Scholars@Duke
Liping Feng

Liping Feng

Associate Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Reproductive Sciences
feng0007@mc.duke.edu
Box 103208, Durham, NC 27710
701 W Main St, Durham, NC 27701

Selected Publications

PFBS disrupts lipid metabolism and mitochondrial function in human trophoblast cells.

Journal Article Toxicology · December 2025 Perfluorobutanesulfonic acid (PFBS) is an emerging short-chain per- and polyfluoroalkyl substance (PFAS), a group of persistent environmental contaminants associated with adverse reproductive outcomes. The placenta plays a critical role in the pathogenesis ... Full text Link to item Cite

Abstract 4365028: HIV Antiretroviral Therapy and Drinking Water Contaminant Exposures Induce Cardiac Function Changes in Women of Childbearing Age

Conference Circulation · November 4, 2025 Objective: The majority of individuals living with human immunodeficiency virus (HIV) are female. Although combined antiretroviral therapy (cART) can greatly improve prognosis and prev ... Full text Cite

Perinatal Exposure to Perfluoroalkyl Substances Impairs Maternal Care and Induces Depressive-like Behavior in Mice.

Journal Article Toxicol Sci · October 27, 2025 Postpartum mental health disorders are a critical yet understudied aspect of maternal health. Exposure to environmental toxicants such as per- and polyfluoroalkyl substances (PFAS) has been associated with adverse health outcomes, including reproductive an ... Full text Link to item Cite

A call to standardize the nomenclature of human fetal membrane at the feto-maternal interface.

Journal Article Placenta · October 2025 Despite being one of the largest intrauterine tissues in surface area, the fetal membrane that lines the intrauterine cavity is often overlooked, forgotten, or misidentified in clinical and basic science research. The feto-maternal interface is comprised o ... Full text Link to item Cite

Effects of Perfluorobutane Sulfonate (PFBS) on Female Reproduction, Pregnancy, and Birth Outcomes.

Journal Article Obstet Gynecol Surv · October 2025 IMPORTANCE: Perfluorobutane sulfonate (PFBS) is a short-chain per- and polyfluoroalkyl substance (PFAS) that has emerged as a significant public health concern due to its widespread environmental contamination and persistent nature. While PFBS is considere ... Full text Link to item Cite

PIEZO1 drives trophoblast fusion and placental development.

Journal Article Nat Commun · July 26, 2025 PIEZO1, a mechanosensor in endothelial cells, plays a critical role in fetal vascular development during embryogenesis. However, its expression and function in placental trophoblasts remain unexplored. Here, we demonstrate that PIEZO1 is expressed in place ... Full text Link to item Cite

PIEZO1 Drives Trophoblast Fusion and Placental Development.

Journal Article bioRxiv · March 26, 2025 PIEZO1, a mechanosensor1,2 in endothelial cells, plays a critical role in fetal vascular development during embryogenesis3,4. However, its expression and function in placental trophoblasts remain unexplored. Here, we demonstrate that PIEZO1 is expressed in ... Full text Link to item Cite

Three-dimensional diffractive acoustic tomography.

Journal Article Nat Commun · January 29, 2025 Acoustically probing biological tissues with light or sound, photoacoustic and ultrasound imaging can provide anatomical, functional, and/or molecular information at depths far beyond the optical diffusion limit. However, most photoacoustic and ultrasound ... Full text Link to item Cite

Intergenerational metabolic toxicity of perfluorooctanesulfonic acid exposure in adult offspring rats: a multi-omics approach.

Journal Article Front Endocrinol (Lausanne) · 2025 INTRODUCTION: Perfluorooctane sulfonate (PFOS), known as a critical endocrine disruptor, was linked to potential intergenerational effect in population studies. Yet, the toxic metabolic mechanisms remain unclear, particularly at relatively low PFOS concent ... Full text Link to item Cite

Unraveling the long-term gastrointestinal impact of perinatal perfluorobutane sulfonate exposure on rat offspring: Intestinal barrier dysfunction and Th17/Treg imbalance.

