Sven Eric Jordt
Associate Professor in Anesthesiology
Research in the Jordt laboratory focuses on the mechanisms that enable humans and animals to sense touch, pain and irritation. These fundamental sensations originate in peripheral sensory neurons which contain signaling pathways that translate environmental physical and chemical stimuli into neural activity. Our aims are to identify the molecular components of these pathways and to understand how sensory neurons become activated and sensitized during injury, inflammation and chronic painful conditions. The lab uses molecular, genetic and physiological techniques with a focus on models that closely mimic human conditions.
Current projects focus on:
1) Ion channels and New Targets in Pain: The Jordt lab investigates the role of Transient Receptor Potential (TRP) ion channels, a group of ion channels that activate sensory neurons and pain sensations in response to thermal (hot, cold) and chemical stimuli. TRP channels were identified through their interactions with natural products such as capsaicin (in chili peppers), mustard oil (in mustard and wasabi) and menthol (in peppermint), and were shown to be involved in many painful conditions, including arthritis, diabetes and infections. The Jordt lab is studying the actions of TRP channel inhibitors in pain models and investigates mechanisms through which natural products such as menthol and eucalyptol inhibit acute and inflammatory pain.
2) Allergies, Asthma and Itch: Sensory neurons mediate the sensations of itch, irritation and respiratory discomfort in allergic conditions. Research in the Jordt laboratory has revealed that blocking sensory nerves by targeting their receptors alleviates asthmatic conditions and also diminishes itch and inflammation in allergic contact dermatitis. We developed a unique model of poison ivy contact dermatitis we study to identify novel treatments to suppress itch in conditions unresponsive to antihistamines.
3) Chemical Exposure Injuries and Tear Gas Agents: Supported by the National Institute of Environmental Health Sciences (NIEHS) and the NIH Countermeasures Against Chemical Threats Program (CounterACT)since 2006, the Jordt laboratory has made key contributions to research understanding the injury mechanisms following toxic chemical exposures. We identified TRPA1 as a target of chlorine gas and many other toxic exposures eliciting incapacitating pain, inflammation and organ injury. The Jordt laboratory is actively working with federal agencies and industry partners to identify additional targets and develop countermeasures that improve health outcomes following chemical exposures. Other studies focus on tear gas agents (CS, CN) and their potentially toxic effects, a topic Dr. Jordt has been interviewed on frequently by the public press.
4) Tobacco Regulatory Science: Menthol cigarettes are increasingly popular, especially with adolescent beginning smokers. Applying our expertise in chemical sensory biology the Jordt lab demonstrated that menthol reduces the irritation sensed when inhaling smoke and increases markers of nicotine uptake. These effects are mediated by TRPM8, the cold/menthol receptor in sensory neurons innervating the respiratory system. This work is funded by programs from the FDA Center for Tobacco Products (CTP) and the National Institute on Drug Abuse (NIDA) through a Tobacco Center of Regulatory Science (TCORS) in collaboration with Yale University, also supporting studies on flavor additives in electronic cigarettes and smokeless tobacco.
Current Appointments & Affiliations
- Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2014
- Associate Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2022
Contact Information
- 3 Genome Ct., Msrb3, Room 6122, Durham, NC 27710-3094
- 3094, Ms27, Durham, NC 27710-3094
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sven.jordt@duke.edu
(919) 684-1327
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Jordt Lab Webpage
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Twitter @sejordt
- Background
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Education, Training, & Certifications
- Ph.D., Free University of Berlin (Germany) 1997
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Previous Appointments & Affiliations
- Instructor Temporary in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2014
- Adjunct Associate Professor in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2013 - 2014
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Leadership & Clinical Positions at Duke
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Assistant Research Quality Officer
Department of Anesthesiology
2020 - present
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Assistant Research Quality Officer
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Academic Positions Outside Duke
- Associate Professor (Adjunct) of Psychiatry, Yale School of Medicine. 2014 - 2019
- Associate Professor of Pharmacology, Yale University School of Medicine. 2010 - 2014
- Assistant Professor of Pharmacology, Yale University School of Medicine. 2005 - 2010
- Postgraduate Researcher, University of California, San Francisco. 2003 - 2005
- Postdoctoral Fellow, University of California, San Francisco. 2001 - 2003
- Postdoctoral Associate, University of California, San Francisco. 1998 - 2001
- Postdoctoral Fellow, Center for Molecular Neurobiology, Hamburg, Germany. 1997 - 1998
- Recognition
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In the News
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JAN 30, 2023 South China Morning Post / ABC News / AP -
JAN 11, 2023 New York Times -
JAN 11, 2023 New York Times -
OCT 14, 2022 Fort Worth Star-Telegram -
OCT 5, 2022 CBS Mornings -
OCT 4, 2022 CBS News -
SEP 8, 2022 STAT+ -
AUG 9, 2022 CBS 17 -
MAY 17, 2022 The Sun -
MAY 16, 2022 Healio -
APR 29, 2022 ABC11 -
APR 21, 2022 ConsumerNotice.org -
MAR 8, 2022 New York Times -
DEC 7, 2021 Nobelprize.org -
NOV 17, 2021 WGHP Fox 8 News @7:43:24 -
OCT 4, 2021 @dukemedschool -
AUG 19, 2021 Scientific American -
JUN 15, 2021 Daily Mail (UK) -
JUN 11, 2021 Discover Magazine -
MAY 27, 2021 Sierra Magazine -
MAY 1, 2021 New York Times -
MAY 1, 2021 The Seattle Times -
MAY 1, 2021 The Baltimore Sun -
APR 30, 2021 The Guardian -
APR 29, 2021 The Guardian -
APR 3, 2021 Motherboard - Tech by Vice -
MAR 20, 2021 Washington Post -
JAN 16, 2021 VerywellHealth -
OCT 20, 2020 Washington Post -
SEP 6, 2020 Suara.com, Indonesia -
SEP 5, 2020 Newshub, New Zealand -
SEP 3, 2020 La Repubblica, Italy -
SEP 3, 2020 Daily Mail, UK -
SEP 3, 2020 Nach Welt, Germany -
SEP 3, 2020 La Verdad, Mexico -
SEP 3, 2020 US News -
SEP 3, 2020 The Sun -
SEP 2, 2020 Daily Mirror, UK -
AUG 26, 2020 Fast Company -
AUG 12, 2020 Associated Press News -
AUG 6, 2020 Associated Press News -
JUL 29, 2020 OPB, Oregon Public Broadcasting -
JUL 21, 2020 Forbes -
JUL 2, 2020 BYU Radio: Top of the Mind with Julie Rose -
JUN 16, 2020 New York Times -
JUN 13, 2020 Medpage Today -
JUN 8, 2020 WXXI National Public Radio -
JUN 7, 2020 WUNC - National Public Radio (Audio) -
JUN 7, 2020 CBS 17 (Video) -
JUN 6, 2020 The Guardian -
JUN 5, 2020 National Geographic -
JUN 5, 2020 National Public Radio NPR -
JUN 5, 2020 Slate -
JUN 4, 2020 Grist -
JUN 3, 2020 New York Times -
JUN 3, 2020 ProPublica -
JUN 3, 2020 OneZero -
JUN 3, 2020 Inside Edition (Video) -
JUN 3, 2020 Washington Post -
JUN 1, 2020 Prevention Magazine -
MAY 29, 2020 Buzzfeed -
APR 3, 2020 Science Magazine -
MAR 23, 2020 SSRN -
JAN 15, 2020 Duke Chronicle -
JAN 8, 2020 EurekAlert, AAAS -
