Micah Alan Luftig
Associate Professor of Molecular Genetics and Microbiology
We use cutting-edge, cross-disciplinary and highly collaborative approaches to characterize the temporal dynamics and single cell heterogeneity of EBV infection. With these strategies, we aim to discover fundamental molecular circuits underlying transcriptional control, viral manipulation of host signaling pathways, and metabolic regulation that collectively influence infected cell fate decisions. By understanding the nature of viral control of infected host cells, we are also well positioned to discover vulnerabilities in EBV-associated diseases and characterize new therapeutic interventions in cell-based and pre-clinical animal models.
Current Appointments & Affiliations
- Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2015
- Vice-Chair in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2017
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017
- Associate Professor of Immunology, Immunology, Basic Science Departments 2019
- Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007
Contact Information
- 213 Research Dr, CARL 0036, Box 3054, Durham, NC 27710
- Duke Box 3054, 424 CARL, Durham, NC 27710
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micah.luftig@duke.edu
(919) 668-3091
- Background
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Education, Training, & Certifications
- Ph.D., Harvard University 2003
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2012 - 2017
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2008 - 2015
- Instructor, Temporary in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2007 - 2008
- Recognition
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In the News
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NOV 27, 2018 -
JAN 19, 2016 -
JAN 19, 2016 Duke Today
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- Expertise
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Subject Headings
- 3' Untranslated Regions
- Actin Cytoskeleton
- Adult
- Algorithms
- Animals
- Antibodies, Monoclonal
- Apoptosis
- Automation
- B-Lymphocytes
- Base Sequence
- Biological Markers
- Cell Adhesion Molecules
- Cell Cycle Proteins
- Cell Growth Processes
- Cell Line
- Cell Line, Transformed
- Cell Line, Tumor
- Cell Nucleus
- Cell Proliferation
- Cell Survival
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Cells, Cultured
- Chromatin Immunoprecipitation
- Clone Cells
- Coculture Techniques
- Crystallography, X-Ray
- DNA Damage
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- Epithelial Cells
- Epstein-Barr Virus Infections
- Epstein-Barr Virus Nuclear Antigens
- Epstein-barr Virus
- Exome
- Feeder Cells
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Gene Library
- Gene Order
- Genes, Reporter
- Genes, cdc
- Genetic Heterogeneity
- Genetic Variation
- Genetic Vectors
- HIV Envelope Protein gp41
- HIV-1
- Herpesvirus 1, Human
- Herpesvirus 4, Human
- High-Throughput Nucleotide Sequencing
- Host-Pathogen Interactions
- Humans
- Hydrophobic and Hydrophilic Interactions
- Interleukin-1 Receptor-Associated Kinases
- Leucine
- Leukemia, Lymphocytic, Chronic, B-Cell
- Luciferases
- Lymphocyte Activation
- Lymphoma, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Lymphoproliferative Disorders
- Macrophages
- Mass Spectrometry
- Mice
- MicroRNAs
- Microscopy, Electron
- Models, Biological
- Models, Molecular
- Molecular Sequence Data
- Molecular Targeted Therapy
- Molecular Weight
- Mutation
- NF-kappa B
- Neutralization Tests
- Oligonucleotide Array Sequence Analysis
- Oncogenes
- Oncogenic Viruses
- Peptide Fragments
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Piperazines
- Protein Binding
- Protein Conformation
- Protein Kinases
- Protein Structure, Quaternary
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Protein Transport
- Protein-Serine-Threonine Kinases
- Proteins
- Proto-Oncogene Proteins c-kit
- RNA
- RNA, Messenger
- RNA, Viral