Journal Article Sci Total Environ · December 10, 2024 Per- and polyfluoroalkyl substances (PFAS), especially long-chain perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are increasingly acknowledged as a potential inflammatory bowel diseases (IBD) risk factor. Perfluorobutane sulfonate (PFB ... Full text Link to item Cite

Whole mount preparation and analysis of rabbit mammary gland.

Journal Article Reprod Toxicol · December 2024 The mammary gland undergoes dynamic structural and compositional changes throughout life, influenced significantly by hormonal fluctuations and environmental factors. From embryonic development through menopause, this tissue adapts to accommodate phases su ... Full text Link to item Cite

Perinatal exposure to perfluorooctane sulfonate and the risk of hepatic inflammation in rat offspring: Perturbation of gut-liver crosstalk.

Journal Article Environ Res · October 15, 2024 Perfluorooctane sulfonate (PFOS) exposure is associated with harmful hepatic outcomes. Growing evidence indicates that crosstalk between the gut microbiome, immune system, and liver plays a vital role in the pathogenesis of liver diseases. However, the und ... Full text Link to item Cite

Investigating the Bidirectional Association of Rheumatoid Arthritis and Thyroid Function: A Methodologic Assessment of Mendelian Randomization.

Journal Article Arthritis Care Res (Hoboken) · August 2024 OBJECTIVE: Rheumatoid arthritis (RA) and thyroid dysfunction are frequently observed in the same patient. However, whether they co-occur or exhibit a causal relationship remains uncertain. We aimed to systematically investigate the causal relationship betw ... Full text Link to item Cite

Depletion of placental brain-derived neurotrophic factor (BDNF) is attributed to premature ovarian insufficiency (POI) in mice offspring.

Journal Article J Ovarian Res · July 9, 2024 INTRODUCTION: Premature ovarian insufficiency (POI) is one of the causes of female infertility. Unexplained POI is increasingly affecting women in their reproductive years. However, the etiology of POI is diverse and remains elusive. We and others have sho ... Full text Link to item Cite

Multi-omics reveal disturbance of glucose homeostasis in pregnant rats exposed to short-chain perfluorobutanesulfonic acid.

Journal Article Ecotoxicol Environ Saf · June 15, 2024 Perfluorobutanesulfonic acid (PFBS), a short-chain alternative to perfluorooctanesulfonic acid (PFOS), is widely used in various products and is increasingly present in environmental media and human bodies. Recent epidemiological findings have raised conce ... Full text Link to item Cite

Longitudinal intravital imaging of mouse placenta.

Journal Article Sci Adv · March 22, 2024 Studying placental functions is crucial for understanding pregnancy complications. However, imaging placenta is challenging due to its depth, volume, and motion distortions. In this study, we have developed an implantable placenta window in mice that enabl ... Full text Open Access Link to item Cite

Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.

Journal Article Sci Total Environ · March 20, 2024 Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants ubiquitous in the environment and humans. In-utero PFAS exposure is associated with numerous adverse health impacts. However, little is known about how prenatal PFAS mixture expos ... Full text Open Access Link to item Cite

Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile.

Journal Article Sci Total Environ · February 20, 2024 Ambient fine particular matter (PM2.5) exposure has been associated with numerous adverse effects including triggering functional disorders of the placenta and inducing immune imbalance in offspring. However, how maternal PM2.5 exposure impacts immune deve ... Full text Link to item Cite

Progesterone receptor membrane component 2 is critical for human placental extravillous trophoblast invasion.

Journal Article Biol Reprod · November 15, 2023 Proper extravillous trophoblast invasion is essential for normal placentation and pregnancy. However, the molecular mechanisms by which cytotrophoblasts differentiate into extravillous trophoblast are unclear. We discovered that in the first-trimester plac ... Full text Link to item Cite

Early life exposure to low-dose perfluorooctane sulfonate disturbs gut barrier homeostasis and increases the risk of intestinal inflammation in offspring.

Journal Article Environ Pollut · July 15, 2023 Perfluorooctane sulfonate (PFOS), one of the legacy per- and poly-fluoroalkyl substances (PFAS), is associated with multiple adverse health effects on children. However, much remains to be known about its potential impacts on intestinal immune homeostasis ... Full text Link to item Cite

Effects of maternal urban particulate matter SRM 1648a exposure on birth outcomes and offspring growth in mice.

