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Sven Eric Jordt

Associate Professor in Anesthesiology
Anesthesiology
3094, MS27, Durham, NC 27710-3094
3 Genome Ct., MSRB3, Room 6122, Durham, NC 27710-3094

Selected Publications


Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.

Conference Pain · February 27, 2024 Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the ... Full text Link to item Cite

Recapitulation of Human Pathophysiology and Identification of Forensic Biomarkers in a Translational Model of Chlorine Inhalation Injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · February 6, 2024 Chlorine gas (Cl2) has been repeatedly used as a chemical weapon, first in World War I and most recently in Syria. Life-threatening Cl2 exposures frequently occur in domestic and occupational environments, and in transportation accidents. Modeling the huma ... Full text Link to item Cite

Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent-Induced Cutaneous Injuries.

Journal Article J Pharmacol Exp Ther · January 17, 2024 Deployment of the tear gas agent 2-chlorobenzalmalononitrile (CS) for riot control has significantly increased in recent years. The effects of CS have been believed to be transient and benign. However, CS induces severe pain, blepharospasm, lachrymation, a ... Full text Link to item Cite

Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review.

Journal Article Tob Control · November 2023 E-cigarettes with cooling flavours have diversified in ways that complicate tobacco control with the emergence of: (1) Ice-hybrid flavours (eg, 'Raspberry Ice') that combine cooling and fruity/sweet properties; and (2) Products containing non-menthol synth ... Full text Link to item Cite

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Journal Article Br J Pharmacol · October 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions wit ... Full text Link to item Cite

Synthetic cooling agent in oral nicotine pouch products marketed as 'Flavour-Ban Approved'.

Journal Article Tobacco control · June 2023 BackgroundUS sales of oral nicotine pouches (ONPs) have rapidly increased, with cool/mint-flavoured ONPs the most popular flavour category. Restrictions on sales of flavoured tobacco products have either been implemented or proposed by several US ... Full text Cite

Synthetic Cooling Agent and Candy Flavors in California-marketed "non-Menthol" Cigarettes.

Journal Article bioRxiv · May 18, 2023 RATIONALE: The ban of menthol cigarettes is one of the key strategies to promote smoking cessation in the United States. Menthol cigarettes are preferred by young beginning smokers for smoking initiation. Almost 90% of African American smokers use menthol ... Full text Link to item Cite

Synthetic nicotine has arrived.

Journal Article Tob Control · April 2023 The introduction of a new product line of the popular disposable electronic cigarette brand Puffbar, advertised as containing synthetic nicotine, has drawn attention to the increasing use of synthetic nicotine in marketed products and its uncertain regulat ... Full text Open Access Link to item Cite

The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report.

Journal Article Ann Am Thorac Soc · January 2023 E-cigarette or vaping product use-associated lung injury (EVALI) is a severe pulmonary illness associated with the use of e-cigarettes or vaping products that was officially identified and named in 2019. This American Thoracic Society workshop was convened ... Full text Link to item Cite

Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2023 Cite

High Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not Learned

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2023 Cite

Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.

Conference Pain · February 27, 2024 Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the ... Full text Link to item Cite

Recapitulation of Human Pathophysiology and Identification of Forensic Biomarkers in a Translational Model of Chlorine Inhalation Injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · February 6, 2024 Chlorine gas (Cl2) has been repeatedly used as a chemical weapon, first in World War I and most recently in Syria. Life-threatening Cl2 exposures frequently occur in domestic and occupational environments, and in transportation accidents. Modeling the huma ... Full text Link to item Cite

Pharmacologic Inhibition of Transient Receptor Potential Ion Channel Ankyrin 1 Counteracts 2-Chlorobenzalmalononitrile Tear Gas Agent-Induced Cutaneous Injuries.

Journal Article J Pharmacol Exp Ther · January 17, 2024 Deployment of the tear gas agent 2-chlorobenzalmalononitrile (CS) for riot control has significantly increased in recent years. The effects of CS have been believed to be transient and benign. However, CS induces severe pain, blepharospasm, lachrymation, a ... Full text Link to item Cite

Ice flavours and non-menthol synthetic cooling agents in e-cigarette products: a review.

Journal Article Tob Control · November 2023 E-cigarettes with cooling flavours have diversified in ways that complicate tobacco control with the emergence of: (1) Ice-hybrid flavours (eg, 'Raspberry Ice') that combine cooling and fruity/sweet properties; and (2) Products containing non-menthol synth ... Full text Link to item Cite

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels.