- Real-Time Polymerase Chain Reaction
- Receptor, Platelet-Derived Growth Factor alpha
- Receptors, Virus
- Recombinant Fusion Proteins
- Recombinant Proteins
- Retroviridae
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Analysis, RNA
- Sequence Homology, Nucleic Acid
- Signal Transduction
- Structure-Activity Relationship
- TNF Receptor-Associated Factor 6
- Transcription Factors
- Transduction, Genetic
- Transfection
- Tryptophan
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins
- Tumor Virus Infections
- Up-Regulation
- Vero Cells
- Viral Envelope Proteins
- Viral Matrix Proteins
- Viral Proteins
- Virus Internalization
- Virus Latency
- Virus Replication
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Global Scholarship
- Research
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Selected Grants
- Defining and exploiting EBV-infected cell heterogeneity in non-Hodgkin lymphomas awarded by National Institutes of Health 2022 - 2027
- Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program awarded by National Institutes of Health 2022 - 2027
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- Host pathways regulating Epstein-Barr virus-mediated B cell growth transformation awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Defining the Mechanisms of Epstein-Barr Virus Persistence and Recurrence awarded by National Institutes of Health 2016 - 2026
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Basic Immunology Training Program awarded by National Institutes of Health 2020 - 2025
- Metabolic regulation of Epstein-Barr Virus-infected tonsillar B cells by EBNA-LP awarded by National Institutes of Health 2022 - 2025
- Dissecting the role of EBV and P. falciparum in endemic Burkitt lymphoma pathogenesis awarded by National Institutes of Health 2019 - 2024
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2024
- Resolving the Origins of Restricted Fates in Epstein-Barr Virus-Infected B Lymphocyte Proliferation awarded by American Cancer Society, Inc. 2022 - 2024
- The Role and Regulation of Monocarboxylate Transporters 1 and 4 in Epstein-Barr Virus-mediated B Lymphocyte Tumorigenesis awarded by National Institutes of Health 2021 - 2024
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG) awarded by National Institutes of Health 2018 - 2023
- NIAID Virology Quality Assurance - Year 4 Option 3 awarded by National Institutes of Health 2019 - 2023
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- The role of EBNA3A in the survival of Epstein-Barr Virus-infected tonsillar B cells awarded by National Institutes of Health 2018 - 2019
- Novel regulatory controls of Hepatitis C Virus envelopment and secretion by the viral NS4A protein awarded by National Institutes of Health 2018
- Evaluation of the host immune response and viral molecular phenotype in lung transplant recipients with PTLD awarded by Mount Sinai School of Medicine 2017 - 2018
- Structural Studies of EBV Nuclear Proteins and Host Factors Important for Establishing Latency awarded by National Institutes of Health 2016 - 2018
- Temporal regulation of the essential Epstein-Barr virus oncoprotein LMP1 awarded by National Institutes of Health 2013 - 2016
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External Relationships
- Evrys Bio
- Moderna Therapeutics, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Goodrum, Felicia, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, et al. “Virology under the Microscope-a Call for Rational Discourse.” Mbio, January 26, 2023, e0018823. https://doi.org/10.1128/mbio.00188-23.Full Text Link to Item
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Goodrum, Felicia, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, et al. “Virology under the Microscope-a Call for Rational Discourse.” Msphere, January 26, 2023, e0003423. https://doi.org/10.1128/msphere.00034-23.Full Text Link to Item