Journal Article Environ Geochem Health · May 2023 The association between exposure to particulate matter (PM) during pregnancy and abnormal birth outcomes is still inconclusive. This study aims to provide more evidence for this public health concern by investigating birth outcomes and the growth of offspr ... Full text Link to item Cite

BDNF promotes mouse follicular development and reverses ovarian aging by promoting cell proliferation.

Journal Article J Ovarian Res · April 27, 2023 BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in ovarian function including follicle development and oocyte maturation, and embryonic development. However, whether BDNF treatment can reimpose ovarian aging and impaired fertil ... Full text Link to item Cite

Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.

Journal Article Toxicol Sci · February 17, 2023 Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal and i ... Full text Link to item Cite

Disrupted metabolic signatures in amniotic fluid associated with increased risk of intestinal inflammation in cesarean section offspring.

Journal Article Front Immunol · 2023 INTRODUCTION: Children born by cesarean section (CS) are at a greater risk of inflammatory bowel disease (IBD). However, the mechanisms underlying the association are not yet well understood. Herein, we investigated the impact of CS delivery on colonic inf ... Full text Link to item Cite

Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.

Journal Article Sci Total Environ · September 10, 2022 Mixtures of per- and polyfluoroalkyl substances (PFAS) are often found in drinking water, and serum PFAS are detected in up to 99% of the population. However, very little is known about how exposure to mixtures of PFAS affects maternal and fetal health. Th ... Full text Link to item Cite

Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.

Journal Article Elife · June 7, 2022 TMEM16F, a Ca2+-activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization, however, how TMEM16F is activated during cell fusion is unclear. Here, using troph ... Full text Open Access Link to item Cite

Maternal urban particulate matter exposure and signaling pathways in fetal brains and neurobehavioral development in offspring.

Journal Article Toxicology · May 30, 2022 It is well understood that exposure to particulate matter (PM) can have adverse effects on the nervous system. When pregnant women are exposed to PM, their fetuses are also affected through the placenta. However, the mechanisms by which fetal brain develop ... Full text Link to item Cite

Transcriptomics integrated with metabolomics reveals the effect of Bisphenol F (BPF) exposure on intestinal inflammation.

Journal Article Sci Total Environ · April 10, 2022 As a viable alternative to Bisphenol A (BPA), Bisphenol F (BPF) has been detected in humans at comparable concentrations and detection frequencies. Emerging evidence reveals that BPF induces intestinal toxicity. However, less information is available conce ... Full text Link to item Cite

Low-dose aspirin prevents LPS-induced preeclampsia-like phenotype via AQP-1 and the MAPK/ERK 1/2 pathway.

Journal Article Placenta · April 2022 INTRODUCTION: Clinical studies suggest that early pregnancy is the critical window for the prevention of preeclampsia by low-dose aspirin (LDA). Abnormal extravillous trophoblast (EVT) cell invasion and spiral artery remodeling during early placentation ha ... Full text Link to item Cite

Effects of triclosan exposure on placental extravillous trophoblast motility, relevant IGF2/H19 signaling and DNA methylation-related enzymes of HTR-8/SVneo cell line

Journal Article Ecotoxicology and Environmental Safety · December 25, 2021 Triclosan (TCS) is an antimicrobial agent widely used in personal care products and a potential endocrine disruptor chemical (EDC). TCS can pass through the placental barrier. Any influence of EDCs on epigenetic changes of placenta and embryo may bring pro ... Full text Cite

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses.

Journal Article Cell Rep Med · July 20, 2021 Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1 env gene from 12 in utero transmissio ... Full text Link to item Cite

Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage.

Journal Article NPJ Biofilms Microbiomes · March 17, 2021 A dysregulation of cytokine networks has been suggested to be involved in the pathogenesis of unexplained pregnancy loss. Gut microbiota affects host immune response and induces an imbalance in cytokine levels. However, how gut microbial dysbiosis disturbs ... Full text Link to item Cite

Triglyceride Induced Metabolic Inflammation: Potential Connection of Insulin Resistance and Recurrent Pregnancy Loss.

