Skip to main content

Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

Publication ,  Journal Article
Juang, T; Stauffer, PR; Craciunescu, OA; Maccarini, PF; Yuan, Y; Das, SK; Dewhirst, MW; Inman, BA; Vujaskovic, Z
Published in: Int J Hyperthermia
May 2014

PURPOSE: The aim of this paper is to report thermal dosimetry characteristics of external deep regional pelvic hyperthermia combined with intravesical mitomycin C (MMC) for treating bladder cancer following transurethral resection of bladder tumour, and to use thermal data to evaluate reliability of delivering the prescribed hyperthermia dose to bladder tissue. MATERIALS AND METHODS: A total of 14 patients were treated with MMC and deep regional hyperthermia (BSD-2000, Sigma Ellipse or Sigma 60). The hyperthermia objective was 42° ± 2 °C to bladder tissue for ≥40 min per treatment. Temperatures were monitored with thermistor probes and recorded values were used to calculate thermal dose and evaluate treatment. Anatomical characteristics were examined for possible correlations with heating. RESULTS: Combined with BSD-2000 standard treatment planning and patient feedback, real-time temperature monitoring allowed thermal steering of heat sufficient to attain the prescribed thermal dose to bladder tissue within patient tolerance in 91.6% of treatments. Mean treatment time for bladder tissue >40 °C was 61.9 ± 11.4 min and mean thermal dose was 21.3 ± 16.5 CEM43. Average thermal doses obtained in normal tissues were 1.6 ± 1.2 CEM43 for the rectum and 0.8 ± 1.3 CEM43 in superficial normal tissues. No significant correlation was seen between patient anatomical characteristics and thermal dose achieved in bladder tissue. CONCLUSIONS: This study demonstrates that a hyperthermia prescription of 42° ± 2 °C for 40-60 min can be delivered safely to bladder tissue with external radiofrequency phased array applicators for a typical range of patient sizes. Using the available thermometry and treatment planning, the BSD-2000 hyperthermia system was shown to be an effective method of focusing heat regionally around the bladder with good patient tolerance.

Duke Scholars

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

May 2014

Volume

30

Issue

3

Start / End Page

176 / 183

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tomography, X-Ray Computed
  • Patient Satisfaction
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Hyperthermia, Induced
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Juang, T., Stauffer, P. R., Craciunescu, O. A., Maccarini, P. F., Yuan, Y., Das, S. K., … Vujaskovic, Z. (2014). Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia, 30(3), 176–183. https://doi.org/10.3109/02656736.2014.898338
Juang, Titania, Paul R. Stauffer, Oana A. Craciunescu, Paolo F. Maccarini, Yu Yuan, Shiva K. Das, Mark W. Dewhirst, Brant A. Inman, and Zeljko Vujaskovic. “Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.Int J Hyperthermia 30, no. 3 (May 2014): 176–83. https://doi.org/10.3109/02656736.2014.898338.
Juang T, Stauffer PR, Craciunescu OA, Maccarini PF, Yuan Y, Das SK, et al. Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia. 2014 May;30(3):176–83.
Juang, Titania, et al. “Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.Int J Hyperthermia, vol. 30, no. 3, May 2014, pp. 176–83. Pubmed, doi:10.3109/02656736.2014.898338.
Juang T, Stauffer PR, Craciunescu OA, Maccarini PF, Yuan Y, Das SK, Dewhirst MW, Inman BA, Vujaskovic Z. Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia. 2014 May;30(3):176–183.

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

May 2014

Volume

30

Issue

3

Start / End Page

176 / 183

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tomography, X-Ray Computed
  • Patient Satisfaction
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Hyperthermia, Induced
  • Humans
  • 3202 Clinical sciences
  • 1103 Clinical Sciences