DEC 4, 2019 Time Magazine -
DEC 1, 2019 CNN -
NOV 25, 2019 Marketwatch -
NOV 19, 2019 Popular Science -
NOV 18, 2019 Vice -
NOV 5, 2019 Bloomberg Business -
NOV 1, 2019 Environmental Factor -
OCT 8, 2019 CBS17 - Raleigh, Durham, Fayetteville -
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OCT 4, 2019 CNN Español -
OCT 4, 2019 ITV This Morning, UK -
OCT 2, 2019 Univision -
SEP 21, 2019 ABC News -
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SEP 18, 2019 Wired -
SEP 18, 2019 Mingpao, Hong Kong -
SEP 17, 2019 Der Tagesspiegel, Berlin, Germany -
SEP 16, 2019 The Telegraph -
SEP 16, 2019 Duke Health News -
SEP 16, 2019 Daily Mail -
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SEP 16, 2019 The Sun -
SEP 9, 2019 Wisconsin Public Radio -
SEP 7, 2019 Gizmodo -
SEP 6, 2019 Daily Mail, UK -
SEP 3, 2019 Popular Mechanics -
AUG 27, 2019 Kaiser Health News -
AUG 20, 2019 Wired -
AUG 16, 2019 Gizmodo -
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AUG 1, 2019 ABC11 Eyewitness News, Raleigh, Durham, Fayetteville -
JUL 31, 2019 Futurity -
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JUN 18, 2019 Slate -
MAY 31, 2019 Gizmodo -
MAY 11, 2019 Liberation (France) -
MAY 8, 2019 Fox8 WGHP -
MAY 1, 2019 Environmental Factor -
FEB 7, 2019 Society of Toxicology Communiqué Blog -
JAN 31, 2019 Gizmodo -
JAN 23, 2019 -
JAN 15, 2019 American Academy of Pediatrics News -
DEC 3, 2018 Expansión (Mexico) -
DEC 2, 2018 PBS News Hour -
NOV 29, 2018 Scientific American -
NOV 29, 2018 CNN -
NOV 27, 2018 USA Today -
NOV 26, 2018 Washington Post -
NOV 26, 2018 Newsweek -
NOV 19, 2018 Daily Mail, UK -
NOV 18, 2018 Expansión (Mexico) -
NOV 16, 2018 The New York Times -
NOV 13, 2018 Gizmodo -
OCT 31, 2018 The Daily Tar Heel -
OCT 23, 2018 Duke Health News -
OCT 20, 2018 Gazzetta del Sud (Italy) -
OCT 20, 2018 Il Messagero, Italy -
OCT 20, 2018 CBC, Canada -
OCT 18, 2018 Mirror, UK -
OCT 18, 2018 The Verge -
OCT 18, 2018 Daily Mail -
JUN 23, 2018 Le Monde, France -
FEB 7, 2018 WCOM 103.5FM - Radio In Vivo -
APR 11, 2017 The Independent, UK -
JAN 12, 2017 Alternet -
JAN 1, 2017 Environmental Factor -
NOV 11, 2016 -
NOV 10, 2016 CBS News -
NOV 10, 2016 Chemical & Engineering News -
NOV 10, 2016 Scientific American -
DEC 1, 2015 Environmental Factor -
DEC 1, 2015 Environmental Factor -
APR 29, 2015 ABC News “World News Tonight -
APR 29, 2015 ABC News “World News Tonight” -
APR 8, 2015 Wired -
MAR 1, 2015 Environmental Factor -
FEB 18, 2015 Newswise -
NOV 25, 2014 The Independent, UK -
OCT 2, 2014 Mingpao Daily (Hong Kong) -
AUG 28, 2014 -
AUG 25, 2014 MSNBC -
AUG 21, 2014 New York Magazine -
AUG 19, 2014 USA Today Network -
AUG 15, 2014 Scientific American -
AUG 15, 2014 Vox -
AUG 14, 2014 Washington Post -
AUG 14, 2014 Gizmodo -
AUG 1, 2014 Environmental Factor -
JUN 21, 2014 Science Magazine -
JUL 1, 2013 Environmental Factor -
JUN 21, 2013 National Geographic -
JUN 12, 2013 National Geographic -
NOV 5, 2012 Frankfurter Allgemeine, Germany -
FEB 1, 2012 Environmental Factor -
NOV 23, 2011 PRI - Public Radio International, NPR -
OCT 1, 2011 Environmental Factor -
SEP 5, 2011 Washington Post -
OCT 1, 2010 Environmental Factor -
SEP 7, 2010 The Wall Street Journal -
MAR 1, 2009 Environmental Factor -
JAN 1, 2009 Environmental Factor -
DEC 1, 2007 Environmental Factor -
NOV 1, 2007 The White House - President George W. Bush -
NOV 1, 2006 Environmental Factor -
APR 10, 2006 Bloomberg -
MAR 23, 2006 EurekAlert! -
JAN 1, 2004 Der Spiegel, Germany
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Awards & Honors
- Leading Edge in Basic Science Award. Society of Toxicology. 2019
- Extension Award. American Asthma Foundation. 2010
- Early Excellence Award. American Asthma Foundation (AAF). 2007
- Presidential Early Career Award for Scientists and Engineers (PECASE). President of the United States. 2007
- Outstanding New Environmental Scientist Award (ONES). National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH). 2006
- ESN Young Investigator Lectureship Award. European Society for Neurochemistry (ESN). 2003
- Postdoctoral Scholarship. German National Academy of Sciences - Leopoldina. 1998
- Lifetime Membership. German Academic Scholarship Foundation (Studenstiftung des Deutschen Volkes), Germany. 1994
- Undergraduate Award. German Academic Scholarship Foundation (Studenstiftung des Deutschen Volkes), Germany. 1992
- Expertise
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Subject Headings
- Acrolein
- Afferent Pathways
- Analgesia
- Analgesics
- Asthma
- Bronchial Hyperreactivity
- Calcitonin Gene-Related Peptide
- Calcium Channels
- Calcium Signaling
- Capsaicin
- Chlorine
- Cough
- Dermatitis, Allergic Contact
- Electronic cigarettes
- Electrophysiology
- Environmental Exposure
- Flavor
- Flavoring Agents
- Fruit--Flavor and odor
- HEK293 Cells
- Heat
- Hydrochloric Acid
- Inflammation
- Inhalation Exposure
- Ion Channels
- Irritants
- Isocyanates
- Isothiocyanates
- Membrane Potentials
- Menthol
- Multiple Chemical Sensitivity
- Natural products
- Neuropeptides
- Neurotoxicity Syndromes
- Nociceptors
- Occupational Exposure
- Oxidants
- Oxidative Stress
- Pain
- Patch-Clamp Techniques
- Peripheral Nervous System Diseases
- Pneumonia
- Receptors, Drug
- Reflex
- Respiratory System
- Sensory Receptor Cells
- Sensory neurons
- Sesquiterpenes
- Signal Transduction
- Smoke
- Smoking
- Sympathetic Nervous System
- TRP channels
- TRPM Cation Channels
- TRPV Cation Channels
- Tear Gases
- Thermoreceptors
- Transient Receptor Potential Channels
- Trigeminal Ganglion
- Trigeminal Nerve
- Vaping
- Vasodilation
- Visceral Pain
- Research
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Selected Grants
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
- Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries awarded by National Institutes of Health 2022 - 2025
- Duke University Program in Environmental Health awarded by National Institutes of Health 2019 - 2024
- S/R-Nicotine in Commercial Products Containing Synthetic Nicotine: Product Survey by Chemical Analysis and Toxicological Properties awarded by Yale University 2023
- Nicotine Pouches: Chemical Composition, Toxicity and Behavioral Effects of a New Tobacco Product Category awarded by National Institutes of Health 2022 - 2023
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2013 - 2023
- Intraganglionic Analgesic Adeno-Associated Virus (AAV) Gene Vector Optimization in Large Animals awarded by Interventional AnalgesiX, Inc. 2020 - 2023
- Specialized pro-resolving mediators as potential medical countermeasures in a pig model of chlorine gas-induced acute lung injury awarded by National Institutes of Health 2020 - 2023
- Anesthetic and synthetic cooling flavors in E-cigarettes: Chemistry, respiratory effects and behavioral pharmacology awarded by National Institutes of Health 2018 - 2022
- Cellular Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes awarded by Yale University 2019 - 2021
- Biomarkers of lung injury in methyl isocyanate exposed rodents and pigs awarded by University of Colorado - Denver 2016 - 2021
- RAPID Inexpensive, rapidly manufacturable respiratory monitor to provide safe emergency ventilation during COVID19 pandemic awarded by Convergent Engineering 2021
- YALE SUBAWARD - Project 1: Effects of Flavors on Nicotine Choice and Central Reward Me awarded by Yale University 2014 - 2018
- Mechanisms of Itch in Poison Ivy-Induced Allergic Contact Dermatitis awarded by National Institutes of Health 2016 - 2018
- Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity awarded by National Institutes of Health 2014 - 2018