Journal Article Front Endocrinol (Lausanne) · 2021 The underlying correlative mechanisms between Insulin resistance (IR) and recurrent pregnancy loss (RPL) in patients without polycystic ovarian syndrome (PCOS) remain inconclusive. To investigate the association between triglyceride (TG) levels, lymphocyte ... Full text Link to item Cite

Exposure to Perfluoroalkyl Substances During Pregnancy and Fetal BDNF Level: A Prospective Cohort Study.

Journal Article Front Endocrinol (Lausanne) · 2021 BACKGROUND: Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect fetal neurodevelopment. Brain-derived neurotrophic factor (BDNF) is an important factor in neurodevelopment, but its role in PFAS-induced neurotoxicit ... Full text Link to item Cite

Perfluoroalkyl and Polyfluoroalkyl substance exposure and association with sex hormone concentrations: Results from the NHANES 2015-2016.

Journal Article Environ Sci Eur · 2021 BACKGROUND: There is increasing global concern regarding the health impacts of perfluoroalkyl and polyfluoroalkyl substances (PFAS), which are emerging environmental endocrine disruptors. Results from previous epidemiological studies on the associations be ... Full text Link to item Cite

Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast.

Journal Article Front Endocrinol (Lausanne) · 2021 BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that have become globally ubiquitous in humans and the environment. In utero PFAS exposure is associated with neurodevelopmental effects; however, the mechanism is poo ... Full text Link to item Cite

Exposure to perfluorobutane sulfonate and perfluorooctanesulfonic acid disrupts the production of angiogenesis factors and stress responses in human placental syncytiotrophoblast.

Journal Article Reprod Toxicol · December 2020 Poly- and per-fluoroalkyl substances (PFAS) have attracted widespread attention in recent years due to their bioaccumulation, toxicity, and ubiquitous nature. We and others have reported that maternal exposure to PFAS is associated with adverse birth outco ... Full text Link to item Cite

Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.

Journal Article FASEB J · November 2020 We reported that maternal PFBS, an emerging pollutant, exposure is positively associated with preeclampsia which can result from aberrant trophoblasts invasion and subsequent placental ischemia. In this study, we investigated the effects of PFBS on trophob ... Full text Link to item Cite

Perfluoroalkyl and polyfluroalkyl substances and maternal thyroid hormones in early pregnancy.

Journal Article Environ Pollut · September 2020 BACKGROUND: The development of the embryo and fetal brain depends on maternal transfer of thyroid hormones (THs) in early pregnancy. Perfluoroalkyl and polyfluoralkyl substances (PFAS) may disrupt maternal TH homeostasis in pregnancy, but findings from epi ... Full text Link to item Cite

Perfluoroalkyl substances exposure in early pregnancy and preterm birth in singleton pregnancies: a prospective cohort study.

Journal Article Environ Health · June 3, 2020 BACKGROUND: Preterm birth (PTB, < 37 completed weeks' gestation) is one of the global public health concerns. Epidemiologic evidence on the potential impact of perfluoroalkyl substances (PFAS) on PTB is still limited and inconsistent. We aimed to investiga ... Full text Link to item Cite

Perfluoroalkyl substances in early pregnancy and risk of hypertensive disorders of pregnancy: A prospective cohort study.

Journal Article Environ Int · May 2020 BACKGROUND: Perfluoroalkyl substances (PFASs) were reported to be associated with hypertensive disorders of pregnancy (HDP) but the results were inconsistent and prospective data are scarce. We aimed to examine these associations in a large prospective bir ... Full text Link to item Cite

TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.

Journal Article Sci Adv · May 2020 Cell-cell fusion or syncytialization is fundamental to the reproduction, development, and homeostasis of multicellular organisms. In addition to various cell type-specific fusogenic proteins, cell surface externalization of phosphatidylserine (PS), a unive ... Full text Link to item Cite

Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.

