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Scott Michael Palmer Jr.

Donald F. Fortin, M.D. Distinguished Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 103002, Durham, NC 27710
2085 MSRB2 2 Genome Ct, Durham, NC 27710

Overview


Dr. Palmer is a physician investigator, clinician, and academic leader. He is a Donald F. Fortin, MD Distinguished Professor of Medicine at Duke University, Vice Chair for Research in the Department of Medicine, Director of Medicine Plus Therapeutic Area at the Duke Clinical Research Institute, and Director of Clinical Research in the Duke Transplant Center. He is an expert in the care of patients with advanced lung diseases, such as interstitial lung diseases (ILDs), chronic obstructive pulmonary disease (COPD), and lung transplantation.

Dr. Palmer’s successful research career includes over 20 years of continuous NIH funding and over 300 publications. He has held key leadership roles in national and international pulmonary and transplant societies, has chaired many sessions at national and international meetings, served on the editorial board for prominent journals, and serves regularly on grant review study sections. He has received numerous honors including election into Alpha Omega Alpha (AOA), the American Society for Clinical Investigation (ASCI), and the Association of American Physicians (AAP). 

During his career, he has led numerous multicenter clinical trials, data coordinating centers, registries and large real-world data studies across different lung diseases.  His research in lung diseases has defined the best clinical practices, discovered novel biomarkers, and identified genetic risk factors.  His work in idiopathic pulmonary fibrosis (IPF) advanced the clinical development of LPA1 antagonism as a treatment. His work in bronchiolitis obliterans syndrome (BOS) identified immune mechanisms that alter airway cell biology and underly disease development. He continues to lead multicenter studies that generate high quality evidence to guide patient care and to utilize cutting edge translational approaches such as single cell and spatial transcriptomics of human lung tissue to discover lung disease mechanisms.

Dr. Palmer is a dedicated mentor to trainees and junior faculty, having personally mentored over 40 pre- and post-doctoral trainees, many of whom are now engaged in their own successful research careers. He also co-leads multiple institutional training programs, including R38 and T32 grants, reflecting his deep commitment to training the next generation of academic investigators.

Current Duke Appointments & Affiliations


Donald F. Fortin, M.D. Distinguished Professor of Medicine · 2022 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Professor of Medicine · 2015 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Vice-Chair for Research in the Department of Medicine · 2013 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Professor in Integrative Immunobiology · 2016 - Present Integrative Immunobiology, Basic Science Departments
Professor in Population Health Sciences · 2020 - Present Population Health Sciences, Basic Science Departments
Member in the Duke Clinical Research Institute · 2003 - Present Duke Clinical Research Institute, Institutes and Centers

Recent News Items


Published June 3, 2024
DCRI
DCRI Unveils New Imaging and Translational Biomarker Evidence in Pulmonary Fibrosis and Lung Disease from the IPF-PRO/ILD-PRO Registry
Published August 9, 2022
DOM
Meet New Distinguished Professor Scott Palmer, MD, Master Physician-Scientist
Published December 14, 2021
Duke Health
$21M NIH Grant Extends National Lung Transplant Research

View All News Items

Recent Scholarly Works


Early pulmonary isolation of non-tuberculous mycobacterial organisms is associated with increased risk of death and CLAD: A Lung Transplant Outcomes Group Cohort Study.

Journal article J Heart Lung Transplant · August 31, 2026 BACKGROUND: How pulmonary non-tuberculous mycobacteria (NTM) impact lung transplant outcomes is unknown. We evaluated the effect of pulmonary isolation of NTM on death or re-transplantation and chronic lung allograft dysfunction (CLAD). METHODS: We perform ... Full text Link to item Cite

Re-evaluating the role of oxygen delivery and radiographs in the definition of primary graft dysfunction after lung transplantation: A Lung Transplant Outcomes Group Cohort Study.

Journal article J Heart Lung Transplant · August 31, 2026 BACKGROUND: Primary graft dysfunction (PGD) is severe lung injury following lung transplantation. Variable radiograph interpretation and changes in mechanical ventilation and extracorporeal membrane oxygenation (ECMO) support for hypoxemia may limit the cu ... Full text Link to item Cite

The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort.

Journal article EBioMedicine · August 5, 2026 BACKGROUND: Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the human leukocyte antigen (HLA) region have long been recognised as key determinants of graft surv ... Full text Link to item Cite
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Recent Grants


The Post-Lung Transplant Impact of Alveolar Macrophage Senescence in Aged Donor Lungs

ResearchMentor · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2030

2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Center for Advancing Translational Sciences · 2025 - 2030

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Education


Duke University · 2000 M.H.S.
Duke University · 1993 M.D.