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Goodrum, Felicia, Anice Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael Imperiale, Walter Atwood, et al. “Virology under the Microscope-a Call for Rational Discourse.” J Virol, January 26, 2023, e0008923. https://doi.org/10.1128/jvi.00089-23.Full Text Link to Item
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SoRelle, Elliott D., Joanne Dai, Nicolás M. Reinoso-Vizcaino, Ashley P. Barry, Cliburn Chan, and Micah A. Luftig. “Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection.” Cell Rep 40, no. 9 (August 30, 2022): 111286. https://doi.org/10.1016/j.celrep.2022.111286.Full Text Link to Item
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Whitson, Heather E., Carol Colton, Joseph El Khoury, David Gate, Alison Goate, Michael T. Heneka, Rima Kaddurah-Daouk, et al. “Infection and inflammation: New perspectives on Alzheimer's disease.” Brain Behav Immun Health 22 (July 2022): 100462. https://doi.org/10.1016/j.bbih.2022.100462.Full Text Link to Item
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SoRelle, Elliott D., Nicolás M. Reinoso-Vizcaino, Gillian Q. Horn, and Micah A. Luftig. “Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro.” Front Immunol 13 (2022): 1001145. https://doi.org/10.3389/fimmu.2022.1001145.Full Text Link to Item
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SoRelle, Elliott D., Joanne Dai, Emmanuela N. Bonglack, Emma M. Heckenberg, Jeffrey Y. Zhou, Stephanie N. Giamberardino, Jeffrey A. Bailey, Simon G. Gregory, Cliburn Chan, and Micah A. Luftig. “Correction: Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines.” Elife 10 (November 11, 2021). https://doi.org/10.7554/eLife.75422.Full Text Link to Item
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Yellen, Benjamin B., Jon S. Zawistowski, Eric A. Czech, Caleb I. Sanford, Elliott D. SoRelle, Micah A. Luftig, Zachary G. Forbes, Kris C. Wood, and Jeff Hammerbacher. “Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses.” Sci Adv 7, no. 38 (September 17, 2021): eabf9840. https://doi.org/10.1126/sciadv.abf9840.Full Text Open Access Copy Link to Item
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Zaffiri, Lorenzo, Courtney Frankel, Erika J. Bush, Megan L. Neely, Elizabeth N. Pavlisko, Irina L. Mokrova, Micah A. Luftig, and Scott M. Palmer. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.” J Med Virol 93, no. 8 (August 2021): 5040–47. https://doi.org/10.1002/jmv.26936.Full Text Link to Item
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Padmanabhan, Nisha, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, et al. “Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.” Genome Biol 22, no. 1 (June 17, 2021): 181. https://doi.org/10.1186/s13059-021-02405-z.Full Text Link to Item
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Bonglack, Emmanuela N., Joshua E. Messinger, Jana M. Cable, James Ch’ng, K Mark Parnell, Nicolás M. Reinoso-Vizcaíno, Ashley P. Barry, et al. “Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas.” Proceedings of the National Academy of Sciences of the United States of America 118, no. 25 (June 2021): e2022495118. https://doi.org/10.1073/pnas.2022495118.Full Text
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Padmanabhan, Nisha, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, et al. “Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.” Genome Biol 22, no. 1 (June 1, 2021): 167. https://doi.org/10.1186/s13059-021-02375-2.Full Text Link to Item
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SoRelle, Elliott D., Joanne Dai, Emmanuela N. Bonglack, Emma M. Heckenberg, Jeffrey Y. Zhou, Stephanie N. Giamberardino, Jeffrey A. Bailey, Simon G. Gregory, Cliburn Chan, and Micah A. Luftig. “Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines.” Elife 10 (January 27, 2021). https://doi.org/10.7554/eLife.62586.Full Text Link to Item
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Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.Full Text