- CARRYOVER Request - Irritant Flavor Products in Heated E-Cigarette Liquids and Vapors awarded by Yale University 2015 - 2017
- Irritant Flavor Products in Heated E-Cigarette Liquids and Vapors awarded by Yale University 2015 - 2016
- Counter-Irritation by Menthol: Molecular Targets and Role in Airway Disease-Supplement awarded by National Institutes of Health 2014 - 2015
- Counter-Irritation by Menthol: Molecular Targets and Role in Airway Disease awarded by National Institutes of Health 2011 - 2015
- Accelerating Inflammation Resolution to Counteract Chemical Injury awarded by National Institutes of Health 2012 - 2015
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Fellowships, Supported Research, & Other Grants
- Leopoldina Postdoctoral Fellowship awarded by Leopoldina National Academy of Sciences, Germany 1998 - 2001
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External Relationships
- GlaxoSmithKline
- Hydra Biosciences
- Research Institute for Fragrance Materials
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Rebuli, Meghan E., Jason J. Rose, Alexandra Noël, Daniel P. Croft, Neal L. Benowitz, Alan H. Cohen, Maciej L. Goniewicz, et al. “The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report.” Annals of the American Thoracic Society 20, no. 1 (January 2023): 1–17. https://doi.org/10.1513/annalsats.202209-796st.Full Text
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Rezk-Hanna, Mary, Reinskje Talhout, and Sven-Eric Jordt. “Sugars and Sweeteners in Tobacco and Nicotine Products: FDA Regulatory Implications.” Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, September 2022, ntac222. https://doi.org/10.1093/ntr/ntac222.Full Text
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Marcus, Alan David, Satyanarayana Achanta, and Sven-Eric Jordt. “Protocol for non-invasive assessment of spontaneous movements of group-housed animals using remote video monitoring.” Star Protoc 3, no. 2 (June 17, 2022): 101326. https://doi.org/10.1016/j.xpro.2022.101326.Full Text Link to Item
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Jabba, Sairam V., Hanno C. Erythropel, Deyri Garcia Torres, Lauren A. Delgado, Jackson G. Woodrow, Paul T. Anastas, Julie B. Zimmerman, and Sven-Eric Jordt. “Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment.” Nicotine Tob Res 24, no. 7 (June 15, 2022): 1037–46. https://doi.org/10.1093/ntr/ntac046.Full Text Link to Item
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Leventhal, Adam M., Alayna P. Tackett, Lauren Whitted, Sven Eric Jordt, and Sairam V. Jabba. “Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review.” Tob Control, April 28, 2022. https://doi.org/10.1136/tobaccocontrol-2021-057073.Full Text Link to Item
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Jordt, Sven-Eric. “Synthetic nicotine has arrived.” Tob Control, September 7, 2021. https://doi.org/10.1136/tobaccocontrol-2021-056626.Full Text Open Access Copy Link to Item
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Jabba, Sairam V., Hanno C. Erythropel, Deyri Garcia Torres, Lauren A. Delgado, Jackson G. Woodrow, Paul T. Anastas, Julie B. Zimmerman, and Sven-Eric Jordt. “Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment,” June 10, 2021. https://doi.org/10.1101/2021.06.09.446946.Full Text
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Achanta, Satyanarayana, and Sven-Eric Jordt. “Toxic effects of chlorine gas and potential treatments: a literature review.” Toxicol Mech Methods 31, no. 4 (May 2021): 244–56. https://doi.org/10.1080/15376516.2019.1669244.Full Text Link to Item
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Jordt, Sven-Eric. “TRPA1: An asthma target with a zing.” J Exp Med 218, no. 4 (April 5, 2021). https://doi.org/10.1084/jem.20202507.Full Text Link to Item
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Ye, Lihua, Munhyung Bae, Chelsi D. Cassilly, Sairam V. Jabba, Daniel W. Thorpe, Alyce M. Martin, Hsiu-Yi Lu, et al. “Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.” Cell Host Microbe 29, no. 2 (February 10, 2021): 179-196.e9. https://doi.org/10.1016/j.chom.2020.11.011.Full Text Link to Item
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Jabba, Sairam V., Alexandra N. Diaz, Hanno C. Erythropel, Julie B. Zimmerman, and Sven-Eric Jordt. “Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.” Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco 22, no. Suppl 1 (December 2020): S25–34. https://doi.org/10.1093/ntr/ntaa185.Full Text
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Achanta, Satyanarayana, and Sven-Eric Jordt. “Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.” Ann N Y Acad Sci 1480, no. 1 (November 2020): 73–103. https://doi.org/10.1111/nyas.14472.Full Text Link to Item
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Jabba, Sairam V., and Sven-Eric Jordt. “Turbocharged Juul device challenges European tobacco regulators.” Eur Respir J 56, no. 2 (August 2020). https://doi.org/10.1183/13993003.02430-2020.Full Text Link to Item
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Kuebler, Wolfgang M., Sven-Eric Jordt, and Wolfgang B. Liedtke. “Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.” American Journal of Physiology. Lung Cellular and Molecular Physiology 318, no. 6 (June 2020): L1239–43. https://doi.org/10.1152/ajplung.00161.2020.Full Text
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Kaelberer, Melanie Maya, Ana Isabel Caceres, and Sven-Eric Jordt. “Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.” Am J Physiol Lung Cell Mol Physiol 318, no. 5 (May 1, 2020): L953–64. https://doi.org/10.1152/ajplung.00403.2019.Full Text Link to Item
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Erythropel, Hanno C., Paul T. Anastas, Suchitra Krishnan-Sarin, Stephanie S. O’Malley, Sven Eric Jordt, and Julie B. Zimmerman. “Differences in flavourant levels and synthetic coolant use between USA, EU and Canadian Juul products.” Tobacco Control, April 2020, tobaccocontrol-2019-055500. https://doi.org/10.1136/tobaccocontrol-2019-055500.Full Text
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Jabba, Sairam V., and Sven-Eric Jordt. “Estimating Fluid Consumption Volumes in Electronic Cigarette Use-Reply.” Jama Intern Med 180, no. 3 (March 1, 2020): 468–69. https://doi.org/10.1001/jamainternmed.2019.6630.Full Text Link to Item
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Eissenberg, Thomas, Aruni Bhatnagar, Simon Chapman, Sven-Eric Jordt, Alan Shihadeh, and Eric K. Soule. “Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes.” Am J Public Health 110, no. 2 (February 2020): 161–62. https://doi.org/10.2105/AJPH.2019.305424.Full Text Link to Item
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Jabba, Sairam V., and Sven-Eric Jordt. “Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products.” Jama Intern Med 179, no. 12 (December 1, 2019): 1721–23. https://doi.org/10.1001/jamainternmed.2019.3649.Full Text Link to Item
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“What are the respiratory effects of e-cigarettes?” Bmj, October 15, 2019, l5980–l5980. https://doi.org/10.1136/bmj.l5980.Full Text
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Gotts, Jeffrey E., Sven-Eric Jordt, Rob McConnell, and Robert Tarran. “What are the respiratory effects of e-cigarettes?” Bmj 366 (September 30, 2019): l5275. https://doi.org/10.1136/bmj.l5275.Full Text Link to Item
