Liping Feng | Scholars@Duke

Liping Feng
Associate Professor of Obstetrics and Gynecology

Liping Feng, MD's research has focused on understanding the mechanisms of pregnancy complications associated with placental development. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Dr. Feng devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of placenta-originated pregnancy complications such as preeclampsia and still birth, which are important causes of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, cell aging, and environmental exposure in placental development and subsequent pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Current Research Interests

Maternal Environmental Exposure of Endocrine Disrupting Chemicals and Pregnancy Outcomes.

Ureaplasma Parvum Infection and Preterm Premature Rupture of Fetal Membranes.

PGRMC1 Functions and cell aging in Fetal Membranes and Placentas.

Current Appointments & Affiliations

Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2019
Assistant Professor in Pathology, Pathology, Clinical Science Departments 2018
Affiliate, Duke Global Health Institute, Duke Global Health Institute, University Institutes and Centers 2016

Contact Information

701 W Main St, Durham, NC 27701
Box 103208, Durham, NC 27710
feng0007@mc.duke.edu (919) 613-1459
Liping Feng

Background
Education, Training, & Certifications
- M.S., Chinese Center for Disease Control and Prevention (China) 2000
- M.D., Harbin Medical University (China) 1997
Duke Appointment History
- Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2018 - 2019
- Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2011 - 2018
Leadership & Clinical Positions at Duke
- OB/GYN department Inclusive and Diversity Committee member
Academic Positions Outside Duke
- Visiting Professor , Shanghai Xinhua Hospital . 2018 - 2023
Recognition
In the News
- FEB 3, 2020
  
