Nicole A. Larrier | Scholars@Duke

Nicole A. Larrier
Associate Professor of Radiation Oncology

Pediatric Malignancies
Sarcomas and tumors of the bone

Current Appointments & Affiliations

Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018

Contact Information

201 Trent Drive, Box 3085, Durham, NC 27710
Department of Radiation Oncolo, Box 3085, Durham, NC 27710
nicole.larrier@duke.edu (919) 668-7342

Background
Education, Training, & Certifications
- Resident, Radiation Oncology, Duke University 2000 - 2004
- Intern, Internal Medicine, Greater Baltimore Medical Center 1999 - 2000
- M.D., Johns Hopkins University 1999
- M.S., Massachusetts Institute of Technology 1995
- B.S., Massachusetts Institute of Technology 1994
Duke Appointment History
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2007 - 2018
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2006 - 2007
- Associate in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2004 - 2006
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Dial, Brian L., David L. Kerr, Alexander L. Lazarides, Anthony A. Catanzano, Cindy L. Green, Thomas Risoli, Dan G. Blazer, et al. “The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database.” Spine (Phila Pa 1976) 45, no. 12 (June 15, 2020): E742–51. https://doi.org/10.1097/BRS.0000000000003406.
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  - Brown, Patrick, Hiroto Inaba, Colleen Annesley, Jill Beck, Susan Colace, Mari Dallas, Kenneth DeSantes, et al. “Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 18, no. 1 (January 2020): 81–112. https://doi.org/10.6004/jnccn.2020.0001.
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  - Catanzano, Anthony A., David L. Kerr, Alexander L. Lazarides, Brian L. Dial, Whitney O. Lane, Dan G. Blazer, Nicole A. Larrier, David G. Kirsch, Brian E. Brigman, and William C. Eward. “Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study.” Sarcoma 2019 (2019): 4878512. https://doi.org/10.1155/2019/4878512.
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  - Leung, Nicole, Adela R. Cardones, and Nicole Larrier. “Long-term improvement of recalcitrant Darier disease with photon and electron beam radiation therapy.” Jaad Case Rep 4, no. 10 (November 2018): 1062–64. https://doi.org/10.1016/j.jdcr.2018.08.017.
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  - Leung, Nicole, Adela R. Cardones, and Nicole Larrier. “Long-term improvement of recalcitrant Hailey-Hailey disease with electron beam radiation therapy: Case report and review.” Pract Radiat Oncol 8, no. 5 (September 2018): e259–61. https://doi.org/10.1016/j.prro.2018.02.011.
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  - Lee, Andrew R., Dilraj S. Grewal, Thomas J. Cummings, Laura B. Enyedi, Nicole A. Larrier, and Prithvi Mruthyunjaya. “Multifocal iris melanoma in a 2-year-old managed with I-125 plaque brachytherapy.” J Aapos 21, no. 5 (October 2017): 410–12. https://doi.org/10.1016/j.jaapos.2017.03.014.
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  - Larrier, Nicole A., Brian G. Czito, and David G. Kirsch. “Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy.” Surg Oncol Clin N Am 25, no. 4 (October 2016): 841–60. https://doi.org/10.1016/j.soc.2016.05.012.
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  - Whitley, Melodi Javid, Diana M. Cardona, Alexander L. Lazarides, Ivan Spasojevic, Jorge M. Ferrer, Joan Cahill, Chang-Lung Lee, et al. “A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.” Sci Transl Med 8, no. 320 (January 6, 2016): 320ra4. https://doi.org/10.1126/scitranslmed.aad0293.
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  - Larrier, N. “Genitourinary,” September 3, 2015, 283–96. https://doi.org/10.1007/978-3-319-16435-9_15.
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  - Larrier, Nicole A., David G. Kirsch, Richard F. Riedel, Howard Levinson, William C. Eward, and Brian E. Brigman. “Practical radiation oncology for extremity sarcomas.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 433–43. https://doi.org/10.1016/j.soc.2013.02.004.