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Erythropel, Hanno C., Lucy M. Davis, Tamara M. de Winter, Sven E. Jordt, Paul T. Anastas, Stephanie S. O’Malley, Suchitra Krishnan-Sarin, and Julie B. Zimmerman. “Flavorant-Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol.” Am J Prev Med 57, no. 3 (September 2019): 425–27. https://doi.org/10.1016/j.amepre.2019.04.004.Full Text Link to Item
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Erythropel, Hanno C., Sairam V. Jabba, Tamara M. DeWinter, Melissa Mendizabal, Paul T. Anastas, Sven E. Jordt, and Julie B. Zimmerman. “Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.” Nicotine Tob Res 21, no. 9 (August 19, 2019): 1248–58. https://doi.org/10.1093/ntr/nty192.Full Text Link to Item
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Liu, Boyi, Yan Tai, Boyu Liu, Ana I. Caceres, Chengyu Yin, and Sven-Eric Jordt. “Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.” Jci Insight 5, no. 14 (June 11, 2019). https://doi.org/10.1172/jci.insight.124497.Full Text Link to Item
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Jordt, Sven-Eric, and Sairam Jabba. “Tobacco industry's investment in sweetness comes full circle.” Bmj 365 (June 10, 2019): l2338. https://doi.org/10.1136/bmj.l2338.Full Text Link to Item
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Jordt, Sven E., and Sairam Jabba. “Sweeteners are added to modify consumer behaviour.” Bmj 364 (January 25, 2019): l366. https://doi.org/10.1136/bmj.l366.Full Text Link to Item
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Zheng, Xiaoli, Yan Tai, Dongwei He, Boyu Liu, Chuan Wang, Xiaomei Shao, Sven-Eric Jordt, and Boyi Liu. “ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.” Mol Pain 15 (2019): 1744806919842473. https://doi.org/10.1177/1744806919842473.Full Text Link to Item
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Erythropel, Hanno C., Grace Kong, Tamara M. deWinter, Stephanie S. O’Malley, Sven E. Jordt, Paul T. Anastas, and Julie B. Zimmerman. “Presence of High-Intensity Sweeteners in Popular Cigarillos of Varying Flavor Profiles.” Jama 320, no. 13 (October 2, 2018): 1380–83. https://doi.org/10.1001/jama.2018.11187.Full Text Link to Item
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Achanta, Satyanarayana, Narendranath Reddy Chintagari, Marian Brackmann, Shrilatha Balakrishna, and Sven-Eric Jordt. “TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.” Toxicol Lett 293 (September 1, 2018): 140–48. https://doi.org/10.1016/j.toxlet.2018.03.007.Full Text Link to Item
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Liu, Boyi, and Sven-Eric Jordt. “Cooling the Itch via TRPM8.” J Invest Dermatol 138, no. 6 (June 2018): 1254–56. https://doi.org/10.1016/j.jid.2018.01.020.Full Text Link to Item
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Moore, Carlene, Rupali Gupta, Sven-Eric Jordt, Yong Chen, and Wolfgang B. Liedtke. “Regulation of Pain and Itch by TRP Channels.” Neurosci Bull 34, no. 1 (February 2018): 120–42. https://doi.org/10.1007/s12264-017-0200-8.Full Text Link to Item
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Zhang, Linlin, Niccolò Terrando, Zhen-Zhong Xu, Sangsu Bang, Sven-Eric Jordt, William Maixner, Charles N. Serhan, and Ru-Rong Ji. “Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.” Front Pharmacol 9 (2018): 412. https://doi.org/10.3389/fphar.2018.00412.Full Text Link to Item
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Fait, Benjamin W., David C. Thompson, Tenna N. Mose, Peter Jatlow, Sven E. Jordt, Marina R. Picciotto, and Yann S. Mineur. “Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.” Behavioural Brain Research 334 (September 2017): 72–77. https://doi.org/10.1016/j.bbr.2017.07.027.Full Text
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Tai, Yan, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, and Boyi Liu. “Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.” Scientific Reports 7, no. 1 (August 2017): 7532. https://doi.org/10.1038/s41598-017-07651-5.Full Text
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Peter, J., C. Kasper, M. Kaufholz, R. Buschow, J. Isensee, T. Hucho, F. W. Herberg, et al. “Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.” Eur J Pain 21, no. 6 (July 2017): 1072–86. https://doi.org/10.1002/ejp.1008.Full Text Link to Item
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Achanta, Satyanarayana, and Sven-Eric Jordt. “TRPA1: Acrolein meets its target.” Toxicol Appl Pharmacol 324 (June 1, 2017): 45–50. https://doi.org/10.1016/j.taap.2017.03.007.Full Text Link to Item
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Summerhill, Eleanor M., Gary W. Hoyle, Sven-Eric Jordt, Bronwen J. Jugg, James G. Martin, Sadis Matalon, Steven E. Patterson, et al. “An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.” Ann Am Thorac Soc 14, no. 6 (June 2017): 1060–72. https://doi.org/10.1513/AnnalsATS.201704-297WS.Full Text Link to Item
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Caceres, Ana I., Boyi Liu, Sairam V. Jabba, Satyanarayana Achanta, John B. Morris, and Sven-Eric Jordt. “Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.” Br J Pharmacol 174, no. 9 (May 2017): 867–79. https://doi.org/10.1111/bph.13760.Full Text Link to Item
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Liu, Boyi, Yan Tai, Satyanarayana Achanta, Melanie M. Kaelberer, Ana I. Caceres, Xiaomei Shao, Jianqiao Fang, and Sven-Eric Jordt. “IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.” Proc Natl Acad Sci U S A 113, no. 47 (November 22, 2016): E7572–79. https://doi.org/10.1073/pnas.1606608113.Full Text Link to Item
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Miao, Shida, Evan S. Beach, Toby J. Sommer, Julie B. Zimmerman, and Sven-Eric Jordt. “High-Intensity Sweeteners in Alternative Tobacco Products.” Nicotine Tob Res 18, no. 11 (November 2016): 2169–73. https://doi.org/10.1093/ntr/ntw141.Full Text Link to Item
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Fan, Lu, Shrilatha Balakrishna, Sairam V. Jabba, Pamela E. Bonner, Seth R. Taylor, Marina R. Picciotto, and Sven-Eric Jordt. “Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.” Tob Control 25, no. Suppl 2 (November 2016): ii50–54. https://doi.org/10.1136/tobaccocontrol-2016-053209.Full Text Link to Item
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Fan, L., S. Balakrishna, S. V. Jabba, P. E. Bonner, S. R. Taylor, M. R. Picciotto, and S. E. Jordt. “Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism (Accepted).” Tobacco Control, October 19, 2016. https://doi.org/10.1136/annrheumdis-2016-053209.Full Text
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Rothenberg, Craig, Satyanarayana Achanta, Erik R. Svendsen, and Sven-Eric Jordt. “Tear gas: an epidemiological and mechanistic reassessment.” Annals of the New York Academy of Sciences 1378, no. 1 (August 2016): 96–107. https://doi.org/10.1111/nyas.13141.Full Text
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Smith, Gregory J., Joseph A. Cichocki, Bennett J. Doughty, Jose E. Manautou, Sven-Eric Jordt, and John B. Morris. “Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.” Environ Health Perspect 124, no. 5 (May 2016): 642–50. https://doi.org/10.1289/ehp.1509851.Full Text Link to Item
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Kaelberer, Melanie Maya, and Sven-Eric Jordt. “A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice.” J Vis Exp, no. 110 (April 19, 2016). https://doi.org/10.3791/53917.Full Text Link to Item
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Liu, Boyi, Yan Tai, Ana I. Caceres, Satyanarayana Achanta, Shrilatha Balakrishna, Xiaomei Shao, Junfan Fang, and Sven-Eric Jordt. “Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.” Plos One 11, no. 11 (2016): e0165200. https://doi.org/10.1371/journal.pone.0165200.Full Text Link to Item
