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Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.

Publication ,  Journal Article
Marchese, MJ; Zhu, T; Hawkey, AB; Wang, K; Yuan, E; Wen, J; Be, SE; Levin, ED; Feng, L
Published in: Sci Total Environ
March 20, 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants ubiquitous in the environment and humans. In-utero PFAS exposure is associated with numerous adverse health impacts. However, little is known about how prenatal PFAS mixture exposure affects offspring's neurobehavioral function. This study aims to determine the causal relationship between in-utero PFAS mixture exposure and neurobehavioral changes in Sprague-Dawley rat offspring. Dams were exposed via drinking water to the vehicle (control), an environmentally relevant PFAS mixture, or a high-dose PFAS mixture. The environmentally relevant mixture was formulated to resemble measured tap water levels in Pittsboro, NC, USA (10 PFAS compounds; sum PFAS =758.6 ng/L). The high-dose PFAS load was 3.8 mg/L (5000×), within the range of exposures in the experimental literature. Exposure occurred seven days before mating until birth. Following exposure to PFAS-laden water or the vehicle during fetal development, neurobehavioral toxicity was assessed in male and female offspring with a battery of motor, cognitive, and affective function tests as juveniles, adolescents, and adults. Just before weaning, the environmentally relevant exposure group had smaller anogenital distances compared to the vehicle and high-dose groups on day 17, and males in the environmentally relevant exposure group demonstrated lower weights than the high-dose group on day 21 (p < 0.05). Reflex development delays were seen in negative geotaxis acquisition for both exposure groups compared to vehicle-exposed controls (p = 0.009). Our post-weaning behavioral measures of anxiety, depression, and memory were not found to be affected by maternal PFAS exposure. In adolescence (week five) and adulthood (week eight), the high PFAS dose significantly attenuated typical sex differences in locomotor activity. Maternal exposure to an environmentally relevant PFAS mixture produced developmental delays in the domains of pup weight, anogenital distance, and reflex acquisition for rat offspring. The high-dose PFAS exposure significantly decreased typical sex differences in locomotor activity.

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Published In

Sci Total Environ

DOI

EISSN

1879-1026

Publication Date

March 20, 2024

Volume

917

Start / End Page

170459

Location

Netherlands

Related Subject Headings

  • Reproduction
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Male
  • Humans
  • Fluorocarbons
  • Female
  • Environmental Sciences
 

Citation

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ICMJE
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Marchese, M. J., Zhu, T., Hawkey, A. B., Wang, K., Yuan, E., Wen, J., … Feng, L. (2024). Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ, 917, 170459. https://doi.org/10.1016/j.scitotenv.2024.170459
Marchese, Melissa J., Tianyi Zhu, Andrew B. Hawkey, Katherine Wang, Emi Yuan, Jinchen Wen, Sara E. Be, Edward D. Levin, and Liping Feng. “Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.Sci Total Environ 917 (March 20, 2024): 170459. https://doi.org/10.1016/j.scitotenv.2024.170459.
Marchese MJ, Zhu T, Hawkey AB, Wang K, Yuan E, Wen J, et al. Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ. 2024 Mar 20;917:170459.
Marchese, Melissa J., et al. “Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.Sci Total Environ, vol. 917, Mar. 2024, p. 170459. Pubmed, doi:10.1016/j.scitotenv.2024.170459.
Marchese MJ, Zhu T, Hawkey AB, Wang K, Yuan E, Wen J, Be SE, Levin ED, Feng L. Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development. Sci Total Environ. 2024 Mar 20;917:170459.
Journal cover image

Published In

Sci Total Environ

DOI

EISSN

1879-1026

Publication Date

March 20, 2024

Volume

917

Start / End Page

170459

Location

Netherlands

Related Subject Headings

  • Reproduction
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Male
  • Humans
  • Fluorocarbons
  • Female
  • Environmental Sciences