Journal Article Genet Test Mol Biomarkers · April 2020 Aims: Cervical cancer is the second most common cause of cancer-related deaths in developing nations. Human papillomavirus prophylactic vaccines are not widely available, and there are shortages of gynecologists and cytologists in the already overburdened ... Full text Link to item Cite

Association between triclocarban and triclosan exposures and the risks of type 2 diabetes mellitus and impaired glucose tolerance in the National Health and Nutrition Examination Survey (NHANES 2013-2014).

Journal Article Environ Int · March 2020 BACKGROUND: There has been increasing interest in the concept that exposure to environmental chemicals may be contributing factors to epidemics of diabetes mellitus (DM). Triclocarban and triclosan (TCs) are synthetic antibacterial chemicals that are widel ... Full text Link to item Cite

Functional Genomics of Healthy and Pathological Fetal Membranes.

Journal Article Front Physiol · 2020 Premature preterm rupture of membranes (PPROM), rupture of fetal membranes before 37 weeks of gestation, is the leading identifiable cause of spontaneous preterm births. Often there is no obvious cause that is identified in a patient who presents with PPRO ... Full text Link to item Cite

Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells.

Journal Article Front Physiol · 2020 Preterm premature rupture of membranes is a leading cause of preterm births. Cytokine induced matrix metalloproteinase1 and interleukin 8 production from amnion mesenchymal cells may contribute to fetal membrane weakening and rupture. Progestins inhibit in ... Full text Link to item Cite

Preterm Birth in China Between 2015 and 2016.

Journal Article Am J Public Health · November 2019 Objectives. To describe the incidence, risk factors, and potential causes of preterm birth (PTB) in China between 2015 and 2016.Methods. The China Labor and Delivery Survey was a population-based multicenter study conducted from 2015 to 2016. We assigned e ... Full text Link to item Cite

Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells.

Journal Article Reprod Sci · September 2019 Progestins have been recommended for preterm birth prevention in high-risk women; however, their mechanism of action still remains an area of debate. Medroxyprogesterone acetate (MPA) has previously been shown to significantly inhibit tumor necrosis factor ... Full text Link to item Cite

Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery.

Journal Article Environ Int · September 2019 BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt the thyroid function. But epidemiological evidence on the association between PFAS and thyroid hormone (TH) levels in cord blood is scarce and controversial. We ... Full text Link to item Cite

Is ELABELA a reliable biomarker for hypertensive disorders of pregnancy?

Journal Article Pregnancy Hypertens · July 2019 OBJECTIVE: We aimed to examine the ELABELA levels at different stages of pregnancy among normotensive controls and women with hypertensive disorders of pregnancy (HDP). STUDY DESIGN: A total of 336 blood samples of 169 women were collected from pre-pregnan ... Full text Link to item Cite

Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells.

Journal Article Reprod Sci · March 2019 INTRODUCTION: Oxidative stress-mediated fetal membrane cell aging is activated prematurely in preterm premature rupture of membranes (PPROMs). The mechanism of this phenomenon is largely understudied. Progesterone receptor membrane component 1 (PGRMC1) has ... Full text Link to item Cite

Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2.

Journal Article FASEB J · February 2019 Preeclampsia leads to adverse outcomes for pregnant women. Bisphenol A (BPA) is an environmental endocrine disruptor and has been shown to be positively associated with increased risk of preeclampsia in human studies. We investigated whether BPA exposure c ... Full text Link to item Cite

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy.

Journal Article Environ Health · January 9, 2019 BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been reported to disrupt endocrine system and reproduction. However, epidemiological evidence on the association between PFAS and preeclampsia is inconsistent. We aimed to investigate th ... Full text Link to item Cite

Evidence of biomechanical and collagen heterogeneity in uterine fibroids.

Journal Article PLoS One · 2019 OBJECTIVE: Uterine fibroids (leiomyomas) are common benign tumors of the myometrium but their molecular pathobiology remains elusive. These stiff and often large tumors contain abundant extracellular matrix (ECM), including large amounts of collagen, and c ... Full text Link to item Cite

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Journal Article Am J Obstet Gynecol · January 2019 Full text Link to item Cite

Aspirin use during pregnancy and hypoxia-related placental pathology.

