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Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

Publication ,  Journal Article
Bessac, BF; Jordt, S-E
Published in: Physiology (Bethesda)
December 2008

New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome.

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Published In

Physiology (Bethesda)

DOI

ISSN

1548-9213

Publication Date

December 2008

Volume

23

Start / End Page

360 / 370

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • TRPA1 Cation Channel
  • Reflex
  • Physiology
  • Oxidative Stress
  • Nerve Tissue Proteins
  • Multiple Chemical Sensitivity
  • Humans
  • Cough
 

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Bessac, B. F., & Jordt, S.-E. (2008). Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda), 23, 360–370. https://doi.org/10.1152/physiol.00026.2008
Bessac, Bret F., and Sven-Eric Jordt. “Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.Physiology (Bethesda) 23 (December 2008): 360–70. https://doi.org/10.1152/physiol.00026.2008.
Bessac BF, Jordt S-E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 2008 Dec;23:360–70.
Bessac, Bret F., and Sven-Eric Jordt. “Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.Physiology (Bethesda), vol. 23, Dec. 2008, pp. 360–70. Pubmed, doi:10.1152/physiol.00026.2008.
Bessac BF, Jordt S-E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 2008 Dec;23:360–370.

Published In

Physiology (Bethesda)

DOI

ISSN

1548-9213

Publication Date

December 2008

Volume

23

Start / End Page

360 / 370

Location

United States

Related Subject Headings

  • Transient Receptor Potential Channels
  • TRPV Cation Channels
  • TRPA1 Cation Channel
  • Reflex
  • Physiology
  • Oxidative Stress
  • Nerve Tissue Proteins
  • Multiple Chemical Sensitivity
  • Humans
  • Cough