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Micah Alan Luftig

Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
Duke Box 3054, 424 CARL, Durham, NC 27710
213 Research Dr, CARL 0036, BOX_3054, Durham, NC 27710

Selected Publications


Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression.

Journal Article PLoS pathogens · October 2024 Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states. Here, we have interrogated the hos ... Full text Cite

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence.

Journal Article J Virol · September 17, 2024 Science is humanity's best insurance against threats from nature, but it is a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates a natural origin for SARS-CoV-2. Yet, the theory that SARS-CoV-2 was e ... Full text Link to item Cite

Data from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <div>Abstract<p>PIK3CA is the second most mutated gene in cancer leading to aberrant PI3K/AKT/mTOR signaling and increased translation, proliferation, and survival. Some 4-25% of gastric cancers display activating PIK3CA mutations inclu ... Full text Cite

Figure S6 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S6 shows down-regulation of RUNX1 in BYL719 resistant cells</p> ... Full text Cite

Table S8 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Antibody dilutions for primary and secondary antibodies used</p> ... Full text Cite

Figure S7 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S7 shows loss of PIM1 re-sensitizes resistant cells to BYL719</p> ... Full text Cite

Table S3 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Beta scores generated for DMSO and BYL719 treated populations using MAGeCK analysis pipeline</p> ... Full text Cite

Figure S3 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S3 shows that Dasatinib renders cells hyper-sensitive to BYL719</p> ... Full text Cite

Table S4 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Z-transformed difference scores for each cell line as calculated from beta scores</p> ... Full text Cite

Figure S4 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S4 shows loss of BCL-XL and BYL719 treatment in additional gastric cancer cell line</p> ... Full text Cite

Figure S6 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S6 shows down-regulation of RUNX1 in BYL719 resistant cells</p> ... Full text Cite

Table S1 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Genes included in the CRISPR screening library</p> ... Full text Cite

Figure S4 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Figure S4 shows loss of BCL-XL and BYL719 treatment in additional gastric cancer cell line</p> ... Full text Cite

Table S2 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Raw read counts for each guide RNA in screen</p> ... Full text Cite

Table S8 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Antibody dilutions for primary and secondary antibodies used</p> ... Full text Cite

Table S2 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Raw read counts for each guide RNA in screen</p> ... Full text Cite

Table S6 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Sequences of guide RNAs used to generate genetic knockouts</p> ... Full text Cite

Table S9 from CBF-beta mitigates PI3K-alpha-specific inhibitor killing through PIM1 in PIK3CA mutant gastric cancer

Other · September 16, 2024 <p>Quantification of Human Phospho-Proteome Array</p> ... Full text Cite