Brizel, K. Blackwell, Z. Vujaskovic, T. Wong, E. Jones, N. Larrier, J. Macfall, and M. Dewhirst. “SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites.” In Medical Physics, Vol. 33, 2006. https://doi.org/10.1118/1.2240901.
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    • Yin, F., L. Marks, Z. Wang, J. Kirkpatrick, J. Wu, S. Yoo, N. Larrier, J. Meyer, and C. Willett. “SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy.” In Medical Physics, Vol. 33, 2006. https://doi.org/10.1118/1.2240992.
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• Teaching & Mentoring
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  Recent Courses

  • RADONC 220C: Brief Experience in Clinical Radiation/Oncology 2019
  • RADONC 415C: Clinical Radiation Oncology 2019

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