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Stanland, Lyla J., and Micah A. Luftig. “The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis.” Viruses 12, no. 11 (October 28, 2020). https://doi.org/10.3390/v12111222.Full Text Link to Item
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Kaymaz, Yasin, Cliff I. Oduor, Ozkan Aydemir, Micah A. Luftig, Juliana A. Otieno, John Michael Ong’echa, Jeffrey A. Bailey, and Ann M. Moormann. “Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma.” J Virol 94, no. 17 (August 17, 2020). https://doi.org/10.1128/JVI.02007-19.Full Text Link to Item
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Purdy, John G., and Micah A. Luftig. “Reprogramming of cellular metabolic pathways by human oncogenic viruses.” Curr Opin Virol 39 (December 2019): 60–69. https://doi.org/10.1016/j.coviro.2019.11.002.Full Text Link to Item
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Panea, Razvan I., Cassandra L. Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann M. Moormann, Juliana A. Otieno, et al. “The whole-genome landscape of Burkitt lymphoma subtypes.” Blood 134, no. 19 (November 7, 2019): 1598–1607. https://doi.org/10.1182/blood.2019001880.Full Text Link to Item
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Messinger, Joshua E., Joanne Dai, Lyla J. Stanland, Alexander M. Price, and Micah A. Luftig. “Identification of Host Biomarkers of Epstein-Barr Virus Latency IIb and Latency III.” Mbio 10, no. 4 (July 2, 2019). https://doi.org/10.1128/mBio.01006-19.Full Text Link to Item
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Stanland, Lyla J., and Micah A. Luftig. “Molecular features and translational outlook for Epstein-Barr virus-associated gastric cancer.” Future Virol 13, no. 11 (November 2018): 803–18. https://doi.org/10.2217/fvl-2018-0071.Full Text Link to Item
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Dai, Joanne, and Micah A. Luftig. “Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.” J Immunol 200, no. 5 (March 1, 2018): 1727–36. https://doi.org/10.4049/jimmunol.1701473.Full Text Link to Item
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Price, Alexander M., Joshua E. Messinger, and Micah A. Luftig. “c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection.” J Virol 92, no. 2 (January 15, 2018). https://doi.org/10.1128/JVI.01178-17.Full Text Link to Item
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Poling, Brigid Chiyoko, Alexander M. Price, Micah A. Luftig, and Bryan R. Cullen. “The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis.” Virology 512 (December 2017): 113–23. https://doi.org/10.1016/j.virol.2017.09.015.Full Text Link to Item
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Hafez, Amy Y., and Micah A. Luftig. “Characterization of the EBV-Induced Persistent DNA Damage Response.” Viruses 9, no. 12 (December 1, 2017). https://doi.org/10.3390/v9120366.Full Text Link to Item
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Hafez, A. Y., J. E. Messinger, K. McFadden, G. Fenyofalvi, C. N. Shepard, G. M. Lenzi, B. Kim, and M. A. Luftig. “Limited nucleotide pools restrict Epstein-Barr virus-mediated B-cell immortalization.” Oncogenesis 6, no. 6 (June 12, 2017): e349. https://doi.org/10.1038/oncsis.2017.46.Full Text Link to Item
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Price, Alexander M., Joanne Dai, Quentin Bazot, Luv Patel, Pavel A. Nikitin, Reza Djavadian, Peter S. Winter, et al. “Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.” Elife 6 (April 20, 2017). https://doi.org/10.7554/eLife.22509.Full Text Open Access Copy Link to Item
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Stanfield, Brent A., and Micah A. Luftig. “Recent advances in understanding Epstein-Barr virus.” F1000res 6 (2017): 386. https://doi.org/10.12688/f1000research.10591.1.Full Text Link to Item
