Overview
Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 100 of the most commonly used medicines in children. These trials are conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.
The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.
Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.
Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school, college graduate school, and medical students that recruits and mentors ~30 students each academic year. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to establish their own independent research programs; six of whom are now Distinguished Professors.
Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 1,000 recreation league, travel league, and scholastic baseball games. He is the head coach for Smith Middle School Baseball, perennially southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged and special-needs school-aged boys and girls.
Current Duke Appointments & Affiliations
Recent Scholarly Works
Conducting multicenter trials through the trial innovation network comprehensive consultation.
Journal article Contemp Clin Trials · July 2026 Effective design and execution of multicenter clinical trials remain critical yet challenging for advancing clinical care. The Trial Innovation Network (TIN) Comprehensive Consultation process was established to improve the feasibility and success of inves ... Full text Link to item CiteVariation of caffeine use in late preterm infants in U.S. NICUs over time: A 12-year cohort study.
Journal article J Perinatol · June 22, 2026 OBJECTIVE: Describe caffeine use in late preterm infants (LPIs) in neonatal intensive care units (NICUs) over time METHODS: Cohort study of infants born 34-36 weeks gestation discharged from Pediatrix Medical Group NICUs from 2011-2022. RESULTS: Of 233,804 ... Full text Link to item CiteEvaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.
Journal article J Perinatol · June 2026 OBJECTIVE: Determine if preterm infants have prolonged therapeutic post-discontinuation antibiotic exposures (PDAE) following empiric ampicillin. STUDY DESIGN: Prospective study of 27 infants ≤7 days and <37 weeks gestational age (GA) receiving ampicillin ... Full text Link to item CiteRecent Grants
BPCA PTN 3.0 TO#1 Core Function Activities_ Option Period 1
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2032INNOVATE (Integrated National Network for Obstetric and Pediatric AdVAncement in Therapeutic Education)
Inst. Training Prgm or CMECo-Principal Investigator · Awarded by National Institutes of Health · 2026 - 2031PTN 3.0 Task Order #2_ BPCA Pediatric Drug Development Clinical Trial Infrastructure
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2030View All Grants