  Replacement chemicals may put pregnancies at risk
- MAY 14, 2018 DukeMed Alumni
  
  MEDx Bridging the Gap Monday, May 14, 2018
- FEB 25, 2014
  
  Stimulating Global Health Research With DGHI Pilot Funds
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Effects of PFBS exposure on adverse pregnancy outcomes and fetal development awarded by National Institutes of Health 2017 - 2022
- Cellular and Molecular Systems Biology of Preterm Birth awarded by University of Chicago 2015 - 2019
- Mechanisms of Progesterone mediated effect on cytokine induced Metalloproteinase activity in human trophoblast cells awarded by Society for Obstetric Anesthesia and Perinatology 2012 - 2014
- Progesterone Receptor Membrane Component 1 (PGRMC1) as a Predictor of Preterm Birth awarded by The Biomarker Factory 2013 - 2014
- SAFETY AND IMMUNOGENICITY OF TDAP VACCINE IN HEALTHY PREGNANT WOMEN, SAFETY IN THEIR NEONATES, AND EFFECT OF MATERNAL IMMUNIZATION ON INFANT IMMUNE RESPONSES TO DTAP VACCINE - DMID 05-0048 awarded by University of Maryland 2010 - 2012
- DMID 09-0005 Safety and Immunogenicity awarded by University of Maryland 2010 - 2012
- 09-0056 A Phase II Study in Pregnant Women to Assess the Safety and Immunogenicity of an Unadjuvanted Sanofi Pasteur H1N1 Inactivated Influenza Vaccine Administered at Two Dose Levels awarded by University of Maryland 2009 - 2010
- A randomized double-blind trial on the safety and immunogenicity of inactivated trivalent influenza vaccine in pregnant women. awarded by University of Maryland 2009 - 2010
Fellowships, Supported Research, & Other Grants
- The Impacts of E-waste Exposure on birth outcomes in a Major E-waste Recycling City in China awarded by Duke Bass Connections 2019 - 2020
- The development of a novel platform closely mimicking the human placental barrier awarded by MEDx Biomedical Research Fund 2017 - 2018
- Maternal exposure to e-waste in Guiyu, China and birth outcomes awarded by Duke Global Health Institute GEM Pilot Grant 2017 - 2018
- Understanding the pathogenicity of U. parvum among women and infants awarded by Duke Perinatal Research Fund 2015
External Relationships
- Shanghai Jiao Tong University XInhua Hospital
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Pham, Angela, Jun Zhang, and Liping Feng. “Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast.” Reprod Toxicol, November 2, 2020. https://doi.org/10.1016/j.reprotox.2020.10.013.
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  - Marinello, William P., Zahra S. Mohseni, Sarah J. Cunningham, Christine Crute, Rong Huang, Jun J. Zhang, and Liping Feng. “Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.” Faseb J 34, no. 11 (November 2020): 14182–99. https://doi.org/10.1096/fj.202000716RR.
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  - Aimuzi, Ruxianguli, Kai Luo, Rong Huang, Xiaona Huo, Min Nian, Fengxiu Ouyang, Yatao Du, et al. “Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy.” Environ Pollut 264 (September 2020): 114557. https://doi.org/10.1016/j.envpol.2020.114557.
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  - Huo, Xiaona, Lin Zhang, Rong Huang, Liping Feng, Weiye Wang, Jun Zhang, and Jun Shanghai Birth Cohort. “Perfluoroalkyl substances exposure in early pregnancy and preterm birth in singleton pregnancies: a prospective cohort study.” Environ Health 19, no. 1 (June 3, 2020): 60. https://doi.org/10.1186/s12940-020-00616-8.
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  - Huo, Xiaona, Rong Huang, Yuexin Gan, Kai Luo, Ruxianguli Aimuzi, Min Nian, Junjie Ao, et al. “Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study.” Environ Int 138 (May 2020): 105656. https://doi.org/10.1016/j.envint.2020.105656.
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  - Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.” Sci Adv 6, no. 19 (May 2020): eaba0310. https://doi.org/10.1126/sciadv.aba0310.
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  - Zheng, Shaoling, Ruixin Li, Jiayu Liang, Zihao Wen, Xiuxia Huang, Xiuben Du, Shirui Dong, et al. “Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.” Genet Test Mol Biomarkers 24, no. 4 (April 2020): 188–94. https://doi.org/10.1089/gtmb.2019.0147.
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  - Xie, Xin, Congying Lu, Min Wu, Jiayu Liang, Yuting Ying, Kailiang Liu, Xiuxia Huang, et al. “Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013-2014).” Environ Int 136 (March 2020): 105445. https://doi.org/10.1016/j.envint.2019.105445.
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  - Cunningham, Sarah J., Liping Feng, Terrence K. Allen, and Timothy E. Reddy. “Functional Genomics of Healthy and Pathological Fetal Membranes.” Front Physiol 11 (2020): 687. https://doi.org/10.3389/fphys.2020.00687.
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  - Marinello, William, Liping Feng, and Terrence K. Allen. “Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells.” Front Physiol 11 (2020): 900. https://doi.org/10.3389/fphys.2020.00900.
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  - Chen, Chang, Jin Wen Zhang, Hong Wei Xia, Hui Xin Zhang, Ana Pilar Betran, Lin Zhang, Xiao Lin Hua, et al. “Preterm Birth in China Between 2015 and 2016.” American Journal of Public Health 109, no. 11 (November 2019): 1597–1604. https://doi.org/10.2105/ajph.2019.305287.