Journal Article Br J Pharmacol · October 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions wit ... Full text Link to item Cite

Synthetic cooling agent in oral nicotine pouch products marketed as 'Flavour-Ban Approved'.

Journal Article Tobacco control · June 2023 BackgroundUS sales of oral nicotine pouches (ONPs) have rapidly increased, with cool/mint-flavoured ONPs the most popular flavour category. Restrictions on sales of flavoured tobacco products have either been implemented or proposed by several US ... Full text Cite

Synthetic Cooling Agent and Candy Flavors in California-marketed "non-Menthol" Cigarettes.

Journal Article bioRxiv · May 18, 2023 RATIONALE: The ban of menthol cigarettes is one of the key strategies to promote smoking cessation in the United States. Menthol cigarettes are preferred by young beginning smokers for smoking initiation. Almost 90% of African American smokers use menthol ... Full text Link to item Cite

Synthetic nicotine has arrived.

Journal Article Tob Control · April 2023 The introduction of a new product line of the popular disposable electronic cigarette brand Puffbar, advertised as containing synthetic nicotine, has drawn attention to the increasing use of synthetic nicotine in marketed products and its uncertain regulat ... Full text Open Access Link to item Cite

The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report.

Journal Article Ann Am Thorac Soc · January 2023 E-cigarette or vaping product use-associated lung injury (EVALI) is a severe pulmonary illness associated with the use of e-cigarettes or vaping products that was officially identified and named in 2019. This American Thoracic Society workshop was convened ... Full text Link to item Cite

Soluble Epoxide Hydrolase Inhibitors and ACE Inhibitors Ameliorate Phosgene Inhalation Injuries

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2023 Cite

High Toxicity of Cinnamon-flavored Electronic Cigarette Liquids: A Lesson Not Learned

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2023 Cite

Protocol for non-invasive assessment of spontaneous movements of group-housed animals using remote video monitoring.

Journal Article STAR Protoc · June 17, 2022 Frequent monitoring of laboratory animals is critical for ensuring animal welfare and experimental data collection. To minimize the adverse and confounding effects caused by current monitoring protocols and human presence, we developed a low-cost, non-inva ... Full text Link to item Cite

Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment.

Journal Article Nicotine Tob Res · June 15, 2022 INTRODUCTION: Menthol, through its cooling and pleasant sensory effects, facilitates smoking and tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E-cigarettes. More recently, E-cigarette vendors started marketing synthe ... Full text Open Access Link to item Cite

Biomarkers and Drugs Targets for Phosgene Induced Pulmonary Inhalation Injuries

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2022 Cite

Toxic effects of chlorine gas and potential treatments: a literature review.

Journal Article Toxicol Mech Methods · May 2021 Chlorine gas is one of the highly produced chemicals in the USA and around the world. Chlorine gas has several uses in water purification, sanitation, and industrial applications; however, it is a toxic inhalation hazard agent. Inhalation of chlorine gas, ... Full text Link to item Cite

TRPA1: An asthma target with a zing.

Journal Article J Exp Med · April 5, 2021 Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammati ... Full text Link to item Cite

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.

Journal Article Cell Host Microbe · February 10, 2021 The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous system, but whether they also relay signals from intestinal microbes remains un ... Full text Link to item Cite

Synthetic Cooling Agents in US-marketed E-cigarette Refill Liquids and Popular Disposable E-cigarettes: Chemical Analysis and Risk Assessment

Journal Article · 2021 Background Menthol, through its cooling and pleasant sensory effects, facilitates smoking and tobacco product initiation, resulting in the high popularity of mint/menthol-flavored E-cigarettes. More recently, E-cigarette vendors started marketing ... Full text Cite

Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Chlorinated Tyrosine Adducts as Biomarkers of Chlorine Gas Exposure in a Swine Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2021 Cite

Chemical Adducts of Reactive Flavor Aldehydes Formed in E-Cigarette Liquids Are Cytotoxic and Inhibit Mitochondrial Function in Respiratory Epithelial Cells.

Journal Article Nicotine Tob Res · December 15, 2020 INTRODUCTION: Flavor aldehydes in e-cigarettes, including vanillin, ethyl vanillin (vanilla), and benzaldehyde (berry/fruit), rapidly undergo chemical reactions with the e-liquid solvents, propylene glycol, and vegetable glycerol (PG/VG), to form chemical ... Full text Link to item Cite

Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.

