Liping Feng | Scholars@Duke

Liping Feng
Assistant Professor of Obstetrics and Gynecology

Current Appointments & Affiliations

Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine/Midwifery Service, Obstetrics and Gynecology 2011
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2016

Contact Information

Box 103208, Durham, NC 27710
Research Drive, 245 Sands, Durham, NC 27710
feng0007@mc.duke.edu (919) 613-1459

Background
Education, Training, & Certifications
- M.D., Harbin Medical University (China) 1997
Research
Selected Grants
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development awarded by National Institutes of Health 2017 - 2022
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Allen, TK, Feng, L, Marinello, W, Buhimischi, IA, and Murtha, AP. "Progestins Inhibit IL1 beta Induced MMP9 Activity and GM-CSF Production from Primary Chorion Cells." March 2017. Link to Item
  - Feng, L, Antonia, A, Murtha, A, and Ko, D. "Racial Disparity in Ureaplasma Parvum Induced Inflammatory Responses." March 2017. Link to Item
  - Allen, T, Nazzal, M, Feng, L, Buhimschi, I, and Murtha, A. "The Role of PGRMC1 in Cytokine Induced MMP1, COX-2 and PGE(2) Expression in Amnion Mesenchymal Cells." March 2016. Link to Item
  - Kim, E, Allen, TK, Feng, L, Nazzal, MK, and Murtha, AP. "The Effect of Cytokines on Neutrophil Gelatinase-Associated Lipocalin (NGAL) mRNA Expression in a Cytotrophoblast Cell Line." March 2016. Link to Item
  - Potts, LC, Feng, L, Jayes, FL, and Murtha, AP. "341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum." January 2016. Full Text
  - Thompson, J, Feng, L, Antczak, B, Seed, P, and Murtha, A. "13: Inhibition of toll-like receptors and inflammatory response in primary chorion cells." December 2015. Full Text
  - Thompson, J, Fortner, K, Antczak, B, Feng, L, Thomas, S, Grotegut, C, Seed, P, and Murtha, A. "791: Immunohistochemical distribution of toll-like receptors in human fetal membranes." January 2014. Full Text
  - Smrtka, MP, Grotegut, CA, Feng, L, and Murtha, AP. "Thrombin-Induced Tissue Factor Expression in Human Decidual Cells Is Not Affected by Enoxaparin." March 2013. Link to Item
  - Thompson, JL, Antczak, BC, Feng, L, Grotegut, CA, Seed, PC, and Murtha, AP. "Distribution of Toll-Like Receptor 4 in Preterm Fetal Membranes." March 2013. Link to Item
  - Kraus, D, Feng, L, Heine, RP, Brown, H, Murtha, A, and Grotegut, C. "Smoking and preeclamspia protection: cigarette smoke increases placental adrenomedullin expression and improves trophoblast invasion via the adrenomedullin pathway." January 2013. Full Text Link to Item
  - Gunatilake, R, Feng, L, Swamy, G, Heine, RP, Murtha, A, and Grotegut, C. "Oxytocin receptor expression in uterine myometrium is not influenced by body mass index." January 2011. Full Text Link to Item
  - Murtha, A, Grotegut, C, Heine, RP, and Feng, L. "Progesterone receptor membrane component 1 (PGRMC1) inhibits Ca2+mediated cell death in human cytotrophoblast cells." January 2011. Full Text Link to Item
  - Feng, L, Jayes, FL, Jung, S-H, and Leppert, PC. "VITAMIN D RECEPTOR (VDR) IS OVER-EXPRESSED IN THE CENTER OF UTERINE FIBROIDS." September 2010. Full Text Link to Item
  - Feng, L, and Murtha, AP. "R5020 Inhibits Calcium Ionophore-Induced Apoptosis in Trophoblast Cells by Regulating Intracellular Calcium." March 2010. Link to Item
  - Roeder, HA, Jayes, FL, Feng, L, and Leppert, PC. "Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells." March 2010. Link to Item
  - Johnson, LNC, Jayes, FL, Feng, L, and Leppert, PC. "Factors Involved in Early Uterine Fibroid Development: The Initiation of Early Wound Healing Responses in Myometrial Cells." 2010. Link to Item