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  - Aimuzi, Ruxianguli, Kai Luo, Qian Chen, Hui Wang, Liping Feng, Fengxiu Ouyang, and Jun Zhang. “Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery.” Environ Int 130 (September 2019): 104929. https://doi.org/10.1016/j.envint.2019.104929.
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  - Allen, Terrence K., Matthew N. Nazzal, Liping Feng, Irina A. Buhimschi, and Amy P. Murtha. “Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells.” Reprod Sci 26, no. 9 (September 2019): 1193–1202. https://doi.org/10.1177/1933719118811646.
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  - Huang, Rong, Jing Zhu, Lin Zhang, Xiaolin Hua, Weiping Ye, Chang Chen, Kun Sun, et al. “Is ELABELA a reliable biomarker for hypertensive disorders of pregnancy?” Pregnancy Hypertens 17 (July 2019): 226–32. https://doi.org/10.1016/j.preghy.2019.06.007.
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  - Feng, Liping, Terrence K. Allen, William P. Marinello, and Amy P. Murtha. “Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells.” Reprod Sci 26, no. 3 (March 2019): 394–403. https://doi.org/10.1177/1933719118776790.
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  - Ye, Yunzhen, Yao Tang, Yu Xiong, Liping Feng, and Xiaotian Li. “Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2.” Faseb J 33, no. 2 (February 2019): 2732–42. https://doi.org/10.1096/fj.201800934RRR.
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  - Huang, Rong, Qian Chen, Lin Zhang, Kai Luo, Lin Chen, Shasha Zhao, Liping Feng, and Jun Zhang. “Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy.” Environmental Health : A Global Access Science Source 18, no. 1 (January 9, 2019): 5. https://doi.org/10.1186/s12940-018-0445-3.
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  - Feng, Liping. “Reply.” Am J Obstet Gynecol 220, no. 1 (January 2019): 126. https://doi.org/10.1016/j.ajog.2018.09.031.
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  - Jayes, Friederike L., Betty Liu, Liping Feng, Nydea Aviles-Espinoza, Sergey Leikin, and Phyllis C. Leppert. “Evidence of biomechanical and collagen heterogeneity in uterine fibroids.” Plos One 14, no. 4 (2019): e0215646. https://doi.org/10.1371/journal.pone.0215646.
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  - Ye, Jiangfeng, Yan Chen, Jing Zhu, Chang Chen, Xiaoyong Zhu, Liping Feng, Weiping Ye, and Jun Zhang. “Aspirin use during pregnancy and hypoxia-related placental pathology.” Pregnancy Hypertens 14 (October 2018): 177–88. https://doi.org/10.1016/j.preghy.2018.07.009.
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  - Feng, Liping, Terrence K. Allen, William P. Marinello, and Amy P. Murtha. “Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).” American Journal of Obstetrics and Gynecology 219, no. 1 (July 2018): 101.e1-101.e12. https://doi.org/10.1016/j.ajog.2018.04.014.
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  - Ye, Yunzhen, Qiongjie Zhou, Liping Feng, Jiangnan Wu, Yu Xiong, and Xiaotian Li. “Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study.” European Journal of Public Health 27, no. 6 (December 2017): 1102–7. https://doi.org/10.1093/eurpub/ckx148.
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  - Smrtka, Michael P., Liping Feng, Amy P. Murtha, and Chad A. Grotegut. “Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin.” Reprod Sci 24, no. 8 (August 2017): 1154–63. https://doi.org/10.1177/1933719116678685.
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  - Wang, Xu, Fengxiu Ouyang, Liping Feng, Xia Wang, Zhiwei Liu, and Jun Zhang. “Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study.” Environ Health Perspect 125, no. 6 (June 27, 2017): 067017. https://doi.org/10.1289/EHP500.
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  - Ju, Rujin, Nazema Siddiqui, Joanne Garrett, Liping Feng, and Michael Heit. “A validated translation of a survey for measuring incontinence knowledge in Chinese-speaking American immigrants.” Int Urogynecol J 28, no. 6 (June 2017): 851–56. https://doi.org/10.1007/s00192-016-3215-1.
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  - Feng, Liping, Friederike L. Jayes, Lauren N. C. Johnson, David W. Schomberg, and Phyllis C. Leppert. “Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.” Current Protein & Peptide Science 18, no. 2 (January 2017): 155–66. https://doi.org/10.2174/1389203717666160322145731.
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  - Meng, Yan, Amy P. Murtha, and Liping Feng. “Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells.” Reprod Sci 23, no. 9 (September 2016): 1168–78. https://doi.org/10.1177/1933719116630412.
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  - Potts, Lauren C., Liping Feng, Patrick C. Seed, Friederike L. Jayes, Maragatha Kuchibhatla, Brian Antczak, Matthew K. Nazzal, and Amy P. Murtha. “Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System.” Biol Reprod 94, no. 5 (May 2016): 119. https://doi.org/10.1095/biolreprod.115.137596.
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  - Feng, Liping, Carla E. Ransom, Matthew K. Nazzal, Terrence K. Allen, Yi-Ju Li, Tracy Truong, Lauren C. Potts, Patrick C. Seed, and Amy P. Murtha. “The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection.” Plos One 11, no. 12 (2016): e0168102. https://doi.org/10.1371/journal.pone.0168102.