Journal Article Ann N Y Acad Sci · November 2020 The lung is highly sensitive to chemical injuries caused by exposure to threat agents in industrial or transportation accidents, occupational exposures, or deliberate use as weapons of mass destruction (WMD). There are no antidotes for the majority of the ... Full text Link to item Cite

Exposure biomarkers in a pig model of chlorine inhalation injury

Conference Occupational and environmental health · September 7, 2020 Full text Cite

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.

Journal Article American journal of physiology. Lung cellular and molecular physiology · June 2020 Lethality of coronavirus disease (COVID-19) during the 2020 pandemic, currently still in the exponentially accelerating phase in most countries, is critically driven by disruption of the alveolo-capillary barrier of the lung, leading to lung edema as a dir ... Full text Cite

Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.

Journal Article Am J Physiol Lung Cell Mol Physiol · May 1, 2020 The lungs and the immune and nervous systems functionally interact to respond to respiratory environmental exposures and infections. The lungs are innervated by vagal sensory neurons of the jugular and nodose ganglia, fused together in smaller mammals as t ... Full text Link to item Cite

Differences in flavourant levels and synthetic coolant use between USA, EU and Canadian Juul products.

Journal Article Tob Control · April 27, 2020 BACKGROUND: 'Juul' is the dominant US e-cigarette brand and was recently introduced to Canada, UK, France, Germany and Italy, with several flavours available across countries. US/Canadian products are sold with 5%, 3% and 1.5% (Canada only) nicotine conten ... Full text Link to item Cite

COVID-19: urgent reconsideration of lung edema as a preventable outcome Inhibition of TRPV4 as a promising and feasible approach.

Internet Publication · March 23, 2020 Lethality of Covid-19 during the 2020 pandemic, currently in the exponentially-accelerating phase in most countries, is critically driven by disruption of the alveolo-capillary barrier of the lung, leading to lung edema as a direct consequence of SARS-CoV- ... Full text Link to item Cite

Biomarkers of Chlorine Gas Exposure in a Swine Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Risk Analysis for the Carcinogen Pulegone in Mint- and Menthol-Flavored e-Cigarettes and Smokeless Tobacco Products.

Journal Article JAMA Intern Med · December 1, 2019 This analysis assesses the levels of the carcinogen pulegone in top-marketed brands of e-cigarettes and smokeless tobacco products. ... Full text Link to item Cite

What are the respiratory effects of e-cigarettes?

Journal Article BMJ · October 15, 2019 Full text Cite

What are the respiratory effects of e-cigarettes?

Journal Article BMJ · September 30, 2019 Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to c ... Full text Link to item Cite

Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids.

Journal Article Nicotine Tob Res · August 19, 2019 INTRODUCTION: "Vaping" electronic cigarettes (e-cigarettes) is increasingly popular with youth, driven by the wide range of available flavors, often created using flavor aldehydes. The objective of this study was to examine whether flavor aldehydes remain ... Full text Link to item Cite

Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis.

Journal Article JCI Insight · June 11, 2019 In the United States, poison ivy exposure is the most common naturally occurring allergen to cause allergic contact dermatitis (ACD). The immune and pruritic mechanisms associated with poison ivy ACD remain largely unexplored. Here, we compared skin whole ... Full text Link to item Cite

ETAR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia.

Journal Article Mol Pain · 2019 Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in ... Full text Link to item Cite

Presence of High-Intensity Sweeteners in Popular Cigarillos of Varying Flavor Profiles.

Journal Article JAMA · October 2, 2018 This Research Letter evaluates the amount of sugars found in cigarillos by brand. ... Full text Link to item Cite

TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.

Journal Article Toxicol Lett · September 1, 2018 The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used ... Full text Link to item Cite

Cooling the Itch via TRPM8.

Journal Article J Invest Dermatol · June 2018 Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstra ... Full text Link to item Cite

Regulation of Pain and Itch by TRP Channels.

Journal Article Neurosci Bull · February 2018 Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechani ... Full text Link to item Cite

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

Journal Article Front Pharmacol · 2018 Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammator ... Full text Link to item Cite

Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.