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Ha, Michael A., Gregory J. Smith, Joseph A. Cichocki, Lu Fan, Yi-Shiuan Liu, Ana I. Caceres, Sven Eric Jordt, and John B. Morris. “Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.” Plos One 10, no. 2 (2015): e0117128. https://doi.org/10.1371/journal.pone.0117128.Full Text Open Access Copy Link to Item
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Balakrishna, Shrilatha, Weifeng Song, Satyanarayana Achanta, Stephen F. Doran, Boyi Liu, Melanie M. Kaelberer, Zhihong Yu, et al. “TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.” Am J Physiol Lung Cell Mol Physiol 307, no. 2 (July 15, 2014): L158–72. https://doi.org/10.1152/ajplung.00065.2014.Full Text Link to Item
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Gui, Junhong, Boyi Liu, Guan Cao, Andrew M. Lipchik, Minervo Perez, Zoltan Dekan, Mehdi Mobli, et al. “A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.” Curr Biol 24, no. 5 (March 3, 2014): 473–83. https://doi.org/10.1016/j.cub.2014.01.013.Full Text Link to Item
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Liu, Boyi, Lu Fan, Shrilatha Balakrishna, Aiwei Sui, John B. Morris, and Sven-Eric Jordt. “TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.” Pain 154, no. 10 (October 2013): 2169–77. https://doi.org/10.1016/j.pain.2013.06.043.Full Text Link to Item
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Liu, Boyi, Jasmine Escalera, Shrilatha Balakrishna, Lu Fan, Ana I. Caceres, Eve Robinson, Aiwei Sui, et al. “TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.” Faseb J 27, no. 9 (September 2013): 3549–63. https://doi.org/10.1096/fj.13-229948.Full Text Link to Item
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Willis, Daniel N., Boyi Liu, Michael A. Ha, Sven-Eric Jordt, and John B. Morris. “Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants.” Faseb J 25, no. 12 (December 2011): 4434–44. https://doi.org/10.1096/fj.11-188383.Full Text Link to Item
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Schulze, Christin, Margit McGowan, Sven-Eric Jordt, and Barbara E. Ehrlich. “Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy.” Clin Colorectal Cancer 10, no. 2 (June 2011): 126–33. https://doi.org/10.1016/j.clcc.2011.03.010.Full Text Link to Item
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Jordt, Sven-Eric. “Trigeminal TRPs and the scent of pain.” Pain 152, no. 1 (January 2011): 4–5. https://doi.org/10.1016/j.pain.2010.10.026.Full Text Link to Item
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Bessac, Bret F., and Sven-Eric Jordt. “Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.” Proc Am Thorac Soc 7, no. 4 (July 2010): 269–77. https://doi.org/10.1513/pats.201001-004SM.Full Text Link to Item
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Lanosa, Michael J., Daniel N. Willis, Sven Jordt, and John B. Morris. “Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.” Toxicol Sci 115, no. 2 (June 2010): 589–95. https://doi.org/10.1093/toxsci/kfq057.Full Text Link to Item
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Jordt, S. E. “Response to Shusterman.” Faseb Journal 24, no. 4 (April 1, 2010): 980. https://doi.org/10.1096/fj.10-0405LTR.Full Text
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Caceres, Ana I., Marian Brackmann, Maxwell D. Elia, Bret F. Bessac, Donato del Camino, Marc D’Amours, JoAnn S. Witek, et al. “A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.” Proc Natl Acad Sci U S A 106, no. 22 (June 2, 2009): 9099–9104. https://doi.org/10.1073/pnas.0900591106.Full Text Link to Item
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Bessac, Bret F., Michael Sivula, Chrisitan A. von Hehn, Ana I. Caceres, Jasmine Escalera, and Sven E. Jordt. “TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases.” Faseb Journal 23 (April 1, 2009).Link to Item
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Bessac, Bret F., Michael Sivula, Christian A. von Hehn, Ana I. Caceres, Jasmine Escalera, and Sven-Eric Jordt. “Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.” Faseb J 23, no. 4 (April 2009): 1102–14. https://doi.org/10.1096/fj.08-117812.Full Text Link to Item
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Bessac, Bret F., and Sven-Eric Jordt. “Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.” Physiology (Bethesda) 23 (December 2008): 360–70. https://doi.org/10.1152/physiol.00026.2008.Full Text Link to Item
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Escalera, Jasmine, Christian A. von Hehn, Bret F. Bessac, Michael Sivula, and Sven-Eric Jordt. “TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.” J Biol Chem 283, no. 35 (August 29, 2008): 24136–44. https://doi.org/10.1074/jbc.M710280200.Full Text Link to Item
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Bessac, Bret F., Michael Sivula, Christian A. von Hehn, Jasmine Escalera, Lauren Cohn, and Sven-Eric Jordt. “TRPA1 is a major oxidant sensor in murine airway sensory neurons.” J Clin Invest 118, no. 5 (May 2008): 1899–1910. https://doi.org/10.1172/JCI34192.Full Text Link to Item
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Streng, Tomi, Helena E. Axelsson, Petter Hedlund, David A. Andersson, Sven-Eric Jordt, Stuart Bevan, Karl-Erik Andersson, Edward D. Högestätt, and Peter M. Zygmunt. “Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.” Eur Urol 53, no. 2 (February 2008): 391–99. https://doi.org/10.1016/j.eururo.2007.10.024.Full Text Link to Item
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Bautista, Diana M., Jan Siemens, Joshua M. Glazer, Pamela R. Tsuruda, Allan I. Basbaum, Cheryl L. Stucky, Sven-Eric Jordt, and David Julius. “The menthol receptor TRPM8 is the principal detector of environmental cold.” Nature 448, no. 7150 (July 12, 2007): 204–8. https://doi.org/10.1038/nature05910.Full Text Link to Item
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Boehmerle, Wolfgang, Kun Zhang, Michael Sivula, Felix M. Heidrich, Yashang Lee, Sven-Eric Jordt, and Barbara E. Ehrlich. “Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.” Proc Natl Acad Sci U S A 104, no. 26 (June 26, 2007): 11103–8. https://doi.org/10.1073/pnas.0701546104.Full Text Link to Item
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Jordt, S. E., and B. E. Ehrlich. “TRP channels in disease.” Subcell Biochem 45 (2007): 253–71. https://doi.org/10.1007/978-1-4020-6191-2_9.Full Text Link to Item
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Bautista, Diana M., Sven-Eric Jordt, Tetsuro Nikai, Pamela R. Tsuruda, Andrew J. Read, Jeannie Poblete, Ebenezer N. Yamoah, Allan I. Basbaum, and David Julius. “TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.” Cell 124, no. 6 (March 24, 2006): 1269–82. https://doi.org/10.1016/j.cell.2006.02.023.Full Text Link to Item
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Bautista, Diana M., Pouya Movahed, Andrew Hinman, Helena E. Axelsson, Olov Sterner, Edward D. Högestätt, David Julius, Sven-Eric Jordt, and Peter M. Zygmunt. “Pungent products from garlic activate the sensory ion channel TRPA1.” Proc Natl Acad Sci U S A 102, no. 34 (August 23, 2005): 12248–52. https://doi.org/10.1073/pnas.0505356102.Full Text Link to Item
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Jordt, Sven-Eric, Diana M. Bautista, Huai-Hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Ian D. Meng, and David Julius. “Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.” Nature 427, no. 6971 (January 15, 2004): 260–65. https://doi.org/10.1038/nature02282.Full Text Link to Item