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  - Feng, Liping, Fengxiu Ouyang, Liangpo Liu, Xu Wang, Xia Wang, Yi-Ju Li, Amy Murtha, Heqing Shen, Junfeng Zhang, and Jun Jim Zhang. “Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai.” Journal of Environmental and Public Health 2016 (January 2016): 9416054. https://doi.org/10.1155/2016/9416054.
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  - Allen, Terrence K., Liping Feng, Matthew Nazzal, Chad A. Grotegut, Irina A. Buhimschi, and Amy P. Murtha. “The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro.” Anesth Analg 120, no. 5 (May 2015): 1085–94. https://doi.org/10.1213/ANE.0000000000000708.
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  - Feng, Liping, Terrence K. Allen, Matthew K. Nazzal, and Amy P. Murtha. “P4 and Progesterone Membrane Component 1 (PGRMC1) Inhibit Ureaplasma Parvum Induced Inflammation in Amnion and Chorion Cells.” Reproductive Sciences 22 (March 1, 2015): 236A-237A.
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  - Feng, Liping, Terrence K. Allen, and Amy P. Murtha. “Role of P4 and Progesterone Receptor Membrane Component 1 (PGRMC1) in Sirtuin1 and Sirtuin 3 Regulation in Chorion Cells Under Oxidative Stress.” Reproductive Sciences 22 (March 1, 2015): 326A-326A.
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  - Huang, Lisu, Jihong Liu, Liping Feng, Yan Chen, Jun Zhang, and Weiye Wang. “Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions.” Placenta 35, no. 8 (August 2014): 563–69. https://doi.org/10.1016/j.placenta.2014.05.006.
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  - Feng, L., B. C. Antczak, L. Lan, C. A. Grotegut, J. L. Thompson, T. K. Allen, and A. P. Murtha. “Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM).” Placenta 35, no. 5 (May 2014): 331–33. https://doi.org/10.1016/j.placenta.2014.03.008.
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  - Allen, Terrence K., Liping Feng, Chad A. Grotegut, and Amy P. Murtha. “Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro.” Reprod Sci 21, no. 2 (February 2014): 260–68. https://doi.org/10.1177/1933719113493514.
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  - Fortner, Kimberly B., Chad A. Grotegut, Carla E. Ransom, Rex C. Bentley, Liping Feng, Lan Lan, R Phillips Heine, Patrick C. Seed, and Amy P. Murtha. “Bacteria localization and chorion thinning among preterm premature rupture of membranes.” Plos One 9, no. 1 (2014): e83338. https://doi.org/10.1371/journal.pone.0083338.
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  - Kraus, Daniel M., Liping Feng, R Phillips Heine, Haywood L. Brown, Kathleen M. Caron, Amy P. Murtha, and Chad A. Grotegut. “Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.” Reprod Sci 21, no. 1 (January 2014): 63–71. https://doi.org/10.1177/1933719113488456.
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  - Grotegut, Chad A., Ravindu P. Gunatilake, Liping Feng, R Phillips Heine, and Amy P. Murtha. “The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy.” Reprod Sci 20, no. 12 (December 2013): 1471–77. https://doi.org/10.1177/1933719113488446.
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  - Canzoneri, Bernard J., Liping Feng, Chad A. Grotegut, Rex C. Bentley, R Phillips Heine, and Amy P. Murtha. “The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes.” Reprod Sci 20, no. 10 (October 2013): 1246–54. https://doi.org/10.1177/1933719113483009.
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  - Beiswenger, Timothy R., Liping Feng, Haywood L. Brown, R Phillips Heine, Amy P. Murtha, and Chad A. Grotegut. “The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin.” Reprod Sci 19, no. 5 (May 2012): 526–33. https://doi.org/10.1177/1933719111426600.
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  - Allen, T. K., L. Feng, C. A. Grotegut, and A. P. Murtha. “Progestins Diminish Cytokine Induced MMP9 Activity in a Human Cytotrophoblast Cell Line Not Expressing the Nuclear Progesterone Receptor.” Reproductive Sciences 19, no. S3 (March 1, 2012): 294A-294A.
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  - Feng, Liping, Brian Antczak, Jennifer Thompson, Chad A. Grotegut, and Amy P. Murtha. “PGRMC1 Expression in Fetal Membrane Layers among Women with Preterm Premature Rupture of the Membranes (PPROM).” Reproductive Sciences 19, no. S3 (March 1, 2012): 295A-295A.
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  - Gunatilake, Ravindu, Jason Yeh, Liping Feng, Friederike Jayes, Phyllis Leppert, R Phillips Heine, Amy Murtha, and Chad Grotegut. “An Elevated Leptin Obese Mouse Model Demonstrates Uterine Fibrosis and Decreased Uterine Contractility in Response to Oxytocin.” Reproductive Sciences 19, no. S3 (March 1, 2012): 195A-196A.
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  - Ransom, C. E., P. C. Seed, K. B. Fortner, L. Feng, L. Lan, M. Yu, and A. P. Murtha. “Differential Cytokine and Tissue Remodeling Responses in Chorion and Decidua Exposed to Ureaplasma parvum.” Reproductive Sciences 19, no. S3 (March 1, 2012): 362A-363A.
