Cryptococcosis: a model for the understanding of infectious diseases.

Journal Article (Journal Article)

The increase in immunosuppressed patient populations has correlated with a rise in clinical fungal infections, including cryptococcosis. Patient outcome following Cryptococcus infection is linked to initial fungal burden in cerebrospinal fluid (CSF) and fungal clearance following treatment; however, the role of the pathogen in disease prognosis is poorly defined. In this issue of the JCI, Sabiiti and colleagues have directly correlated phenotypic traits of Cryptococcus neoformans with clinical outcome of infected patients. A better understanding of both the host and pathogen contributions to disease etiology will provide more options for targeted treatment strategies.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR

Published Date

  • May 2014

Published In

Volume / Issue

  • 124 / 5

Start / End Page

  • 1893 - 1895

PubMed ID

  • 24743152

Pubmed Central ID

  • PMC4001560

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI75241


  • eng

Conference Location

  • United States