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  - Craciunescu, Oana I., Beverly A. Steffey, Chris R. Kelsey, Nicole A. Larrier, Cathy J. Paarz-Largay, Robert G. Prosnitz, Nelson Chao, et al. “Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial.” Int J Radiat Oncol Biol Phys 79, no. 4 (March 15, 2011): 1248–55. https://doi.org/10.1016/j.ijrobp.2010.05.036.
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  - McMahon, Ryan L., Nicole A. Larrier, and Q Jackie Wu. “An image-guided technique for planning and verification of supine craniospinal irradiation.” J Appl Clin Med Phys 12, no. 2 (January 31, 2011): 3310. https://doi.org/10.1120/jacmp.v12i2.3310.
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  - McMahon, R. L., N. A. Larrier, and Q. J. Wu. “An image-guided technique for planning and verification of supine craniospinal irradiation.” Journal of Applied Clinical Medical Physics 12, no. 2 (January 1, 2011): 184–90. https://doi.org/10.1120/jacmp.v12i2.3310.
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  - Nelson, John W., David S. Yoo, John H. Sampson, Robert E. Isaacs, Nicole A. Larrier, Lawrence B. Marks, Fang-Fang Yin, Q Jackie Wu, Zhiheng Wang, and John P. Kirkpatrick. “Stereotactic body radiotherapy for lesions of the spine and paraspinal regions.” Int J Radiat Oncol Biol Phys 73, no. 5 (April 1, 2009): 1369–75. https://doi.org/10.1016/j.ijrobp.2008.06.1949.
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  - Riedel, Richard F., Nicole Larrier, Leslie Dodd, David Kirsch, Salutario Martinez, and Brian E. Brigman. “The clinical management of chondrosarcoma.” Curr Treat Options Oncol 10, no. 1–2 (April 2009): 94–106. https://doi.org/10.1007/s11864-009-0088-2.
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  - Gururangan, Sridharan, Jeanne Krauser, Melody A. Watral, Tim Driscoll, Nicole Larrier, David A. Reardon, Jeremy N. Rich, et al. “Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma.” Neuro Oncol 10, no. 5 (October 2008): 745–51. https://doi.org/10.1215/15228517-2008-044.
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  - Miles, Edward F., Nicole A. Larrier, Christopher R. Kelsey, Jessica L. Hubbs, Jinli Ma, Sua Yoo, and Lawrence B. Marks. “Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience.” Int J Radiat Oncol Biol Phys 71, no. 4 (July 15, 2008): 1143–50. https://doi.org/10.1016/j.ijrobp.2007.11.011.
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  - Yin, Fang-Fang, Zhiheng Wang, Sua Yoo, Q Jackie Wu, John Kirkpatrick, Nicole Larrier, Jeffrey Meyer, Christopher G. Willett, and Lawrence B. Marks. “Integration of cone-beam CT in stereotactic body radiation therapy.” Technol Cancer Res Treat 7, no. 2 (April 2008): 133–39. https://doi.org/10.1177/153303460800700206.
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  - Wang, Zhiheng, Q Jackie Wu, Lawrence B. Marks, Nicole Larrier, and Fang-Fang Yin. “Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions.” Int J Radiat Oncol Biol Phys 69, no. 5 (December 1, 2007): 1618–24. https://doi.org/10.1016/j.ijrobp.2007.08.030.
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  - Mao, Jingfang, Zafer Kocak, Sumin Zhou, Jennifer Garst, Elizabeth S. Evans, Junan Zhang, Nicole A. Larrier, Donna R. Hollis, Rodney J. Folz, and Lawrence B. Marks. “The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response.” Int J Radiat Oncol Biol Phys 67, no. 5 (April 1, 2007): 1360–69. https://doi.org/10.1016/j.ijrobp.2006.11.003.
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  - Larrier, Nicole A., and Lawrence B. Marks. “What radiation dose is safe in patients with non-small-cell lung cancer?” Nat Clin Pract Oncol 4, no. 2 (February 2007): 80–81. https://doi.org/10.1038/ncponc0689.