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Jordt, Sven-Eric, David D. McKemy, and David Julius. “Lessons from peppers and peppermint: the molecular logic of thermosensation.” Curr Opin Neurobiol 13, no. 4 (August 2003): 487–92. https://doi.org/10.1016/s0959-4388(03)00101-6.Full Text Link to Item
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Jordt, Sven-Eric, and David Julius. “Molecular basis for species-specific sensitivity to "hot" chili peppers.” Cell 108, no. 3 (February 8, 2002): 421–30. https://doi.org/10.1016/s0092-8674(02)00637-2.Full Text Link to Item
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Chuang, H. H., E. D. Prescott, H. Kong, S. Shields, S. E. Jordt, A. I. Basbaum, M. V. Chao, and D. Julius. “Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.” Nature 411, no. 6840 (June 21, 2001): 957–62. https://doi.org/10.1038/35082088.Full Text Link to Item
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Bösl, M. R., V. Stein, C. Hübner, A. A. Zdebik, S. E. Jordt, A. K. Mukhopadhyay, M. S. Davidoff, A. F. Holstein, and T. J. Jentsch. “Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.” Embo J 20, no. 6 (March 15, 2001): 1289–99. https://doi.org/10.1093/emboj/20.6.1289.Full Text Link to Item
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Mukhopadhyay, A. K., M. R. Bosl, V. Stein, C. Hubner, S. E. Jordt, M. S. Davidoff, A. F. Holstein, and T. J. Jentsch. “Disruption of chloride channel 2 (ClC-2) leads to aspermatogenesis and infertility without affecting Leydig cell function.” Biology of Reproduction 64 (January 1, 2001): 208–208.Link to Item
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Jordt, S. E., M. Tominaga, and D. Julius. “Acid potentiation of the capsaicin receptor determined by a key extracellular site.” Proc Natl Acad Sci U S A 97, no. 14 (July 5, 2000): 8134–39. https://doi.org/10.1073/pnas.100129497.Full Text Link to Item
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Pusch, M., S. E. Jordt, V. Stein, and T. J. Jentsch. “Chloride dependence of hyperpolarization-activated chloride channel gates.” J Physiol 515 ( Pt 2), no. Pt 2 (March 1, 1999): 341–53. https://doi.org/10.1111/j.1469-7793.1999.341ac.x.Full Text Link to Item
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Clark, S., S. E. Jordt, T. J. Jentsch, and A. Mathie. “Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.” J Physiol 506 ( Pt 3), no. Pt 3 (February 1, 1998): 665–78. https://doi.org/10.1111/j.1469-7793.1998.665bv.x.Full Text Link to Item
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Jordt, S. E., and T. J. Jentsch. “Molecular dissection of gating in the ClC-2 chloride channel.” Embo J 16, no. 7 (April 1, 1997): 1582–92. https://doi.org/10.1093/emboj/16.7.1582.Full Text Link to Item
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Book Sections
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Krishnan-Sarin, Suchitra, Stephanie S. O’Malley, Barry G. Green, and Sven Jordt. “The science of flavour in tobacco products.” In WHO Study Group on Tobacco Product Regulation. Report on the Scientific Basis of Tobacco Product Regulation: Seventh Report of a WHO Study Group, Vol. 1015. Geneva: WHO Press, World Health Organization, 2019.Link to Item
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Digital Publications
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Kuebler, Wolfgang, Sven-Eric Jordt, and Wolfgang Liedtke. “COVID-19: Urgent Reconsideration of Lung Edema as a Preventable Outcome: Inhibition of TRPV4 As a Promising and Feasible Approach.,” March 23, 2020. https://doi.org/10.2139/ssrn.3558887.Full Text Link to Item
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Conference Papers
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Achanta, S., A. Marcus, A. Caceres, I. Merutka, and S. E. Jordt. “Biomarkers and Drugs Targets for Phosgene Induced Pulmonary Inhalation Injuries.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.Link to Item
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Jordt, S. E., H. Erythropel, D Garcia Torres, L. A. Delgado, P. T. Anastas, J. B. Zimmerman, and S. V. Jabba. “Synthetic Cooling Agents in US-Marketed E-cigarette Refill Liquids and Disposable E-cigarettes: Chemical Analysis and Risk Assessment.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.Link to Item
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Achanta, S., B. Pantazides, B. Crow, J. Quinones-Gonzalez, J. Perez, T. Blake, and S. E. Jordt. “Chlorinated Tyrosine Adducts as Biomarkers of Chlorine Gas Exposure in a Swine Model.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.Link to Item
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Caceres, A., M. M. Kaelberer, and S. E. Jordt. “The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.Link to Item
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Jabba, S. V., A. N. Diaz, A. I. Caceres, H. C. Erythropel, V. Kumar, S. Varghese, J. B. Zimmerman, and S. E. Jordt. “Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.Link to Item
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Jabba, Sairam V., Alexandra N. Diaz, Hanno C. Erythropel, Julie B. Zimmerman, and Sven E. Jordt. “Chemical Adducts of Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Jabba, Sairam V., Alexandra N. Diaz, Hanno C. Erythropel, Julie B. Zimmerman, and Sven E. Jordt. “Chemical Adducts of Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.” In Chemical Senses, Vol. 46, 2021.Link to Item
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Caceres, Ana Isabel, Melanie Maya Kaelberer, and Sven-Eric Jordt. “Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation.” In Molecular Pathology and Funct. Genomics. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.902.Full Text
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Erythropel, Hanno, Paul T. Anastas, Suchitra Krishnan-Sarin, Stephanie S. O’Malley, Sven E. Jordt, and Julie B. Zimmerman. “Late Breaking Abstract - Differences in flavorant levels and synthetic coolant use between USA, EU and Canadian Juul products.” In Tobacco, Smoking Control and Health Educ. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.4382.Full Text
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Jordt, Sven-Eric, Ana I. Caceres, Hanno Erythropel, Julie B. Zimmerman, Tamara Dewinter, and Sairam V. Jabba. “Flavor-solvent reaction products in electronic cigarette liquids activate respiratory irritant receptors and elicit cytotoxic metabolic responses in airway epithelial cell.” In Tobacco, Smoking Control and Health Educ. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.4384.Full Text
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Jordt, Sven-Eric, Carolyn J. Albert, Kevin A. Schultz, David A. Ford, Rakesh Patel, and Satyanarayana Achanta. “Exposure biomarkers in a pig model of chlorine inhalation injury.” In Occupational and Environmental Health. European Respiratory Society, 2020. https://doi.org/10.1183/13993003.congress-2020.1308.Full Text
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Achanta, S., C. Albert, K. Schultze, D. Ford, R. Patel, and S. E. Jordt. “Biomarkers of Chlorine Gas Exposure in a Swine Model.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.Link to Item
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Caceres, A., M. Kaelberer, and S. E. Jordt. “The Airway Sensory Nerve Transcriptome: Evidence for Neuropathic Injury Following Lipopolysaccharide Induced Lung Inflammation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.Link to Item