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Grossman, Lisa, Chris Chang, Joanne Dai, Pavel A. Nikitin, Dereje D. Jima, Sandeep S. Dave, and Micah A. Luftig. “Epstein-Barr Virus Induces Adhesion Receptor CD226 (DNAM-1) Expression during Primary B-Cell Transformation into Lymphoblastoid Cell Lines.” Msphere 2, no. 6 (2017). https://doi.org/10.1128/mSphere.00305-17.Full Text Link to Item
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McFadden, Karyn, Amy Y. Hafez, Rigel Kishton, Joshua E. Messinger, Pavel A. Nikitin, Jeffrey C. Rathmell, and Micah A. Luftig. “Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.” Proc Natl Acad Sci U S A 113, no. 6 (February 9, 2016): E782–90. https://doi.org/10.1073/pnas.1517141113.Full Text Link to Item
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Price, Alexander M., and Micah A. Luftig. “To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis.” Plos Pathog 11, no. 3 (March 2015): e1004656. https://doi.org/10.1371/journal.ppat.1004656.Full Text Link to Item
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Luftig, Micah A. “Viruses and the DNA Damage Response: Activation and Antagonism.” Annu Rev Virol 1, no. 1 (November 2014): 605–25. https://doi.org/10.1146/annurev-virology-031413-085548.Full Text Link to Item
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Nikitin, Pavel A., Alexander M. Price, Karyn McFadden, Christopher M. Yan, and Micah A. Luftig. “Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest.” Plos One 9, no. 1 (2014): e87299. https://doi.org/10.1371/journal.pone.0087299.Full Text Link to Item
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Price, Alexander M., and Micah A. Luftig. “Dynamic Epstein-Barr virus gene expression on the path to B-cell transformation.” Adv Virus Res 88 (2014): 279–313. https://doi.org/10.1016/B978-0-12-800098-4.00006-4.Full Text Link to Item
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Luftig, Micah. “Heavy LIFting: tumor promotion and radioresistance in NPC.” J Clin Invest 123, no. 12 (December 2013): 4999–5001. https://doi.org/10.1172/JCI73416.Full Text Link to Item
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Homa, Nicholas J., Raul Salinas, Eleonora Forte, Timothy J. Robinson, Mariano A. Garcia-Blanco, and Micah A. Luftig. “Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.” J Virol 87, no. 22 (November 2013): 12291–301. https://doi.org/10.1128/JVI.02464-13.Full Text Open Access Copy Link to Item
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Olive, Virginie, Erich Sabio, Margaux J. Bennett, Caitlin S. De Jong, Anne Biton, James C. McGann, Samantha K. Greaney, et al. “A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.” Elife 2 (October 15, 2013): e00822. https://doi.org/10.7554/eLife.00822.Full Text Link to Item
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Zhang, Jenny, Vladimir Grubor, Cassandra L. Love, Anjishnu Banerjee, Kristy L. Richards, Piotr A. Mieczkowski, Cherie Dunphy, et al. “Genetic heterogeneity of diffuse large B-cell lymphoma.” Proc Natl Acad Sci U S A 110, no. 4 (January 22, 2013): 1398–1403. https://doi.org/10.1073/pnas.1205299110.Full Text Link to Item
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Forte, Eleonora, and Micah A. Luftig. “Use of viral systems to study miRNA-mediated regulation of gene expression in human cells.” Methods Mol Biol 936 (2013): 143–56. https://doi.org/10.1007/978-1-62703-083-0_12.Full Text Link to Item
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McFadden, Karyn, and Micah A. Luftig. “Interplay between DNA tumor viruses and the host DNA damage response.” Curr Top Microbiol Immunol 371 (2013): 229–57. https://doi.org/10.1007/978-3-642-37765-5_9.Full Text Link to Item
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Price, Alexander M., Jason P. Tourigny, Eleonora Forte, Raul E. Salinas, Sandeep S. Dave, and Micah A. Luftig. “Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.” J Virol 86, no. 20 (October 2012): 11096–106. https://doi.org/10.1128/JVI.01069-12.Full Text Open Access Copy Link to Item
