Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.

Journal Article (Journal Article)

Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.

Full Text

Duke Authors

Cited Authors

  • McDonald, SL; Hendrick, CE; Wang, Q

Published Date

  • April 2014

Published In

Volume / Issue

  • 53 / 18

Start / End Page

  • 4667 - 4670

PubMed ID

  • 24668522

Pubmed Central ID

  • PMC4668583

Electronic International Standard Serial Number (EISSN)

  • 1521-3773

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/anie.201311029


  • eng