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Jabba, S. V., and S. E. Jordt. “Activation of Respiratory Irritant Receptors by Pulegone, A Toxic Flavor Chemical in Mint- or Menthol-Flavored Electronic Cigarettes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.Link to Item
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Caceres, Ana Isabel, and Sven-Eric Jordt. “The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury.” In Airway Pharmacology and Treatment. European Respiratory Society, 2019. https://doi.org/10.1183/13993003.congress-2019.pa3885.Full Text
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Achanta, S., B. Liu, M. A. Gentile, A. Caceres, D. J. Behm, M. E. Burgert, M. H. Costell, I. M. Cheifetz, M. D. Gunn, and S. E. Jordt. “TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.Link to Item
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Jordt, S. E., A. I. Caceres, and S. Jabba. “Flavor-Solvent Adducts In Electronic Cigarette Liquids Are Modulators of Respiratory Irritant Receptors with Distinct Toxicological Effects on Lung Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.Link to Item
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Jordt, S. E., S. Jabba, K. Ghoreshi, G. J. Smith, and J. B. Morris. “Propylene Glycol and Glycerin in E-Cigarettes Elicit Respiratory Irritation Responses and Modulate Human Sensory Irritant Receptor Function.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.Link to Item
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Jabba, Sairam V., Hanno C. Erythropel, Tamara M. DeWinter, Mark Falinski, Paul T. Anastas, Julie B. Zimmerman, and Sven-Eric Jordt. “Chemical Adducts of Flavorants in E-cigarette Liquid Solvents Act As Modulators of Respiratory Irritant Receptors.” In Chemical Senses, 43:E238–E238. OXFORD UNIV PRESS, 2018.Link to Item
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Jabba, Sairam V., Lu Fan, Shrilatha Balakrishna, Pamela Bonner, Seth R. Taylor, Kayvon Ghoreshi, Gregory J. Smith, et al. “TRP Ion Channels as Key Targets of Tobacco and Electronic Cigarette Irritants and Flavor Additives.” In Chemical Senses, 43:E4–E4. OXFORD UNIV PRESS, 2018.Link to Item
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Erythropel, H. C., S. V. Jabba, T. M. DeWinter, M. Falinski, P. T. Anastas, J. B. Zimmerman, and S. E. Jordt. “Chemical Adducts Of Flavorants With E-Cigarette Liquid Solvents Act As Modulators Of Respiratory Irritant Receptors.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.Link to Item
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Caceres Bustos, Anabel de, Boyi Liu, Sairam Jabba, John Morris, and Sven-Eric Jordt. “The anti-inflammatory effects of eucalyptol in a mouse model of LPS-induced pulmonary inflammation are mediated by TRPM8.” In 5.1 Airway Pharmacology and Treatment. European Respiratory Society, 2016. https://doi.org/10.1183/13993003.congress-2016.oa4541.Full Text
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Caceres, Ana Isabel, Boyi Liu, Sairam V. Jabba, John B. Morris, and Sven-Eric Jordt. “TRPM8 Mediates the Anti-inflammatory Effects of Eucalyptol in a Mouse Model of LPS-Induced Pulmonary Inflammation.” In Faseb Journal, Vol. 30. FEDERATION AMER SOC EXP BIOL, 2016.Link to Item
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Jordt, Sven-Eric, Michael A. Ha, J. Smith, Joseph A. Cichocki, Shrilatha Balakrishna, Lu Fan, Yi-Shiuan Liu, Ana I. Caceres, Marina R. Picciotto, and John B. Morris. “Menthol Attenuates Chemosensory Irritation and Elevates blood Cotinine in Cigarette Smoke Exposed Mice.” In Chemical Senses, 40:596–596. OXFORD UNIV PRESS, 2015.Link to Item
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Picciotto, Marina R., Sven-Eric Jordt, and Yann S. Mineur. “Nicotine addiction: molecular basis of behaviors at the complex interface between reward, food intake and taste.” In Chemical Senses, 40:535–535. OXFORD UNIV PRESS, 2015.Link to Item
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Jordt, S. E., M. M. Kaelberer, B. Liu, A. I. Caceres, G. J. Smith, J. A. Cichocki, M. A. Ha, and J. B. Morris. “Activation Of Chemosensory Receptors And Respiratory Irritation Responses By Electronic Cigarette Flavorants And Vapors.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.Link to Item
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Smith, G. J., J. A. Cichocki, J. E. Manautou, S. E. Jordt, and J. B. Morris. “Acetaminophen Potentiates Respiratory Responses To Environmental Tobacco Smoke.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.Link to Item
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Liu, Boyi, and Sven-Eric Jordt. “TRPA1 Controls Inflammation and Pruritogen Responses in Allergic Contact Dermatitis.” In Journal of General Physiology, 144:10A-10A. ROCKEFELLER UNIV PRESS, 2014.Link to Item
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Liu, Boyi, J. Escalera, S. Balakrishna, Lu Fan, A. I. Caceres, E. Robinson, A. Sui, et al. “TRPA1 CONTROLS INFLAMMATION AND PRURITOGEN RESPONSES IN ALLERGIC CONTACT DERMATITIS.” In Acta Dermato Venereologica, 93:616–616. ACTA DERMATO-VENEREOLOGICA, 2013.Link to Item
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Smith, G. J., M. A. Ha, J. A. Cichocki, B. Liu, L. Fan, S. E. Jordt, and J. B. Morris. “Menthol Blocks Respiratory Irritation Responses To Cigarette Smoke Via Trpm8 Receptor Pathways.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.Link to Item
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Jordt, Sven-Eric. “Sensory TRP Channels in Airway Chemosensation and Inflammation.” In Journal of General Physiology, 140:5A-5A. ROCKEFELLER UNIV PRESS, 2012.Link to Item
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Gui, Junhong, Yufeng Zhou, Sven-Eric Jordt, and Michael N. Nitabach. “Screening Spider Toxin Libraries for TRP Channel Inhibitors.” In Biophysical Journal, 100:108–108. CELL PRESS, 2011.Link to Item
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Caceres, Ana Isabel, Marian Brackmann, Bret F. Bessac, Lauren Cohn, and Sven Eric Jordt. “Decreased Ovalbumin-induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1.” In Faseb Journal, Vol. 23. FEDERATION AMER SOC EXP BIOL, 2009.Link to Item
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Caceres, A. I., M. Brackmann, B. F. Bessac, A. Sui, L. Cohn, and S. E. Jordt. “Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1.” In American Journal of Respiratory and Critical Care Medicine, Vol. 179. AMER THORACIC SOC, 2009.Link to Item
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Bautista, Diana M., Sven E. Jordt, Jan Siemens, and David Julius. “Molecular and Cellular Mechanisms of Trigeminal Chemosensation.” In Chemical Senses, 33:S31–S31. OXFORD UNIV PRESS, 2008.Link to Item
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Boehmerle, Wolfgang, Michael Sivula, Sven-Eric Jordt, and Barbara Ehrlich. “Paclitaxel induces alterations in InsP(3) mediated calcium signaling via calpain mediated NCS-1 degradation in neuronal cells.” In Biophysical Journal, 594A-595A. BIOPHYSICAL SOCIETY, 2007.Link to Item
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Jordt, S. E., D. M. Bautista, H. Chuang, D. D. McKemy, P. M. Zygmunt, E. D. Hogestatt, I. D. Meng, and D. Julius. “Mustard oils and cannabinoids excite sensory nerve fibers via the trp channel TRPA1.” In Journal of Neurochemistry, 94:222–222. WILEY-BLACKWELL PUBLISHING, INC, 2005.Link to Item