Journal Article Pregnancy Hypertens · October 2018 OBJECTIVE: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathologi ... Full text Link to item Cite

Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).

Journal Article Am J Obstet Gynecol · July 2018 BACKGROUND: Preterm premature rupture of membranes is a leading contributor to maternal and neonatal morbidity and death. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently preterm premat ... Full text Open Access Link to item Cite

Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study.

Journal Article Eur J Public Health · December 1, 2017 BACKGROUND: Although recent studies have indicated the potential adverse effects of maternal bisphenol A (BPA) exposure on pregnancy such as increasing the risk of pre-eclampsia, epidemiological evidence is limited. We aimed to evaluate the relationship be ... Full text Link to item Cite

Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin.

Journal Article Reprod Sci · August 2017 OBJECTIVE: Thrombin (Thr) generation at the uteroplacental interface induces inflammation and weakens fetal membranes. Tissue factor (TF) is a powerful procoagulant that is increased by Thr in decidual cells (DCs). The TF expression may play an important r ... Full text Link to item Cite

Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study.

Journal Article Environ Health Perspect · June 27, 2017 BACKGROUND: Triclosan (TCS) is a synthetic antibacterial chemical widely used in personal care products. TCS exposure has been associated with decreased thyroid hormone levels in animals, but human studies are scarce and controversial. OBJECTIVE: We evalua ... Full text Link to item Cite

A validated translation of a survey for measuring incontinence knowledge in Chinese-speaking American immigrants.

Journal Article Int Urogynecol J · June 2017 INTRODUCTION AND HYPOTHESIS: Urinary incontinence is common amongst Chinese immigrants. These women are a rapidly growing population in the USA who require unique assessment tools due to language barriers. Presently, there are no Chinese language surveys t ... Full text Link to item Cite

Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.

Journal Article Curr Protein Pept Sci · 2017 Utilizing both primary myometrial cells and a myometrial cell line, we show here that myometrial cells undergo transition to a myofibroblast-like phenotype after a biological insult of 72 hours serum starvation and serum add-back (SB: 1% to 10% FBS). We al ... Full text Link to item Cite

Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells.

Journal Article Reprod Sci · September 2016 Progesterone receptor membrane component 1 (PGRMC1) is an important novel mediator of progesterone (P4) function in fetal membrane cells. We demonstrated previously that PGRMC1 is differentially expressed in fetal membranes among pregnancy subjects and dim ... Full text Link to item Cite

Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System.

Journal Article Biol Reprod · May 2016 Preterm premature rupture of membranes (PPROM) is often associated with intra-amniotic inflammation and infection. Current understanding of the pathogenesis of PPROM includes activation of pro-inflammatory cytokines and proteolytic enzymes leading to compr ... Full text Link to item Cite

341: Novel ex vivo system to evaluate inflammation of gestational membranes in response to U. parvum

Conference American Journal of Obstetrics and Gynecology · January 2016 Full text Cite

The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection.

Journal Article PLoS One · 2016 Ureaplasma parvum (U. parvum) is gaining recognition as an important pathogen for chorioamnionitis and preterm premature rupture of membranes. We aimed to investigate the roles of progesterone (P4) and a novel progesterone receptor, progesterone receptor m ... Full text Link to item Cite

Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai.

Journal Article J Environ Public Health · 2016 Flame retardants are widely used in consumer products to reduce their flammability. Previously used flame retardants have been sequentially banned due to their environmental and human toxicity. Currently, tris(1,3-dichloropropyl) phosphate (TDCIPP) and tri ... Full text Open Access Link to item Cite

691: Evidence of PGRMC1 expression in cervical and vaginal epithelial cells during pregnancy

Conference American Journal of Obstetrics and Gynecology · January 2016 Full text Cite

13: Inhibition of toll-like receptors and inflammatory response in primary chorion cells

Conference American Journal of Obstetrics and Gynecology · December 2015 Full text Cite

The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro.