  - Beiswenger, T, Grotegut, C, Feng, L, Heine, P, and Murtha, A. "The effects of cigarette smoke on cell viability and angiogenic factors in a cytotrophoblast cell line." December 2009. Full Text Link to Item
  - Gavrilova-Jordan, LP, Schomberg, D, Feng, L, Jayes, FL, Murtha, A, and Price, TM. "Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium." March 2009. Link to Item
  - Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." March 2009. Link to Item
  - Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium." March 2009. Link to Item
  - Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." March 2009. Link to Item
  - Feng, L, Behera, M, Jayes, F, and Leppert, P. "Uterine fibroids: Development of a cell model of early fibroid growth." February 2008. Link to Item
  - Grotegut, CA, Canzoneri, BJ, Feng, L, Heine, P, and Murtha, AP. "Cigarette smoke extract causes cell death in cultured human chorion and decidua cells." February 2008. Link to Item
  - Murtha, A, Feng, L, Yonish, B, Bone, J, Heine, P, and Schomberg, DW. "Progesterone causes altered proinflammatory, cytoprotective gene expression in fetal chorion cells." December 2007. Full Text Link to Item
  - Murtha, A, Feng, L, Yonish, B, and Schomberg, D. "Progesterone protects chorion and decidua cells from calcium induced cell death in primary cell culture." December 2006. Full Text
  - Mills, A, Yonish, B, Feng, L, and Murtha (F), A. "Characterization of progesterone receptor isoform expression in fetal membranes." December 2005. Full Text
  - Yan, H, Yin, P, Park, SH, Li, HY, Feng, LP, Guan, XJ, Liu, DG, Reif, JH, and LaBean, TH. "Self-assembled DNA structures for nanoconstruction." 2004. Link to Item
  - LaBean, TH, Yan, H, Park, SH, Feng, LP, Yin, P, Li, HY, Ahn, SJ, Liu, D, Guan, XJ, and Reif, JH. "Overview of new structures for DNA-Based nanofabrication and computation." 2003. Link to Item
- Journal Articles
  - Ye, Y, Zhou, Q, Feng, L, Wu, J, Xiong, Y, and Li, X. "Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study." European journal of public health 27, no. 6 (December 2017): 1102-1107. Full Text
  - Smrtka, MP, Feng, L, Murtha, AP, and Grotegut, CA. "Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin." Reproductive sciences (Thousand Oaks, Calif.) 24, no. 8 (August 2017): 1154-1163. Full Text
  - Wang, X, Ouyang, F, Feng, L, Wang, X, Liu, Z, and Zhang, J. "Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study." Environmental health perspectives 125, no. 6 (June 27, 2017): 067017-. Full Text
  - Ju, R, Siddiqui, N, Garrett, J, Feng, L, and Heit, M. "A validated translation of a survey for measuring incontinence knowledge in Chinese-speaking American immigrants." International urogynecology journal 28, no. 6 (June 2017): 851-856. Full Text
  - Feng, L, Jayes, FL, Johnson, LNC, Schomberg, DW, and Leppert, PC. "Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin." Current protein & peptide science 18, no. 2 (January 2017): 155-166. Full Text
  - Meng, Y, Murtha, AP, and Feng, L. "Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells." Reproductive sciences (Thousand Oaks, Calif.) 23, no. 9 (September 2016): 1168-1178. Full Text
  - Potts, LC, Feng, L, Seed, PC, Jayes, FL, Kuchibhatla, M, Antczak, B, Nazzal, MK, and Murtha, AP. "Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System." Biology of reproduction 94, no. 5 (May 2016): 119-. Full Text