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Jordt, S. -. E. “Acid potentiation of the capsaicin receptor determined by a key extracellular site.” In Journal of Neurochemistry, 85:6–6. Wiley, 2003. https://doi.org/10.1046/j.1471-4159.85.s2.6_3.x.Full Text
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Jordt, S. -. E., and D. Julius. “Molecular determinants of ligand interaction with the capsaicin receptor.” In Journal of Neurochemistry, 85:4–4. Wiley, 2003. https://doi.org/10.1046/j.1471-4159.85.s2.4_3.x.Full Text
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Preprints
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Achanta, Satyanarayana, Michael Gentile, Carolyn Albert, Kevin Schulte, Brooke Pantazides, Brian Crow, Jennifer Quiñones-González, et al. “Recapitulation of Human Pathophysiology and Identification of Forensic Biomarkers in a Translational Swine Model of Chlorine Inhalation Injury.” BioRxiv, 2022. https://doi.org/10.1101/2022.02.09.479576.Full Text
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Achanta, Satyanarayana, Narendranath Reddy Chintagari, Shrilatha Balakrishna, Boyi Liu, and Sven-Eric Jordt. “Accelerating Inflammation Resolution to Counteract Chemical Cutaneous Injury.” BioRxiv, 2019. https://doi.org/10.1101/749184.Full Text
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- Teaching & Mentoring
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Teaching Activities
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2019
CBI/PHR/BCH/MCB 762 Module II - Intracellular Signaling and Disease
Ion Channels (Basic, Model Systems), 4 Lectures 2/11, 13, 15, 18
Lecture 1: Ion Channels – Basic Mechanisms and Discovery
Lecture 2: Ion Channels – Channelopathies and Ion Channel Pharmacology
Lecture 3: Ion Channels – Sensory Functions and Pain
Lecture 4: Ion Channels – Pain 2 and Ion Channels as Research Tools
2018
CBI/PHR/BCH/MCB 762 Module II - Intracellular Signaling and Disease
Ion Channels (Basic, Model Systems), 4 Lectures
Lecture 1: Ion Channels – Basic Mechanisms and Discovery
Lecture 2: Ion Channels – Channelopathies and Ion Channel Pharmacology
Lecture 3: Ion Channels – Sensory Functions and Pain
Lecture 4: Ion Channels – Pain 2 and Ion Channels as Research Tools
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- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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Service to the Profession
- Grant Application Reviewer. Progress Review Meeting. Science Foundation Ireland (SFI). July 2, 2019 - July 4, 2019 2019
- NIH Grant Application Reviewer. ZRG1 BST-T (55) R RFA Panel: Tobacco Regulatory Biomedical Science - Basic . National Institutes of Health (NIH) - Center for Scientific Review (CSR). May 30, 2019 2019
- Moderator, Minisymposium. Chemical threats and injury: mechanisms and treatment. American Thoracic Society. May 19, 2019 2019
- Co-Chair, Basic Science Network (BSN). Society for Research on Nicotine and Tobacco (SRNT). May 2019 2019
- NIH Grant Application Reviewer. ZAT1 AJT 10 - NCCIH Training and Education Review Panel (CT) Review Panel . National Institutes of Health (NIH) - National Center for Complementary and Integrative Health (NCCIH). March 27, 2019 2019
- NIH Grant Application Reviewer. NIH-CSR-RES SEP-ZRG1 CVRS-H: R21 and R01 applications on Electronic Nicotine Delivery Systems: Basic Mechanisms of Health Effects.. National Institutes of Health (NIH) - Center for Scientific Review (CSR). March 22, 2019 - March 23, 2019 2019
- NIH Grant Application Reviewer. 2018 ZRG1-CVRS-N(03): R21 and R01 applications on Electronic Nicotine Delivery Systems: Basic Mechanisms of Health Effects. National Institutes of Health (NIH) - Center for Scientific Review (CSR). December 4, 2018 - December 5, 2018 2018
- NIH Grant Application Reviewer. ZRG1 MDCN-B(55) Countermeasures Against Chemical Threats Special Emphasis Panel, Baltimore, MD. National Institutes of Health (NIH) - Center for Scientific Review (CSR). June 21, 2018 2018
- Ad hoc reviewer. 2018 2018
- Consultant. Sanofi. 2018 2018
- Chair, Section on Terrorism and Inhalation Disasters (TID). American Thoracic Society. May 2017 - May 2019 2017 - 2019
- NIH Grant Application Reviewer. ZRG1 MDCN-B(55) Countermeasures Against Chemical Threats Special Emphasis Panel, Baltimore, MD. National Institutes of Health (NIH) - Center for Scientific Review (CSR). July 8, 2016 2016
- Associate Editor. Tobacco Regulatory Science. 2016 2016
- Program Committee Member, Assembly on Environmental, Occupational and Public Health (EOPH). American Thoracic Society. 2016 2016
- NIH Grant Application Reviewer. ZRG1 MDCN-B(55) Countermeasures Against Chemical Threats Special Emphasis Panel, Baltimore, MD. National Institutes of Health (NIH) - Center for Scientific Review (CSR). July 16, 2015 2015
- Planning Committee Member, Assembly on Environmental, Occupational and Public Health (EOPH). American Thoracic Society. 2015 - 2016 2015 - 2016
- NIH Grant Application Reviewer. ZRG1 MDCN-B(55) Countermeasures Against Chemical Threats Special Emphasis Panel, Baltimore, MD. National Institutes of Health (NIH) - Center for Scientific Review (CSR). July 11, 2014 2014
- NIH Grant Application Reviewer. ZRG1 MDCN-B(55) Countermeasures Against Chemical Threats Special Emphasis Panel, Baltimore, MD. National Institutes of Health (NIH) - Center for Scientific Review (CSR). June 4, 2013 2013
- NIH Grant Application Reviewer. ZRG1 MDCN-J54 / J50 CounterACT special emphasis panel. National Institutes of Health (NIH) - Center for Scientific Review (CSR). March 19, 2013 2013
- NIH Grant Application Reviewer. ZDC1 SRB-R (39). Clinical Research Center Grants (P50), FDA-sponsored tobacco regulatory research. National Institutes of Health (NIH) - Center for Scientific Review (CSR). January 31, 2013 2013
- NIH Grant Application Reviewer. NIH Intramural Center for Tobacco Regulatory Science. National Institutes of Health (NIH) . October 22, 2012 2012
- NIH Grant Application Reviewer. ZAT1 SM (25), NCCAM, Asthma mechanisms. National Institutes of Health (NIH) - Center for Scientific Review (CSR). July 19, 2012 - July 20, 2012 2012
- NIH Grant Application Reviewer. ZRG1-IFCN-B-02M , R01 applications on sensory biology. National Institutes of Health (NIH) - Center for Scientific Review (CSR). June 1, 2011 - June 2, 2011 2011
- NIH Grant Application Reviewer. MDCN J54 / J50, Countermeasures Against Chemical Threats Special Emphasis Panel. National Institutes of Health (NIH) - Center for Scientific Review (CSR). March 22, 2011 2011
- NIH Grant Application Reviewer. ZRG1-IFCN-B-51,R01 applications in sensory biology. National Institutes of Health (NIH) - Center for Scientific Review (CSR). February 22, 2011 - February 23, 2011 2011
- Consultant. Boehringer Ingelheim. 2011 2011
- Consultant. Cubist Pharmaceuticals. 2011 2011
- Consulting. Abbott Laboratories. 2011 2011
- NIH Grant Application Reviewer. ZRG1-IFCN-B-03M, R01 applications in sensory biology. National Institutes of Health (NIH) - Center for Scientific Review (CSR). September 29, 2010 - September 30, 2010 2010
- Consultant. Ono Pharmaceuticals, Japan. 2009 2009
- NIH Grant Application Reviewer. ZRG1-F02B-Y-20L, NRSA Fellowship Applications. National Institutes of Health (NIH) - Center for Scientific Review (CSR). 2009 2009
- Ad hoc reviewer. Journal of Clinical Investigation (JCI). 2008 2008
- Consultant. Forrest Laboratories, LLC. 2008 2008
- Consultant. Research Planning Workshop. Health Effects Institute. 2008 2008
- Member, Scientific Advisory Board. Hydra Biosciences Inc.. 2006 - 2018 2006 - 2018
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Service to Duke
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.