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Fluconazole prophylaxis for prevention of invasive candidiasis in infants.

Publication ,  Journal Article
Ericson, JE; Benjamin, DK
Published in: Curr Opin Pediatr
April 2014

PURPOSE OF REVIEW: Invasive candidiasis is a serious infection in hospitalized infants that results in significant mortality and morbidity. Fluconazole is approved by the US Food and Drug Administration for prophylaxis of invasive candidiasis in patients undergoing bone marrow transplantation but is not approved for use in infants. This review will describe the history of fluconazole use for prophylaxis in infants. RECENT FINDINGS: Limiting fluconazole prophylaxis to infants with risk factors, in addition to low birth weight and early gestational age, reduces the number of infants treated with fluconazole and the duration of fluconazole therapy for each infant. SUMMARY: Fluconazole prophylaxis appears to be well tolerated for use in premature infants. Reduction in the incidence of invasive candidiasis is observed even when prophylaxis is limited to infants with multiple risk factors. Centers with a low incidence of invasive candidiasis may not benefit from fluconazole prophylaxis. Significant short-term and long-term toxicity and increases in fluconazole-resistant organisms have not been observed with fluconazole use in the intensive care nursery.

Duke Scholars

Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

April 2014

Volume

26

Issue

2

Start / End Page

151 / 156

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Assessment
  • Practice Guidelines as Topic
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Infant
 

Citation

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Ericson, J. E., & Benjamin, D. K. (2014). Fluconazole prophylaxis for prevention of invasive candidiasis in infants. Curr Opin Pediatr, 26(2), 151–156. https://doi.org/10.1097/MOP.0000000000000060
Ericson, Jessica E., and Daniel K. Benjamin. “Fluconazole prophylaxis for prevention of invasive candidiasis in infants.Curr Opin Pediatr 26, no. 2 (April 2014): 151–56. https://doi.org/10.1097/MOP.0000000000000060.
Ericson JE, Benjamin DK. Fluconazole prophylaxis for prevention of invasive candidiasis in infants. Curr Opin Pediatr. 2014 Apr;26(2):151–6.
Ericson, Jessica E., and Daniel K. Benjamin. “Fluconazole prophylaxis for prevention of invasive candidiasis in infants.Curr Opin Pediatr, vol. 26, no. 2, Apr. 2014, pp. 151–56. Pubmed, doi:10.1097/MOP.0000000000000060.
Ericson JE, Benjamin DK. Fluconazole prophylaxis for prevention of invasive candidiasis in infants. Curr Opin Pediatr. 2014 Apr;26(2):151–156.

Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

April 2014

Volume

26

Issue

2

Start / End Page

151 / 156

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Assessment
  • Practice Guidelines as Topic
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Infant