Journal Article Behav Brain Res · September 15, 2017 Menthol is a commonly used flavorant in tobacco and e-cigarettes, and could contribute to nicotine sensitivity. To understand how menthol could contribute to nicotine intake and addiction, it is important to determine whether specific mechanisms related to ... Full text Link to item Cite

Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone.

Journal Article Sci Rep · August 8, 2017 Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products f ... Full text Link to item Cite

Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.

Journal Article Eur J Pain · July 2017 BACKGROUND: The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling events ... Full text Link to item Cite

TRPA1: Acrolein meets its target.

Journal Article Toxicol Appl Pharmacol · June 1, 2017 Full text Link to item Cite

An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.

Journal Article Ann Am Thorac Soc · June 2017 This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, ... Full text Link to item Cite

Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.

Journal Article Br J Pharmacol · May 2017 BACKGROUND AND PURPOSE: Eucalyptol (1,8-cineol), the major ingredient in the essential oil of eucalyptus leaves and other medicinal plants, has long been known for its anti-inflammatory properties. Eucalyptol interacts with the TRP cation channels among ot ... Full text Link to item Cite

Chemical Adducts Of Flavorants With E-Cigarette Liquid Solvents Act As Modulators Of Respiratory Irritant Receptors

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy.

Journal Article Proc Natl Acad Sci U S A · November 22, 2016 Poison ivy-induced allergic contact dermatitis (ACD) is the most common environmental allergic condition in the United States. Case numbers of poison ivy ACD are increasing due to growing biomass and geographical expansion of poison ivy and increasing cont ... Full text Link to item Cite

High-Intensity Sweeteners in Alternative Tobacco Products.

Journal Article Nicotine Tob Res · November 2016 INTRODUCTION: Sweeteners in tobacco products may influence use initiation and reinforcement, with special appeal to adolescents. Recent analytical studies of smokeless tobacco products (snuff, snus, dissolvables) detected flavorants identical to those adde ... Full text Link to item Cite

Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism.

Journal Article Tob Control · November 2016 BACKGROUND: Nicotine is a major oral irritant in smokeless tobacco products and has an aversive taste. Mentholated smokeless tobacco products are highly popular, suggesting that menthol increases their palatability and may facilitate initiation of product ... Full text Link to item Cite

Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism

Journal Article Tobacco Control · October 19, 2016 © 2016 by the BMJ Publishing Group Ltd. Background Nicotine is a major oral irritant in smokeless tobacco products and has an aversive taste. Mentholated smokeless tobacco products are highly popular, suggesting that menthol increases their palatability an ... Full text Cite

Tear gas: an epidemiological and mechanistic reassessment.

Journal Article Ann N Y Acad Sci · August 2016 Deployments of tear gas and pepper spray have rapidly increased worldwide. Large amounts of tear gas have been used in densely populated cities, including Cairo, Istanbul, Rio de Janeiro, Manama (Bahrain), and Hong Kong. In the United States, tear gas was ... Full text Link to item Cite

Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.

Journal Article Environ Health Perspect · May 2016 BACKGROUND: Although it is known that acetaminophen causes oxidative injury in the liver, it is not known whether it causes oxidative stress in the respiratory tract. If so, this widely used analgesic may potentiate the adverse effects of oxidant air pollu ... Full text Link to item Cite

A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice.

Journal Article J Vis Exp · April 19, 2016 Somatosensory nerves transduce thermal, mechanical, chemical, and noxious stimuli caused by both endogenous and environmental agents. The cell bodies of these afferent neurons are located within the sensory ganglia. Sensory ganglia innervate a specific org ... Full text Link to item Cite

Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice.

Journal Article PLoS One · 2016 Oxidation products of the naturally occurring phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine (PAPC), which are known as OxPAPC, accumulate in atherosclerotic lesions and at other sites of inflammation in conditions such as septic ... Full text Link to item Cite

Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Journal Article PLoS One · 2015 Addition of menthol to cigarettes may be associated with increased initiation of smoking. The potential mechanisms underlying this association are not known. Menthol, likely due to its effects on cold-sensing peripheral sensory neurons, is known to inhibit ... Full text Open Access Link to item Cite

Acetaminophen Potentiates Respiratory Responses To Environmental Tobacco Smoke

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Activation Of Chemosensory Receptors And Respiratory Irritation Responses By Electronic Cigarette Flavorants And Vapors

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Journal Article Am J Physiol Lung Cell Mol Physiol · July 15, 2014 The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel e ... Full text Link to item Cite

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Journal Article Curr Biol · March 3, 2014 BACKGROUND: The venoms of predators have been an excellent source of diverse highly specific peptides targeting ion channels. Here we describe the first known peptide antagonist of the nociceptor ion channel transient receptor potential ankyrin 1 (TRPA1). ... Full text Link to item Cite

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.