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  - Roeder, Hilary, Friederike Jayes, Liping Feng, and Phyllis C. Leppert. “CDB-4124 does not cause apoptosis in cultured fibroid cells.” Reprod Sci 18, no. 9 (September 2011): 850–57. https://doi.org/10.1177/1933719111399929.
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  - Feng, Liping, Chad Grotegut, David Schomberg, and Amy P. Murtha. “Progesterone Receptor Membrane Component 1 Mediated Signaling Inhibits Increase in Intracellular Ca2+ in Human Cytotrophoblast Cells.” Reproductive Sciences 18, no. 3 (March 2011): 312A-313A.
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  - Fortner, Kimberly B., Carla E. Ransom, Bernard J. Canzoneri, Rex C. Bentley, Liping Feng, Patrick C. Seed, and Amy P. Murtha. “Bacteria Localization in Fetal Membranes among Subjects with Preterm Premature Rupture of Membranes.” Reproductive Sciences 18, no. 3 (March 2011): 238A-238A.
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  - Grotegut, Chad A., Liping Feng, Lan Mao, R Phillips Heine, Amy P. Murtha, and Howard A. Rockman. “β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.” Am J Physiol Endocrinol Metab 300, no. 3 (March 2011): E468–77. https://doi.org/10.1152/ajpendo.00390.2010.
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  - Wu, Jianhong, Liping Feng, and Tao-shih Hsieh. “Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells.” Proc Natl Acad Sci U S A 107, no. 14 (April 6, 2010): 6228–33. https://doi.org/10.1073/pnas.1001855107.
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  - Jung, Sin-Ho, Insuk Sohn, Stephen L. George, Liping Feng, and Phyllis C. Leppert. “Sample size calculation for microarray experiments with blocked one-way design.” Bmc Bioinformatics 10 (May 28, 2009): 164. https://doi.org/10.1186/1471-2105-10-164.
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  - Jayes, Friederike L., Alan D. Proia, Rajesh C. Dash, Liping Feng, and Phyllis C. Leppert. “The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research.” Reproductive Sciences 16, no. 3 (March 1, 2009): 210A-211A.
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  - Murtha, Amy P., Liping Feng, Chad Grotegut, and David Schomberg. “Expression of COX2 and GPX2 Are Altered by Calcimycin but Not Progesterone in Fetal Chorion Cells.” Reproductive Sciences 16, no. 3 (March 2009): 295A-296A.
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  - Wu, Jianhong, Christopher Capp, Liping Feng, and Tao-shih Hsieh. “Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.” Dev Biol 323, no. 1 (November 1, 2008): 130–42. https://doi.org/10.1016/j.ydbio.2008.08.006.
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  - Behera, M. A., L. Feng, B. Yonish, W. Catherino, S. H. Jung, and P. Leppert. “Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline (Reproductive Sciences (2007) 14, 8, (63S-76S) DOI: 10.1177/1933719107309591).” Reproductive Sciences 15, no. 1 (January 1, 2008): 97. https://doi.org/10.1177/1933719108314501.
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  - Behera, Millie A., Liping Feng, Bryan Yonish, William Catherino, Sin-Ho Jung, and Phyllis Leppert. “Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.” Reprod Sci 14, no. 8 Suppl (December 2007): 63–76. https://doi.org/10.1177/1933719107309591.
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  - Murtha, Amy P., Liping Feng, Bryan Yonish, Phyllis C. Leppert, and David W. Schomberg. “Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.” Am J Obstet Gynecol 196, no. 3 (March 2007): 257.e1-257.e5. https://doi.org/10.1016/j.ajog.2007.01.007.
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  - Mills, Alyssa A., Bryan Yonish, Liping Feng, David W. Schomberg, R Phillips Heine, and Amy P. Murtha. “Characterization of progesterone receptor isoform expression in fetal membranes.” Am J Obstet Gynecol 195, no. 4 (October 2006): 998–1003. https://doi.org/10.1016/j.ajog.2006.06.040.
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  - Yan, Hao, Liping Feng, Thomas H. LaBean, and John H. Reif. “Parallel molecular computations of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly.” J Am Chem Soc 125, no. 47 (November 26, 2003): 14246–47. https://doi.org/10.1021/ja036676m.
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  - Feng, Liping, Sung Ha Park, John H. Reif, and Hao Yan. “A two-state DNA lattice switched by DNA nanoactuator.” Angew Chem Int Ed Engl 42, no. 36 (September 22, 2003): 4342–46. https://doi.org/10.1002/anie.200351818.
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  - Yan, Hao, Thomas H. LaBean, Liping Feng, and John H. Reif. “Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices.” Proc Natl Acad Sci U S A 100, no. 14 (July 8, 2003): 8103–8. https://doi.org/10.1073/pnas.1032954100.
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- Conference Papers
  - Liu, Yongjie, Jun Zhang, and Liping Feng. “Intestinal Dysbacteriosis is Associated with the Imbalanced Cytokines Network in Unexplained Miscarriage.” In Reproductive Sciences, 27:205A-205A. SPRINGER HEIDELBERG, 2020.
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  - Allen, Terrence K., William Marinello, Liping Feng, Amy Murtha, and Irina Buhimschi. “Progestins Inhibit IL1b-Induced MMP1 and IL8 mRNA Expression in Amnion Mesenchymal Cells through the Glucocorticoid Receptor.” In Reproductive Sciences, 25:260A-260A. SAGE PUBLICATIONS INC, 2018.