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Robinson, Timothy J., Eleonora Forte, Raul E. Salinas, Shaan Puri, Matthew Marengo, Mariano A. Garcia-Blanco, and Micah A. Luftig. “SplicerEX: a tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.” Rna 18, no. 8 (August 2012): 1435–45. https://doi.org/10.1261/rna.033621.112.Full Text Open Access Copy Link to Item
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Forte, Eleonora, Raul E. Salinas, Christina Chang, Ting Zhou, Sarah D. Linnstaedt, Eva Gottwein, Cassandra Jacobs, et al. “The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells.” J Virol 86, no. 12 (June 2012): 6889–98. https://doi.org/10.1128/JVI.07056-11.Full Text Open Access Copy Link to Item
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Hwang, Kwan-Ki, Xi Chen, Daniel M. Kozink, Marietta Gustilo, Dawn J. Marshall, John F. Whitesides, Hua-Xin Liao, et al. “Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells.” Blood 119, no. 7 (February 16, 2012): e35–44. https://doi.org/10.1182/blood-2011-08-371203.Full Text Link to Item
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Nikitin, P. A., and M. A. Luftig. “The DNA damage response in viral-induced cellular transformation.” Br J Cancer 106, no. 3 (January 31, 2012): 429–35. https://doi.org/10.1038/bjc.2011.612.Full Text Link to Item
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Skalsky, Rebecca L., David L. Corcoran, Eva Gottwein, Christopher L. Frank, Dong Kang, Markus Hafner, Jeffrey D. Nusbaum, et al. “The viral and cellular microRNA targetome in lymphoblastoid cell lines.” Plos Pathog 8, no. 1 (January 2012): e1002484. https://doi.org/10.1371/journal.ppat.1002484.Full Text Link to Item
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Forte, Eleonora, and Micah A. Luftig. “The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.” Microbes Infect 13, no. 14–15 (December 2011): 1156–67. https://doi.org/10.1016/j.micinf.2011.07.007.Full Text Link to Item
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Di Giovine, Paolo, Ethan C. Settembre, Arjun K. Bhargava, Micah A. Luftig, Huan Lou, Gary H. Cohen, Roselyn J. Eisenberg, Claude Krummenacher, and Andrea Carfi. “Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1.” Plos Pathog 7, no. 9 (September 2011): e1002277. https://doi.org/10.1371/journal.ppat.1002277.Full Text Link to Item
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Nikitin, Pavel A., and Micah A. Luftig. “At a crossroads: human DNA tumor viruses and the host DNA damage response.” Future Virol 6, no. 7 (July 2011): 813–30. https://doi.org/10.2217/fvl.11.55.Full Text Link to Item
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Nikitin, Pavel A., Christopher M. Yan, Eleonora Forte, Alessio Bocedi, Jason P. Tourigny, Robert E. White, Martin J. Allday, et al. “An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells.” Cell Host Microbe 8, no. 6 (December 16, 2010): 510–22. https://doi.org/10.1016/j.chom.2010.11.004.Full Text Link to Item
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Jima, Dereje D., Jenny Zhang, Cassandra Jacobs, Kristy L. Richards, Cherie H. Dunphy, William W. L. Choi, Wing Yan Au, et al. “Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.” Blood 116, no. 23 (December 2, 2010): e118–27. https://doi.org/10.1182/blood-2010-05-285403.Full Text Link to Item
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Linnstaedt, Sarah D., Eva Gottwein, Rebecca L. Skalsky, Micah A. Luftig, and Bryan R. Cullen. “Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus.” J Virol 84, no. 22 (November 2010): 11670–78. https://doi.org/10.1128/JVI.01248-10.Full Text Link to Item
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Montgomery, D. L., Y. J. Wang, R. Hrin, M. Luftig, B. Su, M. D. Miller, F. Wang, et al. “Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41.” Mabs 1, no. 5 (September 1, 2009): 458–69.
