Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation.
Journal Article (Journal Article)
Direct amination of heteroarenes and arenes has been achieved in a one-pot CH zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using CH amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines.
Full Text
Duke Authors
Cited Authors
- McDonald, SL; Hendrick, CE; Wang, Q
Published Date
- April 2014
Published In
Volume / Issue
- 53 / 18
Start / End Page
- 4667 - 4670
PubMed ID
- 24668522
Pubmed Central ID
- PMC4668583
Electronic International Standard Serial Number (EISSN)
- 1521-3773
International Standard Serial Number (ISSN)
- 1433-7851
Digital Object Identifier (DOI)
- 10.1002/anie.201311029
Language
- eng