Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

Journal Article (Journal Article;Review)

New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome.

Full Text

Duke Authors

Cited Authors

  • Bessac, BF; Jordt, S-E

Published Date

  • December 2008

Published In

Volume / Issue

  • 23 /

Start / End Page

  • 360 - 370

PubMed ID

  • 19074743

Pubmed Central ID

  • PMC2735846

International Standard Serial Number (ISSN)

  • 1548-9213

Digital Object Identifier (DOI)

  • 10.1152/physiol.00026.2008


  • eng

Conference Location

  • United States