Journal Article Pain · October 2013 Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful conditions. Menthol induces the sensation of cooling by activating T ... Full text Link to item Cite

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.

Journal Article FASEB J · September 2013 Allergic contact dermatitis is a common skin disease associated with inflammation and persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory neurons mediate acute inflammatory and pruritic responses following exoge ... Full text Link to item Cite

Menthol Blocks Respiratory Irritation Responses To Cigarette Smoke Via Trpm8 Receptor Pathways

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Sensory TRP Channels in Airway Chemosensation and Inflammation.

Conference JOURNAL OF GENERAL PHYSIOLOGY · July 1, 2012 Link to item Cite

Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants.

Journal Article FASEB J · December 2011 Menthol, the cooling agent in peppermint, is added to almost all commercially available cigarettes. Menthol stimulates olfactory sensations, and interacts with transient receptor potential melastatin 8 (TRPM8) ion channels in cold-sensitive sensory neurons ... Full text Link to item Cite

Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy.

Journal Article Clin Colorectal Cancer · June 2011 BACKGROUND: Oxaliplatin is a platinum-based cytotoxic agent commonly used to treat colorectal cancers. Despite its effectiveness, oxaliplatin administration is associated with the development of cold-induced peripheral neuropathy. This potentially permanen ... Full text Link to item Cite

Screening Spider Toxin Libraries for TRP Channel Inhibitors

Conference BIOPHYSICAL JOURNAL · February 2, 2011 Link to item Cite

Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.

Journal Article Proc Am Thorac Soc · July 2010 The inhalation of reactive gases and vapors can lead to severe damage of the airways and lung, compromising the function of the respiratory system. Exposures to oxidizing, electrophilic, acidic, or basic gases frequently occur in occupational and ambient e ... Full text Link to item Cite

Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.

Journal Article Toxicol Sci · June 2010 The current study was aimed at examining the role of cytochrome P450 (CYP450) activation and the electrophile-sensitive transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene. Toward ... Full text Link to item Cite

Response to Shusterman

Journal Article FASEB Journal · April 1, 2010 Full text Cite

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.

Journal Article Proc Natl Acad Sci U S A · June 2, 2009 Asthma is an inflammatory disorder caused by airway exposures to allergens and chemical irritants. Studies focusing on immune, smooth muscle, and airway epithelial function revealed many aspects of the disease mechanism of asthma. However, the limited effi ... Full text Link to item Cite

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.

Journal Article FASEB J · April 2009 The release of methyl isocyanate in Bhopal, India, caused the worst industrial accident in history. Exposures to industrial isocyanates induce lacrimation, pain, airway irritation, and edema. Similar responses are elicited by chemicals used as tear gases. ... Full text Link to item Cite

Decreased Ovalbumin-Induced Airway Inflammation in Mice Deficient in the Sensory Neuronal Ion Channel TRPA1

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.

Journal Article Physiology (Bethesda) · December 2008 New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation ... Full text Link to item Cite

TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.

Journal Article J Biol Chem · August 29, 2008 Plants, fungi, and animals generate a diverse array of deterrent natural products that induce avoidance behavior in biological adversaries. The largest known chemical family of deterrents are terpenes characterized by reactive alpha,beta-unsaturated dialde ... Full text Link to item Cite

TRPA1 is a major oxidant sensor in murine airway sensory neurons.

Journal Article J Clin Invest · May 2008 Sensory neurons in the airways are finely tuned to respond to reactive chemicals threatening airway function and integrity. Nasal trigeminal nerve endings are particularly sensitive to oxidants formed in polluted air and during oxidative stress as well as ... Full text Link to item Cite

Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.

Journal Article Eur Urol · February 2008 OBJECTIVES: To investigate the distribution of the transient receptor potential (TRP) A1 ion channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H(2)S) and known TRPA1 activators on micturition in conscious rats and on heterol ... Full text Link to item Cite

The menthol receptor TRPM8 is the principal detector of environmental cold.