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  - Allen, T. K., L. Feng, W. Marinello, I. A. Buhimischi, and A. P. Murtha. “Progestins Inhibit IL1 beta Induced MMP9 Activity and GM-CSF Production from Primary Chorion Cells.” In Reproductive Sciences, 24:113A-113A. SAGE PUBLICATIONS INC, 2017.
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  - Feng, Liping, Alex Antonia, Amy Murtha, and Dennis Ko. “Racial Disparity in Ureaplasma Parvum Induced Inflammatory Responses.” In Reproductive Sciences, 24:174A-174A. SAGE PUBLICATIONS INC, 2017.
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  - Allen, T., M. Nazzal, L. Feng, I. Buhimschi, and A. Murtha. “The Role of PGRMC1 in Cytokine Induced MMP1, COX-2 and PGE(2) Expression in Amnion Mesenchymal Cells.” In Reproductive Sciences, 23:130A-131A. SAGE PUBLICATIONS INC, 2016.
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  - Feng, Liping, Nerlyne Desravine, Matthew Nazzal, Katherine Pryor, and Amy Murtha. “Characterization of Progesterone Receptor Membrane Component 1 in Peripheral Blood Mononuclear Cells and Plasma During Pregnancy.” In Reproductive Sciences, 23:292A-292A. SAGE PUBLICATIONS INC, 2016.
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  - Kim, EuiHyeok, Terrence K. Allen, Liping Feng, Matthew K. Nazzal, and Amy P. Murtha. “The Effect of Cytokines on Neutrophil Gelatinase-Associated Lipocalin (NGAL) mRNA Expression in a Cytotrophoblast Cell Line.” In Reproductive Sciences, 23:325A-325A. SAGE PUBLICATIONS INC, 2016.
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  - Potts, Lauren C., Liping Feng, Friederike L. Jayes, and Amy P. Murtha. “341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum.” In American Journal of Obstetrics and Gynecology, 214:S192–93. Elsevier BV, 2016. https://doi.org/10.1016/j.ajog.2015.10.381.
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  - Pryor, Katherine, Sarahn Wheeler, Regina Whitaker, Liping Feng, and Amy Murtha. “691: Evidence of PGRMC1 expression in cervical and vaginal epithelial cells during pregnancy.” In American Journal of Obstetrics and Gynecology, 214:S365–S365. Elsevier BV, 2016. https://doi.org/10.1016/j.ajog.2015.10.738.
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  - Thompson, J., L. Feng, B. Antczak, P. Seed, and A. Murtha. “13: Inhibition of toll-like receptors and inflammatory response in primary chorion cells.” In American Journal of Obstetrics and Gynecology, 213:901–901. Elsevier BV, 2015. https://doi.org/10.1016/j.ajog.2015.09.045.
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  - Thompson, Jennifer, Kimberly Fortner, Brian Antczak, Liping Feng, Samantha Thomas, Chad Grotegut, Patrick Seed, and Amy Murtha. “791: Immunohistochemical distribution of toll-like receptors in human fetal membranes.” In American Journal of Obstetrics and Gynecology, 210:S387–S387. Elsevier BV, 2014. https://doi.org/10.1016/j.ajog.2013.10.824.
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  - Smrtka, Michael P., Chad A. Grotegut, Liping Feng, and Amy P. Murtha. “Thrombin-Induced Tissue Factor Expression in Human Decidual Cells Is Not Affected by Enoxaparin.” In Reproductive Sciences, 20:241A-241A. SAGE PUBLICATIONS INC, 2013.
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  - Thompson, Jennifer L., Brian C. Antczak, Liping Feng, Chad A. Grotegut, Patrick C. Seed, and Amy P. Murtha. “Distribution of Toll-Like Receptor 4 in Preterm Fetal Membranes.” In Reproductive Sciences, 20:241A-242A. SAGE PUBLICATIONS INC, 2013.
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  - Kraus, Daniel, Liping Feng, R Phillips Heine, Haywood Brown, Amy Murtha, and Chad Grotegut. “43: Smoking and preeclamspia protection: cigarette smoke increases placental adrenomedullin expression and improves trophoblast invasion via the adrenomedullin pathway.” In American Journal of Obstetrics and Gynecology, 208:S26–S26. Elsevier BV, 2013. https://doi.org/10.1016/j.ajog.2012.10.217.
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  - Gilner, Jennifer B., Amy Murtha, and Liping Feng. “Progesterone Protects Chorion Cells from Apoptosis Induced by Reactive Oxygen Species.” In Reproductive Sciences, 19:296A-296A. SAGE PUBLICATIONS INC, 2012.
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  - Choi, Seong Jin, Liping Feng, Jennifer Gilner, and Amy Murtha. “523: The effect of progesterone on TNF-α induced MMP 9 activity in human fetal membranes.” In American Journal of Obstetrics and Gynecology, 206:S236–37. Elsevier BV, 2012. https://doi.org/10.1016/j.ajog.2011.10.541.
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  - Gunatilake, Ravindu, Liping Feng, Geeta Swamy, R Phillips Heine, Amy Murtha, and Chad Grotegut. “318: Oxytocin receptor expression in uterine myometrium is not influenced by body mass index.” In American Journal of Obstetrics and Gynecology, 204:S131–S131. Elsevier BV, 2011. https://doi.org/10.1016/j.ajog.2010.10.336.
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  - Murtha, Amy, Chad Grotegut, R Phillips Heine, and Liping Feng. “46: Progesterone receptor membrane component 1 (PGRMC1) inhibits Ca2+ mediated cell death in human cytotrophoblast cells.” In American Journal of Obstetrics and Gynecology, 204:S27–S27. Elsevier BV, 2011. https://doi.org/10.1016/j.ajog.2010.10.057.