Journal Article Anesth Analg · May 2015 BACKGROUND: Current treatment modalities for preventing preterm premature rupture of membranes are limited, but progestins may play a role. Tumor necrosis factor α (TNFα) enhances matrix metalloproteinase-9 (MMP-9) gene expression and activity in fetal mem ... Full text Link to item Cite

Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions.

Journal Article Placenta · August 2014 INTRODUCTION: Prepregnancy obesity is associated with increased morbidity and mortality for mother and offspring. The objective of our study is to estimate the effect of maternal prepregnancy weight on placental pathological lesions.. METHODS: Data used fo ... Full text Link to item Cite

Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM).

Journal Article Placenta · May 2014 PGRMC1 function is implicated in maintaining fetal membrane (FM) integrity. PGRMC1 was detectable primarily in the cytoplasm of FM cells and was actively regulated in FMs and relevant for PGRMC1-mediated progesterone action. By cell type, PGRMC1 expression ... Full text Link to item Cite

Progesterone receptor membrane component 1 as the mediator of the inhibitory effect of progestins on cytokine-induced matrix metalloproteinase 9 activity in vitro.

Journal Article Reprod Sci · February 2014 Progesterone (P4) and the progestin, 17α-hydroxyprogesterone caproate, are clinically used to prevent preterm births (PTBs); however, their mechanism of action remains unclear. Cytokine-induced matrix metalloproteinase 9 (MMP-9) activity plays a key role i ... Full text Link to item Cite

Bacteria localization and chorion thinning among preterm premature rupture of membranes.

Journal Article PLoS One · 2014 OBJECTIVE: Bacterial colonization of the fetal membranes and its role in pathogenesis of membrane rupture is poorly understood. Prior retrospective work revealed chorion layer thinning in preterm premature rupture of membranes (PPROM) subjects. Our objecti ... Full text Open Access Link to item Cite

791: Immunohistochemical distribution of toll-like receptors in human fetal membranes

Conference American Journal of Obstetrics and Gynecology · January 2014 Full text Cite

Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.

Journal Article Reprod Sci · January 2014 Smoking in pregnancy reduces preeclampsia risk, but the mechanism of this effect is unknown. Prior studies have demonstrated that women with preeclampsia have lower placental adrenomedullin (AM) expression, and cigarette smoke extract (CSE) treatment of pl ... Full text Link to item Cite

The influence of maternal body mass index on myometrial oxytocin receptor expression in pregnancy.

Journal Article Reprod Sci · December 2013 Obese pregnant women have higher rates of dysfunctional labor patterns, need for oxytocin augmentation, labor induction, postdates pregnancy, and cesarean delivery compared to normal weight pregnant women. We tested the hypothesis that myometrial oxytocin ... Full text Link to item Cite

The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes.

Journal Article Reprod Sci · October 2013 Preterm premature rupture of the membranes (PPROM) is an important etiology of preterm birth and source of significant neonatal morbidity. We propose that PPROM occurs in the setting of long-standing altered tissue remodeling, which creates a vulnerable en ... Full text Link to item Cite

The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin.

Journal Article Reprod Sci · May 2012 We tested the hypothesis that cigarette smoke extract (CSE) leads to differences in expression of genes involved in angiogenesis and affects cell viability and migration in a first-trimester cytotrophoblast cell line (HTR-8/SVneo). HTR-8/SVneo cells were t ... Full text Link to item Cite

523: The effect of progesterone on TNF-α induced MMP 9 activity in human fetal membranes

Conference American Journal of Obstetrics and Gynecology · January 2012 Full text Cite

CDB-4124 does not cause apoptosis in cultured fibroid cells.

Journal Article Reprod Sci · September 2011 OBJECTIVE: Selective progesterone receptor modulators (SPRMs), such as asoprisnil (J867) and ulipristal (CDB-2914), have been shown to reduce fibroid volume in vivo and to induce apoptosis in vitro. CDB-4124 (telapristone), a SPRM with different side group ... Full text Link to item Cite

β-Arrestin mediates oxytocin receptor signaling, which regulates uterine contractility and cellular migration.