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  - Anscher, Mitchell S., Jennifer Garst, Lawrence B. Marks, Nicole Larrier, Frank Dunphy, James E. Herndon, Robert Clough, et al. “Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury.” Int J Radiat Oncol Biol Phys 66, no. 2 (October 1, 2006): 477–82. https://doi.org/10.1016/j.ijrobp.2006.05.031.
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  - Mazur, Melissa A., Sridharan Gururangan, Julia A. Bridge, Thomas J. Cummings, Srinivasan Mukundan, Herbert Fuchs, Nicole Larrier, and Edward C. Halperin. “Intracranial Ewing sarcoma.” Pediatr Blood Cancer 45, no. 6 (November 2005): 850–56. https://doi.org/10.1002/pbc.20430.
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  - Rosoff, Philip M., Nicole Larrier, and Henry E. Rice. “Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.” Pediatr Blood Cancer 45, no. 5 (October 15, 2005): 728–31. https://doi.org/10.1002/pbc.20288.
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  - Anscher, Mitchell S., Liguang Chen, Zahid Rabbani, Song Kang, Nicole Larrier, Hong Huang, Thaddeus V. Samulski, et al. “Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.” Int J Radiat Oncol Biol Phys 62, no. 1 (May 1, 2005): 255–59. https://doi.org/10.1016/j.ijrobp.2005.01.040.
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  - Chen, Liguang, David M. Brizel, Zahid N. Rabbani, Thaddeus V. Samulski, Catherine L. Farrell, Nicole Larrier, Mitchell S. Anscher, and Zeljko Vujaskovic. “The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats.” Int J Radiat Oncol Biol Phys 60, no. 5 (December 1, 2004): 1520–29. https://doi.org/10.1016/j.ijrobp.2004.07.729.
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  - DeWeese, T. L., J. M. Shipman, N. A. Larrier, N. M. Buckley, L. R. Kidd, J. D. Groopman, R. G. Cutler, H. te Riele, and W. G. Nelson. “Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.” Proc Natl Acad Sci U S A 95, no. 20 (September 29, 1998): 11915–20. https://doi.org/10.1073/pnas.95.20.11915.
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- Book Sections
  - Larrier, N., W. C. Eward, and R. F. Riedel. “Bone Sarcomas.” In Cancer Consult: Expertise for Clinical Practice, 687–95, 2014. https://doi.org/10.1002/9781118589199.ch105.
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- Conference Papers
  - Craciunescu, O., J. Macfall, B. Soher, P. Stauffer, P. Maccarini, E. Jones, N. Larrier, et al. “WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update.” In Medical Physics, 36:2760, 2009. https://doi.org/10.1118/1.3182470.
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  - Craciunescu, O., B. Steffey, S. Yoo, N. Larrier, C. Paarz‐largay, K. Sullivan, and R. Prosnitz. “TU‐EE‐A2‐05: Challenges in Limiting Kidney Dose When Delivering Total Body Irradiation (TBI) for Patients with Severe Systemic Sclerosis (SSc).” In Medical Physics, 34:2568, 2007. https://doi.org/10.1118/1.2761426.
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  - Wang, Z., J. Nelson, S. Yoo, Q. J. wu, J. Kirkpatrick, N. Larrier, J. Meyer, C. Willett, and F. Yin. “SU‐FF‐T‐252: Improvement of Localization Accuracy by Using 3D Cone Beam CT for Stereotactic Body Radiation Therapy of Liver, Lung and Spine Lesions.” In Medical Physics, 34:2459, 2007. https://doi.org/10.1118/1.2760913.
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  - Craciunescu, O., T. Raidy, D. Brizel, K. Blackwell, Z. Vujaskovic, T. Wong, E. Jones, N. Larrier, J. Macfall, and M. Dewhirst. “SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites.” In Medical Physics, 33:2049, 2006. https://doi.org/10.1118/1.2240901.
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  - Yin, F., L. Marks, Z. Wang, J. Kirkpatrick, J. Wu, S. Yoo, N. Larrier, J. Meyer, and C. Willett. “SU‐FF‐T‐66: A Technique for Cone‐Beam CT‐Guided Stereotactic Body Radiation Therapy.” In Medical Physics, 33:2063, 2006. https://doi.org/10.1118/1.2240992.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses