Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM).

Journal Article (Journal Article)

PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression was higher in amnion and chorion compared with decidua. By clinical phenotype, PGRMC1 expression was higher among preterm-no-labor and term-no-labor subjects compared to PPROM. PGRMC1 expression appears to be diminished in PPROM subjects.

Full Text

Duke Authors

Cited Authors

  • Feng, L; Antczak, BC; Lan, L; Grotegut, CA; Thompson, JL; Allen, TK; Murtha, AP

Published Date

  • May 2014

Published In

Volume / Issue

  • 35 / 5

Start / End Page

  • 331 - 333

PubMed ID

  • 24680695

Electronic International Standard Serial Number (EISSN)

  • 1532-3102

Digital Object Identifier (DOI)

  • 10.1016/j.placenta.2014.03.008


  • eng

Conference Location

  • Netherlands