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  - Feng, L., F. L. Jayes, S. -. H. Jung, and P. C. Leppert. “Vitamin D receptor (VDR) is over-expressed in the center of uterine fibroids.” In Fertility and Sterility, 94:S75–S75. Elsevier BV, 2010. https://doi.org/10.1016/j.fertnstert.2010.07.291.
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  - Feng, Liping, and Amy P. Murtha. “R5020 Inhibits Calcium Ionophore-Induced Apoptosis in Trophoblast Cells by Regulating Intracellular Calcium.” In Reproductive Sciences, 17:332A-332A, 2010.
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  - Roeder, Hilary A., Friederike L. Jayes, Liping Feng, and Phyllis C. Leppert. “Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells.” In Reproductive Sciences, 17:273A-273A. SAGE PUBLICATIONS INC, 2010.
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  - Johnson, Lauren N. C., Friederike L. Jayes, Liping Feng, and Phyllis C. Leppert. “Factors Involved in Early Uterine Fibroid Development: The Initiation of Early Wound Healing Responses in Myometrial Cells.” In Biology of Reproduction, 128–29. SOC STUDY REPRODUCTION, 2010.
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  - Beiswenger, Timothy, Chad Grotegut, Liping Feng, Phillip Heine, and Amy Murtha. “775: The effects of cigarette smoke on cell viability and angiogenic factors in a cytotrophoblast cell line.” In American Journal of Obstetrics and Gynecology, 201:S278–79. Elsevier BV, 2009. https://doi.org/10.1016/j.ajog.2009.10.792.
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  - Gavrilova-Jordan, Larisa P., David Schomberg, Liping Feng, Friederike L. Jayes, Amy Murtha, and Thomas M. Price. “Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium.” In Reproductive Sciences, 16:114A-114A. SAGE PUBLICATIONS INC, 2009.
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  - Gavrilova-Jordan, Larisa P., Li Zhang, David Schomberg, Frederike L. Jayes, Liping Feng, and Thomas M. Price. “Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues.” In Reproductive Sciences, 16:189A-189A. SAGE PUBLICATIONS INC, 2009.
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  - Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium.” In Reproductive Sciences, 16:214A-214A. SAGE PUBLICATIONS INC, 2009.
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  - Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium.” In Reproductive Sciences, 16:216A-216A. SAGE PUBLICATIONS INC, 2009.
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  - Feng, Liping, Millie Behera, Friederike Jayes, and Phyllis Leppert. “Uterine fibroids: Development of a cell model of early fibroid growth.” In Reproductive Sciences, 15:297A-298A. SAGE PUBLICATIONS INC, 2008.
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  - Grotegut, Chad A., Bernard J. Canzoneri, Liping Feng, Phil Heine, and Amy P. Murtha. “Cigarette smoke extract causes cell death in cultured human chorion and decidua cells.” In Reproductive Sciences, 15:261A-261A. SAGE PUBLICATIONS INC, 2008.
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  - Murtha, Amy, Liping Feng, Bryan Yonish, Jenna Bone, Phillip Heine, and David W. Schomberg. “52: Progesterone causes altered proinflammatory, cytoprotective gene expression in fetal chorion cells.” In American Journal of Obstetrics and Gynecology, 197:S23–S23. Elsevier BV, 2007. https://doi.org/10.1016/j.ajog.2007.10.058.
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  - Murtha, Amy, Liping Feng, Bryan Yonish, and David Schomberg. “Progesterone protects chorion and decidua cells from calcium induced cell death in primary cell culture.” In American Journal of Obstetrics and Gynecology, 195:S5–S5. Elsevier BV, 2006. https://doi.org/10.1016/j.ajog.2006.10.013.
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  - Mills, Alyssa, Bryan Yonish, Liping Feng, and Amy Murtha (F). “Characterization of progesterone receptor isoform expression in fetal membranes.” In American Journal of Obstetrics and Gynecology, 193:S57–S57. Elsevier BV, 2005. https://doi.org/10.1016/j.ajog.2005.10.180.
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  - Yan, H., P. Yin, S. H. Park, H. Y. Li, L. P. Feng, X. J. Guan, D. G. Liu, J. H. Reif, and T. H. LaBean. “Self-assembled DNA structures for nanoconstruction.” In Dna Based Molecular Electronics, edited by W. Fritzsche, 725:43–52. AMER INST PHYSICS, 2004.
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  - LaBean, T. H., H. Yan, S. H. Park, L. P. Feng, P. Yin, H. Y. Li, S. J. Ahn, D. Liu, X. J. Guan, and J. H. Reif. “Overview of new structures for DNA-Based nanofabrication and computation.” In Proceedings of the 7th Joint Conference on Information Sciences, edited by S. H. Chen, H. D. Cheng, D. K. Y. Chiu, S. Das, R. Duro, E. E. Kerre, H. V. Leong, et al., 1475–78. ASSOC INTELLIGENT MACHINERY, 2003.
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Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Mentor to fellows and residents in OB/GYN department including: Drs. Daniel Kraus, Kimberly Fortner, Ravindu Gunatilake, Carla Ransom, Jennifer Thomson, Michael Smrtka, James Edwards, Amber Wood, Sarahn Wheeler.
  