  - Feng, L, Ouyang, F, Liu, L, Wang, X, Wang, X, Li, Y-J, Murtha, A, Shen, H, Zhang, J, and Zhang, JJ. "Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai." Journal of environmental and public health 2016 (January 2016): 9416054-. Full Text Open Access Copy
  - Feng, L, Ransom, CE, Nazzal, MK, Allen, TK, Li, Y-J, Truong, T, Potts, LC, Seed, PC, and Murtha, AP. "The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection." PloS one 11, no. 12 (January 2016): e0168102-. Full Text
  - Allen, TK, Feng, L, Nazzal, M, Grotegut, CA, Buhimschi, IA, and Murtha, AP. "The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro." Anesthesia and analgesia 120, no. 5 (May 2015): 1085-1094. Full Text
  - Feng, L, Allen, TK, Nazzal, MK, and Murtha, AP. "P4 and Progesterone Membrane Component 1 (PGRMC1) Inhibit Ureaplasma Parvum Induced Inflammation in Amnion and Chorion Cells." REPRODUCTIVE SCIENCES 22 (March 2015): 236A-237A. Link to Item
  - Feng, L, Allen, TK, and Murtha, AP. "Role of P4 and Progesterone Receptor Membrane Component 1 (PGRMC1) in Sirtuin1 and Sirtuin 3 Regulation in Chorion Cells Under Oxidative Stress." REPRODUCTIVE SCIENCES 22 (March 2015): 326A-326A. Link to Item
  - Huang, L, Liu, J, Feng, L, Chen, Y, Zhang, J, and Wang, W. "Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions." Placenta 35, no. 8 (August 2014): 563-569. Full Text
  - Feng, L, Antczak, BC, Lan, L, Grotegut, CA, Thompson, JL, Allen, TK, and Murtha, AP. "Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM)." Placenta 35, no. 5 (May 2014): 331-333. Full Text
  - Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro." Reprod Sci 21, no. 2 (February 2014): 260-268. Full Text Link to Item
  - Murtha, AP, Fortner, KB, Grotegut, CA, Ransom, CE, Bentley, RC, Feng, L, Lan, L, Heine, RP, and Seed, PC. "Bacteria Localization and Chorion Thinning among Preterm Premature Rupture of Membranes." PLoS One (January 8, 2014). (Academic Article) Full Text Open Access Copy
  - Kraus, DM, Feng, L, Heine, RP, Brown, HL, Caron, KM, Murtha, AP, and Grotegut, CA. "Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion." Reprod Sci 21, no. 1 (January 2014): 63-71. Full Text Link to Item
  - Grotegut, CA, Gunatilake, RP, Feng, L, Heine, RP, and Murtha, AP. "The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy." Reprod Sci 20, no. 12 (December 2013): 1471-1477. Full Text Link to Item
  - Canzoneri, BJ, Feng, L, Grotegut, CA, Bentley, RC, Heine, RP, and Murtha, AP. "The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes." Reprod Sci 20, no. 10 (October 2013): 1246-1254. Full Text Link to Item
  - Beiswenger, TR, Feng, L, Brown, HL, Heine, RP, Murtha, AP, and Grotegut, CA. "The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin." Reprod Sci 19, no. 5 (May 2012): 526-533. Full Text Link to Item
  - Allen, TK, Feng, L, Grotegut, CA, and Murtha, AP. "Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 294A-294A. Link to Item
  - Feng, L, Antczak, B, Thompson, J, Grotegut, CA, and Murtha, AP. "PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM)." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 295A-295A. Link to Item
  - Gunatilake, R, Yeh, J, Feng, L, Jayes, F, Leppert, P, Heine, RP, Murtha, A, and Grotegut, C. "An Elevated Leptin Obese Mouse Model Demonstrates Uterine Fibrosis and Decreased Uterine Contractility in Response to Oxytocin." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 195A-196A. Link to Item
  - Ransom, CE, Seed, PC, Fortner, KB, Feng, L, Lan, L, Yu, M, and Murtha, AP. "Differential Cytokine and Tissue Remodeling Responses in Chorion and Decidua Exposed to Ureaplasma parvum." REPRODUCTIVE SCIENCES 19, no. S3 (March 2012): 362A-363A. Link to Item
