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What are the respiratory effects of e-cigarettes?

Publication ,  Journal Article
Gotts, JE; Jordt, S-E; McConnell, R; Tarran, R
Published in: BMJ
September 30, 2019

Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable glycerin. Vaping is now a multibillion dollar industry that appeals to current smokers, former smokers, and young people who have never smoked. E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices. Their effectiveness as a smoking cessation intervention, their impact at a population level, and whether they are less harmful than combustible tobacco products are highly controversial. Here, we review the evidence on the effects of e-cigarettes on respiratory health. Studies show measurable adverse biologic effects on organ and cellular health in humans, in animals, and in vitro. The effects of e-cigarettes have similarities to and important differences from those of cigarettes. Decades of chronic smoking are needed for development of lung diseases such as lung cancer or chronic obstructive pulmonary disease, so the population effects of e-cigarette use may not be apparent until the middle of this century. We conclude that current knowledge of these effects is insufficient to determine whether the respiratory health effects of e-cigarette are less than those of combustible tobacco products.

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Published In

BMJ

DOI

EISSN

1756-1833

Publication Date

September 30, 2019

Volume

366

Start / End Page

l5275

Location

England

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Smoking Prevention
  • Smoking Cessation
  • Humans
  • General & Internal Medicine
  • Electronic Nicotine Delivery Systems
  • 52 Psychology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Gotts, J. E., Jordt, S.-E., McConnell, R., & Tarran, R. (2019). What are the respiratory effects of e-cigarettes? BMJ, 366, l5275. https://doi.org/10.1136/bmj.l5275
Gotts, Jeffrey E., Sven-Eric Jordt, Rob McConnell, and Robert Tarran. “What are the respiratory effects of e-cigarettes?BMJ 366 (September 30, 2019): l5275. https://doi.org/10.1136/bmj.l5275.
Gotts JE, Jordt S-E, McConnell R, Tarran R. What are the respiratory effects of e-cigarettes? BMJ. 2019 Sep 30;366:l5275.
Gotts, Jeffrey E., et al. “What are the respiratory effects of e-cigarettes?BMJ, vol. 366, Sept. 2019, p. l5275. Pubmed, doi:10.1136/bmj.l5275.
Gotts JE, Jordt S-E, McConnell R, Tarran R. What are the respiratory effects of e-cigarettes? BMJ. 2019 Sep 30;366:l5275.

Published In

BMJ

DOI

EISSN

1756-1833

Publication Date

September 30, 2019

Volume

366

Start / End Page

l5275

Location

England

Related Subject Headings

  • Tobacco Use Cessation Devices
  • Smoking Prevention
  • Smoking Cessation
  • Humans
  • General & Internal Medicine
  • Electronic Nicotine Delivery Systems
  • 52 Psychology
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1117 Public Health and Health Services