Journal Article Am J Physiol Endocrinol Metab · March 2011 Desensitization of the oxytocin receptor (OXTR) in the setting of prolonged oxytocin exposure may lead to dysfunctional labor, which increases the risk for cesarean delivery, and uterine atony, which may result in postpartum hemorrhage. The molecular mecha ... Full text Link to item Cite

318: Oxytocin receptor expression in uterine myometrium is not influenced by body mass index

Conference American Journal of Obstetrics and Gynecology · January 2011 Full text Cite

Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells.

Journal Article Proc Natl Acad Sci U S A · April 6, 2010 Topoisomerase IIIalpha (topo IIIalpha), a member of the conserved Type IA subfamily of topoisomerases, is required for the cell proliferation in mitotic tissues, but has a lesser effect on DNA endoreplication. The top3alpha gene encodes two forms of protei ... Full text Link to item Cite

Proellex Does Not Cause Apoptosis in Cultured Fibroid Cells.

Conference REPRODUCTIVE SCIENCES · March 1, 2010 Link to item Cite

Sample size calculation for microarray experiments with blocked one-way design.

Journal Article BMC Bioinformatics · May 28, 2009 BACKGROUND: One of the main objectives of microarray analysis is to identify differentially expressed genes for different types of cells or treatments. Many statistical methods have been proposed to assess the treatment effects in microarray experiments. R ... Full text Link to item Cite

Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.

Journal Article Dev Biol · November 1, 2008 Members of the RecQ family play critical roles in maintaining genome integrity. Mutations in human RecQL4 cause a rare genetic disorder, Rothmund-Thomson syndrome. Transgenic mice experiments showed that the RecQ4 null mutant causes embryonic lethality. Al ... Full text Link to item Cite

Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.

Journal Article Reprod Sci · December 2007 Uterine fibroids are composed of altered collagen fibrils and represent an arrested response to injury-initiating fibrosis. In many tissues, TSP-1 is secreted by adult macrophages and monocytes upon wounding and is involved in the activation of transformin ... Full text Link to item Cite

Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death.

Journal Article Am J Obstet Gynecol · March 2007 OBJECTIVE: The purpose of this study was to determine whether progesterone exerts a protective effect in chorion and decidua cells when exposed to calcimycin. STUDY DESIGN: Fetal membrane samples were collected from term elective repeat cesarean deliveries ... Full text Link to item Cite

Characterization of progesterone receptor isoform expression in fetal membranes.

Journal Article Am J Obstet Gynecol · October 2006 OBJECTIVE: To quantify expression of progesterone receptor (PR) messenger RNA (mRNA) isoforms in fetal membranes, and to determine whether these levels change in culture. STUDY DESIGN: Placentas from women undergoing term cesarean delivery before labor wer ... Full text Link to item Cite

Characterization of progesterone receptor isoform expression in fetal membranes

Conference American Journal of Obstetrics and Gynecology · December 2005 Full text Cite

Self-assembled DNA structures for nanoconstruction

Conference DNA-BASED MOLECULAR ELECTRONICS · January 1, 2004 Link to item Cite

Parallel molecular computations of pairwise exclusive-or (XOR) using DNA "string tile" self-assembly.

Journal Article J Am Chem Soc · November 26, 2003 Self-assembling DNA nanostructures are an efficient means of executing parallel molecular computations. However, previous experimental demonstrations of computations by DNA tile self-assembly only allowed for one set of distinct input to be processed at a ... Full text Link to item Cite

A two-state DNA lattice switched by DNA nanoactuator.

Journal Article Angew Chem Int Ed Engl · September 22, 2003 Full text Link to item Cite

Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices.

Journal Article Proc Natl Acad Sci U S A · July 8, 2003 The programmed self-assembly of patterned aperiodic molecular structures is a major challenge in nanotechnology and has numerous potential applications for nanofabrication of complex structures and useful devices. Here we report the construction of an aper ... Full text Link to item Cite

Overview of new structures for DNA-Based nanofabrication and computation

Conference PROCEEDINGS OF THE 7TH JOINT CONFERENCE ON INFORMATION SCIENCES · January 1, 2003 Link to item Cite