Heavy LIFting: tumor promotion and radioresistance in NPC.


Journal Article

The epithelial-derived nasopharyngeal carcinoma (NPC) is a rare tumor in most of the world; however, it is common in southern China, northern Africa, and Alaska. NPC is often left undiagnosed and untreated until a late stage of disease. Furthermore, while radiation therapy is effective against this tumor, local recurrence due to radioresistance is an important clinical problem. In this issue, Liu et al. report on their identification of the IL-6 family cytokine leukemia inhibitory factor (LIF) as a serum predictor of local NPC recurrence following radiation therapy. The authors developed this initial finding to discover a role for the LIF/LIFR/mTORC1 signaling axis in NPC tumor cell growth as well as radioresistance.

Full Text

Duke Authors

Cited Authors

  • Luftig, M

Published Date

  • December 2013

Published In

Volume / Issue

  • 123 / 12

Start / End Page

  • 4999 - 5001

PubMed ID

  • 24270417

Pubmed Central ID

  • 24270417

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI73416


  • eng

Conference Location

  • United States