Journal Article Nature · July 12, 2007 Sensory nerve fibres can detect changes in temperature over a remarkably wide range, a process that has been proposed to involve direct activation of thermosensitive excitatory transient receptor potential (TRP) ion channels. One such channel--TRP melastat ... Full text Link to item Cite

Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.

Journal Article Proc Natl Acad Sci U S A · June 26, 2007 Paclitaxel (Taxol) is a well established chemotherapeutic agent for the treatment of solid tumors, but it is limited in its usefulness by the frequent induction of peripheral neuropathy. We found that prolonged exposure of a neuroblastoma cell line and pri ... Full text Link to item Cite

TRP channels in disease.

Journal Article Subcell Biochem · 2007 The transient receptor potential (TRP) channels are a large family of proteins with six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups. The sheer number of ... Full text Link to item Cite

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

Journal Article Cell · March 24, 2006 TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain. Using TRPA1-deficient mice, we ... Full text Link to item Cite

Pungent products from garlic activate the sensory ion channel TRPA1.

Journal Article Proc Natl Acad Sci U S A · August 23, 2005 Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many health benefits have been ascribed to Allium extracts, including hypoten ... Full text Link to item Cite

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.

Journal Article Nature · January 15, 2004 Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammation and robust hypersensitivi ... Full text Link to item Cite

Lessons from peppers and peppermint: the molecular logic of thermosensation.

Journal Article Curr Opin Neurobiol · August 2003 Sensory neurons report a wide range of temperatures, from noxious heat to noxious cold. Natural products that elicit psychophysical sensations of hot or cold, such as capsaicin or menthol, were instrumental in the discovery of thermal detectors belonging t ... Full text Link to item Cite

Molecular determinants of ligand interaction with the capsaicin receptor

Conference Journal of Neurochemistry · June 2003 Birds are indifferent to the pain‐producing effects of capsaicin. However, avian primary sensory neurons exhibit heat‐evoked membrane currents resembling those carried by mammalian capsaicin receptors. We aimed to identify an avian capsaicin recept ... Full text Cite

Acid potentiation of the capsaicin receptor determined by a key extracellular site

Conference Journal of Neurochemistry · June 2003 The capsaicin receptor, VR1, is a sensory neuron‐specific ion channel that serves as a detector of pain‐producing chemical and physical stimuli. The response of VR1 to capsaicin or heat is dynamically potentiated by extracellular protons within a p ... Full text Cite

Molecular basis for species-specific sensitivity to "hot" chili peppers.

Journal Article Cell · February 8, 2002 Chili peppers produce the pungent vanilloid compound capsaicin, which offers protection from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and therefore serve as vectors for seed dispersal. Here, we determine the molec ... Full text Link to item Cite

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

Journal Article Nature · June 21, 2001 Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to noxious stimuli. Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2 ... Full text Link to item Cite

Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption.

Journal Article EMBO J · March 15, 2001 The functions of some CLC Cl(-) channels are evident from human diseases that result from their mutations, but the role of the broadly expressed ClC-2 Cl(-) channel is less clear. Several important functions have been attributed to ClC-2, but contrary to t ... Full text Link to item Cite

Acid potentiation of the capsaicin receptor determined by a key extracellular site.

Journal Article Proc Natl Acad Sci U S A · July 5, 2000 The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli. The response of VR1 to capsaicin or noxious heat is dynamically potentiated by extracellu ... Full text Link to item Cite

Chloride dependence of hyperpolarization-activated chloride channel gates.

Journal Article J Physiol · March 1, 1999 1. ClC proteins are a class of voltage-dependent Cl- channels with several members mutated in human diseases. The prototype ClC-0 Torpedo channel is a dimeric protein; each subunit forms a pore that can gate independently from the other one. A common slowe ... Full text Link to item Cite

Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.

Journal Article J Physiol · February 1, 1998 1. Dissociated rat superior cervical ganglion (SCG) neurons have been shown to possess a hyperpolarization-activated inwardly rectifying chloride current. The current was not altered by changes in external potassium concentration, replacing external cation ... Full text Link to item Cite

Molecular dissection of gating in the ClC-2 chloride channel.

Journal Article EMBO J · April 1, 1997 The ClC-2 chloride channel is probably involved in the regulation of cell volume and of neuronal excitability. Site-directed mutagenesis was used to understand ClC-2 activation in response to cell swelling, hyperpolarization and acidic extracellular pH. Si ... Full text Link to item Cite