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Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.

Publication ,  Journal Article
Zaffiri, L; Frankel, C; Bush, EJ; Neely, ML; Pavlisko, EN; Mokrova, IL; Luftig, MA; Palmer, SM
Published in: J Med Virol
August 2021

Epstein-Barr virus (EBV)-driven posttransplant lymphoproliferative disorder (PTLD) is a serious complication following lung transplant. The extent to which the presence of EBV in PTLD tissue is associated with survival is uncertain. Moreover, whether the heterogeneity in expression of EBV latency programs is related to the timing of PTLD onset remains unexplored. We retrospectively performed a comprehensive histological evaluation of EBV markers at the tissue level in 34 adult lung transplant recipients with early- and late-onset PTLD. Early-onset PTLD, occurring within the first 12 months posttransplant, had higher odds to express EBV markers. The presence of EBV in PTLD was not associated with a difference in survival relative to EBV-negative tumors. However, we found evidence of heterogeneous expression of EBV latency programs, including type III, IIb, IIa, and 0/I. Our study suggests that the heterogeneous expression of EBV latency programs may represent a mechanism for immune evasion in patients with PLTD after lung transplants. The recognition of multiple EBV latency programs can be used in personalized medicine in patients who are nonresponsive to traditional types of chemotherapy and can be potentially evaluated in other types of solid organ transplants.

Duke Scholars

Published In

J Med Virol

DOI

EISSN

1096-9071

Publication Date

August 2021

Volume

93

Issue

8

Start / End Page

5040 / 5047

Location

United States

Related Subject Headings

  • Virus Latency
  • Virology
  • Viral Proteins
  • Transplant Recipients
  • Retrospective Studies
  • Organ Transplantation
  • Middle Aged
  • Male
  • Lymphoproliferative Disorders
  • Lung
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zaffiri, L., Frankel, C., Bush, E. J., Neely, M. L., Pavlisko, E. N., Mokrova, I. L., … Palmer, S. M. (2021). Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder. J Med Virol, 93(8), 5040–5047. https://doi.org/10.1002/jmv.26936
Zaffiri, Lorenzo, Courtney Frankel, Erika J. Bush, Megan L. Neely, Elizabeth N. Pavlisko, Irina L. Mokrova, Micah A. Luftig, and Scott M. Palmer. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.J Med Virol 93, no. 8 (August 2021): 5040–47. https://doi.org/10.1002/jmv.26936.
Zaffiri L, Frankel C, Bush EJ, Neely ML, Pavlisko EN, Mokrova IL, et al. Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder. J Med Virol. 2021 Aug;93(8):5040–7.
Zaffiri, Lorenzo, et al. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.J Med Virol, vol. 93, no. 8, Aug. 2021, pp. 5040–47. Pubmed, doi:10.1002/jmv.26936.
Zaffiri L, Frankel C, Bush EJ, Neely ML, Pavlisko EN, Mokrova IL, Luftig MA, Palmer SM. Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder. J Med Virol. 2021 Aug;93(8):5040–5047.
Journal cover image

Published In

J Med Virol

DOI

EISSN

1096-9071

Publication Date

August 2021

Volume

93

Issue

8

Start / End Page

5040 / 5047

Location

United States

Related Subject Headings

  • Virus Latency
  • Virology
  • Viral Proteins
  • Transplant Recipients
  • Retrospective Studies
  • Organ Transplantation
  • Middle Aged
  • Male
  • Lymphoproliferative Disorders
  • Lung