  Visiting Scholars: Drs. Seong Jin, Terrence Allen, Liwen Zhang, Yan Meng, Chunxia Jin.
  
  Students: Patrick, Jane, Yechen Hu, Henry Chen, Kuanlin (Franky) Du, Angela Pham, Maya Iskandarani, Aneesha Raj.
  
  Current Trainees: Christina Crute (a PhD student), Sarah Cunningham (a PhD student), Tae Yokouchi (postdoc).
  
  Bass Connections Team : Christine Crute (PhD student); Nadratun Chowdhury (PhD student); Connie Xiong (Master Student); Yan Sun (Master Student); Duke Undergraduate students: Julia Murphy, Amy Zhou, Aneesha Raj, Angela Pham, Ashley Choi, Elizabeth Lamb, Afreen Ashraf, Alice Carroll, Xavier Heidelberg, Jenny Li, Kathy Lu, Amelia Martin, Xueqing Yun.
Teaching Activities
- Lecture for Duke Asian-Pacific Studies Institute, AMES 270T-5
  
  Biology Independent Study (Duke Undergraduate Students Course)
  
  GLHLTH 395-05 (Duke Undergraduate Student Course, Global Health)
  
  GLHLTH 795-05 (Duke Graduate Student Course, Global Health)
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
Service to Duke
- OB/GYN Inclusive and Diversity Committee. 2017 2017
- Duke Medical School Admission. 2016 - 2018 2016 - 2018
Academic & Administrative Activities
- OB/GYN Department Inclusive and Diversity Committee Member
  Medical Student Recruitment

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