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Forte, Eleonora, and Micah A. Luftig. “MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival.” J Virol 83, no. 6 (March 2009): 2491–99. https://doi.org/10.1128/JVI.01681-08.Full Text Link to Item
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Montgomery, Donna L., Ying-Jie Wang, Renee Hrin, Micah Luftig, Bin Su, Michael D. Miller, Fubao Wang, et al. “Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41.” Mabs 1, no. 5 (2009): 462–74. https://doi.org/10.4161/mabs.1.5.9214.Full Text Link to Item
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Luftig, Micah A., Marco Mattu, Paolo Di Giovine, Romas Geleziunas, Renee Hrin, Gaetano Barbato, Elisabetta Bianchi, Michael D. Miller, Antonello Pessi, and Andrea Carfí. “Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.” Nat Struct Mol Biol 13, no. 8 (August 2006): 740–47. https://doi.org/10.1038/nsmb1127.Full Text Link to Item
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Johannsen, Eric, Micah Luftig, Michael R. Chase, Steve Weicksel, Ellen Cahir-McFarland, Diego Illanes, David Sarracino, and Elliott Kieff. “Proteins of purified Epstein-Barr virus.” Proc Natl Acad Sci U S A 101, no. 46 (November 16, 2004): 16286–91. https://doi.org/10.1073/pnas.0407320101.Full Text Link to Item
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Yasui, Teruhito, Micah Luftig, Vishal Soni, and Elliott Kieff. “Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling.” Proc Natl Acad Sci U S A 101, no. 1 (January 6, 2004): 278–83. https://doi.org/10.1073/pnas.2237224100.Full Text Link to Item
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Luftig, Micah, Teruhito Yasui, Vishal Soni, Myung-Soo Kang, Nils Jacobson, Ellen Cahir-McFarland, Brian Seed, and Elliott Kieff. “Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.” Proc Natl Acad Sci U S A 101, no. 1 (January 6, 2004): 141–46. https://doi.org/10.1073/pnas.2237183100.Full Text Link to Item
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Luftig, Micah, Efthimios Prinarakis, Teruhito Yasui, Theodore Tsichritzis, Ellen Cahir-McFarland, Jun-Ichiro Inoue, Hiroyasu Nakano, et al. “Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.” Proc Natl Acad Sci U S A 100, no. 26 (December 23, 2003): 15595–600. https://doi.org/10.1073/pnas.2136756100.Full Text Link to Item
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Luftig, M. A., E. Cahir-McFarland, G. Mosialos, and E. Kieff. “Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.” J Biol Chem 276, no. 18 (May 4, 2001): 14602–6. https://doi.org/10.1074/jbc.C100103200.Full Text Link to Item
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Baghian, A., M. Luftig, J. B. Black, Y. X. Meng, C. P. Pau, T. Voss, P. E. Pellett, and K. G. Kousoulas. “Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.” Virology 269, no. 1 (March 30, 2000): 18–25. https://doi.org/10.1006/viro.2000.0198.Full Text Link to Item
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Book Sections
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McFadden, Karyn, and Micah A. Luftig. “Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.” In Current Topics in Microbiology and Immunology, 229–57. Springer Berlin Heidelberg, 2013. https://doi.org/10.1007/978-3-642-37765-5_9.Full Text
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Conference Papers
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Luftig, Micah, Pavel Nikitin, Chris Yan, Eleonora Forte, Jason Tourigny, Alex Price, and Sandeep Dave. “Studies at the oncogenic virus/host interface: Dynamic regulation of Epstein-Barr virus-mediated B cell immortalization.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 62:58–58, 2013.Link to Item
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Jacobs, Cassandra L., Amee Patel, Dereje Jima, Qingquan Liu, Adrienne Greenough, Jenny Zhang, Cherie Dunphy, et al. “Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma.” In Blood, 116:351–52. AMER SOC HEMATOLOGY, 2010.Link to Item
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Jacobs, Cassandra L., Dereje D. Jima, Jenny Zhang, Cherie Dunphy, Kristy L. Richards, William W. L. Choi, Gopesh Srivastava, et al. “A Comprehensive Identification of the Microrna Transcriptome and Its Application in B Cell Malignancies.” In Blood, 114:948–49. AMER SOC HEMATOLOGY, 2009.Link to Item
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Pessi, A., E. Bianchi, R. Geleziunas, S. Lennard, M. Luftig, P. Ingallinella, M. Finotto, et al. “Towards the design of a peptide mimetic HIV vaccine targeting the viral fusion machinery.” In Journal of Peptide Science, 12:101–101, 2006.Link to Item
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Service to the Profession
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