  - Roeder, H, Jayes, F, Feng, L, and Leppert, PC. "CDB-4124 does not cause apoptosis in cultured fibroid cells." Reprod Sci 18, no. 9 (September 2011): 850-857. Full Text Link to Item
  - Feng, L, Grotegut, C, Schomberg, D, and Murtha, AP. "Progesterone Receptor Membrane Component 1 Mediated Signaling Inhibits Increase in Intracellular Ca2+ in Human Cytotrophoblast Cells." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 312A-313A. Link to Item
  - Fortner, KB, Ransom, CE, Canzoneri, BJ, Bentley, RC, Feng, L, Seed, PC, and Murtha, AP. "Bacteria Localization in Fetal Membranes among Subjects with Preterm Premature Rupture of Membranes." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 238A-238A. Link to Item
  - Grotegut, CA, Feng, L, Mao, L, Heine, RP, Murtha, AP, and Rockman, HA. "β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration." Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468-E477. Full Text Link to Item
  - Wu, J, Feng, L, and Hsieh, T-S. "Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells." Proc Natl Acad Sci U S A 107, no. 14 (April 6, 2010): 6228-6233. Full Text Link to Item
  - Jung, S-H, Sohn, I, George, SL, Feng, L, and Leppert, PC. "Sample size calculation for microarray experiments with blocked one-way design. (Published online)" BMC Bioinformatics 10 (May 28, 2009): 164-. Full Text Link to Item
  - Jayes, FL, Proia, AD, Dash, RC, Feng, L, and Leppert, PC. "The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 210A-211A. Link to Item
  - Murtha, AP, Feng, L, Grotegut, C, and Schomberg, D. "Expression of COX2 and GPX2 Are Altered by Calcimycin but Not Progesterone in Fetal Chorion Cells." REPRODUCTIVE SCIENCES 16, no. 3 (March 2009): 295A-296A. Link to Item
  - Wu, J, Capp, C, Feng, L, and Hsieh, T-S. "Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development." Dev Biol 323, no. 1 (November 1, 2008): 130-142. Full Text Link to Item
  - Behera, MA, Feng, L, Yonish, B, Catherino, W, Jung, S-H, and Leppert, P. "Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline (Reproductive Sciences (2007) 14, 8, (63S-76S) DOI: 10.1177/1933719107309591)." Reproductive Sciences 15, no. 1 (2008): 97--. Full Text
  - Behera, MA, Feng, L, Yonish, B, Catherino, W, Jung, S-H, and Leppert, P. "Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline." Reprod Sci 14, no. 8 Suppl (December 2007): 63-76. Full Text Link to Item
  - Murtha, AP, Feng, L, Yonish, B, Leppert, PC, and Schomberg, DW. "Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death." Am J Obstet Gynecol 196, no. 3 (March 2007): 257.e1-257.e5. Full Text Link to Item
  - Mills, AA, Yonish, B, Feng, L, Schomberg, DW, Heine, RP, and Murtha, AP. "Characterization of progesterone receptor isoform expression in fetal membranes." Am J Obstet Gynecol 195, no. 4 (October 2006): 998-1003. Full Text Link to Item
  - Yan, H, Feng, L, LaBean, TH, and Reif, JH. "Parallel molecular computations of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly." J Am Chem Soc 125, no. 47 (November 26, 2003): 14246-14247. Full Text Link to Item
  - Feng, L, Park, SH, Reif, JH, and Yan, H. "A two-state DNA lattice switched by DNA nanoactuator." Angew Chem Int Ed Engl 42, no. 36 (September 22, 2003): 4342-4346. Full Text Link to Item
  - Yan, H, LaBean, TH, Feng, L, and Reif, JH. "Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices." Proc Natl Acad Sci U S A 100, no. 14 (July 8, 2003): 8103-8108. Full Text Link to Item

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Education, Training, & Certifications

Selected Grants

Selected Publications

Conference Papers

Journal Articles